This work put forward a novel approach to enhancing high-temperature creep resistance of 7055 Al alloy via inducing reinforcements including in-situ (Al2O3 + ZrB2) nanoparticles and Al3(Er, Zr). Creep steady-state rates of the (Al2O3 + ZrB2)/7055 Al composites enhanced by synergistic Er, Zr were lower than the (Al2O3 + ZrB2)/7055 Al composites, indicating the values of stress component (n) and apparent activation energy (Q) were 1.05–1.15 and 1.06–1.08 times of (Al2O3 + ZrB2)/7055 Al composites. The dislocation climb mechanism was considered as the dominative creep mechanism because the suitable true stress exponent was 5. The uniform distribution of Al2O3 and Al3(Er, Zr) and their influence on improving the distribution of ZrB2 aggregates gave rise to relative uniform deformation during creep process. The built interface models that induce Al3(Er, Zr) between the nanoparticle/Al interface could lead to a more thermodynamically stable and well-bonded interface. The coupling effect of attachments containing Al2O3, ZrB2 and Al3(Er, Zr) played an enhanced role in terms of vacancy-trapping, precipitate-nucleation, dislocation motion during creep process. The nanoparticles and Al3(Er, Zr) together with nuclear sites containing solute atoms, vacancies and misfits nearby, caused an expansion-inhibiting effect on the helical dislocations. The in-grain misorientation axes (IGMA) concentration of some deformed grains associated with Schmid factor (SF) analysis were related to 〈001〉, 〈111〉 and 〈101〉 direction. The calculation of creep resistance mechanisms was quantified. Additionally, typical intergranular fracture appeared within the composites due to the relatively uniform reinforcements, resulting in the complex crack path.