Hereditary Characteristics Research Articles

A review on bioinformatics using data mining techniques

Bioinformatics alludes to the accumulation, grouping, storage and the investigation of biochemical and organic information. It uses PCs particularly, as executed toward sub-atomic hereditary qualities and genomics. Data mining is utilized to extract the data from a lot of information. Data mining comprise of two models, they are predictive and descriptive. Managing data intends to assemble data into an arrangement of classes either with the end goal to learn new antiquities or see new domains. For this reason specialists have dependably searched for the shrouded examples in information that can be characterized and contrasted and other known thoughts dependent on the comparability or disparity of their credits as indicated by all around characterized rules. We have shown the overview of different information digging algorithms for the combination of different examination instruments material specifically explore errands. There is no particular clustering algorithm, however different algorithm are used dependent on domain of information that establishes a group and the level of proficiency required. Clustering techniques are classified dependent on various methodologies. This paper is a review of few clustering methods out of numerous in data mining. The Clustering techniques which have been reviewed are: K-medoids, Fuzzy C-means, K-means, Density-Based Spatial Clustering of Applications with Noise and Self-Organizing Map grouping. This paper overviewed the some algorithm gives the best outcome. The scientists utilized diverse arrangement algorithm in which are to be specific K-Nearest Neighbor classifiers, Artificial Neural Networks, Bayesian system, Decision tree, Support Vector Machine.

Molecular nature of dominant naked pupa mutation reveals novel insights into silk production in Bombyx mori

Silks are natural protein biopolymers with desirable mechanical properties and play crucial roles in insect survival and reproduction. However, the mechanisms by which large amounts of silk fibroin are efficiently secreted from the protein production organs (silk glands) remain elusive. Here, we focus on a dominant silkworm mutation, naked pupa (Nd), which enables carriers to lose spinning behaviors, produce a deficiency of silk fibroin production, and result in degenerate posterior silk gland (PSG). Linkage mapping and sequencing analyses revealed a deletion of 19 bp of the fibroin heavy chain (FibH), which results in a frameshift-caused deletion of the C-terminal domain (CT) responsible for the Nd locus. Immunofluorescence and immunoblot analysis showed that the PSG cells with truncated FibH exhibit blockades in the secretion of all three fibroins (FibH, FibL, and P25) from silk gland cell to silk gland lumen (a secretion-deficiency). By comparing the hereditary characters of three naked silkworm mutations (Nd, Nd-s, and fibH-ko), we explored the relationship between dominant and recessive inheritances in naked silkworms and found that high-molecular-weight/repetitive FibH with secretion-deficiency was in positive correlation with PSG atrophy phenotype, and moreover, the repetitive region of Nd-FibH accounted for the dominant phenotypes of fibroin secretion-deficiency, PSG atrophy, and naked pupa in B. mori. Our results uncovered the molecular nature of the silkworm Nd mutation and significantly improved our understanding of fibroin synthesis and secretion in silk-spinning caterpillars.

Multilocus Sequence Typing and Population Genetic Analysis of Enterocytozoon bieneusi: Host Specificity and Its Impacts on Public Health.

Microsporidia comprise a large class of unicellular eukaryotic pathogens that are medically and agriculturally important, but poorly understood. There have been nearly 1,500 microsporidian species described thus far, which are variable in biology, genetics, genomics, and host specificity. Among those, Enterocytozoon bieneusi is the well-known species responsible for the most recorded cases of human microsporidian affections. The pathogen can colonize a broad range of mammals and birds and most of the animals surveyed share some genotypes with humans, posing a threat to public health. Based on DNA sequence analysis of the ribosomal internal transcribed spacer (ITS) and phylogenetic analysis, several hundreds of E. bieneusi genotypes have been defined and clustered into different genetic groups with varied levels of host specificity. However, single locus-based typing using ITS might have insufficient resolution to discriminate among E. bieneusi isolates with complex genetic or hereditary characteristics and to assess the elusive reproduction or transmission modes of the organism, highlighting the need for exploration and application of multilocus sequence typing (MLST) and population genetic tools. The present review begins with a primer on microsporidia and major microsporidian species, briefly introduces the recent advances on E. bieneusi ITS genotyping and phylogeny, summarizes recent MLST and population genetic data, analyzes the inter- and intragroup host specificity at the MLST level, and interprets the public health implications of host specificity in zoonotic or cross-species transmission of this ubiquitous fungus.

