Multilevel inverters have become popular in recent years in high power applications; they provide an effective solution for increasing power and minimizing the harmonics of AC waveforms. The fast response and robust method of conventional direct torque control are used in variable speed drives for the reduction of torque ripple. However, major problems occur at steady-state notable torque, flux, and current pulsations in direct torque control drives. This paper presents various strategies in the direct torque and flux control of induction motors for the reduction of torque ripple based on a multilevel neutral point clamped (NPC) inverter. This kind of inverter is used to achieve better harmonic reductions than the traditional two-level voltage source inverters and the related control scheme serves to minimize semiconductor losses. The performance of an induction motor depends upon a mathematical model that comprises the variations in parameters, common-mode voltage, noise, flux variation, and levels of harmonics in a machine. Here, the torque ripples and voltage saturations are the most substantial problems in electrical drive applications. To overcome this problem, the direct torque and flux control (DTFC) technique based on multilevel NPC inverter topology is developed. Moreover, the various control strategies-based DTFC is proposed for the minimization of torque ripple in IM drives. An improved control scheme is used to optimize the regulation of torque and speed with less torque response. This paper proposes the comparative study of the THD analysis of different control techniques (PI, fuzzy, ANFIS) that is effectively used for harmonic moderation in the design of different NPC multilevel inverter; this goal is achieved as shown from the comparison of simulation results using the MATLAB/SIMULINK environment.