Objective To explore the effects of health education pathway on the quality of life, mental status, nursing satisfaction, hemostasis time, hospitalization duration and hospitalization expenses in patients with liver cirrhosis complicated with upper gastrointestinal hemorrhage. Methods From January to December 2016, a total of 140 patients with cirrhosis and upper gastrointestinal hemorrhage in the Second Affiliated Hospital of Wenzhou Medical University were enrolled by convenience sampling method, and divided into observation group and control group with 70 cases in each group according to the random number table method. The patients in the control group were given routine health education, while the patients in the observation group were educated with health education path. The quality of life, the scores of Self-Rated Anxiety Scale (SAS) and Self-Rated Depression scale (SDS) , the nursing satisfaction, hemostasis time, hospitalization duration and hospitalization expenses of both groups were collected and compared before and after intervention. Results Before intervention, there were no significant differences in the quality of life, the score of SAS and SDS between the two groups (P>0.05) . After intervention, the scores of 8 aspects of the quality of life of the observation group were all higher than those of the control group. Meanwhile, the scores of SAS and SDS were lower than those of the control group. All the differences were statistically significant (P<0.01) . The hemostasis time, hospitalization time and hospitalization expenses of the observation group were all lower than those of the control group, while the nursing satisfaction of the observation group was higher than that of the control group, and all the differences were statistically significant (P<0.01) . Conclusions Health education pathways can improve the quality of life, anxiety and depression in patients with cirrhosis complicated with upper gastrointestinal hemorrhage and improve the therapeutic effect. Key words: Health education; Liver cirrhosis; Quality of life; Anxiety; Depression; Upper gastrointestinal hemorrhage