A Computational Method Based on the Moving Least-Squares Approach for Pricing Double Barrier Options in a Time-Fractional Black–Scholes Model

The mathematical modeling in trade and finance issues is the key purpose in the computation of the value and considering option during preferences in contract. This paper investigates the pricing of double barrier options when the price change of the underlying is considered as a fractal transmission system. Due to the outstanding memory effect present in the fractional derivatives, approximating financial options with regards to their hereditary characteristics can be well interpreted and stated. Motivated by the reason mentioned, relatively reliable and also efficient numerical approaches have to be found while facing with fractional differential equations. The main objective of the current paper is to obtain the approximation solution of the time fractional Black–Scholes model of order $$0<\alpha \le 1$$ governing European options based on the moving least-squares (MLS) method. In proposed method, firstly, the mentioned equation is discretized in the time sense based on finite difference scheme of order $${\mathcal {O}}(\delta t^{2-\alpha })$$ and then approximated by using MLS approach in the space variable. Furthermore, the stability and convergence of the proposed method are discussed in detail throughout the paper. Numerical evidences and comparisons demonstrate that the proposed method is very accurate and efficient.

Review on Application of Plant Tissue Culture in Plant Breeding

Plant breeders employ a variety of techniques to improve the genetic composition of crops and a successful strategy is dependent on the physical, physiological and hereditary characteristics of the plant. Plant tissue culture is one of the method used in plant breeding used in disease free plant development, genetic transformation, Somatic embryogenesis, embryo rescue, and anther and ovule culture for post fertilizer barrier and polyploidy induction. It play great role in plant/crop improvement as it involves in variation creation, conservation of germplasm and shorten the breeding cycle by developing homozygous parents with single a generation. So, the review is designed to assess application of tissue culture in improvement of field crop, ornamental, forest tree or plants as whole for human benefits. Keywords: plant , tissue culture, breeding DOI : 10.7176/JNSR/9-3-03

Hormonal Imprinting: The First Cellular-level Evidence of Epigenetic Inheritance and its Present State.

Hormonal imprinting takes place perinatally at the first encounter between the developing hormone receptor and its target hormone. This process is needed for the normal function of the receptor-hormone pair and its effect is life-long. However, in this critical period, when the developmental window is open, related molecules (members of the same hormone family, synthetic hormones and hormone-like molecules, endocrine disruptors) also can be bound by the receptor, causing life-long faulty imprinting. In this case, the receptors’ binding capacity changes and alterations are caused at adult age in the sexual and behavioral sphere, in the brain and bones, inclination to diseases and manifestation of diseases, etc. Hereby, faulty hormonal imprinting is the basis of metabolic and immunological imprinting as well as the developmental origin of health and disease (DOHaD). Although the perinatal period is the most critical for faulty imprinting, there are other critical periods as weaning and adolescence, when the original imprinting can be modified or new imprintings develop. Hormonal imprinting is an epigenetic process, without changing the base sequence of DNA, it is inherited in the cell line of the imprinted cells and also transgenerationally (up to 1000 generations in unicellulars and up to the 3rd generation in mammals are justified). Considering the enormously growing number and amount of faulty imprinters (endocrine disruptors) and the hereditary character of faulty imprinting, this latter is threatening the whole human endocrine system.

