Hypertriglyceridemic Waist Research Articles

Impaired fasting glucose: Pro-diabetic, “atheroprotective” and modified by metabolic syndrome

To investigate whether impaired fasting glucose (IFG) confers cardiovascular risk. A non-diabetic population-based sample representative of middle-aged and elderly Turks was studied at 8.5 years' follow-up for incident diabetes and coronary heart disease (CHD). Metabolic syndrome (MetS) was defined by ATP-III criteria modified for male abdominal obesity, and IFG and type 2 diabetes were identified by criteria of the American Diabetes Association. Stratification by presence of MetS was used. Outcomes were predicted providing estimates for hazard ratio (HR) obtained by use of Cox proportional hazards regression analysis in models that controlled for potential confounders. In 3181 adults (aged 52 ± 11.5 years at baseline), analysis stratified by MetS, gender and IFG status distinguished normoglycemic subjects by a "hypertriglyceridemic waist" phenotype consisting of significantly higher waist circumference, fasting triglyceride and lower high-density lipoprotein-cholesterol, regardless of gender and MetS. Additionally, lipoprotein (Lp) (a) tended to be lower in (especially female) participants with MetS. Multivariable linear regression in a subset of the sample demonstrated decreased Lp (a) levels to be associated with increased fasting glucose and insulin concentrations, again particularly in women. In Cox regression analysis, compared with normoglycemia, baseline IFG adjusted for major confounders significantly predicted incident diabetes at a 3-fold HR in men and only women with MetS. Cox models for developing CHD in 339 individuals, adjusted for conventional risk factors, revealed that IFG status protected against CHD risk [HR = 0.37 (95%CI: 0.14-0.998)] in subjects free of MetS, a protection that attenuated partly in male and fully in female participants with MetS. IFG status in non-diabetic people without MetS displays reduced future CHD risk, yet is modulated by MetS, likely due to autoimmune activation linked to serum Lp (a).

Hypertriglyceridemic waist phenotype: association with metabolic abnormalities in adolescents

ObjectiveThis study aimed to identify the prevalence of hypertriglyceridemic waist (HTW) phenotype, and to evaluate its association with metabolic abnormalities in adolescents of low socioeconomic status. MethodThis was a cross-sectional study with a random sample of 1,076 adolescents between 11 and 17 years, of both genders, from public schools. The participants underwent anthropometric measurements (weight, height, and waist circumference), and levels of total cholesterol, low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol (HDL-C), non-HDL cholesterol, triglyceride (TG), and fasting glucose were measured. Information regarding the socioeconomic status of the participants’ families was obtained. The HTW phenotype was defined by the simultaneous presence of increased waist circumference (≥ 90th percentile for age and gender) and serum triglyceride levels (≥ 100mg/dL). A logistic regression analysis was used to evaluate the associations of interest. ResultsThe prevalence of HTW phenotype was 7.2% among the adolescents, being higher in the presence of obesity (63.4%) and high levels of non-HDL cholesterol (16.6%) and LDL-C (13.7%). The bivariate analysis indicated that, of the metabolic variables, only blood glucose was not associated with the HTW phenotype. Multivariate analysis adjusted for age and gender indicated that the HTW phenotype was positively associated with high non-HDL cholesterol (odds ratio: 7.0; 95% CI: 3.9-12.6) and low HDL-C levels (odds ratio: 2.7; 95% CI: 1.5-4.8). ConclusionsThis study demonstrated that the HTW phenotype was associated with an atherogenic lipid profile, and this phenotype is suggested as a screening tool to identify adolescents with metabolic alterations.

Hypertriglyceridemic Waist Phenotype: Association with Metabolic Abnormalities in Adolescents

