Ideal Wound Dressing Research Articles

A COMPREHENSIVE REVIEW ON WOUND DRESSING USAGE IN CLINICAL SETTINGS

Wound repair is a complex phenomenon of dermal and epidermal tissue regeneration, consisting of several phases including haemostasis, inflammation, migration, proliferation, and remodelling. The wound management procedures have evolved from ancient times that used honey, plant fibres, and animal fats to biopolymers. With the emergence of modern wound dressings, the wound healing process has been accelerated with extraordinary properties of dressing material. The dressings material contacts with the wound and provides optimal conditions, for example, moist environment, absorption of excessive exudates, and permeability to gaseous exchange, etc., for healing. The main purpose of dressing is to stop the bleeding, prevention of exsanguination, protection from infection, and renewal of function. With the myriad of dressing types available in the clinical settings such as hydrogels, hydrocolloids, alginates, and anti-microbial-impregnated dressing, etc., the understanding behind the usage of a particular dressing for a specific wound type remains conjectural. In this comprehensive review, we first discussed the wound repair process in brief followed by wound dressing, characteristics of ideal wound dressing, and its categorization. This review aims to provide a state-of-the-art overview of different aspects of wound dressing type contributing to the effective treatment of particular skin wounds.

Emerging Trend of Thiolated Polymers/materials and nanomedicine in wound healing

Antimicrobial therapy failure against wound infections and arise of extended resistance highly encourages the discovery of novel mechanisms to overcome underlying issues. Major causative agent for causing wound infection is “Staphylococcus aureus” and recent medications lack antibacterial action,mucoadhesion and patient compliance. Thiolation proves itself as a novel technique for treatment of wound infections via topical application. Thiomers possesses features such as higher porosity, bio degradation, and swelling index. Thiolated products are resistant to the harsh environmental changes. Similarly, with the advancements in drug delivery, various smart drug delivery techniques lead to enhancement in drug delivery. Nano particles allow the drugs to penetrate the cells by diffusion or energy dependent process and degrade themselves at specified siteof action by either attachment of recognition ligands or responsive stimuli. Overall, the Thiolated polymers and Nano medicines depicted potential to cure wounds with increased severity meeting the required features of an ideal wound dressing.

In situ wound sprayable double-network hydrogel: Preparation and characterization

In clinical settings the wound-dressing was required easy to use and can match the wound area immediately, at the same time they need to have the properties of hemostats, anti-inflammation and promoting wound healing. To get an ideal wound dressing, we developed a type of gel-like wound adhesive patch from spraying double-network hydrogel, which own the properties of self-antibacterial and can promote wound healing. By spraying, the gel-like wound adhesive patch can match the wound area immediately and form a gel-film in 10 s. Sodium carboxymethyl cellulose as pH sensitive materials accelerated the speed to form the gel-film and enhanced ductility of the wound adhesive patch. In vitro experiments show that, this gel-like wound adhesive patch can promote cell proliferation and reduce cell apoptosis. In vivo studies show that, compared with commercialized wound dressings in clinic using, the spraying gel-like wound adhesive patch from our work has a better effect on wound healing. In conclusion, the spraying gel-like wound patch in our work is easy to use and can form a gel-film match on wound area in a short time, also it has the properties of hemostats, anti-inflammation and promoting wound healing. Its feasibility for mass production shows a good potential for commercial use.

A collagen-based bi-layered composite dressing for accelerated wound healing

Aim of the studyThe aim of the study was to fabricate collagen-based composite dressings, evaluate the efficiency for wound healing and reveal the mechanism of promoting wound healing. Materials and methodsAn innovative bi-layered composite wound dressing was developed using two marine biomacromolecules (collagen and chitosan). Full-thickness skin defect model was performed to evaluate the wound healing activity in vivo. The levels of inflammatory cytokines including tumor necrosis factor alpha (TNF-α), interleukin (IL-1, IL-6, IL-8) and growth factors like transforming growth factor beta (TGF-β), vascular epidermal growth factor (VEGF) and basic fibroblast growth factor (bFGF) were quantified by ELISA assays. The total amount of collagen was quantified by hydroxyproline content. The proliferation and viability of fibroblast cells cultured on collagen sponges were determined by CCK-8 assay. ResultsThe results of wound closure and histopathological analysis indicated that non-crosslinked collagen-based bi-layered composite dressing stimulated wound healing, accelerated re-epithelialization and accomplished wound healing within a time span of 28 days. The results of levels of inflammatory cytokines and growth factors showed that collagen-based composite dressings could reduce the inflammatory response and upregulate growth factors levels to accelerate the wound healing. The results of hydroxyproline content and CCK-8 assay indicated that collagen-based composite dressings could also promote collagen synthesis and fibroblasts viability and proliferation. ConclusionThe non-crosslinked collagen-based bi-layered composite dressing could be applied for an efficient and ideal wound dressing. Therefore, the findings provided the essential theoretical basis for the potential of collagen-based composite dressing applied in wound healing fields.

