Human Body Research Articles

The Effectiveness of Ylang Ylang Oil (Cananga Odorata) as a Deparaffinizing Agent in Hematoxylin-Eosin Staining

Histological staining usually requires deparaffinization before starting the staining process. Deparaffinization is a paraffin removal step that often uses a xylol solution. Deparaffinization with xylol has disadvantages, including being toxic, harmful to the human body, and hazardous to the environment. A safer alternative to xylol is required. Ylang-ylang oil, which contains β-caryophyllene, is non-polar and can be used as a substitute for xylol. This study aimed to compare the staining quality of guinea pig liver tissue slides with and without heating as a deparaffinization agent in hematoxylin-eosin (HE) staining. The research set up a quasi-experimental approach using samples of guinea pig liver tissue slides. The sample size was calculated using the Federer formula (n-1) (t-1) ≥ 15, resulting in a total sample of 27 slides divided into three treatment groups: xylol, ylang-ylang oil with and without heating. The Kruskal-Wallis test was used to examine the data. The quality staining of guinea pig liver slides deparaffinized with xylol was 100% good, and deparaffinization of ylang-ylang oil with heating was 100% good, whereas deparaffinization with ylang-ylang oil without heating was 11.1% less good, and the quality was good with an 88.9%. The normality test indicated that the data were not normally distributed (p0.05). The Kruskal-Wallis test was then used.

Mechanics of human embryo compaction.

The shaping of human embryos begins with compaction, during which cells come into close contact1,2. Assisted reproductive technology studies indicate that human embryos fail compaction primarily because of defective adhesion3,4. On the basis of our current understanding of animal morphogenesis5,6, other morphogenetic engines, such as cell contractility, could be involved in shaping human embryos. However, the molecular, cellular and physical mechanisms driving human embryo morphogenesis remain uncharacterized. Using micropipette aspiration on human embryos donated to research, we have mapped cell surface tensions during compaction. This shows a fourfold increase of tension at the cell-medium interface whereas cell-cell contacts keep a steady tension. Therefore, increased tension at the cell-medium interface drives human embryo compaction, which is qualitatively similar to compaction in mouse embryos7. Further comparison between human and mouse shows qualitatively similar but quantitively different mechanical strategies, with human embryos being mechanically least efficient. Inhibition of cell contractility and cell-cell adhesion in human embryos shows that, whereas both cellular processes are required for compaction, only contractility controls the surface tensions responsible for compaction. Cell contractility and cell-cell adhesion exhibit distinct mechanical signatures when faulty. Analysing the mechanical signature of naturally failing embryos, we find evidence that non-compacting or partially compacting embryos containing excluded cells have defective contractility. Together, our study shows that an evolutionarily conserved increase in cell contractility is required to generate the forces driving the first morphogenetic movement shaping the human body.

The potential of MOFs embedded in banana cellulose materials for application in dialysis

The accumulation of uremic toxins in the human body presents a fatal issue that leads to the development of chronic kidney disease. The effective removal of these toxins from the bloodstream is crucial for enhancing the efficacy of hemodialysis and improving the survival rate. A comprehensive understanding of the interactions between an adsorbent and the uremic toxins is vital in the development of efficient materials for the elimination of these hazardous compounds. In this study, we investigate the adsorption behavior of various toxins, namely cresol sulfate, and creatinine, using banana cellulose and its modified form with MOFs, namely Ni-BTC, Cu-BTC, and Co-BTC. The adsorption behavior is characterized using the Langmuir and Freundlich models. The analysis reveals that the Langmuir model provides a better fit to the isotherm data compared to the Freundlich model. Furthermore, the adsorption kinetics data indicate that both banana cellulose and its modified form with MOFs adhere to the pseudo-second-order rate models rather than the pseudo-first-order model. The capacities for adsorption of cresol sulfate by banana cellulose, Ni-BTC@cellulose, Cu-BTC@cellulose, and Co-BTC@cellulose were measured to be 115, 402, 509, and 577 mg/g, respectively. Conversely, the capacities for adsorption of creatinine were found to be 166, 514, 605, and 704 mg/g, respectively. The underlying mechanism of adsorption is contingent upon the van der Waals interactions and π–π interactions. Furthermore, even after undergoing five cycles, the removal efficiency for cresol sulfate and creatinine remained at 88 % and 85 %, respectively. These findings demonstrate the renderability of MOFs@cellulose. The antimicrobial activity of the prepared MOFs was recorded for all MOFs composites against tested pathogenic microbes. Additionally, the MOFs@cellulose exhibited a satisfactory level of blood compatibility. Consequently, these exceptional MOFs@cellulose present a promising opportunity for reducing costs associated with clinical hemodialysis.