ObjectiveThis study aimed to identify the prevalence of hypertriglyceridemic waist (HTW) phenotype, and to evaluate its association with metabolic abnormalities in adolescents of low socioeconomic status. MethodThis was a cross-sectional study with a random sample of 1,076 adolescents between 11 and 17 years, of both genders, from public schools. The participants underwent anthropometric measurements (weight, height, and waist circumference), and levels of total cholesterol, low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol (HDL-C), non-HDL cholesterol, triglyceride (TG), and fasting glucose were measured. Information regarding the socioeconomic status of the participants’ families was obtained. The HTW phenotype was defined by the simultaneous presence of increased waist circumference (≥ 90th percentile for age and gender) and serum triglyceride levels (≥ 100mg/dL). A logistic regression analysis was used to evaluate the associations of interest. ResultsThe prevalence of HTW phenotype was 7.2% among the adolescents, being higher in the presence of obesity (63.4%) and high levels of non-HDL cholesterol (16.6%) and LDL-C (13.7%). The bivariate analysis indicated that, of the metabolic variables, only blood glucose was not associated with the HTW phenotype. Multivariate analysis adjusted for age and gender indicated that the HTW phenotype was positively associated with high non-HDL cholesterol (odds ratio: 7.0; 95% CI: 3.9-12.6) and low HDL-C levels (odds ratio: 2.7; 95% CI: 1.5-4.8). ConclusionsThis study demonstrated that the HTW phenotype was associated with an atherogenic lipid profile, and this phenotype is suggested as a screening tool to identify adolescents with metabolic alterations.

Interaction of both hypertriglyceridemic waist and impaired fasting glucose on the incidence of diabetes mellitus

To study the use of hypertriglyceridemic waist (HTGW) to predict the occurrence of diabetes. Also to independently study whether there was an interaction between HTGW and impaired fasting glucose impaired fasting glucose (IFG) on the cause of diabetes. We undertook a cohort study based on data from the "Prevention of Multiple Metabolic Disorders and Metabolic Syndrome (MS) Study in Jiangsu Province, China". We used the logistic regression model to analyze the relations between both HTGW, IFG and diabetes mellitus and to evaluate the multiplied interaction between HTGW and IFG to include product terms method. Counting additive interaction was carried out under the Excel Calculation Sheet, compiled by Anderson and his colleagues. After adjusted for general risk factors and baseline fasting plasma glucose (FPG), results showed that subjects with HTGW had a 2.10 (95% CI: 1.36 - 3.25) adjusted relative risk (HR) of developing a diabetes when compared with those individuals without HTGW at the baseline study. When IFG was stratified, participants with HTGW were significantly associated with diabetes, regardless of IFG. The multi-adjusted HRs of diabetes were 3.09 (1.70 - 5.61) and 2.09 (1.08 - 4.02), respectively. Compared to the participants with non-HTGW and their FPG level below the threshold, those having HTGW and their FPG level was above the threshold, had the highest adjusted HR values [12.05 (95% CI: 6.89 - 21.07)]. Data from the additive interaction analysis showed that RERI as 7.00 (95% CI: 0.49 - 13.51), AP as 0.57 (95% CI: 0.32 - 0.82) and SI as 2.66 (95% CI: 1.36 - 5.21). HTGW could predict the occurrence of diabetes, independent from IFG while the presence of HTGW with IFG could have an additive interaction on the cause of diabetes.

The Hypertriglyceridemic Waist, Waist-to-Height Ratio, and Cardiometabolic Risk

To investigate whether the hypertriglyceridemic waist (HW) phenotype and waist-to-height ratio (WHTR) are associated with cardiometabolic disorders in children and adolescents. This was a cross-sectional design study. Anthropometry, biochemical variables, and cardiorespiratory fitness were assessed in 234 participants (122 girls) aged 10-19 years from Bedfordshire, United Kingdom. The HW phenotype was defined as a waist circumference ≥90(th) percentile for age and sex, and triglyceride concentrations ≥1.24 mmol/L, and a high WHTR defined as >0.5. ANCOVA and logistic regression were used in the analysis. In participants with the HW phenotype, the odds of having high cardiorespiratory fitness (mL/kg/min) were lower (0.045; 95% CI 0.01, 0.42), and the odds of having low high-density lipoprotein cholesterol (4.41; 1.50, 12.91), impaired fasting glucose (3.37; 1.06, 10.72), and ≥1 (4.78; 1.32, 17.29) and ≥2 risk factors (7.16; 2.38, 21.54) were higher than those without the phenotype. Those with a high WHTR had higher odds of having low high-density lipoprotein cholesterol (2.57; 1.11, 5.95), high diastolic blood pressure (3.21; 1.25, 8.25), and ≥2 risk factors (5.57; 2.05, 15.17) than those with normal WHTR. The HW phenotype may be a better simple marker than WHTR for identifying children and adolescents at risk for cardiometabolic disorders.

