The NHERI Lehigh Experimental Facility, as part of the NSF funded Natural Hazards Engineering Research Infrastructure (NHERI) site, was established in 2016 as an open-access facility. This facility enables researchers to conduct state-of-art research on natural hazard mitigation in civil infrastructure systems, including high performance numerical and physical testing to improve the resilience and sustainability of the civil infrastructure against natural hazards. The facility has the unique ability to conduct real-time multi-directional hybrid simulation (RTHS) on large-scale structural systems using 3D nonlinear numerical models combined with large-scale physical models of structural and non-structural components. The Lehigh Experimental Facility processes testbeds that include a testbed for testing lateral load resisting system characterization testbed, a non-structural component multi-directional dynamic loading simulator, full-scale and reduced-scale damper testbeds, a tsunami and storm surge debris impact force testbed, and a soil-foundation structure interaction testbed. This paper describes the infrastructure and capabilities of the NHERI Lehigh Experimental Facility. Developments by the facility in advancing large-scale RTHS are given. Examples of research projects performed by users of the facility are then provided, including large-scale RTHS of steel frame buildings with magneto-rheological (MR) dampers and nonlinear viscous dampers subject to strong earthquake ground motions; 3D multi-hazard large-scale RTHS of tall steel buildings subject to multi-directional wind and earthquake ground motions; characterization of a novel semi-active friction device based on band brake technology; and testing of cross-laminated timber self-centering coupled wall-floor diaphragm-gravity systems involving multi-directional loading.