Women report different levels of wayfinding inclinations than men. This study is an exploration of whether individual factors such as personality traits and affect can provide insights into the gender differences observed in wayfinding inclinations, such as in the attitudes toward exploring and spatial anxiety. The study involved 454 adults (271 women) who completed questionnaires on personality traits, affective state, attitudes toward exploring and spatial anxiety. Women reported lower positive attitudes toward exploring and higher spatial anxiety than men. Openness and positive affect were associated with positive attitudes toward exploring places in both genders whereas extraversion was associated with attitudes toward exploring places among men. Higher levels of extraversion were linked to lower spatial anxiety in both genders, higher levels of negative affect were associated with greater spatial anxiety among men, and lower levels of emotional stability were associated with greater spatial anxiety among women. Therefore, gender does not play a singular role in explaining differences in self-reported wayfinding inclinations. Instead, negative affect (at least for men) and low emotional stability (at least among women) tend to hinder such inclinations whereas openness and positive affect contribute to their promotion. These results provide insights into how the patterns of relationships among wayfinding inclinations, personality traits, and affect vary between men and women, with possible implications for assessment and intervention.