P 14: Hypertriglyceridemic waist phenotype in type 2 diabetes: association with higher hs-CRP and lower antioxidative enzyme activity

Background and aim It was previously suggested that hypertriglyceridemic waist (HTgW) phenotype (waist girth ≥90 cm in men and ≥85 cm in women, and triglyceride (Tg) levels ≥2.0 mmol/l) could identify visceral obesity and higher risk for atherosclerosis, but the relationship between HTgW phenotype and different atherosclerosis risk factors has not yet been elucidated. The aim of this study was to analize (a) hs-CRP levels, (b) lipid levels and (c) antioxidant enzyme glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities in the following groups of subjects: 30 patients with type 2 diabetes (T2D) and HTgW (group A), 24 T2D patients with abdominal obesity (higher waist) and normal Tg (group B) and 20 non obese T2D patients without HTgW (group C). Methods CRP levels were detected by Elisa method, GSH-Px and SOD activity were detected by spectrophotometry, total cholesterol (Ch), HDL-Ch, LDL-Ch and Tg levels by enzymatic methods and the insulin resistance (IR) was assessed by using HOMA-IR (calculated from basal insulin levels determined by RIA and fasting glucose levels determined by glucosooxidase method). Results We found significantly higher hs-CRP level in group A compared to group B (6,97+/-2,01 vs 4,72+/-2,01 mg/l; p Conclusions Our results signify that presence of HTgW phenotype in T2D, as a marker of visceral obesity, is strongly associated with marked atherosclerosis risk profile, especially at the level of inflammation, reverse cholesterol metabolism and antioxidative enzyme activity. The results also suggest that in this phenotype detected higher IR might be exerting its atherogenic effect partly on the level of the changes in antioxidative defence.

El fenotipo «hipertrigliceridemia-cintura abdominal aumentada» es un factor de riesgo de aterosclerosis subclínica en pacientes con infección por el virus de la inmunodeficiencia humana

Background and objectiveTo study the association between hypertriglyceridemic waist phenotype and the presence of subclinical atherosclerosis in human immunodeficiency virus (HIV) infected patients. Patients and methodsCross sectional study. Hypertriglyceridemic waist phenotype was considered if the waist was ≥90cm and triglycerides ≥2.0mmol/l (178mg/dl) in men and ≥85cm and ≥1.5mmol/L (133mg/dl) in women, respectively. We used the intima-media thickness (IMT) to detect carotid subclinical atherosclerosis. ResultsWe analyzed 152 patients, of whom 128 (84.2%) were receiving antiretroviral therapy, 40.7% were receiving protease inhibitors and 38.1% were treated with non-nucleoside reverse transcriptase inhibitors. The prevalence of hypertriglyceridemic waist phenotype was 23.6% (95% confidence interval [CI] 16.8-30.3%). Patients with hypertriglyceridemic waist phenotype had higher cardiovascular risk according to the Framingham score (11.09 [7.6] vs 3.88 [4], P=0.001) and lipodystrophy (33.3 vs. 13.7%, P=0.032) and metabolic syndrome (69.4 vs. 1.9%, P<0.001) were more frequent. The IMT was elevated in 21 (13.8%) patients. Hypertriglyceridemic waist phenotype (odds ratio [OR] 4.66 [95%CI 1.05-20.6; P = 0.043]) and metabolic syndrome (OR 3.74 [95%CI 1.25-11.23; P = 0.018]) were independently associated with higher IMT. ConclusionsThe hypertriglyceridemic waist phenotype is a risk factor for subclinical atherosclerosis in HIV infected patients and it is useful to detect patients with lipodystrophy, metabolic syndrome and high cardiovascular risk.