Heavy metals, and their effects on human health

Substantial metals are normally happening components that have a high nuclear weight and a thickness, at any rate, multiple times more noteworthy than of water. Their different man house cleaner improvements mechanical like residential, horticultural, medicinal and innovative applications have prompted their waste transfers wide circulation on the earth; raising worries over their potential consequences for human wellbeing and the earth. Their danger relies upon a few components including the portion, course of introduction, and compound species, just as the age, sexual orientation, hereditary qualities, and dietary status of uncovered people. Due to their high level of danger, arsenic, cadmium, lead, and mercury are in the top position among the need metals that are of general wellbeing importance. These metallic components are viewed as foundational toxicants that are known to prompt different organ harm, even at lower levels of introduction. Overwhelming metal lethality has demonstrated to be a significant danger and there are a few wellbeing dangers related to it. The lethal impacts of these metals, despite the fact that they don&#39;t have any natural job, stay present in a few of the other structure destructive for the human body and its legitimate working. Hardly any metals can be evacuated through disposal exercises, while a few metals get collected in the body and evolved a way of life by bioaccumulation and bio magnification process, and displaying a constant nature. Different general wellbeing measures have been embraced to control, forestall and treat metal danger happening at different levels, for example, word related introduction, mishaps, and ecological factors. This archive gives insights concerning some harmful overwhelming metals and their lethality systems, alongside their wellbeing impacts.

Identification and tracking of different types of crystalline nucleiduring isothermal crystallization of amorphous Ag

The isothermal crystallization of amorphous Ag is investigated by a molecular dynamics (MD) simulation, and the heredity and evolution of different types of crystalline clusters aretracked and analyzed by a reverse tracking method of atom trajectories with the help of cluster-type index method (CTIM) based on Honeycutt-Anderson (H-A) bond-type index. According to the difference in the type of crystalline cluster and the linkage mode, i.e., vertex-sharing (VS), edge-sharing (ES), face-sharing (FS) and intercross-sharing (IS), a cluster analysis method which can efficiently characterize fcc single-crystal, fcc poly-crystal and fcc hydrid-crystal, is proposed. That is, the IS-linkage of fcc basic clusters, i.e., a fcc medium range order, is defined as a fcc single-crystal cluster. The extended cluster of fccbasic clusterslinked by ISand FS modes is named fcc poly-crystal clusters. In the case of IS-linkages, if the majority of core atoms arefcc atoms, the extended cluster composed of fcc, hcp and bcc basic clusters will be regarded as a fcc hydrid-crystal cluster. Moreover, a structural analysis method of critical nuclei distinguishing embryosis also developed in terms of the hereditary characteristics of various crystalline clusters. In this scheme, the extended cluster which has only transient heredity and no continuous heredity is defined as an embryo, while it will be named nuclei if part of core atoms in extended clusters can keep cluster type of atoms unchanged and be continuously passed down in the early stage of crystallization. Thus, corresponding to the onset time/temperature of continuous heredity, the critical nuclei of fcc singe-crystals, fcc poly-crystals and fcc hybrid-crystals can be identified and characterized. It is found that the nuclei of fcc crystalsemerge after the steep drop of total energy of system and before the abrupt increase of sizesof tracked clusters. And regardless of critical sizes or geometric configurations, an evident difference exists among fcc singe-crystal, hybrid-crystal clusters and fcc poly-crystal clusters, of which the fcc single-crystal nucleus is the smallest (~1.6 nm ×1.0 nm × 1.1 nm), followed by poly-crystal nucleus (~1.7 nm × 1.0 nm × 1.6 nm) and hydrid-crystal nucleus (~2.3 nm × 2.0 nm × 2.4 nm) in sequence. There are a few hcp and bcc atoms at surfaces, i.e. shells, of single-crystal and poly-crystal nucleus, but neither hcp nor bcc atom can be detected at the shell of fcc hydrid-crystal nucleus. And theconfiguration of fcc single-crystal, poly-crystal and hydrid-crystal critical nuclei are all non-spherical.

Modern methods of diagnosing addiction to psychoactive substances: neurophysiological aspects

