The selected high-span continuous rigid frame bridge for studying is Mangjiedu Bridge in this paper. Based on the principle of structure dynamics and the method of seismic response analysis, the finite element model of the main bridge in Mangjiedu Bridge under Midas-civil was built according to the structural features, site conditions and seismic fortification intensity of the bridge. Then the characteristics of main bridge structure were studied using Lanzcos modal analysis method, and the seismic responses of main bridge are studied by earthquake response spectrum analysis and time history analysis respectively. The results show that the fundamental frequency of the main bridge is 0.1943Hz, and the transverse vibration mode shapes are most remarkable in the former 10 ordered types of vibration of main bridge. The main bridge is in the conditions of elastic range and does not failure under E1 earthquake. Both response spectrum analysis and time history analysis show that the largest displacement along the main bridge appears at the top of pier and the largest transverse displacement appears in the central position of main span. It also shows that the maximum shear and maximum moment occur at the bottom of main pier.