Redesigning Humans in the Nano-Age

The blurring boundaries between therapy and human enhancement raise a lot of ethical questions that need to be addressed. Therapy is healing and restoring the sick to health; enhancement is improving the normal functioning of the body. With nanomedicine, the boundary becomes even hazier. Nanomedicine refers to the application of nanotechnology to the prevention and treatment of diseases. The European Science Foundation defines it as the science and technology of diagnosing, treating, and preventing disease and traumatic injury, relieving pain, and preserving and improving human health using molecular tools and knowledge of the human body (ESF, 2005). While nanomedicine delivers numerous and unprecedented benefits to the health and general well-being of individuals, nano- enabled human enhancement technologies will be the gateway to the transhumanist vision of immortality. Transhumanism contends that through the advancements in science and technology, we can overcome our physical and cognitive limitations, extend human lifespan, and attain perpetual existence. The blurring boundaries between enhancement will have remarkable consequences on what it means to be a human being. The study will make use of New and Emerging Science and Technology (NEST) Ethics as a framework for addressing dichotomous approaches and polarizing perspectives on human enhancement.

The first two blastomeres contribute unequally to the human embryo.

Retrospective lineage reconstruction of humans predicts that dramatic clonal imbalances in the body can be traced to the 2-cell stage embryo. However, whether and how such clonal asymmetries arise in the embryo is unclear. Here, we performed prospective lineage tracing of human embryos using live imaging, non-invasive cell labeling, and computational predictions to determine the contribution of each 2-cell stage blastomere to the epiblast (body), hypoblast (yolk sac), and trophectoderm (placenta). We show that the majority of epiblast cells originate from only one blastomere of the 2-cell stage embryo. We observe that only one to three cells become internalized at the 8-to-16-cell stage transition. Moreover, these internalized cells are more frequently derived from the first cell to divide at the 2-cell stage. We propose that cell division dynamics and a cell internalization bottleneck in the early embryo establish asymmetry in the clonal composition of the future human body.

Amorphous alloy-based heater combining high electrothermal and mechanical performance

Electrothermal devices have been widely used for many years. However, their applications still mainly rely on wires made of heavy metal alloys which suffer from many disadvantages. Meanwhile, the recently discovered electrothermal materials based on carbon nanostructures are restricted by the expensive large-scale production. Here, we fabricate Fe57.2Ni18B13Si8.5P0.8Cr2.4Cu0.1 amorphous ribbons with good electrothermal and mechanical properties, which can offer overall advantages over prevailing electrothermal materials. The ribbons combine high resistivity of ~160 μΩ·cm, high strength over 2GPa and good thermal stability (Tg=730K). The ribbons can uniformly reach steady-state temperature up to 160°C within 100seconds at a driving voltage of 10V, and the produced infrared radiations are friendly to human bodies. Furthermore, the ribbons exhibit excellent flexibility and mechanical stability, where their electrothermal performance can maintain during bending, twisting and even after hundreds of cycles of deformations. Besides these advantages, amorphous ribbon can be industrially produced at a lower cost, making it possible to be used in broaden fields.

Knotted Artificial Muscles for Bio-Mimetic Actuation under Deepwater.

Muscles featuring high frequency and high stroke linear actuation are essential for animals to achieve superior maneuverability, agility, and environmental adaptability. Artificial muscles are yet to match their biological counterparts, due to inferior actuation speed, magnitude, mode, or adaptability. Inspired by the hierarchical structure of natural muscles, artificial muscles are created that are powerful, responsive, robust, and adaptable. The artificial muscles consist of knots braided from 3D printed liquid crystal elastomer fibers and thin heating threads. The unique hierarchical, braided knot structure offers amplified linear stroke, force rate, and damage-tolerance, as verified by both numerical simulations and experiments. In particular, the square knotted artificial muscle shows reliable cycles of actuation at 1Hz in 3000m depth underwater. Potential application is demonstrated by propelling a model boat. Looking ahead, the knotted artificial muscles can empower novel biomedical devices and soft robots to explore various environments, from inside human body to the mysterious deepsea.

