Relevance. When cultivating seed hemp, comprehensive crop protection is necessary throughout the entire development cycle “from seed to seed”. A comprehensive system of environmentally oriented protective equipment during pre-sowing and foliar treatment of seeds and plants can provide a favorable phytosanitary environment.Methods. The research work was carried out in accordance with the methodological guidelines for conducting field and vegetation experiments with cannabis and the methodology of field experience with the basics of statistical processing of research results.Results. Etching with the insectofungicide “Celest Top, KS” in pure form and in tank mixtures showed a high degree of protection of seeds from infection during germination. The use of “Celest Top, KS” in its pure form and in combination with the growth regulator “Artafit, VRK” and the liquid fertilizer “Megamix. Seeds” is most effective against hemp fleas. Etching “Artafit, VRK”, “Celest Top, KS” and mixtures with the fertilizer “Megamix. Seeds” and foliar top dressing with the antistressant “Artafit, VRK” contributed to an increase in the indicators of the crop structure. A high yield of seeds and stems was obtained on variants with the “Megamix. Seeds” fertilizer, the increase in seed yield was 0.03 t /ha, stems — 0.16 t /ha relative to the control. The use of the fertilizer “Megamix. Seeds” together with the growth regulator “Artafit, VRK” and the insectofungicide “Celest Top, KS” increased the yield of seeds by 0.28 and 0.17 t/ha, the yield of stems by 2.2 and 3.32 t/ha.