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings.

Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dressings suffer from various limitations, including poor antimicrobial activity, etc. Wound dressings that are formulated from biopolymers (e.g., cellulose, chitin, gelatin, chitosan, etc.) demonstrate interesting properties, such as good biocompatibility, non-toxicity, biodegradability, and attractive antimicrobial activity. Although biopolymer-based wound dressings display the aforementioned excellent features, they possess poor mechanical properties. Gelatin, a biopolymer has excellent biocompatibility, hemostatic property, reduced cytotoxicity, low antigenicity, and promotes cellular attachment and growth. However, it suffers from poor mechanical properties and antimicrobial activity. It is crosslinked with other polymers to enhance its mechanical properties. Furthermore, the incorporation of antimicrobial agents into gelatin-based wound dressings enhance their antimicrobial activity in vitro and in vivo. This review is focused on the development of hybrid wound dressings from a combination of gelatin and other polymers with good biological, mechanical, and physicochemical features which are appropriate for ideal wound dressings. Gelatin-based wound dressings are promising scaffolds for the treatment of infected, exuding, and bleeding wounds. This review article reports gelatin-based wound dressings which were developed between 2016 and 2021.

Enhanced blood coagulation and antibacterial activities of carboxymethyl-kappa-carrageenan-containing nanofibers

Ideal wound dressings should be biocompatible, exhibit high antibacterial activity, and promote blood coagulation. To impart these imperative functions, carboxymethyl-kappa-carrageenan was incorporated into poly(vinyl alcohol) nanofibers (PVA-CMKC). The antibacterial activity of the nanofibers was evaluated. Adsorption of two important blood proteins, fibrinogen and albumin, was also assessed. The adhesion and activation of platelets, and the clotting of whole blood were evaluated to characterize the ability of the nanofibers to promote hemostasis. Adhesion and morphology of both Staphylococcus aureus and Pseudomonas aeruginosa were evaluated using fluorescence microscopy and scanning electron microscopy. CMKC-containing nanofibers demonstrated significant increases in platelet adhesion and activation, percentage of coagulation in whole blood clotting test and fibrinogen adsorption, compared to PVA nanofibers, showing blood coagulation activity. Incorporating CMKC also reduces adhesion and viability of S. aureus and P. aeruginosa bacteria after 24 h of incubation. PVA-CMKC nanofibers show potential application as dressings for wound healing applications.

Swelling Behaviour and Water Vapour Transmission Rates of Gellan Gum/Collagen Film Containing Gatifloxacin as Dressing Materials

In an effort to produce ideal wound dressing, gellan gum/collagen hydrogel films containing different concentrations of gatifloxacin were prepared via evaporative casting method. The films were examined in terms of physical appearances, water uptake and water vapour transmission rate (WVTR). All the films showed good physical appearances. Swelling percentages of the films were decreased, whereas WVTR values were increased as the addition of gatifloxacin was increased. Swelling percentage of gellan gum/collagen film with the lowest percentage of gatifloxacin (GG/C-GAT01) has the highest swelling ratio (2057%). Meanwhile, the WVTR value of GG/C-GAT1 has the highest WVTR value among all films which is 1245 g m-2 day-1. The formulation of GG/C films with the addition of gatifloxacin with good water absorbance and acceptable WVTRs value offered promising materials to be applied as wound dressing materials.

