Higher Dissolution Rate Research Articles

NEVIRAPINE SOLID DISPERSION: DESIGN, DEVELOPMENT AND EVALUATION

The objective of the present investigation was to enhance the solubility and dissolution rate of BCS class II drug nevirapine through scalable and commercially feasible solid dispersion approach by using Soluplus® (BASF) as hydrophilic carrier. The solid dispersion produced by melting method (1:5 weight ratio) exhibited highest solubility ~ 15 folds greater than pure drug. The changes in DSC, PXRD, and SEM validated the formation of solid dispersion and transformation of drug from crystalline to amorphous form. Besides, selected solid dispersion had better flow properties and higher dissolution rate than nevirapine. Furthermore, the two dissolution profiles were different (f2 value 33). Hence, preparation of nevirapine-soluplus® solid dispersion by melting method could be an appropriate pharmaco technical strategy to enhance the solubility and dissolution rate of nevirapine and probably other BCS class II drugs.

Analytical model for fines migration due to mineral dissolution during CO2 injection

Recent laboratory studies have proposed carbonate mineral dissolution as a main mechanism for fines migration during CO2 injection. However, existing mathematical models of fines migration ignore mineral dissolution as a mechanism for fines generation. To address this gap, we derive a basic system of governing equations that incorporate fines migration induced by mineral dissolution. An analytical solution is derived for four zones defined based on normalized porosity and carbonate mineral concentration profiles. These profiles are then used to derive the suspended and retained fines concentrations. The analytical solution is found to be in close agreement with the numerical solution of the basic system of governing equations. To validate our model, we perform injection experiments on four Berea sandstone cores. Each core receives injection of CO2-saturated water of designated salinity 0, 0.17, 0.51, or 1.03 M NaCl.The results suggest that two competitive phenomena occur due to carbonate mineral dissolution during CO2-saturated water injection, i) increased porosity that is responsible for the increase in permeability and ii) fines migration that results in permeability reduction. Dissolution of intergranular cement results in fines dislodge, some of which subsequently cause pore blockage and permeability reduction.For 0, 0.17, and 0.51 M salinity, mineral dissolution is found to be dominant, yielding a net increase in rock permeability due to increased porosity. For 1.03 M salinity, higher dissolution rates are found to cause significantly more fines, yielding a net decrease in rock permeability. The comparison of experimental and modelling data shows high agreement with the experimental data, which validates the proposed model.

Thermally Enhanced Bioremediation of NAPL Polluted Soil-Water Resources

The use of conventional techniques for physico-chemical remediation of hydrocarbon such non-aqueous phase liquids (NAPL)-polluted sites may disturb the natural biotic settings of the (sub)-surface. However, natural attenuation has been reported very slow and sometime results as incomplete removal under prevailing site conditions. In particular, microbial growth is quite slow in cold regions, which reduces the applicability of bioremediation in treating NAPL-polluted soil-water. Thus, this study aims to evaluate the thermally enhanced bioremediation techniques to treat NAPL-polluted soil-water using practical experiments. A one-dimensional large column setup was designed and fabricated for this purpose. The column was integrated with automatic temperature controlling baths to maintain different soil-water temperatures (4 °C, 20 °C, 28 °C, and 36 °C), which was circulated through the porous media filled in the column setup. Results show a high dissolution rate of toluene, the selected light NAPL, at an elevated temperature of 28–36 °C. The biodegradation rates of the NAPL were found to be 0.002 mg L/h, 0.008 mg L/h, 0.012 mg L/h, and 0.015 mg L/h at soil-water temperature levels of 4 °C, 20 °C, 28 °C, and 36 °C, respectively. It was found that at high soil-water temperature (28 °C and 36 °C), a significant increment in microbial actions accelerates the biodegradation rate of NAPL in the subsurface system. The outcomes of this study may help in treating NAPL-polluted sites using solar or geo-thermal based heating systems for thermally enhanced bioremediation.