Tribological behavior and biocompatibility of novel Nickel-Free stainless steel manufactured via laser powder bed fusion for biomedical applications

Due to the risk of releasing carcinogenic nickel ions from conventional 316L stainless steel under a corrosive human body environment, a new variant of steel termed nickel-free stainless steel (NiFSS) has been investigated. The present study investigates the tribological properties and biocompatibility of NiFSS manufactured via laser powder bed fusion (PBF-LB/M). The ferritic NiFSS exhibited significantly lower coefficient of friction (0.08 to 0.28) and wear rate (1.60 × 10-6 mm3/Nm to 6.60 × 10-6 mm3/Nm) compared to reported values for austenitic 316L SS, under both dry and simulated body fluid (SBF) conditions and various sliding geometries. This improvement is attributed to the superior hardness (3.394 ± 0.1340 GPa) and elastic modulus (238 ± 9.0797 GPa) of NiFSS. To assess the biocompatibility, the viability of mouse pre-osteoblastic MC3T3-E1 cells was evaluated with an Alamar Blue assay when the cells were cultured on top of PBF-LB/M built NiFSS and 316L SS samples. The results indicated that even though cell growth was most optimal on regular cell culture plastic, cell viability was better maintained on PBF-LB/M built NiFSS compared to 316L SS. Therefore, the results of the present study propose that PBF-LB/M fabricated NiFSS holds promise for application in biomedical devices for joint arthroplasty.

Narrative Testimony and Characteristics of Rottlerin for the Treatment of Various Kinds of Cancer

Abstract: From ancient times until now, scientists have focused on herbal medicaments for treating various diseases. Rottlerin, a potent PKCδ inhibitor, is one of the greatest herbal medications. Over the years, it was identified that rottlerin has several cellular and molecular targets that could be involved in the fight against cancer. The past and present research has clearly shown that rottlerin inhibits the transcription factors, enzymes, and signaling molecules that regulate the death and life of cancer cells. Although the anticancer property of rottlerin has primarily been attributed to the induction of autophagy and apoptosis, current research has revealed the existence of different damage pathways. The major part described in this mini-review is the antitumor/anticancer effects of rottlerin in various organs of the human body affected by breast cancer, pancreatic cell cancer, bladder cancer, NSCLC, prostate cancer, ovarian cancer, nasopharyngeal cancer, etc.

Flexible pressure sensor based on thermoplastic polyurethane/polyvinylidene fluoride nanofiber membranes

The mechanical flexibility of flexible sensors primarily originates from sensitive flexible materials. Therefore, the key to developing new flexible mechanical sensors lies in constructing high-performance sensitive flexible materials. In this study, we employ a coaxial electrostatic spinning technique to prepare thermoplastic polyurethane (TPU)/polyvinylidene fluoride (PVDF) nanofiber membranes (NFM) with a core–shell structure for the construction of flexible piezoelectric mechanosensors. The utilization of TPU/PVDF NFM in flexible mechanosensors for human health monitoring and environmental sensing is investigated. As a result, the excellent performance of this composite membrane was demonstrated by its high mechanical strength and flexibility, resulting in high sensitivity (GF: 0.42 V/kPa), low response time (100 ms), and wide sensing range (0.2∼5.0 kPa). Additionally, The TPU/PVDF NFM not only demonstrates excellent pressure sensing performance but also exhibits exceptional capabilities for human body sensing applications. Therefore, these results highlight that the TPU/PVDF NFM exhibits excellent pressure-sensing properties and holds significant potential for applications in the fields of flexible robotics and wearable devices such as human-computer interfaces, intelligent healthcare systems, and artificial intelligence skin technologies.

Physical education and positivism: some considerations in this scenario

In the historic process of breaking with the aristocracy and the clergy, giving way to the republic, industrialization and the bourgeoisie, Comtean positivism arose with the intention of legitimizing this new social structure, subordinating imagination to observation. In different movements in Physical Education, the presence of positivism is legitimized. The aim of this theoretical essay is to bring up some considerations about the marks of positivist thinking in Physical Education. Physical Education has undergone several transformations, but the biologicist, technicist and experimental character remains part of its essence, whether in professional practice or in research. Through the courses of this social practice, we see the "tool-body" inside and outside the school, the result of restricted perceptions of its possibilities, being the object of political manipulation equated in history. From its inception to its scientific flights, Physical Education emanates the consecrated vestiges of positivism, neglecting its reactive possibilities for understanding the humanized body.

