The degradation of SRAM bit-cells designed in a 65nm bulk CMOS technology in a Sun-Synchronous Low Earth Orbit (LEO) ionizing radiation environment is analyzed. We propose an inflight SEU rate estimation approach based on a modeled heavy ion cross section as opposed to the standard experimental characterization. Effects of irradiation with estimated LET spectrum in SRAM bit cell, i.e. the location of sensitive regions, its tendency to cause upset, magnitude and duration of transient current as well as voltage pulses were determined. It was found with SEU map that 65nm SRAM bit-cell can flip even if high LET particle strikes in close proximity of bit-cell outside the SRAM bit-cell area. The SEU sensitive parameters required to predict SEU rate of on-board target device, i.e., 65nm SRAM were calculated with typical aluminum spot shielding using fully physical mechanism simulation. In order to characterize the robustness of scaled CMOS devices, state of the art simulation tools such as Visual TCAD/Genius, GSEAT/Visual Particle, runSEU, were utilized whereas LEO radiation environment assessment, upset rate prediction was accomplished with the help of OMERE-TRAD software.