In Vitro Evaluation of Dalbergia sissoo and Acacia modesta gum as Pharmaceutical Binders for Drug Delivery System

The present study aimed to compare the crude, modified and hydrolyzed gums of Dalbergia sissoo and Acacia modesta as a biodegradable binder for drug delivery system using acetaminophen as a model drug. The physiochemical properties such as pH, fluorescence analysis and swelling index were determined. The gums were hydrolyzed and modified. Acetaminophen tablets were prepared using wet granulation technique and the gum solutions were used as a binder. Hydroxypropyl methylcellulose was used as a synthetic binder. Different properties of granules and tablets were evaluated. Results showed that both gums were acidic in nature, while D. sissoo and A. modesta showed light brown and creamy color in fluorescence analysis. The swelling ratio was the highest in water followed by 0.1N HCl and least in phosphate buffer. The prepared tablets showed faster and slower dissolution profiles in the same dissolution system. The crude gums have the highest dissolution rate, and this rate was decreased in the case of modified and hydrolyzed gums samples. The crude gums showing slower release can be useful in sustained-release tablets, while the modified gums having faster release rate are helpful in conventional tablet formulation. Taken together, the selected gums could be a good model for evaluation as a binder or hydrophilic polymer in tablet formulation.

Innovated formulation of oseltamivir powder for suspension with stability study after reconstitution using a developed ion-pair reversed phase high-performance liquid chromatography method.

ABSTRACTOseltamivir is an antiviral neuraminidase inhibitor used for the treatment and prophylaxis of influenza infection with viruses A and B. The mechanism of oseltamivir antiviral activity is by inhibiting the activity of the viral neuraminidase enzyme present on the surface of the virus, which stops viral replication and infectivity. Oral suspensions of oseltamivir phosphate are dispensed orally capsules and suspension. However, the use of oral suspension for pediatric administration is preferable and is prepared as a powder for suspension. The reconstituted suspension degrades rapidly within a few days. The objective of this work is to establish a stable formulation of oseltamivir phosphate as a suspension and to assure the stability conditions for prolonged use after reconstitution in aqueous form. In addition, this required formulation should maintain a high rate of dissolution, which subsequently leads to higher bioavailability. In this study, oseltamivir forms an inclusion complex with the natural and safe polymer hydroxypropyl beta-cyclodextrin, which resembles a host because its structural cavity carries the oseltamivir molecule in the aqueous preparation and provides a protective property against environmental challengers. In addition, a high-performance liquid chromatography (HPLC) stability-indicating method of analysis has been developed using an ion-pair reversed-phase HPLC technique that is validated for precision, accuracy, reproducibility, and specificity for the determination of oseltamivir in suspension. The results of this work show the relatively long shelf life of the reconstituted oseltamivir oral powder for suspension in the new pediatric formulation, and the developed HPLC method was precisely suitable for stability study.

Solubilization and In Vitro Physical and Chemical Properties of the Amorphous Spray‐Dried Lactose‐Luteolin System

Luteolin is a hydrophobic drug with low solubility, which has many limitations in practical use. To improve solubility, a spray drying technique was used to prepare complexes with lactose to promote the solubility and bioavailability of luteolin. The solution samples were spray dried using different ratios of water and ethanol as different dissolution media. By characterizing the spray‐dried powders obtained, we found that the solubility of the different groups of samples obtained by spray drying was improved, and similarly, their dissolution rates were also increased to different degrees. By comparison, both luteolin and the cofactor lactose were able to achieve high dissolution rates at suitable solution ratios and formed amorphous eutectic crystals after the spray drying process, which contributed well to the increased solubility and altered dissolution efficiency of luteolin.

Corrosion behavior and mechanism of CLAM and 316L steels in flowing Pb–17Li alloy under magnetic field

The liquid lead-lithium (Pb–17Li) blanket has many applications in fusion reactors due to its good tritium breeding performance, high heat transfer efficiency and safety. The compatibility of liquid Pb–17Li alloy with the structural material of blanket under magnetic field is one of the concerns. In this study, corrosion experiments China low activation martensitic (CLAM) steel and 316L steel were carried out in a forced convection Pb–17Li loop under 1.0 T magnetic field at 480 °C for 1000 h. The corrosion results on 316L steel showed the characteristic with a superficial porous layer resulted from selective leaching of high-soluble alloy elements and subsequent phase transformation from austenitic matrix to ferritic phase. Then the porous layers were eroded by high-velocity jet fluid. The main corrosion mechanism of CLAM steel was selective dissolution-base corrosion attack on the microstructure boundary regions and exclusively on high residual stress areas. CLAM steel performed a better corrosion resistance than that of 316L steel. The high Ni dissolution rate and the erosion of corroded layers are the main causes for the severe corrosion of 316L steel.