Objective:The study of the features of the higher mental functions of the brain in patients suffering from addiction to psychoactive substances is very important for narcology. It is necessary not only to uncover the mechanisms of addiction, a complete understanding of the neurophysiological processes that determine the nature of the development and severity of the disease, but also to solve practical problems related to the development of treatment methods and the implementation of preventive measures.Method:In the study of patients, a specially designed map was used containing information on the hereditary and demographic characteristics, on the course of the disease, as well as on the socio-cultural status of patients. To determine the functional state of cortical activity in the process of perception of unconscious signals, a special technique was used. The obtained results were subjected to dispersive analysis and the significance of differences was calculated according to Student’s t-criterion.Results:An analysis of premorbid personality traits made it possible to establish the prevalence of instability, pathological conformity, and hysteroidal features in patients. It should be noted that a large percentage of the surveyed had a hereditary burden of alcoholism, mainly in the line of the father. Curiosity, passive submission, imitation of friends were among the motives of the first drug use. All patients in the process of addiction formed the following features: increased excitability, increasing effective disorders (depression, dysphoria), aggravated by exacerbation of craving for the drug, a decline in morals and ethics (egoism, deceit, indifference to one’s fate, hedonism, loss of sense of duty), disorders of the emotional-volitional sphere (emotional instability, hypersensitivity, vulnerability).Conclusion:The analysis of the duration of latent periods and magnitude of the amplitudes of the late positive R3OO wave in patients with heroin addiction revealed clear differences between the data obtained upon presentation of an unconscious neutral and motivationally significant word. Patients who use psychoactive substances, using the method of recording induced potentials of the brain, which is a sensitive indicator of the activity of brain structures in relation to the substance used, revealed a clear diffuse activation of the cerebral cortex in response to an unconscious verbal stimulus related to the motivation prevailing in patients, in particular to “heroin”. Such activation, as well as the difficult dying out of the developed reactions to an unconscious stimulus, indicate certain neurophysiological foundations of the mechanism underlying the changes in the motivational sphere and the stability of the pathological craving for the psychoactive substance.

Hatano rats selectively bred for high- and low-avoidance learning: an overview.

This review compiles the results of a series of studies on Hatano high- and low-avoidance animals (HAA and LAA, respectively) established at the Hatano Research Institute, Food and Drug Safety Center, Japan. The HAA and LAA lines were selected and bred from Sprague Dawley rats for high and low avoidance learning, respectively, in a shuttlebox task since 1985. Although Hatano rats were selected only based on their behavioral traits in the active avoidance task, strain differences between the HAA and LAA lines were also observed in their stress responses and reproductive functions. However, the most noticeable finding of Hatano rats is a matched result in both active and passive avoidance tasks. The HAA and LAA lines are useful for next-generation toxicological studies, because the hereditary characters of behaviors or endocrine functions are well controlled.

76] Hereditary kidney stones: An experience of a nephrology department

Objective To determine clinical and metabolic characteristics and progression of hereditary urinary lithiasis. Genetic factors must be considered in the aetiological diagnosis of urinary lithiasis. Methods A retrospective study was conducted between 2008 and 2018, and 53 patients were included. Patients were referred to our department for aetiological investigation in 36 cases, for chronic renal failure in eight cases, and from paediatric departments to be followed-up in adulthood in nine cases. Results In all, 32 men and 21 women were enrolled in this study with a male/female sex ratio of 1.52. The mean (range) age at the time of diagnosis of the hereditary character of the urinary lithiasis was 29 years (4 days–63 years).The mean (range) delay between the onset of the lithiasis disease and the aetiological diagnosis was 10.5 (1–42) years. We noted 26 cases of cystinuria, 17 cases of primary hyperoxaluria type 1 with two mutations (I244T in 15 cases and 33–34 Insc in two cases), and 10 cases of renal tubulopathy. In all, 14 patients had chronic renal failure, of which five were in end-stage. Crystalluria was positive in 62% of the cases. The morpho-constitutional analysis of stones was conducted in 31 cases; oxalo-dependent lithiasis was identified in nine cases and cystine lithiasis in 22 cases. After a mean follow-up of 82 months for 43 patients, we noted normal renal function in 21 cases, chronic renal failure in 12 cases, and haemodialysis in nine cases, all with primary hyperoxaluria and transplantation in one case. Conclusion The aetiological diagnosis of hereditary urinary lithiasis was made with considerable delay. Cystinuria was the most frequent aetiology and primary hyperoxaluria was the most serious affliction.

