Abstract The Internet era brings to the teaching of mental health courses not only the sharing of the best quality teaching resources, but also will profoundly impact the traditional teaching mode of mental health education classes. Based on Cognitive Behavioral Theory (CBT), this study constructed a hybrid online + offline psychological education teaching mode in the Internet era and designed a controlled experiment between it and the traditional teaching mode to analyze the significant difference through the independent samples t-test method to realize the comparative analysis of the teaching mode. Additionally, the influence factors for evaluating the effectiveness of the teaching method were explored using the CART categorical regression tree model. In Group I, which adopted the blended teaching mode, there were significant differences in the male students’ mental health factors in obsessive-compulsive (p=0.013) and paranoia (p=0.014) and highly significant differences in interpersonal relationships (p=0.006) and academic stress (p=0.002). There is a significant difference in the mental health factors of female students in five factors: compulsion, interpersonal relationship, anxiety, maladjustment, and emotional instability, and there is a highly significant difference in paranoia and academic stress. Only the compulsive (male) factor (p=0.029) and depression (female) factor (p=0.031) showed significant differences in each health factor before and after the experiment in Group II, which used the traditional teaching mode. The teaching mode of this paper has an obvious effect on the improvement of college students’ mental health, which is much better than the traditional teaching mode, thus providing feasible ideas for the construction of a psychological education teaching mode.