Abstract
Hydrogels have gained a niche in the market as wound dressings due to their high water content and plasticity. However, traditional hydrogel wound dressings are difficult to fully adapt to irregular-shaped wound areas. Additionally, excessive reactive oxygen species (ROS) accumulated in the damaged area impede the wound healing process. Therefore, hydrogels with injectable and antioxidant properties offer promising qualities for wound healing, but their design and development remain challenges. In this study, HT/QGA (tyramine-grafted hyaluronic acid/gallic acid-grafted quaternized chitosan) hydrogels with injectable and antioxidant properties were prepared and characterized. This hydrogel exhibited excellent injectability, favorable antioxidant activity, and good biocompatibility. Moreover, we evaluated the therapeutic effect of HT/QGA hydrogel in a full-thickness skin injury model. These results suggested that HT/QGA hydrogel may offer a great potential application in wound healing.
Highlights
Skin, as the largest human organ, is the body’s first line of defense [1,2]
This hydrogel exhibited good injectability, antioxidant activity, stability and biocompatibility. It demonstrated good therapeutic effects in full-thickness skin injury model. These results indicated that HT/quaternized chitosan-gallic chitosan-gallic acid acid (QGA) hydrogel may offer great potential for application in wound dressing
We confirmed the structure of HT and QGA polymers via 1 H NMR
Summary
Wound is a defect in or a breakage of the skin caused by physical, chemical or thermal damage. Hydrogel is considered to be an ideal dressing candidate, because of its 3D structure, good permeability, excellent biocompatibility, and its ability to provide a wet environment for wound repair, which overcomes the shortcomings of traditional dressings [4,10]. HT has already been developed as a protein drug delivery system [12,13], and is widely used in tissue engineering [14,15] It offers the advantages of cell compatibility, biodegradability, and non-immunogenicity [16]. Chitosan (CS) is a natural polysaccharide prepared by the deacetylation of chitin [17,18] It has drawn increasing attention for its biomedical applications, owing to its biocompatibility, biodegradability, non-toxicity, and low-immunogenicity [19]. Gallic acid (GA) is an antioxidant polyphenol that features neuroprotective functions in different models of neurodegeneration, neurotoxicity, and oxidative stress [20]
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