Racismo indeleble y textos escolares de ciencias naturales colombianos (2000-2010)

Racismo indeleble y textos escolares de ciencias naturales colombianos (2000-2010) Racismo indelevel e textos escolares de ciencias naturais colombianos (2000-2010) DOI: 10.5294/edu.2018.21.2.6 The contents of eighth and ninth grade textbooks on the natural sciences, published in Colombia during the years from 2000 to 2010, are analyzed in this article. They can be interpreted as scientific racism within the framework of science teaching, the context, and cultural diversity and difference. The results discussed in this article are part of a doctoral dissertation entitled “Scientific Racism in School Textbooks on the Natural Sciences in Colombia”. A qualitative methodology was used, and content analysis was the methodological design. Scientific racism was apparent in 14 of the 30 texts analyzed, due to legitimizing the biological concept of human races, using racist biological representations and naturalizing eugenics through the contents of genetics, evolution, taxonomy, human populations and biodiversity, with genetic content being the most frequent. The specific contents with manifestations of scientific racism are those related to inheritance and hereditary characteristics, the human genome, the species and variability, natural selection, adaptations, cultural biodiversity and demographic studies.

Analysis of a Stochastic 2D-Navier–Stokes Model with Infinite Delay

Some results concerning a stochastic 2D Navier–Stokes system when the external forces contain hereditary characteristics are established. The existence and uniqueness of solutions in the case of unbounded (infinite) delay are first proved by using the classical technique of Galerkin approximations. The local stability analysis of constant solutions (equilibria) is also carried out by exploiting two approaches. Namely, the Lyapunov function method and by constructing appropriate Lyapunov functionals. The asymptotic stability and hence, the uniqueness of equilibrium solution are obtained by constructing Lyapunov functionals. Moreover, some sufficient conditions ensuring the polynomial stability of the equilibrium solution in a particular case of unbounded variable delay will be provided. Exponential stability for other special cases of infinite delay remains as an open problem.

Detection and Classification of Genetically Transfered Idiopathic Partial Epilepsy to Child:a Four Rule ANFIS based SWT-EBFO Approach

Background:-Hereditary qualities have an influence in numerous sorts of epilepsy. In the event that a parent has idiopathic epilepsy, there is around 5% to 8% chance that the youngster upto 8 years will likewise have epilepsy called as idiopathic partial epilepsy (IPE).Methods:-This exploration work breaks down the epilepsy issue exchange hereditarily by coordinating the best properties of Enhanced Bacterial Foraging Optimization (EBFO) and Least-mean-square (LMS) algorithm with four rule Adaptive Neuro-fuzzy Inference System (ANFIS) Network. Stockwell Transform (SWT) strategy searched for the extraction of decomposed signal. In this work, quantitative tests and statistical tests are performed by utilizing SWT-ANFIS-EBFO and SWT-ANFIS-LMS strategies.Results:-Our proposed statistical results(Accuracy (98.30%), sensitivity (98.23%), specificity (99.53%) and Matthew’s correlation coefficient (97.08%),G-mean (98.88%) and average detection ratio (98.93%)) are calculated withthe network SWT-ANFIS-LMS. Proposed statistical results (accuracy (99.49%), sensitivity (98.78%), specificity (98.56%), and Matthew’s correlation coefficient (97.907%), G-mean (99.172) and average detection ratio (99.174%)) are calculated SWT-ANFIS-EBFO beats. The calculated quantitative test results for network SWT-ANFIS-LMS are (SNR 18.42±0.18, RE 0.11±0.02, CC 61±0.012, MFRE 0.41±0.02) and for network SWT-ANFIS-MFRE are (SNR 18.42±0.18, RE 0.11±0.02, CC 61±0.012, MFRE 0.41±0.02).Conclusion:-In this paper we endeavor to investigate the best capability of SWT based ANFISnetwork trained with EBFO and LMS algorithms for classification of IPE EEG signals.Calculated statisticaland quantative test results of the proposed method outperforms as compared to existing methods. It will end up being a significant trial device in clinical application and advantageous application towards IPE influenced patients.

