ABSTRACT The supercritical boiler is one of the ways to enable sustainable energy development. Its revolution cannot be separated from the study of the characteristics of supercritical carbon dioxide in a spiral pipe. This research article provided an industrially compliant model of a water-cooled wall spiral pipe with one-side heating for heat transfer. The simulation was set for various parameters including P = 30.42 MPa, Tin = 578–643 K, q = 105–180 kW/m2, G = 1784–2348 kg/m2s. The article discussed in detail factors such as buoyancy and secondary flow for these cases. The results showed that in the range of high parameters, mass fluxes, heat fluxes, and inlet temperature all had a substantial influence on the temperature and velocity fields, with the mass flux showing a non-monotonic trend on the HTC and the heat flux having a more subtle influence on the HTC. The inhomogeneous heating pattern affected the buoyancy and secondary flow motion, changing the temperature field in the tube, and enhancing the velocity field at the bend and on the heating side. A new empirical correlation for supercritical CO2 with non-uniform heating was proposed.