A transient, perched aquifer model for banana hole formation: Evidence from San Salvador Island, Bahamas

AbstractBanana holes are karst depressions that have primarily been reported from strandplains within the Bahamian archipelago. Banana holes have been hypothesized to form by downward dissolution in the vadose zone and in the phreatic zone by mixing dissolution and/or spatial variability in organic carbon inputs to the water table. While vadose models have been unable to explain overhanging roofs common in banana holes, phreatic models require anomalously high dissolution rates. In this study, we develop a new model for banana hole formation based on field observations, an airborne LiDAR (light detection and ranging) survey, and published geochemical data on San Salvador Island, Bahamas. We detected 3356 depressions in LiDAR data consistent with banana hole morphologies in Marine isotope substage (MIS) 5e and MIS 9/11 strandplains. No banana holes were detected in Holocene strandplains. All banana holes were found in swales between ridges. Of the banana holes found in MIS 5e strandplains, 109 had floor elevations between 6 and 19 m above sea level. These banana holes could not have formed in the phreatic zone because the MIS 5e freshwater lens reached a maximum elevation of 6 m above modern sea level. We also observed banana holes filled with water during wet seasons. While wells next to banana holes were tidal, pools in the banana holes were not, indicating pools were perched. Our observations, supported by hydrological models, suggest banana holes may form in the vadose zone in transient, perched aquifers on exposure zones. Runoff from ridges infiltrates through vadose fast‐flow routes until encountering low permeability exposure zones, where flow is directed laterally. Dissolution by perching on exposure zones would create thin, laterally‐extensive chambers radiating from injection points. Subsequent roof collapse results in their surface expression. Because dissolution occurs when waters become perched, chambers could form throughout low stands and may therefore not reflect rapid phreatic dissolution.

Construction of Large Non-Localized π-Electron System for Enhanced Sodium-Ion Storage.

Organic electrode materials with the advantages of renewability, environment-friendliness, low cost, and high capacity have received widespread attention in recent years for sodium-ion batteries. However, small molecular organic materials suffer from issues such as low conductivity and the high dissolution rate in electrolytes. Herein, a phthalocyanine derivative (TPcDS) with a large non-localized π-electron system, obtained through thermodynamic polymerization of 4-aminophthalonitrile (AP) monomers, is designed to address these issues. According to the density function theory calculation, six sodium ions can be attracted by one polymer molecule, indicating a high theoretical capacity of 375mAhg-1 . The TPcDS molecule realizes sodium storage through a non-localized π-electron system of phthalocyanine macrocycles. When employed as an anode material for sodium-ion batteries, the functional groups of phthalocyanine macrocycles, such as CN groups in TPcDS, experience obviously reversible structural variation upon discharge/charge. A high reversible capacity of 364mAhg-1 is achieved at a current density of 0.05Ag-1 , and a charge capacity of as high as 246mAhg-1 is still maintained after 500cycles at 0.1Ag-1 . This work provides an effective strategy for the design and synthesis of new oligomeric organic electrode materials.

Direct visualization of kinetic reversibility of crystallization and dissolution behavior at solution growth interface of SiC in Si-Cr solvent

The present study is a challenge to visualizing the solution growth behavior of SiC in a high-temperature solvent of Si-Cr. In situ observation of SiC-solution growth interfaces with a confocal scanning laser microscope was successful, revealing the effects of Cr addition on the solution growth behavior. The most outstanding finding in this study is that the Cr addition significantly enhances the kinetic reversibility with high reaction rates of both elemental crystallization and dissolution at the SiC solution interface, besides the well-known increase of the net crystal growth rate that has been explained primarily from the viewpoint of thermodynamics, i.e., by the strong temperature dependence of carbon solubility in Si-based solvents.

Dissolution kinetics of marmatite in sulfuric acid-ferric sulfate‑sodium chloride‑oxygen media at atmospheric pressure

An experimental investigation was carried out to improve the zinc dissolution rate in the direct atmospheric leaching of marmatite by adding sodium chloride to the sulfuric acid-ferric sulfate‑oxygen media. The experiments were carried out by using mono-sized marmatite particles varying the concentrations of sulfuric acid from 0.1 to 1.3 M, ferric sulfate from 0 to 0.8 M, sodium chloride from 0 to 1.3 M, and temperature in the range of 60 to 95 °C. The results showed that the addition of 0.7 M of sodium chloride improved drastically the direct leaching kinetics of the zinc sulfide; therefore, this leaching media is an excellent alternative to produce zinc from marmatite concentrates at ambient pressure. The sulfuric acid concentration was also found to have a significant effect on the rate of dissolution, indicating that the non-oxidative dissolution of marmatite plays an important role in the reaction mechanism in this system. A shrinking core model with diffusion through a product layer control was found to fit the reaction rate. An apparent activation energy value of 81.8 kJ/mol was found for the temperature range of 60–95 °C. The direct atmospheric leaching of marmatite in H2SO4-Fe(SO4)1.5-NaCl-O2 is an excellent alternative method to extract zinc due to high dissolution rates obtained in the presence of chloride ions, reducing substantially the treatment times.