Mechanical behaviour, in-vitro analysis, hemocompatibility and study of human osteosarcoma cell line proliferation of TiO2 substituted 1393-B3 Borate glass

This investigation aimed to study the effects of adding TiO2 on many aspects of 1393-B3 glasses, including their physio-chemical, mechanical parameters, crystallization behaviour, in-vitro bioactivity, hemocompatibility, and cellular viability. Here, we replaced 1393 glass silica with boric oxide to determine a more effective alternative. 1393-B3 bioactive glasses having the general weight % composition (53-X) B2O3, 6 Na2O, 5 MgO,20 CaO, 12 K2O, 4 P2O5, X TiO2 (where X=0, 1.0, 1.5, 2.0, and 2.5 %) were prepared using solid-state melt quenching method in platinum crucible at 1100ºC for 2 hours in an electric furnace with air as furnace atmosphere. This research aimed to investigate the complete substitution of 1393 glass silica with boric oxide in order to get a reduced melting temperature forming 1393-B3. The objective was to develop a more energy-efficient and economical bioactive glass. Thermal analysis of the samples was obtained up to 700ºC. To evaluate the in-vitro bioactivity, the samples were immersed in simulated body fluid (SBF). These materials undergo XRD, FTIR, and SEM/EDAX analysis both before and after soaking in SBF. These characterization results show the presence of a hydroxyapatite (HA) layer forming on the samples of the bioactive glass surface. The haemolysis process performed on human blood shows its haemocompatibility result. To test these results for the human body. we performed cell proliferation and cell compatibility on the MG-63 cell line to see its effect on osteosarcoma patients. Density (2.31 to 2.48), pH value (7.4 to 8.86), and mechanical parameters such as compressive strength (98 to 125), flexural strength (33 to 54), and elasticity are measured. As a result, physio-chemical, mechanical, biological properties and in-vitro bioactivity of these samples were obtained with increasing concentration of TiO2 in 1393-B3 borate bioactive glass and found to increase with increasing concentration of TiO2.

Amino acids profile in children with acute brucellosis.

Many new cases of brucella infections are seen in Turkey every year, especially in March, April, and May, due to the consumption of local unpasteurized cheese. Amino acids profiles have not been studied in brucellosis so far. The amino acid profiles may be affected by infectious diseases. Our study aims to evaluate the plasma amino acid profile in the progression of acute brucellosis. Plasma amino acid profile was performed by an 8045 LC-MS / MS device (Shimadzu 8045, Japan) using JASEM amino acid kit. Analysis of 45 amino acid profiles was made and results profiles showed significant differences in concentrations and types of amino acids in brucella patients. We observed a significant difference in terms of alanine, arginine, aspartic acid, glutamine, glutamic acid, glycine, isoleucine, ornithine, phenylalanine, proline, tyrosine, valine, alpha-aminoadipic acid, alpha-amino-pimelic acid, argininosuccinic acid, gamma-aminobutyric acid, thiaproline, 1-methylhistidine, 3-methylhistidine, hydroxylysine, hydroxyproline, cystine, serotonin, ethanolamine, and taurine (p-value <0.05 for each). No significant differences were determined regarding asparagine, citrulline, histidine, leucine, alloisoleucine, lysine, methionine, serine, threonine, tryptophan, anserine, alpha aminobutyric acid, beta aminoisobutyric acid, beta-alanine, cystathionine, histamine, and 5-oh-trp (p-value >0.05 for all). Patients with brucellosis have a specific profile of amino acids which may reflect sequelae of pathological and metabolic biochemical changes in the disease process due to the growth of Brucella spp. in the human body leading to an imbalance of amino acid levels.

[Contribution to the world of 3D cell products created by bio 3D printing technology and to the life science field].

We have been making 3D tissues consist of cells only, based on the corporate philosophy of "contributing to dramatic advances in medical care through the practical application of innovative 3D cell stacking technology." Currently, in the field of regenerative medicine, we are working toward obtaining approval from the Ministry of Health, Labor and Welfare and commercializing large artificial organs that are made from patients' own cells and have functions such as nerve regeneration, osteochondral regeneration, and blood vessels. On the other hand, this three-dimensional cell stacking technology can be extended to technology for culturing cells in an environment similar to the human body, and is expected to serve as a new methodology for evaluating the effects of new products in various fields on living organisms. Therefore, we are planning a business to provide developers of pharmaceuticals, foods, cosmetics, etc. with a small device called "Functional Cell Device (FCD)" that reproduces some of the functions of human organs outside the body. As the first step, we have developed a three-dimensional liver construct (3D mini-liver). The in vitro human liver model has a wide range of usage, such as evaluation of hepatotoxicity of drugs, elucidation of drug metabolism mechanism, and model of liver disease. In this report, we will outline it together with actual examples in regenerative medicine.