Differential response to Cadmium exposure by expression of a two and a three-domain metallothionein isoform in the land winkle Pomatias elegans: Valuating the marine heritage of a land snail

Through evolution, marine snails have adapted several times independently to terrestrial life. A prime example for such transitions is the adaptation to terrestrial conditions in members of the gastropod clade of Littorinoidea (Caenogastropoda). Some species of this lineage like the periwinkle (Littorina littorea), live in intertidal habitats, where they are intermittently exposed to semi-terrestrial conditions. Pomatias elegans is a close relative of Littorina littorea that has successfully colonized terrestrial habitats. Evolutionary transitions from marine to terrestrial conditions have often been fostered in marine ancestors by acquisition of physiological pre-adaptations to terrestrial life. Such pre-adaptations are based, among others, on the optimization of a wide repertoire of stress resistance mechanisms, such as the expression of metal inactivating metallothioneins (MTs).The objective of our study was to explore the Cd handling strategy in the terrestrial snail Pomatias elegans in comparison to that observed previously in Littorina littorea. After Cd exposure, the metal is accumulated mainly in the midgut gland of Pomatias elegans, in a similar way as in its marine relative. Upon Cd exposure, Pomatias elegans expresses Cd-specific MTs, as also described from Littorina littorea. In contrast to the latter species, however, the detoxification of Cd in Pomatias elegans is mediated by two different MT isoforms, one two-domain and one three-domain MT. Although the MT proteins of both species are homologous and clearly originate from one common ancestor, the three-domain MT isoform of Pomatias elegans has evolved independently from the three-domain MT of its marine counterpart, probably by addition of a third domain to the pre-existing two-domain MT. Obviously, the occurrence of homologous MT structures in both species is a hereditary character, whereas the differentiation into two distinct MT isoforms with different upregulation capacities in Pomatias elegans is an adaptive feature that probably emerged upon transition to life on land.

ЭФФЕКТИВНОСТЬ ИСПОЛЬЗОВАНИЯ ПРОДУКТИВНОСТИ СЕМЯОБРАЗОВАНИЯ В СЕЛЕКЦИИ PISUM SATIVUM L.

The results of investigations on revealing the features of the structure formation of seed productivity in new genotypes of peas with non-permeable beans are presented. Selection of Kaban, Fregat, Veles varieties and sample KT-6489 with a new trait was aimed at increasing the number of beans and seeds per plant. The increase in seed productivity was accompanied by a decrease in the mass of 1000 seeds and an increase in the performance of beans. Differences in the variability of the examined signs of seed productivity testify to the genotypic characteristics of the reaction to the effect of environmental conditions. The selection value of the “productivity of seed formation” and its hereditary character is grounded. The use of sources with a high seed-forming ability in breeding has contributed to an increase in the proportion of seeds from planted ovules on the plant. In the varieties with soft beans, the values of this feature, depending on environmental conditions, varied within the range 54.4-70.9%. In new breeding developments, these figures were significantly increased to 81.8-91.0%. Statistical analysis proved the reliability and significance of genotypic differentiation of the trait in changing environmental conditions. A high significant effect of the genotype with a share of 83.7% on the variability of seed production was established. The influence of the environment and the interaction of the factors “genotype x environment” on the trait was assessed by a weak impact (3.61 and 3.94%). The presence of stable genotypes in the study group results from the revealed advantage of variance of genotypes over the variance of the “genotype-environment” interaction. A sample of KT-6489 with a weak variability in seed production (1.6%) with variations by years 84.0-86.7% was isolated.

‘Van den vleeschouweren oft pensvrouwen’* De economische mogelijkheden voor vrouwen in het Leuvense vleeshouwersambacht in de vijftiende en zestiende eeuw

Women’s economic activity in the butcher’s guild of fifteenth and sixteenth-century LeuvenThis article examines women’s agency in the butchers’ guild in Leuven during the fifteenth and sixteenth centuries. An analysis of urban ordinances demonstrates that the corporation allowed women of various marital status to work in the trade. Married women acted frequently as active substitutes of their husbands or as part of a family production unit. Unmarried women, most often widows, were allowed to perform certain tasks independently. This contrasts with findings in earlier studies about gendering in butchers’ guilds in other towns. I argue that the changing hereditary character of the corporation influenced women’s agency in the trade.

Stability results for 2D Navier–Stokes equations with unbounded delay

Some results related to 2D Navier–Stokes equations when the external force contains hereditary characteristics involving unbounded delays are analyzed. First, the existence and uniqueness of solutions is proved by Galerkin approximations and the energy method. The existence of stationary solution is then established by means of the Lax–Milgram theorem and the Schauder fixed point theorem. The local stability analysis of stationary solutions is studied by several different methods: the classical Lyapunov function method, the Razumikhin–Lyapunov technique and by constructing appropriate Lyapunov functionals. Finally, we also verify the polynomial stability of the stationary solution in a particular case of unbounded variable delay. Exponential stability in this infinite delay setting remains as an open problem.