Formulation and Evaluation of Sustained Release Bilayer Matrix Tablet of Glimepiride and Metformin Hydrochloride

The aim of the present study was to design and evaluate bilayer tablets of metformin hydrochloride as sustained release form for the treatment of Type-II diabetes mellitus. The basic aim of any Bi-layer tablet formulation is to separate physically or chemically incompatible ingredients and to produce repeat action or prolonged action of tablet. They are many drugs for treating type-II diabetes. Sulphonyl urea and biguanides are used commonly by a wide section of patients. Melt granulation process was used for the formulation of sustained comprising metformin layer and wet granulation of immediate comprising layer of glimepiride. The precompression studies like bulk density, tapped density, angle of repose, compressible index and post formulation studies includes weight variation, hardness, thickness, friability and dissolution study. The in-vitro release profile of Glimepiride was dissolved within 45 min, and Metformin Hydrochloride was able to release more than 12 hrs. They all the formulation was optimized formula due to its higher rate of dissolution and collate all other parameters with the official specifications.

Environmental implications of MoS2 nanosheets on rice and associated soil microbial communities

Molybdenum disulfide (MoS2) is a transition metal dichalcogenides (TMDCs) material that is seeing rapidly increasing use. The wide range of applications will result in significant environmental release. Here, the impact of MoS2 nanosheets on rice and associated soil microbial communities was evaluated. Rice plants were grown for 4 weeks in a natural paddy soil amended with either 1T or 2H phase MoS2 nanosheets at 10 and 100 mg kg−1. The 1T MoS2 nanosheets have a significantly greater dissolution rate (58.9%) compared to 2H MoS2 (4.4%), indicating the instability of 1T MoS2 in environment. High dissolution rate resulted in a high Mo bioaccumulation in rice leaves (272 and 189 mg kg−1 under 1T and 2H exposure at 100 mg kg−1). However, this did not induce overt phytotoxicity, as indicated by a range of phenotypic or biochemical based determine endpoints, e.g., biomass, photosynthetic pigments, and malondialdehyde (MDA) content. Additionally, rice P uptake was significantly increased upon exposure to 1T and 2H MoS2 (10 mg kg−1). Gas chromatography-mass spectrometry (GC-MS) reveals that both phases of MoS2 in soil systematically enhanced the carbon and nitrogen related metabolic pathways in exposed plants. Soil 16S rRNA gene sequencing data show that soil microbial community structure was unchanged upon MoS2 exposure. However, both phases of MoS2 remarkably increased the relative abundance of N2-fixation cyanobacteria, and 2H MoS2 exposure increased a plant growth-promoting rhizobacteria-Bacillus. Overall, our results suggest that MoS2 nanosheets at tested doses did not exert negative impacts on rice plant and the associated soil microbial community.

Zn based hydroxyapatite based coatings deposited on a novel FeMoTaTiZr high entropy alloy used for bone implants

In this paper, a novel biocompatible alloy defined as FeMoTaTiZr was obtained and functionalized by hydroxyapatite-based coatings (HAP) in order to increase their biocompatibility, bioactivity, and resistance to corrosion for to be used as bone implants. To obtain the surface with antibacterial properties, the HAP coatings were doped with small amount of Zn. The alloy was prepared using the VAR (Vacuum Arc Remelting) equipment, while the coatings by RF magnetron sputtering method. The EDS analysis confirmed the presence of Ca and P in the case of all developed coatings, having Ca/P ratio ranged from 1.69 (undoped HAP) to 1.96 (Zn doped HAP). The (Ca+Zn)/P ration was of about 2.15 for the Zn doped HAP coatings. The XRD and ATR-FTIR investigations confirmed the presence of calcium phosphate phases. After coating with HAP, the roughness of uncoated substrates increased with 1.4 times, and it was considerably increased by the Zn addition with 2.4 times. The electrochemical tests showed that the un-doped HAP exhibited good corrosion behavior, while Zn doped HAP coatings have a high dissolution rate in fetal bovine serum, being more proper as a biodegradable material.

Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate.

In the current work, mesoporous magnesium carbonate (MMC) was used to suppress crystallization of the poorly soluble drug celecoxib (CXB). This resulted in both a higher dissolution rate and supersaturation of the substance in vitro as well as an increased transfer of CXB over a Caco-2 cell membrane mimicking the membrane in the small intestine. The CXB flux over the cell membrane showed a linear behavior over the explored time period. These results indicate that MMC may be helpful in increasing the bioavailability and obtaining a continuous release of CXB, and similar substances, in vivo. Neusilin US2 was used as a reference material and showed a more rapid initial release with subsequent crystallization of the incorporated CXB in the release media. The presented results form the foundation of future development of MMC as a potential carrier for poorly soluble drugs.

Effect of Mn Content on the Passivation and Corrosion of Al0.3Cr0.5Fe2MnxMo0.15Ni1.5Ti0.3 Compositionally Complex Face-Centered Cubic Alloys

Al0.3Cr0.5Fe2MnxMo0.15Ni1.5Ti0.3 (x = 0, 0.25, 0.5, 1) compositionally complex alloys are synthesized and annealed at 1,070°C to form two-phase alloys with a face-centered cubic (fcc) matrix and a second phases enriched in Al, Ti, and Ni with slightly reduced density, raw element costs, and passivating elements distributed across both phases. The global corrosion resistance is evaluated in 0.01 M and 0.1 M NaCl at both natural pH and pH 4. Overall corrosion resistance is suggested to be optimized at Mn concentrations of 5.0 at%, indicated by pitting potentials comparable to or exceeding those of 316L stainless steel. Improvements in corrosion resistance and optimization of Mn concentration are further assessed by polarization, impedance, and gravimetric analysis after extended aqueous exposure. The fate of individual elements during the dissolution and passivation processes is evaluated with in situ atomic emission spectroelectrochemistry and ex situ x-ray photoelectron spectroscopy. Passivity was derived from combinations of Ti4+, Cr3+, and Al3+ oxides in an undetermined solid solution or complex oxide. Enhanced corrosion resistance is attributed to the improved chemical homogeneity of passivating elements within the two-phase microstructure, while the decreased corrosion resistance of alloys with higher Mn concentrations is attributed to high Mn dissolution rates and/or destabilization of the passive films. The underlying determinants of the role of Mn in the design of corrosion-resistant lightweight compositionally complex alloys are discussed.

Mechanisms of structural-phase transformations during crystallization of solder melt under conditions of magnetic-dynamic influences for carbide tools

The processes of melt formation were studied by methods of optical and electron scanning microscopy. These processes occur during induction brazing of a hard alloy to a steel holder and contact interaction of low-melting (copper-zinc system alloy) and refractory (iron-nickel) components of the solders. It is shown that the effect of a thermal and magnetic-dynamic high-frequency electromagnetic field on the components of the composite solder is how a high-strength solder joint is formed. The structure is forming by disperse hardening mechanism. The research of the contact interaction process for low-melting and high-melting components of solders during the soldering process of the tool showed that the formation of solder in brazed seams occurs through a number of stages and this does not lead to the formation of microstructures that are characteristic of alloys based on copper-iron-phosphorus, copper-zinc-nickel and copper-zinc-iron. Thus, the use of composite solders can reduce the soldering temperature by 40-50 K and increase the concentration of alloying species in the solder and change its structure. These advantages of composite solders reduce the thermal impact on contact materials, increase the strength of the weld and allow you to control the thickness of the brazed weld, and this is important when soldering hard alloys of WC-TiC (TaC) systems. High initial dissolution rates of nickel particles in the copper-zinc melt and the solubility of copper, zinc in nickel lead to the formation in the melt of quasi-liquid particles of the nickel alloy. When the melt is cooled, particles other than the surrounding alloy composition are formed. They are morphologically related to the grain structure of the solder. The formed alloy (solder) has the structure of a composite material in which the metal particles are enriched in nickel, and have the role of a reinforcing element.

