Abstract
BackgroundThe aim of this study was to evaluate the effect of a simple visceral obesity phenotype, known as the hypertriglyceridemic waist phenotype and its quantitative indicator waist circumference index on the severity of acute pancreatitis.Materials and methodsDiagnosis and severity analysis of acute pancreatitis were determined according to the Atlanta classification guidelines, revised in 2012. We considered the hypertriglyceridemic waist phenotype as characterized by increased waist circumference and elevated triglyceride concentrations. We investigated the association between the acute pancreatitis severity and hypertriglyceridemic waist phenotype, including waist circumference index.ResultsThe hypertriglyceridemic waist phenotype was significantly associated with systemic inflammatory response syndrome, organ failure, and severe acute pancreatitis. The median waist circumference index and demonstration of hypertriglyceridemic waist phenotype were positively correlated with acute pancreatitis severity. In addition, multivariate logistic analysis showed that patients with the hypertriglyceridemic waist phenotype had 1.664 times the risk of organ failure and 1.891 times the risk of systemic inflammatory response syndrome, compared with the other groups.ConclusionUpon admission, the hypertriglyceridemic waist phenotype was strongly associated with acute pancreatitis in patients. This phenotype, including waist circumference index, might be a simple method for evaluating individuals at high risk of severe acute pancreatitis.
Highlights
Acute pancreatitis (AP) is an inflammatory disease of the pancreas and one of the main causes of acute abdominal pain [1]
The hypertriglyceridemic waist phenotype was significantly associated with systemic inflammatory response syndrome, organ failure, and severe acute pancreatitis
The median waist circumference index and demonstration of hypertriglyceridemic waist phenotype were positively correlated with acute pancreatitis severity
Summary
Acute pancreatitis (AP) is an inflammatory disease of the pancreas and one of the main causes of acute abdominal pain [1]. AP, especially severe acute pancreatitis (SAP), imposes a serious burden on patients and society. SAP accounts for 10 to 20% of all AP cases. Recent studies have shown that abnormal lipid metabolism plays an important role in the inflammatory response and prognosis of AP and is related to conditions like obesity and hypertriglyceridemia. A meta-analysis showed that obesity is associated with local complications, organ failure, and high mortality in patients with AP [8].Further studies found that visceral fat, not peripheral fat, is closely related to the formation. The aim of this study was to evaluate the effect of a simple visceral obesity phenotype, known as the hypertriglyceridemic waist phenotype and its quantitative indicator waist circumference index on the severity of acute pancreatitis
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