Cintura hipertrigliceridêmica e risco cardiometabólico em mulheres hipertensas

To evaluate the association between hypertriglyceridemic waist (HW) and cardiometabolic risk factors in women with hypertension. A cross-sectional study was performed in 218 patients monitored by HiperDia (Enrollment and Monitoring Program for Hypertensive and Diabetic Individuals) in two health units in São Luis, MA, Brazil. The dependent variable was HW and the independent variables were sociodemographics, lifestyle, anthropometrics, and health problems. HW was present in 33% of the sample and was predominant in women aged > 60 years (56.4%), non-whites (81.7%), those with eight or fewer years of schooling (57.3%), and those belonging to socioeconomic class C (49%). Excess weight (68.8%) and hypercholesterolemia (68.8%) were observed. HW was associated with: smoking (PR: 2.08; p = 0.017), overweight (PR: 2.46; p = 0.010), obesity (PR: 4.13; p < 0.001), hypercholesterolemia (PR: 1.87; p = 0.015), high levels of high-density lipoproteins (HDL) cholesterol (PR: 3.41; p < 0.001), and fasting glycemia > 100 mg/dL or being diabetic (PR: 1.86; p = 0.006). After adjustment, total cholesterol (PR = 1.78; p = 0.012), HDL-cholesterol (PR: 3.03; p < 0.001), body mass index (BMI) > 25 to < 30 kg/m² (PR = 2.60; p = 0.005), and BMI > 30 kg/m² (PR = 3.61; p < 0.001) remained associated. A high prevalence of HW and its association with altered lipid profile and excess body weight was observed. HW showed to be an important diagnostic tool for the monitoring of hypertensive women with metabolic risk, which is low cost, easily accessible, and useful in clinical practice, especially in primary health care in the Brazilian Unified Health System (Sistema Único de Saúde - SUS).

Hypertriglyceridemic waist may explain ethnic differences in hypertension among patients with type 2 diabetes in Sweden

BackgroundHypertension is common among persons with type 2 diabetes. The aim of this study was to analyze the association between ethnicity and hypertension prevalence after adjusting for age, sex, Hba1c, total cholesterol, elevated triglycerides and hypertriglyceridemic waist. The study population consisted of 354 primary health care patients diagnosed with type 2 diabetes (173 Assyrians/Syrians and 181 Swedes) residing in Södertälje, Sweden. Unconditional logistic regression was used to analyze the data.ResultsHypertension prevalence was higher among Swedes than Assyrians/Syrians, (77% versus 58%; p = 0.001). In the unadjusted logistic regression model, the odds ratio for hypertension in Swedes was twice as high than that in Assyrians/Syrians (OR = 2.44; 95% CI =1.54-3.86). In the age- and sex-adjusted model, odds ratio of hypertension was 2.25 (95% CI 1.41-3.60). After adjustments for total cholesterol was made, the odds ratio of hypertension decreased slightly to 1.73. When elevated triglycerides and hypertriglyceridemic waist were separately introduced, the odds ratio of hypertension was no longer significant between the ethnic groups (1.60 and 1.43 for triglycerides and hypertriglyceridemic waist respectively). In addition, advanced age – 60–69 years old (OR = 1.80, CI 95% 1.00-3.20) and ≥ 70 years old (OR = 2.88, CI 95% 1.40-5.93), elevated total cholesterol (OR = 1.48, CI 95% 1.12-1.95) and presents of hypertriglyceridemic waist (those with high WC and high TG) were significant confounding factors for the increased risk of hypertension independent of ethnicity.ConclusionsThe crude differences in prevalence of hypertension between the Swedes and Assyrians/Syrians in our study population with type 2 diabetes were no longer significant when adjusting for high triglycerides levels or the presence of hypertriglyceridemic waist.

(19) The hypertriglyceridemic waist and the metabolic triad: a weight loss study in clinically obese children

(19) The hypertriglyceridemic waist and the metabolic triad: a weight loss study in clinically obese children