Engineered hemostatic bionanocomposite of poly(lactic acid) electrospun mat and amino‐modified halloysite for potential application in wound healing

AbstractOne of the essential characteristics of an ideal wound dressing is rapid hemostasis. This study aims to investigate the preparation and the characterization of electrospun poly(lactic acid) and halloysite nanotubes (PLA/HNTs) bionanocomposites with either different percentage of pristine and amino‐modified HNTs (i.e., 5, 10, and 20 wt%). The effects of HNT's presence, amount, and modification are evaluated on the physicochemical and biological properties which are essential for hemostatic wound dressing. The energy dispersive spectroscopy indicates HNTs are well embedded and dispersed on PLA nanofibers to induce functional interfacial interactions. The addition of HNTs to the PLA in a concentration of 10 wt% improves moisture properties and increases the Young modulus of mats from 26.4 ± 1.66 to 31.62 ± 1.91 and 40.7 ± 1.99 MPa for pristine and modified HNTs, respectively. Also, the surface charge as an influential factor on hemostasis is increased from −39.1 ± 0.3 to −48.4 ± 0.5 and −43.6 ± 0.2 mV for PLA/pristine and modified HNTs bionanocomposites, respectively. Accordingly, blood clotting formation accelerated from 9 to 4 min for the bionanocomposite mat. Furthermore, biological evaluations show that bionanocomposites have suitable cell supporting. It seems that PLA/amino‐modified HNTs bionanocomposite have potential application for hemostatic wound healing.

Green Tea Derivative Driven Smart Hydrogels with Desired Functions for Chronic Diabetic Wound Treatment

AbstractCurrent treatments for chronic diabetic wounds remain unsatisfactory due to the lack of ideal wound dressings that can integrate matching mechanical strength, fast self‐healability, facile dressing change, and multiple therapeutic effects into one system. In this work, benefiting from the catechol groups and therapeutic effect of epigallocatechin‐3‐gallate (EGCG, green tea derivative), a smart hydrogel dressing can be conveniently obtained through copolymerization of the complex formed by EGCG and 3‐acrylamido phenylboronic acid (APBA) (the formation of boronate ester bond) and acrylamide. The resulting hydrogel features adequate mechanical properties, self‐healing capability, and tissue adhesiveness. Otherwise, the substantial release of EGCG can not only realize anti‐oxidation, antibacterial, anti‐inflammatory and proangiogenic effect, and modulation of macrophage polarization to accelerate wound healing, but also facilitate easy dressing change. This advanced hydrogel provides a facile and effective way for diabetic chronic wound management and may be extended for the therapy of other complicated wound healings.

Dual bio-active factors with adhesion function modified electrospun fibrous scaffold for skin wound and infections therapeutics

Electrospun fibrous scaffolds combined with bioactive factors can display impressive performance as an ideal wound dressing, since they can mimic the composition and physicochemical properties of the extracellular matrix (ECM). The aim of this study was to fabricate a new composite biomaterial (IGF1-DA and Os-DA-modified PLGA electrospun fibrous scaffold) for wound healing, using a rat model for experimental evaluation. A small pentapeptide tag composed of DA–Lys–DA–Lys–DA residues was introduced into insulin-like growth factor 1 (IGF1) and the antimicrobial peptide Os to prepare IGF1 and Os modified with 3,4-dihydroxyphenylalanine (DA) (IGF1-DA and Os-DA). The designed chimeric growth factor and antimicrobial peptide could successfully anchor to PLGA electrospun fibrous scaffolds, and the growth factor and antimicrobial peptide could be controllably released from the electrospun fibrous scaffolds. The results showed that the IGF1-DA and Os-DA-modified PLGA electrospun fibrous scaffolds (PLGA/Os-DA/IGF1-DA) exhibited high hydrophilicity and antimicrobial activity; moreover, the porous network of the scaffolds was similar to that of the natural ECM, which can provide a favourable environment for BALB/C 3T3 cells growth. The in vivo application of PLGA/Os-DA/IGF1-DA electrospun fibrous scaffolds in rat skin wounds resulted in improved wound recovery and tissue regeneration rate. The experimental results indicated that the IGF1-DA and Os-DA could effectively bind to PLGA electrospun fibrous scaffolds, promote wound healing and prevent infection in rats, thereby suggesting that PLGA/Os-DA/IGF1-DA electrospun fibrous scaffolds have a wide application value in the field of skin wound repair.

