Herbal Cream Research Articles

Medicinal Plants: An Insight into Wound Healing

Medicinal plants have been used for centuries to treat trauma, infection, sickness, and injury as these are affordable, easy to access and have fewer side effects than commercial pharmaceuticals. Recent research has shown that several medicinal plants can treat wounds using in vivo and in vitro pre-clinical models of wound recovery. Furthermore, the mechanisms by which these medicinal plants enhance wound therapy have also been revealed. Medicinal herbs have been shown in research to have the ability to have an antioxidant effect, to promote angiogenesis, to activate NF-B, to favor specific pro-inflammatory cytokines, to boost the appearance of iNOS and α-1 type-1 collagen, and to favor certain pro-inflammatory cytokines. All these effects can be brought about by medicinal herbs. Considering this, throughout this evaluation, an effort was made to provide a glimpse into freshly discovered medicinal plants that have wound recovery mechanisms and may be effective in the treatment and the invention of new wound-healing pharmaceuticals. Herbal medicines involve disinfection, debridement, and creating a healing environment. The purpose of the study was to review and gather the evidence related to the use of medicinal plants in wound healing. The use of herbal remedies is found to be both affordable and effective, mainly when used in conjunction with wound healing, bacterial activity and reducing oxidative stress in animals. During this evaluation, the cellular processes of recently discovered medicinal plants with a capacity for wound healing were brought to light. These mechanisms can potentially be helpful in therapeutic practice and the advancement of innovative medications for treating wounds. Several factors can delay the wound-healing process such as anemia, diabetes, nutritional deficiency, hematoma, local infections, etc. In the treatment of wounds, many medicinal plants and other herbal immunomodulators are considered useful. Through different pathways, these herbal ointments promote healing and regeneration of the lost tissues without producing side effects.

Formulation and evaluation of topical anti-microbial herbal cream

Formulation and evaluation of topical anti-microbial herbal cream

Formulation and evaluation of topical anti-microbial herbal cream

Background: The aim of this study was to determine the antimicrobial effect of neem oil with liquid paraffin and coconut oil and their combination on the bacteria E. coli, S. auerus and Candida albicans, which causes skin diseases ,increasingly resistant to many commonly used antibiotics as a result of colonization of the skin. Methods: Nine different emulsions were prepared and evaluation were carried out including Homogeneity, FTIR,Phytochemical tests, Drug content and In-vitro drug release and Anti-Microbial studies were performed. Results: The results revealed that the Phyto chemical Screening of Neem oil found to be presence of Alkaloids, glycosides, Saponins, flavonoids pH of the cream was found to be in the range of 5.8-6.7 which is good for the skin pH. All the formulation were near to the skin pH. The viscosity of the cream was found 28008-28932 cps. Conclusion: Phyto chemical Screening of Neem extract were done and found to be presence of Alkaloids, glycosides, Saponins, flavonoids etc were present. IR studies revealed that there was no drug Excipients interaction. During our physicochemical evaluation studies all the formulation were found to have good ,pH and Viscosity,diffusion .In-vitro drug release studies showed that, the formulation F9 showed optimum drug release 97.17±2.000 in 3 hours. The tested organisms, particularly gram positive, gram-negative organisms and Fungi Candida albicans had shown high resistance towards different Antibiotics, Thus neem oil is effective against drug resistant organisms.

Pemberdayaan PRA Tamantirto Utara melalui Pelatihan Pembuatan Es Krim Jamu dan Sosialisasi DAGUSIBU serta Pemeriksaan Kesehatan

Pimpinan Ranting Aisyiyah (PRA) Tamantirto Utara is part of the Muhammadiyah association. Universitas Muhammadiyah Yogyakarta (UMY), especially the Pharmacist Professional Education Study Program has the responsibility to carry out the guidance and empowerment of PRA. The purpose of this community service activity is to empower PRA Tamantirto Utara in the introduction of health products in the form of training in making herbal ice cream and improving health status through DAGUSIBU (Get, Use, Save and Dispose of) medicine and health checks. This activity is in collaboration with the student hermitage of the UMY Pharmacist Professional Education Study Program. The method used in this activity is through training in making herbal ice cream, DAGUSIBU counseling, health checks (cholesterol checks, blood sugar and uric acid) which ends with the provision of equipment grants. The activity begins with a pretest and ends with a posttest to evaluate the participants' understanding. The management of the PRA Tamantirto Utara received knowledge of herbal medicine processing into ice cream preparations, as well as a comprehensive understanding of DAGUSIBU as evidenced by an increase in the pretest score of 88.57% to 97.62%. The results of the examination showed that only about 19.04% had hypercholesterolemia, 9.52% had hyperglycemia, and 14.28% had hyperuricemia. Education on the handling of metabolic disorders was given to the PRA Tamantirto Utara. This community service activity provides skills and insight into making herbal ice cream, understanding DAGUSIBU and efforts to improve health status for PRA Tamantirto Utara.

