Micromixing and fluid shear stress significantly affect the nucleation and growth of crystals during the precipitation process. The jet-flow high shear reactor (JFHSR) has strong shear rate and high localized energy dissipation rate, making it promising for applications where the size and the morphology of crystals need to be modified. In this paper, the micromixing properties of JFHSR were first investigated using Villermaux/Dushman method, and the intrinsic correlation among micromixing, shear, and BaSO4 crystals was explored. The results show that the stator, the increased Re and θ, the reduced feed tube diameter and the closer the feed position to the rotor promote micromixing. Excellent micromixing promotes burst nucleation by generating uniform supersaturation, while shear is more likely to provide an environment dominated by the secondary nucleation of fluid shear stress. The correlations of XS, tm (about 10−4 s) and d43,P are obtained, providing guidelines for JFHSR design and application