Study on Morphological Properties of Polyvinyl Alcohol/Poly (lactic acid) Wound Dressing Membrane as Drug Delivery Carrier in Wound Healing Treatment

Wound dressing have experienced continuous improvement and changes since ancient time. Electrospinning of polymeric nanofibers have captured the interest of researchers due to its simplicity and cost effective technique that able to produce wound dressing membrane that meet the requirement as ideal wound dressing and drug delivery carrier. In this work, polyvinyl alcohol (PVA) and poly (lactic acid) (PLA) were chosen polymer to produce wound dressing membrane through electrospinning and coating method. PVA was electrospun and then coated with PLA. Preliminary study had been conducted between 1, 4 and 8% concentration for the selection of optimum PLA coating concentration. PLA has been proposed for the use of coating materials at 4%, the coated nanofiber membrane started to exhibit high Ultimate Tensile Strength at 1022.5 ± 9.28 MPa, highest degree of swelling (1850 ± 3.7 %) and optimum water contact angle (60.9 ± 11.46˚). The aim of this study was to investigate the morphological properties of PVA/PLA wound dressing membrane. Based on the results from Atomic Force Microscope, PVA nanofiber coated with 4% PLA exhibit the highest value of Rq which is 0.47 ± 0.19 μm compared to neat PVA nanofibers membrane. Field Emission Scanning Electron Microscope (FE-SEM) image revealed that PVA nanofiber coated with 4% PLA shows porous fiber-like morphology and well incorporated with each other without any gap formed between them. This report clearly suggestive of the fact that synthetic biodegradable polymers such as PLA can be exploited for the synergistic combination with PVA nanofiber for wound dressing application.

Biocompatible and biodegradable wound dressings on the basis of seaweed polysaccharides (review of literature)

The review presents the characteristics of modern biocompatible and biodegradable wound dressings on the basis of seaweed polysaccharides (carrageenans of red algae, fucoidans and alginates of brown algae, ulvans of green algae) and notes the key physicochemical and biological properties that are important for constructing wounds dressings. There are information on various types of wound dressings and results of experimental and clinical tests of dressings in the treatment of wounds of various origins. Particular attention is paid to hydrogel dressings, since hydrogels meet the basic requirements for an ideal wound dressing, and many marine polysaccharides are able to form hydrogels.

Delivery of Therapeutics from Layer-by-Layer Electrospun Nanofiber Matrix for Wound Healing: An Update.

Increasing incidences of chronic wounds urge the development of effective therapeutic wound treatment. As the conventional wound dressings are found not to comply with all the requirements of an ideal wound dressing, the development of alternative and effective dressings is demanded. Over the past few years, electrospun nanofiber has been recognized as a better system for wound dressing and hence has been studied extensively. Most of the electrospun nanofiber dressings were fabricated as single-layer structure mats. However, this design is less favorable for the effective healing of wounds mainly due to its burst release effect. To address this problem and to simulate the organized skin layer's structure and function, a multilayer structure of wound dressing had been proposed. This design enables a sustained release of the therapeutic agent(s), and more resembles the natural skin extracellular matrix. Multilayer structure is also referred to layer-by-layer (LbL), which has been established as an innovative method of drug incorporation and delivery, combines a high surface area of electrospun nanofibers with the multilayer structure mat. This review focuses on LbL multilayer electrospun nanofiber as a superior strategy in designing an optimal wound dressing.

Physicochemical Characterization of Bilayer Hybrid Nanocellulose-Collagen as a Potential Wound Dressing.

The eminent aim for advance wound management is to provide a great impact on the quality of life. Therefore, an excellent strategy for an ideal wound dressing is being developed that eliminates certain drawbacks while promoting tissue regeneration for the prevention of bacterial invasion. The aim of this study is to develop a bilayer hybrid biomatrix of natural origin for wound dressing. The bilayer hybrid bioscaffold was fabricated by the combination of ovine tendon collagen type I and palm tree-based nanocellulose. The fabricated biomatrix was then post-cross-linked with 0.1% (w/v) genipin (GNP). The physical characteristics were evaluated based on the microstructure, pore size, porosity, and water uptake capacity followed by degradation behaviour and mechanical strength. Chemical analysis was performed using energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectrophotometry (FTIR), and X-ray diffraction (XRD). The results demonstrated a uniform interconnected porous structure with optimal pore size ranging between 90 and 140 μm, acceptable porosity (>70%), and highwater uptake capacity (>1500%). The biodegradation rate of the fabricated biomatrix was extended to 22 days. Further analysis with EDX identified the main elements of the bioscaffold, which contains carbon (C) 50.28%, nitrogen (N) 18.78%, and oxygen (O) 30.94% based on the atomic percentage. FTIR reported the functional groups of collagen type I (amide A: 3302 cm−1, amide B: 2926 cm−1, amide I: 1631 cm−1, amide II: 1547 cm−1, and amide III: 1237 cm−1) and nanocellulose (pyranose ring), thus confirming the presence of collagen and nanocellulose in the bilayer hybrid scaffold. The XRD demonstrated a smooth wavy wavelength that is consistent with the amorphous material and less crystallinity. The combination of nanocellulose with collagen demonstrated a positive effect with an increase of Young’s modulus. In conclusion, the fabricated bilayer hybrid bioscaffold demonstrated optimum physicochemical and mechanical properties that are suitable for skin wound dressing.

