ROS mediated DNA damage and induction of apoptosis in cervical cancer cells by Heliotropium indicum L

Rita Kundu

doi:10.7324/japs.2018.8814

Abstract

ROS mediated DNA damage and induction of apoptosis in cervical cancer cells by Heliotropium indicum L

Highlights

Members of heliotropes (Heliotropium indicum, H. ovalifolium, H. ramosissimum, H. steudneri) are used as medicine traditionally in the pantropical regions, where they are found in abundance
The anti-proliferative activity of chloroform fraction of methanolic extract of Heliotropium indicum was studied in a panel of cervical cancer cell lines
From the study, it can be concluded that fatty acid rich chloroform fraction of H. indicum is capable of inducing apoptosis in cervical cancer cells, through ROS mediated DNA damage

Summary

Introduction

Members of heliotropes (Heliotropium indicum, H. ovalifolium, H. ramosissimum, H. steudneri) are used as medicine traditionally in the pantropical regions, where they are found in abundance. The plants are used to treat snakebite/scorpion stings, indicating their antitoxin activity (Duttagupta et al, 1977). Leaf poultices/juices and infusions are used to treat dandruff, skin ailments, kidney dysfunction, and fever. These plants were used as an analgesic, diuretic, and cleanser of wounds by the African people (Togola et al, 2005). H. indicum, commonly known as Indian heliotrope is widely distributed throughout Indian subcontinent though they are probably native to tropical America. In Rajanighantu—an important lexicon of Ayurvedic materia media written in the 12th/13th century, the curative property of H. indicum (hatisundi) against typhoid was mentioned (Karra, 2013). The whole plant is used as diuretic and anodyne, seeds are used

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Discussion

Conclusion