Formulation and Evaluation of Antimicrobial Herbal Ointment containing Colocasia esculenta

Herbal medicine refers to the use of any plant's seeds, berries, roots, leaves, bark, or flowers for medicinal purposes. The objective of the study was to formulate and evaluate the antimicrobial herbal ointment from ethanolic extracts of leaves of Colocasia esculenta. The ointment base was created, and the ointment was made by using the levigation process to incorporate the extract into the base. It was assessed for physicochemical criteria such as colour, odour, pH, spreadability, extrudability, consistency, diffusion studies, solubility, and washability once the formulation was completed. The formulation was further tested for stability at various temperatures, revealing no differences in irritancy, spreadability.

Evaluation of cosmetic creams containing Black cumin (Nigella sativa)-Lemon balm (Melissa officinalis L.)-Aloe vera (Aloe barbadensis miller) essences by modeling with Box Behnken method in Design Expert

In this investigation regarding medicinal and aromatic plants, an experimental study was conducted on the effectiveness of black cumin, lemon balm and Aloe vera essences in cosmetic creams, which were selected for their beneficial biological activities such as anti-inflammatory, moisturizing etc. In line with this study stability test, which was important in the quality evaluation of cosmetic products, was carried out. Cream samples containing different concentrations of black cumin and lemon balm essences were kept at under 3 different temperature conditions as 0 °C, 25 °C and 40 °C and the necessary values were recorded. In this direction, the effects of the temperature on the physical and chemical properties of the cosmetic creams were assessed. Homogenization and colors as physical properties and pH value of the herbal cream samples were examined. It was observed that the pH value, which was an important parameter for skin care products, was 6.5 under the optimum experimental condition and it was an acceptable value for skin creams according to the literature. In the second part of the experimental study, the effect of the essence obtained from the Aloe vera plant on the samples was tested with the optimum condition selected from 17 different experimental sets by using the Design Expert optimization application. In addition, from the production of cosmetic products; it was necessary to pay attention to the environmental conditions stipulated in storage, transportation, and sales points. As a result of the tests, it was seen that the medicinal and aromatic plants used could be evaluated in the field of cosmetics and successful results could be obtained.

Evaluation of wound healing potential of Jatropha curcas leaf extracts ointment based on wound infection in Wistar rats model

This research study was conducted to evaluate the wound healing potential of ointment formulated with Jatropha curcas leaf extracts based on wistrar rat model. The therapeutic activities of the plant extracts were determined by topical application of the herbal ointment. Wound healing rate took place on the 16th day of post treatment with 1.0 g of J. curcas ointment formulation and 12th day with 2.0 g of the ointment, was similar compared with standard drug Gentamicin ointment (12 days). The control untreated group (62.3±0.51%) rate of wound closure observed persisted beyond the 19th day of post-wounding. The haematological parameters of the infected rats treated with herbal ointment and the control group untreated were not significant different (p>0.05). Significant increase in white blood cell (WBC) count in untreated group was recorded when compared with the treated group. However, treatment with the formulated ointments significantly increase the elevated WBC count in the treated group. The toxicological parameters in the serum of the rats are useful makers for the assessment of tissue damage. The serum Aspartate Transaminase (AST) and Alanine Transaminase (ALT) activities in the treated and untreated experimental groups were not significantly (p>0.05) different. The phytochemical components found in J. curcas leaves contain some useful potential antimicrobial agents that possess wound healing properties when formulated into a topical ointment for topical application.

FORMULATION DEVELOPMENT OF GARLIC POWDER (ALLIUM SATIVUM) FOR ANTI-DIABETIC ACTIVITY ALONG WITH PHARMACEUTICAL EVALUATION

Allium sativum is an edible garllic known for its nutritional & bio-medicinal properties. The methanolic extract of Allium stivum for phytochemical screening performed & phytochemical analysis reveals that the extracts were rich source of phytoconstituents containing Alkaloids, Carcogydrate, Glycosides, Protien, Flavanoids, Saponins, Phenolic, Steroids.Some of them are responsible for anti-diabetic activities. In the present study oral administrable dosage form of Allium sativum (garlic) were prepared Herbal Tablets and Cream . A Compressed Tablets were evaluated. Garlic has been utilized securely since antiquated times as both food and medication in human populaces, however investigations of its adequacy in the administration of diabetes have yielded clashing outcome. This study has assessed the hypoglycemic impacts of garlic in patients.