Bacterial Cellulose: Functional Modification and Wound Healing Applications.

Significance: Wound dressings are frequently used for wound covering and healing. Ideal wound dressings should provide a moist environment for wounds and actively promote wound healing and skin recovery. The materials used as ideal wound dressings should possess specific properties, thus accelerating skin tissue regeneration process. Recent Advances: Bacterial cellulose (BC) is a natural polymer synthesized by some bacteria. As a kind of natural biopolymer, BC shows good biological activity, biodegradability, and biological adaptability. It has many unique physical, chemical, and biological properties, such as ultrafine nanofiber network, high crystallinity, high water absorption and retention capacity, and high tensile strength and elastic modulus. These excellent properties of BC have laid the foundation for its application as dressing in wound healing. Critical Issues: To optimize the biocompatibility and antimicrobial activity of BC, different methods including microbial fermentation, physical modification, chemical modification, and compound modification have been adopted to modify BC to ensure a better application in wound healing. BC-based wound dressings have been applied in infected wounds, acute traumatic injuries, burns, and diabetic wounds, showing remarkable therapeutic effects on promoting wound healing. Furthermore, there have been some commercial BC-based dressings and they have been utilized in clinical practice. Future Directions: Because of its excellent physicochemical characteristics and biological properties, BC shows high clinical value to be used as a wound dressing for skin tissue regeneration.

Effect of clinoptilolite on structure and drug release behavior of chitosan/thyme oil γ‐Cyclodextrin inclusion compound hydrogels

AbstractChitosan‐based hydrogels involving γ‐cyclodextrin inclusion compounds of thyme oil were prepared by freeze–thaw cycling method. Clinoptilolite as a natural zeolite was added to investigate its effects on the structural, mechanical, and drug release behaviors of the hydrogels. Zeolite compressed the structure and improved mechanical properties, which decreased swelling values. Release of thyme oil in prepared hydrogels were investigated by UV spectroscopy and drug release mechanism was evaluated by applying various mathematical methods. Rates of water vapor transmission of the samples were calculated as 2247–2998 g m−2 day−1 which are all in the range of an ideal wound dressing. Hydrogels with clinoptilolite had slower drug release (from 56% to 24% for hydrogels containing zeolite 1%) in comparison with that of without zeolite. Based on MTT assay, samples were low‐toxic. Obtained results suggest that drug loaded hydrogels can be applied in biomedical field including drug delivery systems and wound dressings.

In search of ideal donor site wound dressings

Background: Split skin grafting (SSG) is a commonly used reconstructive technique for wound cover. Donor site wounds (DSW) after split-skin graft harvesting are rather clean wounds. Depending on the thickness of the SSG, the DSW should re-epithelialize completely in 7 to 21 days. This study was initiated with a background to look for an ideal dressing for the management of DSW. Aim of the study was to compare efficacy of Cellulose acetate mesh, Collagen sheet, Hydrocolloid dressings and chlorhexidine tulle for donor site wound management after harvesting split thickness skin graft.Methods: 100 patients with 100 donor site wounds were included in the study. Patients were randomized into four different groups of 25 each, depending upon the type of dressings used to cover the wound. Data regarding time to complete wound healing and pain at the donor site were recorded on visual analogue scale (VAS). Requirement of pain killers during post-operative period were recorded. Complications like infection or hyper-granulation were also recorded.Results: The study included 72 males and 28 females. The primary objective was to observe the effectiveness of wound dressings in the treatment of DSWs and time to complete wound healing. In this context, collagen dressing was found to be the most effective in current study (p<0.07) and also the least pain was experienced by the patients where collagen dressings were used.Conclusions: The study concluded that collagen dressings was best amongst the various dressings studied with average healing time of 9 days with least pain score over DSW.

