Abstract
The objective of the present investigation was to enhance the solubility and dissolution rate of BCS class II drug nevirapine through scalable and commercially feasible solid dispersion approach by using Soluplus® (BASF) as hydrophilic carrier. The solid dispersion produced by melting method (1:5 weight ratio) exhibited highest solubility ~ 15 folds greater than pure drug. The changes in DSC, PXRD, and SEM validated the formation of solid dispersion and transformation of drug from crystalline to amorphous form. Besides, selected solid dispersion had better flow properties and higher dissolution rate than nevirapine. Furthermore, the two dissolution profiles were different (f2 value 33). Hence, preparation of nevirapine-soluplus® solid dispersion by melting method could be an appropriate pharmaco technical strategy to enhance the solubility and dissolution rate of nevirapine and probably other BCS class II drugs.
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