Nanotechnology is one of the most rapidly progressing fields of technology, and it has opened up many new frontiers of research for modern society. It deals with the nanoparticles having a size of 1-100 nm in one dimension. These nano-conjugates can be prepared easily by different chemical, physical, and biological approaches. However, the green synthesis approach is the most favoured one because this method is more natural, less hazardous, and eco-friendly. Our present study gives an overview of some common medicinal weeds Heliotropium indicum (Family: Boraginaceae), Tridax procumbens (Family: Asteraceae), Cleome rutidosperma (Family: Cleomaceae), Commelina benghalensis (Family: Commelinaceae), and Euphorbia hirta (Family: Euphorbiaceae) leaf aqueous extract mediated green synthesis of silver nano-conjugates. After synthesis, silver nanoparticles were examined by using advanced characterization techniques, including UV-Vis Spectrophotometer, DLS, and FT-IR. The UV-Vis absorption spectroscopy results highlighted a single peak within the range of 402-429 nm for all the five nano-conjugates. The DLS data highlighted that the particle size of the nano-conjugates ranges between 18.17 nm-105.7 nm. Whereas the similarities between the FT-IR data of the sample and nanoparticle confirm the conjugation of different bioactive compounds of the aqueous leaf extracts with the metal nanoparticles.