Abstract
Aqueous Leaf Extract of Heliotropium Indicum Ameliorates Hyperglycaemia-Induced Tissue Complications in Albino Rats
Highlights
IntroductionDiabetes mellitus (DM) remains an important non-communicable disease of global concern affecting 415 million people with a progressively increasing prevalence in every studied population
Diabetes mellitus (DM) is a chronic progressive metabolic syndrome characterized by hyperglycemia due to inadequacies in insulin secretion and/or action leading to derangements in the metabolism of carbohydrate and abnormalities in protein and lipid metabolism [1]
The serum activities of tissue membrane bound enzymes (ALT, AST, ACP, and alkaline phosphatase (ALP)) which are high in hyperglycemic rats indicating compromised tissue structures in hyperglycaemic control (HC) throughout the experimental period were significantly reduced in the rats treated with aqueous leaf extract of H. indicum (Table 1)
Summary
DM remains an important non-communicable disease of global concern affecting 415 million people with a progressively increasing prevalence in every studied population. It is one of the five principal causes of death in the world led singly to about 5 million deaths in 2015 [2]. Disorders in tissue metabolism resulting from poorly managed hyperglycemia are the main cause of diabetic complications leading to damage to many organs including liver and kidney [3]. Conclusion: Aqueous leaf extract of H. indicum can be explored at the ethnobotanical dose of 30 and 75 mg/kg b.wt on the management of some of the tissue-specific disarrays associated with diabetes.
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