Hypertriglyceridemic waist, cytokines and hyperglycaemia in Chinese

Abdominal obesity and hypertriglyceridemia confer high risk for cardiometabolic disease. Few studies have investigated the associations of hypertriglyceridemic waist with cytokines and hyperglycaemia in Chinese. Anthropometric indexes, fasting plasma concentrations of glucose, glycohemoglobin, insulin, lipid profile, inflammatory factors and adipokines were measured among 3289 Chinese men and women 50-70 years of age. An increment of every 2 cm of waist circumference was associated with increased levels of high-sensitive C-reactive protein (hsCRP), interleukin 6 and RBP 4 by 0·033 mg/L, 0·018 ng/L and 0·556 mg/L and reduced levels of adiponectin by 0·269 mg/L (all P<0·05), respectively, with controlling for potential confounders. For triglycerides, each an increment of 20 mg/dL was associated with increased levels of hsCRP, RBP4, and decreased levels of adiponectin by 0·021 mg/L, 0·655 mg/L, and 0·371 mg/L (all P<0·05), respectively. Individuals with hypertriglyceridemic waist had increased risks of having hyperglycaemia (OR: 1·48; 95% CI: 1·09, 2·00) and diabetes mellitus (OR: 2·12; 95% CI: 1·47, 3·04) compared with those with neither of the phenotypes. Hypertriglyceridemic waist is associated with a worse profile of inflammatory factors and adipokines as well as with an increased risk of having hyperglycaemia among Chinese.

Angiographically-assessed coronary artery disease associates with HDL particle size in women

It has been suggested that a reduced HDL particle size could be another feature of the atherogenic dyslipidemia found among viscerally obese subjects. ObjectiveTo investigate, in women, the relationship between HDL particle size and coronary artery disease (CAD). MethodsAverage HDL particle size was measured in a sample of 239 women on whom CAD was assessed by angiography. ResultsOverall, women who had CAD were characterized by a deteriorated fasting metabolic risk profile, which was accompanied by smaller HDL particles compared to women without CAD (80.4 ± 2.2 Å vs. 81.5 ± 2.7 Å, p < 0.01). In addition, a reduced HDL particle size was a significant correlate of several features of the atherogenic metabolic profile of abdominal obesity such as increased triglyceride and apolipoprotein B concentrations, decreased HDL cholesterol levels, an elevated cholesterol/HDL cholesterol ratio and hyperinsulinemia and was also associated with an increased waist circumference (0.13≤|r|≤0.21, p < 0.05). Odds ratio of being affected by CAD was increased by 2.5-fold (95% CI: 1.4–4.5; p < 0.01) among women with smaller HDL particles compared to women with larger HDL particles. Finally, women characterized by the presence of the NCEP-ATP III clinical criteria or by hypertriglyceridemic waist were characterized by smaller HDL particles compared to women without these clinical phenotypes (p < 0.05). ConclusionHDL particle size appears to be another relevant feature of a dysmetabolic state which is related to CAD risk in women.

Abstract P022: Hypertriglyceridemic Waist Phenotype is Associated with Elevated Inflammatory Biomarker Levels

Introduction: Hypertriglyceridemic waist (TGW) is an easily identifiable clinical phenotype, reflecting visceral obesity. Inflammatory markers and insulin resistance potentially serve as the genetic link between TGW, accelerated atherogenesis and cardiovascular outcomes. We describe characteristics of patients with TGW and the association between inflammatory biomarkers, insulin resistance and TGW. Methods: Our sample consisted of 3328 subjects from the National Health and Nutrition Examination Survey III (1988-1994). Subjects who did not have data regarding waist circumference (WC) or fasting serum triglycerides (TG) were excluded. TGW was defined as WC ≥ 90 cm and TG ≥ 176 mg/dl in males and WC ≥ 85 cm and TG ≥ 132 mg/dl in females. Biomarkers studied were serum ferritin, C Reactive protein (CRP), uric acid, fasting insulin and C-peptide. Stata 11 was used to perform T test (using log-transformed variables), Wilcoxon-Mann-Whitney test and logistic regression. Results: Our data consisted of 51% (1700) males, 56% (1847) Caucasians/16% (537) African Americans, 54% (1791) had hypertension, 12% (406) had diabetes, 38% (1255) had hyperlipidemia and 35% (1169) had TGW. Mean TG was 163+155mg/dl; mean WC was 99+14cm. Patients with TGW were older (61+ 12 vs. 59+13, p&lt;0.001), male (54 vs. 48%, p 0.003), Caucasian (60 vs. 54%, p&lt;0.001), had more hypertension (61 vs. 50%, p&lt;0.001), hyperlipidemia (47 vs. 33%, p&lt;0.001), diabetes (17 vs. 10%, p&lt;0.001). T test and Wilcoxon-Mann-Whitney test revealed ferritin, CRP, uric acid, insulin and C-peptide to be higher among those who had TGW. They predicted TGW after adjustment for age, sex, race, glomerular filtration rate, hypertension, hypertension medications, hyperlipidemia, hyperlipidemia medications, diabetes, end stage renal disease and hemodialysis. (See table 1) Conclusion: Patients with TGW have worse clinical profiles. Inflammatory biomarkers and insulin resistance are associated with TGW. Genetic studies are required for further evaluation. Table 1. Biomarker Ferritin (ng/ml) CRP (mg/dl) Uric acid (mg/dl) Insulin (µU/ml) C peptide (ng/ml) Median (TGW) 115 0.33 5.6 13.3 1.02 Median (no TGW) 92 0.21 5.3 8.2 0.69 Β coefficient 0.202 0.236 0.091 0.543 1.171 95% CI 0.098-0.306 0.123-0.349 0.011-0.185 0.266-0.821 0.786-1.556 P value &lt;0.001 &lt;0.001 0.098 &lt;0.001 &lt;0.001