EFFECTS OF TRIMLINE CUT IN ANKLE FOOT ORTHOSIS: AN EXPERIMENTAL AND FINITE ELEMENT ANALYSIS

An Ankle-foot orthosis (AFO) is a structure that spans from the lower leg to the foot and controls ankle joint movement. It prevents or assists the human body's lower leg and foot in replicating a normal human gait. The purpose of AFO is to achieve a stable gait by controlling the musculoskeletal system adequately. The mechanical features of AFO stiffness will play an essential role in helping gait, if this stiffness is not matching to the patient's conditions, gait will decrease and knee joint motion will be compromised. In general, trimline cut were introduced in the AFO medial and lateral side to control the stiffness of orthosis. However, this will result in stress concentration in the ankle region and lead to failure of AFO. In this study first evaluate the effects of trimline cut in AFOs using finite element analysis with three geometrical shapes like circle, elliptical and slot were introduced on the dorsal side. The stress concentration and stiffness of AFOs in the ankle region were computed. The stiffness of the basic model and trimline cut AFO model were compared and found elliptical trimline cut model is optimum one. The experimental analysis was performed using 3D Printed AFOs and calculated stiffness. It was observed that finite element analysis results, stress concentration of trimline cut models were reduced maximum of 2% with basic model (without trimline cut)., whereas, in the experimental study of 3D-Printed AFO of trimline cut model, stiffness were reduced around 16% compared with basic models. This study clearly indicates that, geometrical shapes trimline cut influencing on stiffness of AFOs. It will give the insight’s for orthosis designers to make custom design of AFOs in particularly foot drop conditions to optimized the stiffness of orthosis.

Multi-hop graph transformer network for 3D human pose estimation

Accurate 3D human pose estimation is a challenging task due to occlusion and depth ambiguity. In this paper, we introduce a multi-hop graph transformer network designed for 2D-to-3D human pose estimation in videos by leveraging the strengths of multi-head self-attention and multi-hop graph convolutional networks with disentangled neighborhoods to capture spatio-temporal dependencies and handle long-range interactions. The proposed network architecture consists of a graph attention block composed of stacked layers of multi-head self-attention and graph convolution with learnable adjacency matrix, and a multi-hop graph convolutional block comprised of multi-hop convolutional and dilated convolutional layers. The combination of multi-head self-attention and multi-hop graph convolutional layers enables the model to capture both local and global dependencies, while the integration of dilated convolutional layers enhances the model’s ability to handle spatial details required for accurate localization of the human body joints. Extensive experiments demonstrate the effectiveness and generalization ability of our model, achieving competitive performance on benchmark datasets.

Eco-friendly wearable textiles: Asymmetric structures for EMI shielding, thermal management, and fire safety

This work focuses on developing multifunctional wearable fabrics, specifically targeting the challenge of flammability in this context. An eco-friendly, asymmetrically structured nylon/cotton blend fabric is prepared through the surface modification of phytic acid-induced polyaniline, the application of silver nanowires (AgNWs) and MXene on both sides and encapsulated by polydimethylsiloxane (PDMS). The AgNWs coating suppresses thermal radiation from the human body to achieve radiative heating, while the MXene coating enhances solar heating, ensuring thermal comfort in cold conditions. The treated fabric also exhibits electrical heating for heat compensation in the absence of sunlight, remarkable EMI shielding performance (55.6 dB) is also achieved. Enhanced fire safety is demonstrated as the treated fabric extinguishes when exposed to flame, reducing heat release by 45.9 % relative to the control nylon/cotton blend fabric (CO/NY). Additionally, the treated fabric exhibits significant antibacterial properties against Gram-negative E. coli and Gram-positive S. aureus, along with a notable water contact angle (WCA) of 130.2°. This work provides a promising method for the development of eco-friendly wearable smart fabrics with well-balanced desirable properties.

