Engineered hemostatic bionanocomposite of poly(lactic acid) electrospun mat and amino‐modified halloysite for potential application in wound healing

Abstract

AbstractOne of the essential characteristics of an ideal wound dressing is rapid hemostasis. This study aims to investigate the preparation and the characterization of electrospun poly(lactic acid) and halloysite nanotubes (PLA/HNTs) bionanocomposites with either different percentage of pristine and amino‐modified HNTs (i.e., 5, 10, and 20 wt%). The effects of HNT's presence, amount, and modification are evaluated on the physicochemical and biological properties which are essential for hemostatic wound dressing. The energy dispersive spectroscopy indicates HNTs are well embedded and dispersed on PLA nanofibers to induce functional interfacial interactions. The addition of HNTs to the PLA in a concentration of 10 wt% improves moisture properties and increases the Young modulus of mats from 26.4 ± 1.66 to 31.62 ± 1.91 and 40.7 ± 1.99 MPa for pristine and modified HNTs, respectively. Also, the surface charge as an influential factor on hemostasis is increased from −39.1 ± 0.3 to −48.4 ± 0.5 and −43.6 ± 0.2 mV for PLA/pristine and modified HNTs bionanocomposites, respectively. Accordingly, blood clotting formation accelerated from 9 to 4 min for the bionanocomposite mat. Furthermore, biological evaluations show that bionanocomposites have suitable cell supporting. It seems that PLA/amino‐modified HNTs bionanocomposite have potential application for hemostatic wound healing.