DEVELOPMENT AND EVALUATION OF HERBAL ANTI-INFLAMMATORY CREAM CONTAINING TURMERIC

Curcuma longa, also known as turmeric, is a Zingiberaceae plant whose rhizomes are used to make the spice. Curcumin is well known for its anti-inflammatory qualities and skin-protective characteristics. Curcumin has long been used to treat skin infections and inflammation in natural herbal medicines. The purpose of this project is to formulate a turmeric-based anti-inflammatory cream. The herbal cream was created utilizing the primary emulsion method. Different physiochemical tests were performed on the turmeric cream, including drug content, spreadability, viscosity, appearance, homogeneity, grittiness, viscosity, pH measurement, and anti-inflammatory action. The study's findings of various physicochemical properties were determined to be satisfactory and consistent with the commercially available turmeric cream. The data was acceptable and in line with the commercial product.

Antimicrobial investigation, Formulation and Evaluation of Andrographis paniculata aqueous herbal cream for topical application

Herbal plants contain substances of medicinal values or precursors for synthesis of important drugs, however, not much have been done in terms of standardization and effective delivery system. Various routes can be employed to deliver herbs, but the topical route is the safest. In this study, aqueous and ethanolic extractions of Andrographis paniculata were carried out. Antimicrobial screening of the extract before and after incorporation into cream base was carried out using standard antimicrobial agents as positive control. Formulated creams were evaluated for organoleptic properties, pH, spreadability, viscosity and stability. Staphylococcus aureus and Candida albicans were used for the sensitivity studies. Percentage yield for ethanolic and aqueous extracts were 17.5%w/w and 13.33%w/w respectively. Both microbes were sensitive to pure ethanolic extract and creams formulated from ethanolic extract, but resistant to aqueous extract. Zones of inhibition for the ethanolic extract ranged from 7.33 ± 0.58 mm to 14.00 ± 0.00 mm (Candida albicans) and 6.00 ± 1.00 mm to 12.33 ± 0.58 mm (Staphylococcus aureus). Minimum Inhibitory Concentrations, MICs, were 25 mg/mL and 200 mg/mL for Candida albicans and Staphylococcus aureus respectively. The MIC for the formulated cream (15% w/w) was 150 mg/mL for both organisms. The pH of formulated creams ranged from 5.54 to 6.84; the viscosity, 18,800 to 60,500 mPas. The spreadability values were between 37.5 ± 0 and 75.0 ± 0.2 g.cm/s. All formulated creams were stable. Thus herbal creams formulated from Andrographis paniculata ethanolic extract retained the antimicrobial properties of the extract and as such can be applied topically for the treatment of skin diseases involving these microorganisms.

Nursing of one case of lower extremity arteriosclerosis obliterans treated by Chinese herbal ointment and massage combined with intradermal acupuncture

Nursing of one case of lower extremity arteriosclerosis obliterans treated by Chinese herbal ointment and massage combined with intradermal acupuncture

Formulation of herbal ointment for assessment of wound healing activity from leaves

has been extensively used as a nutrient herb in traditional Vietnamese remedies for the treatment of various diseases. (Wild.) are widely used plants in Asian folk and traditional medicines. In the present study, we have tried to find out the Phytoconstituents, wound healing activity of the Ethanolic extracts of these plants. It’s been showed that totally different a part of Launaea sarmentosa species as well as leaves, flowers, seed, root, and aerial half possess ethno botanic values could be a crawl herb, native to coastal areas in India, Africa (east coast, Mauritius, and South Asia etc.

A review article on anti-aging herbal cream

Face Cream is used cosmetically For Softening and cleansing the pores and skin like cold cream and vanishing cream. pores and skin like cold cream, vanishing cream, pores, skin Brightening cream, and ointment. Cream-Toiletry consists of many diverse substances inside the form of a thick liquid that possesses soothing as well as moisturizing outcomes while implemented to the skin. there are various sorts of lotions to be had in the marketplace like a light cream, sour cream, half and half the heavy cream, clotted cream, and many others, cause the formula of Anti-aging herbal cream is for reducing darkish Spots.