Development of Fully Redispersible Dried Nanocrystals by Using Sucrose Laurate as Stabilizer for Increasing Surface Area and Dissolution Rate of Poorly Water-Soluble Drugs

There is much interest in converting poorly water-soluble drugs into nanocrystals as they provide extremely high surface area that increases dissolution rate and oral bioavailability. However, nanocrystals are prepared as aqueous suspensions, and once the suspensions are dried for development of solid dosage forms, the nanocrystals agglomerate as large particles to reduce the excess surface energy. For successful development of drug products, it is essential that any agglomeration is reversible, and the dried nanocrystals regain original particle sizes after redispersion in aqueous media. We have established that sucrose laurate serves as a superb stabilizer to ensure complete redispersion of dried nanocrystals in aqueous media with mild agitation. Nanocrystals (150–300 nm) of three neutral drugs (fenofibrate, danazol and probucol) were produced with sucrose laurate by media milling, and suspensions were dried by tray drying under vacuum, spray drying, and lyophilization. Dried solids and their tablets redispersed into original particle sizes spontaneously. Preliminary studies showed that sucrose laurate can also redisperse acidic and basic drugs, indicating its versatile application. Fatty acid ester of another disaccharide, lactose laurate, also performed like sucrose laurate. Thus, we have developed a method of retaining high dissolution rate and, by implication, high bioavailability of nanocrystals from solid formulations.

Lipid-Polymer Hybrid Nanocarriers for Oral Delivery of Felodipine: Formulation, Characterization and Ex-Vivo Evaluation

Purpose: Felodipine, is a calcium-channel antagonist used for hypertension and angina pectoris. It is practically insoluble in aqueous media and shows low oral bioavailability (15%-20%). This investigation aims to prepare and characterize oral felodipine lipid-polymer hybrid nanocarriers (LPHNs) to increase solubility and control delivery for increasing bioavailability and enhance patient compliance. Methods: The newly microwave-based method was prepared with felodipine LPHNs (H1-H35) successfully. The (H1-H35) were subjected to thermodynamic stability experiments. After that, select nine felodipine LPHNs (F1-F9) that have smart physical stability for further optimization of different characterization processes. Results: The felodipine LPHNs (F4) are considered the most optimized formula. It was characterized by lower particle size (33.3 nm), lower PDI (0.314), high zeta potential (13.6 mV), entrapment efficiency is (81.645% w/w), drug loading is (16.329% w/w), the pH value is 4, excellent percent of light transmittance (95.5%), pseudoplastic rheogram, significantly high (P < 0.05) dissolution rate with sustained drug delivery and success ex-vivo intestinal permeation attributes. The (F4) subject for further investigations of Fourier transformed infrared spectroscopy (FTIR), atomic force microscopy (AFM), and transmission electron microscopy (TEM). The results of FTIR, AFM, and TEM indicate there is no interaction between the felodipine and excipients and that the particulate system in the nanoscale dispersion system confirms the high stability. Conclusion: The optimized felodipine LPHNs (F1-F9) formulations were smart formulations for sustained oral delivery of felodipine and that F4 was the most optimized formula according to its characterization processes.

Effect of the Carrier on the Coprecipitation of Curcumin through Supercritical-Assisted Atomization

In this paper, composite systems containing curcumin (CUR) were prepared through supercritical-assisted atomization (SAA), using different carriers. Curcumin is particularly interesting in the pharmaceutical and nutraceutical fields for its antioxidant, antitumoral, and anti-inflammatory properties. However, its therapeutic effect on human health is restricted by its poor water solubility and low dissolution rate, limiting its absorption after its oral administration. To increase the dissolution rate and then the bioavailability of the active compound, CUR was coprecipitated with polymeric, i.e., polyvinylpyrrolidone (PVP) and dextran (DXT), and not polymeric, i.e., hydroxypropyl-β-cyclodextrin (HP-β-CD), carriers. The effects of some operating parameters, namely the concentration of solutes in solution and the active compound/carrier ratio, on the morphology and the particle size distribution of the powders were investigated. Submicrometric particles were produced with all the carriers. Under the best operating conditions, the mean diameters ± standard deviation were equal to 0.69 ± 0.20 μm, 0.40 ± 0.13 μm, and 0.81 ± 0.25 μm for PVP/CUR, DXT/CUR, and HP-β-CD/CUR, respectively. CUR dissolution rates from coprecipitated particles were significantly increased in the case of all the carriers. Therefore, the results are exciting from a pharmaceutical and nutraceutical point of view, to produce supplements containing curcumin, but assuring a high dissolution rate and bioavailability and, consequently, a more effective therapeutic effect.