This paper presents an innovative method to design cyclone separators based on geometrical principles, and incorporates a coupling iterative algorithm to obtain crucial parameters. The proposed approach allows for simultaneous variation of multiple key parameters, including inlet velocity, inlet height, and pressure drop. Thus, effects of varying one parameter on the others are accounted for. The innovative methodology is utilized to design a novel, high-performance cyclone potentially applicable in natural gas filtration. The introduced cyclone has a uniquely large inlet length to diameter ratio and a small curved cone, making it compact and usable in clusters to handle large flow rates. The cyclone is experimentally tested to evaluate its filtration performance. The results indicate that six micron or larger particles are completely separated, and a cut point diameter of 1 μm is achieved. Finally, the introduced cyclone is numerically investigated to analyze the gas flow behavior and visualize particle trajectories.