Formulation and evaluation of anti-fungal and anti-bacterial novel herbal cream using Senna alata, Wrightia tinctoria and Datura metel

The main intention of these studies was to formulate and evaluate a novel herbal cream which includes Senna alata,Wrightia tinctoria and Datura metel for the treatment of secondary skin infections. The most suitable route for skin infection is topical. The development of topical drug transport systems designed to have systemic results appears to be useful for a number of drugs as a result of the numerous advantages over traditional routes of drug administration. In this study a novel herbal cream formulation consisting of Senna alata,Wrightia tinctoria and Datura metel was prepared. This study was subjected to in-vitro diffusion method. Microbiological studies were carried out the safety of materials used inside the formulation. The formulated cream was found to be safe and effective for the treatment of skin infection.

무릎 내측측부인대 손상의 한의학적 치료에 대한 국내외 임상연구 동향 분석

Objectives : This study aimed to review clinical studies on traditional Korean medicine treatment for medial collateral ligament injury of the knee. Methods : Clinical studies on Korean traditional medicine treatment of medial collat- eral ligament injury were conducted. We used five Korean online databases (OASIS, KISS, RISS, DBPia, and ScienceOn) and three foreign databases (PubMed, Cochrane Library, and CNKI). Out of 99 studies that were found, we excluded repeated articles, studies that were not related to Korean medicine, and those not relevant to the topic of the study. Results : Ten randomized controlled trials and 20 case studies were selected. Eight traditional Korean medicine treatments, including acupuncture, herbal medicine, chuna, and herbal ointment, were used in these studies. The most commonly used treatment was found to be acupuncture. Conclusions : Our study showed that traditional Korean medicine for medial collateral ligament injuries was effective. However, there were some limitations. Further clin- ical studies and randomized controlled clinical trials are needed for more evidence on Korean traditional medicine.

Marker Based Standardization of Herbal Sunscreen Formulation by Using Validated High-Performance Thin Layer Chromatography Method

Plant based products are worldwide used and trusted for the care and cure of the health. Herbal sunscreen formulations are gaining popularity for their effectiveness and are devoid of side effects. The present investigation is an effort made to develop herbal sunscreen cream containing methanolic extracts of different plants and its standardization for the presence of bioactive compounds. The leaves of Cymbopogon citratus (Stapf), fruit peel of Punica granatum (Linn), flowers of Butea monosperma (Lam.) and leaves of Neolamarckia cadamba (Roxb.) were selected for the preparation of sunscreen cream. The standardization of herbal formulations is very important to determine its quality based on the concentration of their active phytoconstituents. The herbal cream F-5 (2 % w/w) imparted its sun-protective and antioxidant property. It shows free radicals scavenging activity due the presence of flavonoids and phenolic compounds. High performance thin layer chromatography method is used to determine the quality and quantity of the sun protective phytoconstituents present in the product. The method was validated according to ICH guidelines for the estimation butrin (BT), isobutrin (IBT), quercetin (QC), apigenin (API), chlorogenic acid (CA) and gallic acid (GA) using the optimized solvent systems. The estimation of bioactive markers was carried out on silica gel precoated thin layer chromatography plates with 60F254 as the stationary phase and Camag TC scanner III for densitometric scanning. The average Rf values for the markers were found to be 0.46 for BT, 0.57 for IBT, 0.50 for QC, 0.57 for API, 0.66 for CA and 0.42 for GA. The developed HPTLC method was linear with correlation coefficient 0.999 for BT, 0.998 for IBT, QC, API and 0.9966 for CA and 0.9989 for GA. Limit of detection (LOD) and limit of quantification (LOQ) were recorded. The developed analytical method for quantitative determination of phytoconstituents was found efficient, simple, accurate, and validated.

Dissolvable Microneedle Patch Increases the Therapeutic Effect of Jawoongo on DNCB-Induced Atopic Dermatitis in Mice