Abstract P375: Vitamin D Deficiency is Associated with Hypertriglyceridemic Waist Phenotype

Introduction: Hypertriglyceridemic waist phenotype (TGW) is a clinical indicator of visceral obesity. Studies have shown that TGW predicts adverse cardiovascular outcomes. Vitamin D (Vit D) deficiency is a novel and reversible nutritional risk factor for metabolic syndrome and cardiovascular disease. This is the first study of its kind, looking at whether Vit D deficiency predicted TGW. Methods: We did a post-hoc analysis of 2301 subjects from the National Health and Nutrition Examination Survey III (1988-1994). Patients without Vit D, waist circumference (WC) and serum triglycerides (TG) measurements were excluded. TGW was defined as WC ≤85 cm and 90 cm and TG ≤1.5 mmol/l (132 mg/dl) and 2 mmol/l (177 mg/dl) in females and males respectively. Subjects were divided into equal quartiles based on serum vit D levels. Stata 11 was used to perform chi-square test for categorical variables, t-test for continuous variables and univariate and step-wise multivariate logistic and linear regression. Results: Out of 2301 subjects, 35% (798) met the definition of TGW. Patients with TGW were older (61±12 vs. 60±13 yrs, p 0.01), males (43% vs. 56%, p&lt;0.001), dyslipidemic (58% vs. 42%, p&lt;0.001), diabetic (17% vs. 10%, p&lt;0.001), hypertensive (63% vs. 51%, p&lt;0.001) and had lower serum vit D levels (22.1±8.7 vs. 23.2±9.2, p 0.008). Vit D level was negatively associated with TGW (coef -0.024, CI -0.036 to -0.013, p&lt;0.001). Patients having serum vit D level &gt;28 ng/ml (highest quartile) were significantly less likely to have TGW than patients having vit D level &lt;17 ng/ml (lowest quartile) after adjusting for age, sex, race, GFR, calcium, parathyroid hormone, hypertension, hypertension medications, hyperlipidemia, hyperlipidemia medications, diabetes, end stage renal disease and hemodialysis (OR 0.56, CI 0.42-0.75, p&lt;0.001). Conclusion: Vit D deficiency is an independent predictor of TGW. Randomized controlled trials are needed to determine whether supplementation will improve cardiovascular outcomes. Table 1. Vitamin D Quartile Q1 (&lt;17 ng/ml) reference category Odds ratio 95% CI P value Q2 (17-22) 0.84 0.65 to 1.09 0.19 Q3 (23-28) 0.63 0.48 to 0.83 0.001 Q4 (&gt;28) 0.56 0.42 to 0.75 &lt;0.001

Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance

Background and aimsSpecific Suppressor of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR. Methods and Results780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (p = 0.005) and abdominal obesity (p = 0.002) and allele C carriers showed, in comparison with TT carriers, lower BMI (p = 0.001) and waist circumference (p = 0.001). rs8074124CC- carriers showed lower fasting insulin (p = 0.017) and HOMA-IR (p = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (p = 0.009) and hypertriglyceridemic waist (p = 0.006). rs12051836CC- carriers showed lower fasting insulin (p = 0.043) and HOMA-IR (p = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (p = 0.026) and HDL-C (p = 0.014) as a continuous variable. ConclusionsWe found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders.