Baicalin attenuates acute skin damage induced by ultraviolet B via inhibiting pyroptosis

As the outermost layer of the human body, the skin suffers from various external factors especially light damage, among which ultraviolet B (UVB) irradiation is common and possesses a relatively high biological damage capacity. Pyroptosis is a newly discovered type of programmed cell death, which can induce cell rupture and induce local inflammatory response. However, the molecular mechanisms of pyroptosis in photodamaged skin is poorly understood. Baicalin, a flavonoid extracted from the desiccated root of Scutellaria baicalensis Georgi (Huang Qin). Despite its antioxidant abilities, whether baicalin protects skin by attenuating UVB-induced pyroptosis remains unclear, which was the aim of this study. The UVB-induced acute skin damage model was established by using human immortalized keratinocytes (HaCaT cells) and Kunming (KM) strain mice. The protective dose selection for baicalin is 50 μM in vitro and 100 mg/kg in vivo. In in vitro study, UVB irradiation significantly decreased cell viability, increased cell death and oxidative stress in HaCaT cells, while pretreatment with baicalin improved these phenomena. Furthermore, the baicalin pretreatment notably suppressed nuclear factor kappa B (NF-κB) translocation, the NLRP3 inflammasome activation and gasdermin D (GSDMD) maturation, thus effectively attenuating UVB-induced pyroptosis. In in vivo study, the baicalin pretreatment mitigated epidermal hyperplasia, collagen fiber fragmentation, oxidative stress and pyroptosis in UVB-irradiated mouse skin. In a nutshell, this study suggests that baicalin could be a potential protective agent to attenuate acute skin damage induced by UVB irradiation through decreasing oxidative stress and suppressing NF-κB/NLRP3/GSDMD-involved pyroptosis.

Tunable porous fiber-shaped strain sensor with synergistic conductive network for human motion recognition and tactile sensing

With the rapid development of portable electronic products, smart wearable devices show great application potential in personalized motion monitoring, health monitoring and even in human-machine interaction. In particular, high-performance flexible fiber-shaped strain sensors are receiving more and more attention because they can be well integrated with clothes or human skin for real-time human activities monitoring. However, achieving improved sensitivity, wide detection range, diverse applications and easy operation of them remains a challenge. Here, we adopt a simple wet-spinning technique to prepare a porous fiber-shaped carbon nanotubes (CNTs)/silver nanoparticles (AgNPs)/thermoplastic polyurethane (TPU) fiber (CATF) for high-performance strain sensor, of which the synergistic conductive network of CNTs and AgNPs enables a wide detection range (∼248 %), high sensitivity (GF > 4295), fast response/recovery time (120 ms/140 ms) and excellent stability. Interestingly, strain sensing range and sensitivity of the sensor can be tuned by changing the AgNPs loading to make it suitable for different application scenarios. All the merits of the sensor make it capable for diverse human movements monitoring, pronunciation recognition, and gesture recognition. More importantly, our prepared CATF strain sensor can be easily weaved into wearable smart textiles, showing great potential for tactile sensing to realize multi-touch and pressure tracking. Finally, the CATF also displays efficient photothermal conversion capability even under different tensile strains up to 150 %, showing great potential in human body thermal management to improve the wearing comfort of wearable electronic fabric.

A study of macrodontia of the permanent maxillary central incisors among Delta State University students in Abraka, Nigeria

Macrodontia (or megadontia) is a rare dental anomaly characterized by excessive enlargement of all tooth structures, and in few cases may be associated with morphological anomalies. The goal of this study was to find out how common macrodontia of the maxillary central incisors was among Delta State University students in Abraka. The Research and Ethical Committee of the Department of Human Anatomy and Cell Biology, Delta State University, Abraka, gave approval for this study. A descriptive cross-sectional survey with a representative sample of 102 subjects was conducted (58 female and 44 male). The method used was a simple random sampling technique. The age and sex of each subject were obtained using a data form, and intra-oral measurements of the mesio-distal width of the maxillary right central incisors were taken. Results were arranged according to age and sex to ascertain the occurrence of sexual dimorphism; independent sample t test and chi-square test were used as inferential statistical tools. The prevalence of macrodontia was 35.3%; there was a significant sex difference, as p value was &lt;0.05; there was no significant difference within the age groups, as p-value was &gt; 0.05. The mean mesio-distal width was 8.54±0.25 mm in those who did not have macrodontia and 9.63±0.54 mm in those who did have macrodontia. Macrodontia of central incisors is dominant amid Delta State University learners in Abraka.