Background: Jawoongo (JW) is a topical herbal ointment that has been used as an alternative treatment option for atopic dermatitis. Topical ointments are known to have less bioavailability because the stratum corneum allows only lipophilic and low molecular weight drugs to pass across it. This study aimed to investigate whether applying microneedle patches (MNP) increases the therapeutic effect of 2,4-dinitrochlorobenzene (DNCB)+JW for atopic dermatitis by enhancing transdermal delivery. Methods: Atopic dermatitis was induced by DNCB in BALB/c mice. The combination treatment of JW and MNP was estimated to study the effect of MNP in improving transdermal delivery. Histological analysis, quantitative real-time PCR (qPCR), and immunofluorescence were performed to verify the effect of MNP in enhancing the therapeutic effects of DNCB+JW on atopic dermatitis in mice. Results: Both combination treatment and DNCB+JW treatment ameliorated histological alterations and reduced skin thickness and infiltration of CD4+ T cells in atopic dermatitis-like skin lesions in DNCB-exposed BALB/c mice. However, the improvement of histological alterations was better in the combination treatment, which was almost normal. Furthermore, the combination treatment exhibited a larger decrease in mRNA levels of IL-4, IL-6, IL-13, iNOS, and TNF-α, compared to DNCB+JW only. In addition, skin thickness and infiltration of CD4+ T cells in the sensitized skin were significantly lower using the combination treatment than using DNCB+JW only. Conclusion: Combination treatment with JW and MNP further decreased skin thickness and several inflammatory cytokines in atopic dermatitis like skin lesions compared to treatment using JW alone. These findings suggest that applying a dissolvable MNP after JW application could be useful for treating atopic dermatitis.

Formulation and Evaluation of Polyherbal Face Cream

Herbal medicinal products are most preferable and safer with very less side effects than the synthetic products. Now a days there is a increasing in demand of herbal formulations in the world pharmaceutical market .The main objective of this work is to formulate and evaluate a cosmetic preparation polyherbal face cream made from herbal ingredients. In that aloe vera powder, hibiscus powder, senna powder were procured from the local market in the form of dried powder .extraction of dried crude herbal ingredients were done by the maceration process. After extracting the polyherbal face cream is prepared and evaluated for its various charecteristics. Herbal face creams are used to moisturizing, cleansing, protecting skin from damaging Uv rays, improving skin tone and beautifying skin. Due to anti-bacterial and anti-inflammatory activity of herbs used in the formulation helps to overcomes various problems related to the skin. Thus, in the present work, we founds good quality of herbal face cream, with their beneficial effects.

Preliminary physico – phytochemical and phytocognostical evaluation of the leaves parts and evaluation of herbal ointment using leaves of Achyranthes aspera L. Leaf extract

Herbal plants are huge sources of neutraceuticals, prevent the different disease or maintain healthy life. Plant produces primary metabolites for their basic survival and secondary metabolites for their ecological, taxonomical and biochemical differentiation and diversity. Achyranthes aspera L. (Family Amaranthaceae) are broadly used in traditional system of medicine throughout different part of India, South Andaman Island, Pacific Island, Baluchistan, Tropical Asia, America, and Australia. It has great medicinal importance like to stomach tonic, diuretic, laxative, anthelmintic, anti hyperlipidemic, expectorant, anti-inflammatory, anti-bacterial, anti-fungal, hypoglycemic, anti-asthmatic and anti-allergic etc. The study of diseases and their treatment are important part of our ancient time worldwide. The knowledge of medicinal plants must have been accumulated in the course of many centuries. Herbal medicine prepare different part of plant are used. Herbal drug is design as the alternative formulation for the external use in the form of ointment. For the clinical use the herbal ointment apply externally on human body. The main aims of this research are Preliminary physico–phytochemical & phytocognostical evaluation of the leaves parts and preparation of herbal ointment from the Achyranthes aspera. Achyranthes aspera L. plants used as antibacterial activity. Under this research work, it is design as herbal ointment with the help of Ethanolic extract of Achyranthes aspera and determines the anti-bacterial capacity on it. In vitro study the antibacterial activity of the Ethanolic extracts of dried leaves of Achyranthes aspera L. are determine by using the Agar cup plate method versus different bacteria such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa etc. By blending the Ethanolic extract of Achyranthes aspera L. (10 % w/w) into aqueous cream we formulated herbal ointment. The emulsifying agent and simple ointment bases are added in above herbal ointment for increase the antibacterial effectiveness during in vitro evaluation. The current study deals with the characterization of morphological features, determination of physical constant such as the total cash value, water soluble ash value were 11.25%, 5.25% respectively. Loss of weight drying was 12.9%, foaming index>100, swelling index were1.5cm, the percent yield for petroleum ether 5.25%, chloroform 6.34%, ethanol 7.65%, and aqueous 8.35%, and determination of formulation and evaluation of herbal ointment using Achyranthes aspera L. leave extract.

Preliminary physico – phytochemical and phytocognostical evaluation of the leaves parts and evaluation of herbal ointment using leaves of Achyranthes aspera L. Leaf extract

Preliminary physico – phytochemical and phytocognostical evaluation of the leaves parts and evaluation of herbal ointment using leaves of Achyranthes aspera L. Leaf extract