Popularity in cyberspace is more challenging compared to the Face-to-Face (FtF) environment since popularity plays a significant role in mediated-communication, where it affects the happiness in people’s life. The objective of this study is to identify the relationship between popularity and life happiness amongst Facebook users. A quantitative survey was conducted by distributing a set of a questionnaire via a survey-development website to 402 Facebook users who were selected through snowball sampling technique. Results indicated that more popularity is shown by other Facebook users with lower uncertainty leading towards life unhappiness. Although the emotion of happiness in life occurs in FtF, online interaction could not make them feel the same way. Thus, the presence of mediated-communication is not taking over the FtF approaches. Future work should contribute towards the development of mediated-communication to better fit the dynamic nature of the interpersonal relationship and a worthier understanding of online human behavior.