Preparation and Characterization of Antibacterial Porcine Acellular Dermal Matrices with High Performance.

Infection is a common complication in the process of wound management. An ideal wound dressing is supposed to reduce or even prevent the infection while promoting wound healing. A porcine acellular dermal matrix (pADM) has been already used as a wound dressing in clinic due to its capacity to accelerate wound healing. However, not only is pure pADM not antibacterial, its mechanical properties are poor. In this study, an antibacterial pADM with good performance was prepared by adding two natural products as modifiers, quercetin (QCT) and tea tree oil (TTO). The result of Fourier-transform infrared (FTIR) proved that the addition of modifiers did not break the natural triple-helical structure of collagen. Meanwhile, the results of differential scanning calorimetry (DSC), thermogravimetric analysis (TG), mechanic experiment, and enzymatic degradation demonstrated that pADM handled with QCT and TTO (termed QCT–TTO–pADM) had better thermal stability, mechanical strength, and resistance to enzymatic degradation than pADM. Meanwhile, QCT–TTO–pADM had excellent antibacterial activity and showed an antibacterial rate of over 80%. Furthermore, in the cytocompatibility analysis, QCT–TTO–pADM had no side effects on the adhesion, growth, and proliferation of fibroblasts. QCT–TTO–pADM could even accelerate wound healing more efficiently than pADM and glutaraldehyde-modified pADM (GA-pADM). In conclusion, QCT–TTO–pADM was a potential antibacterial wound dressing with good performance.

Preparation, characterization, and drug release study of ibuprofen-loaded poly (vinyl alcohol)/poly (vinyl pyrrolidone) bilayer antibacterial membrane

Controlling wound pain, absorption of wound exudate, and minimizing the frequency of changing the dressing are necessary parameters to facilitate wound-healing process. Hence, stable hydrophilic hydrogels applied in the form of film with the capability of wound exudate absorption and anti-inflammatory drug release may be used as an ideal wound dressing. Furthermore, physically crosslinked hydrogels are preferred over chemical ones because of being free from remaining harmful chemicals and adverse effects on the entrapped drugs. Thus, in this study, we developed an antibacterial bilayer membrane composed of a combination of polyvinyl alcohol/polyvinyl pyrrolidone (PVA/PVP) with the ability to release Ibuprofen (IBP). First, 1% IBP was incorporated in different ratios of PVA/PVP solution (90:10, 80:20, and 70:30); then, the hydrogels were crosslinked through repetitive freeze-thawing cycles followed by lyophilization, as the bottom layer. Second, the top layer was made in the same way but without the drug. Morphology, mechanical properties, swelling ratio, degradation rate, water vapor transmission rate (WVTR), and in vitro drug release of bilayer membranes were evaluated, then the content of PVP was optimized. The results indicated that the sample with the PVA/PVP ratio of 80:20 encompassed large and interconnected pores and also a proper swelling degree (500% in 48 h), weight loss (60% during 12 days) and WVTR (2721.1 ± 93.3 g/m2); thus, it is considered as the optimized membrane. MTT and antibacterial assays also showed acceptable viability and bactericidal activity for the membranes containing IBP. In conclusion, the prepared bilayer membrane can absorb wound exudate within the dressing matrix, release IBP locally, and keep its stability at the wound site. The bilayer membrane also exhibited an excellent antibacterial feature for accelerating the wound-healing process.

Dextran based amphiphilic nano-hybrid hydrogel system incorporated with curcumin and cerium oxide nanoparticles for wound healing

During injury or diseased condition, wound dressing fails to properly integrate or repair the tissue and restore its function due to various factors like poor bioavailability, systemic delivery of hydrophobic drugs and elevated levels of reactive oxygen species. Here, we fabricated a novel nano-hybrid hydrogel system, based-on gelatin and oxidized dextran, embedded with nano-formulation of curcumin and cerium oxide, dispersed by physical interaction within the hydrogel. The curcumin was entrapped in amphiphilic alkylated-dextran nanoparticles to enhance its bioavailability and release at the injured site while cerium oxide nanoparticles were used without any additional processing. The hydrogel was characterized for various properties and demonstrated a controlled and prolonged drug release (∼63 % in 108 h), accelerated cell migration besides providing a highly significant antioxidant and in-vivo anti-inflammatory activity (∼39 %). The preliminary study suggests that this hybrid system can significantly promote wound healing and the potential to become an ideal wound dressing.