P055 * Tissue doppler imaging provides a new access for detection of early cardiac insult in diabetic patients

P055 * Tissue doppler imaging provides a new access for detection of early cardiac insult in diabetic patients

Poor self-reported health and its association with biomarkers among Canadian Inuit

Objectives. To determine the extent to which demographic characteristics, clinical measurements and biomarkers were associated with poor self-reported health (SRH) among Inuit adults in the Canadian Arctic.Study design. Cross-sectional survey was adopted as the study design.Methods. The International Polar Year Inuit Health Survey carried out in 36 Canadian Arctic communities in 2007 and 2008 included Inuit men and women, aged 18 years or older, recruited from randomly selected households. The main outcome measure was SRH, which was dichotomized into good health (excellent, very good and good responses) and poor health (fair and poor responses).Results. Of the 2,796 eligible households, 1,901 (68%) households and 2,595 participants took part in the survey. The weighted prevalence of poor SRH was 27.8%. Increasing age was significantly associated with poor SRH. The relative risk ratios for poor SRH was 2.0 (95% confidence interval [CI] 1.3–3.1) for men aged 50 years or older and 2.3 (95% CI 1.7–3.0) for women aged 50 years or older, compared with men and women aged 29 years or younger. After adjusting for age, gender and body mass index, poor SRH was significantly associated with smoking status (odds ratio [OR]=1.5; CI 1.1–2.0), at-risk fasting glucose levels (≥6.1 mmol/L) (OR=2.5; 95%; CI 1.5–4.2) and elevated hs C-reactive protein levels (>3–≤10 mg/L) (OR=2.1; 95% CI 1.4–3.1). Poor SRH was also significantly associated with a hypertriglyceridemic waist phenotype (high-risk waist circumference ≥102 cm for men and ≥88 cm for women with high triglyceride levels, ≥1.7 mmol/L), adjusted for age and gender, OR=1.6; 95% CI 1.1–2.3.Conclusions. Clinically relevant indicators of chronic disease risk were related to subjective assessment of SRH among Inuit.

Hypertriglyceridemic waist: a simple clinical phenotype associated with coronary artery disease in women

Hypertriglyceridemic waist: a simple clinical phenotype associated with coronary artery disease in women

Hypertriglyceridemic waist: a simple clinical phenotype associated with coronary artery disease in women

Hypertriglyceridemic waist: a simple clinical phenotype associated with coronary artery disease in women

Dysfunction of high-density lipoprotein and its apolipoproteins: New mechanisms underlying cardiometabolic risk in the population at large

We review the metabolic and residual cardiovascular risk existing in populations with prevailing metabolic syndrome (MetS) or in people prone to impaired glucose tolerance. Evidence is presented that enhanced systemic inflammation, or oxidative stress associated with elevated plasma triglyceride-rich lipoproteins and their remnants, and excess oxidized lipoprotein(a) phospholipids underlie this risk. The adverse risk profile is augmented by loss of the anti-inflammatory, anti-oxidative and atheroprotective properties of high-density lipoprotein and its apolipoproteins (apo). Common clinical manifestations are atherogenic dyslipidemia and hypertriglyceridemia with elevated apoB or hypertriglyceridemic waist phenotype. These manifestations are often accompanied by such inflammatory mediators/markers as elevated serum apoE, C-reactive protein, complement C3, and uric acid levels. Compared with men, peri- and postmenopausal women are more commonly and more strongly affected by multiple inflammation mediators. The long-term effects of cigarette smoking are not adverse in such women, but instead, serve as protection against obesity and other health issues. ApoA-I may become dysfunctional in either gender, even in the absence of MetS and diabetes. The public health implications of this cardiometabolic risk are huge. Much research is needed on this topic to further clarify the impact of apoA-I dysfunction, to elucidate the underlying genetics and mechanisms, and to determine preventive measures and optimal management. Avoiding (abdominal) obesity via lifestyle modifications, including dietary changes, improving physical inactivity, and limiting smoking and alcohol consumption, are mainstay measures in the prevention and management of pro-inflammatory states and HDL dysfunction. Omega-3 fatty acids are a good adjunct to lower plasma triglycerides. When further treatment is needed, extended-release niacin or fibrates, with or without statins, are the best options.