Prenatal sonographic description of fetuses affected by pyruvate dehydrogenase or pyruvate carboxylase deficiency.

Pyruvate dehydrogenase deficiency (PDHD) and pyruvate carboxylase deficiency (PCD) are diseases with severe neonatal forms, and their low prevalence makes them difficult to diagnose during pregnancy. Our objective was to describe prenatal ultrasound features that may be suggestive of these diagnoses. We analyzed 3 cases from our institution and reviewed 12 published cases of PDHD and 6 cases of PCD, recording all of the ultrasound signs, as well as magnetic resonance findings when available. Because of the small number of cases of PCD, we also included postnatal signs that could have been observed during imaging during pregnancy, for a total of 11 cases of PCD. We conclude that PDHD can be suggested in the presence of ventriculomegaly or paraventricular cysts, associated with an abnormality of the cerebral parenchyma such as abnormal gyration or involvement of the corpus callosum. Pyruvate carboxylase deficiency can be suggested in the presence of ventriculomegaly, frontal horn impairment associated with subependymal, and paraventricular cysts. When confronted to the ultrasound abnormalities we described, and after eliminating the most frequent etiologies, a metabolic deficiency should be considered. Furthermore, the hereditary character of these diseases makes that it is important to send the family with genetic advice in particular in case of history of a fetal death in utero or a death neonatal unexplained.

ОЦЕНКА АДАПТИВНЫХ СВОЙСТВ СОРТОВ ЯРОВОГО ЯЧМЕНЯ ПО УРОЖАЙНОСТИ В УСЛОВИЯХ ОМСКОГО ПРИИРТЫШЬЯ

Background. In Omsk Province there is an alternation of dry, medium moisture and wet years (respectively 40%, 30% and 20%). This indicates the need to use barley varieties with a complex of economically valuable traits and properties that ensure their high yields in a wide range of varying environmental conditions. Objects of the research were 9 varieties of spring barley developed by the Siberian Research Institute of Agriculture, Russian Academy of Agricultural Sciences, recommended for cultivation in this region. Materials and methods. The experimental part of the work was carried out during 2011-2017, on the experimental fields of the Siberian Research Institute of Agriculture, RAAS, located in the southern forest-steppe in the vicinity of Omsk. The plot area was 10 m2, with 4 repetitions. The sowing rate was 4 million live grains per 1 hectare. Agricultural practice used for the experiments is generally accepted in the West Siberian region. Mathematical processing was carried out by the method of the analysis of variance; yield adaptability, stability and plasticity parameters were calculated. Results. The average yield of the studied barley varieties in the environments of Omsk's Near-Irtysh area was 3.90 t/ha - it was the mean value for the period of studies. The barley yield varied greatly depending on environmental conditions and hereditary characteristics of varieties, which was confirmed by the results of the variance analysis: the share of the influence of the year of testing factor on the yield was 77.5%. The best conditions for the formation of increased yields during the period of research were observed: in 2011 and 2015 (5.28 and 5.78 t/ha), with a maximum index of environmental conditions (Ij = 1.38 and 1.88, respectively). Unfavorable conditions were noted from 2012 to 2014: yields decreased to 2.33 4 3.54 t/ha, with Ij = -0.36 4 -1.57. All studied varieties exceeded the reference 'Omskiy 91' by 7.0 4 39.3%. The most adaptive among barley varieties as far as their yield is concerned in the conditions of Omsk's Near-Irtysh region were the varieties: 'Podarok Sibiri', 'Omskiy 99', 'Omskiy 100' and 'Omskiy 95'. The sum of the ranks of the above varieties according to their general and specific adaptive abilities, breeding value of the genotype, regression coefficient, stability variance, stability index. and steadiness of the stability index was 20-30. Conclusion. Varieties 'Podarok Sibiri', 'Omskiy 99', 'Omskiy 100' and 'Omskiy 95' are highly adaptable and can provide high stable yields in a wide range of variation in the natural environments of the Near-Irtysh area in Omsk Province.