Risk theories and empirical research indicate that a variety of factors can influence people’s protective decisions for natural hazards. Using data from an online survey that presented coastal U.S. residents with a hypothetical hurricane scenario, this study investigates the relative importance of cognitive risk perceptions, negative affect, efficacy beliefs, and other factors in explaining people’s anticipated evacuation decisions. The analysis finds that multiple factors, including individual and household characteristics, previous experiences, cognitive and affective risk perceptions, and efficacy beliefs, can help predict hurricane evacuation intentions. However, the largest amount of variance in survey participants’ evacuation intentions is explained by their evacuation-related response efficacy (coping appraisals) and their perceived likelihood of getting hurt if they stay home during the storm. Additional analysis explores how risk perceptions and efficacy beliefs interact to influence people’s responses to risk information. Although further investigation in additional situations is needed, these results suggest that persuading people at high risk that evacuating is likely to reduce harm can serve as an important risk communication lever for motivating hurricane evacuation.