Ionic liquids (ILs) are more widely used within the industry than ever before, and accurate models of their physicochemical characteristics are becoming increasingly important during the process optimization. It is especially challenging to simulate the viscosity of ILs since there is no widely agreed explanation of how viscosity is determined in liquids. In this research, genetic programming (GP) and group method of data handling (GMDH) models were used as white-box machine learning approaches to predict the viscosity of pure ILs. These methods were developed based on a large open literature database of 2813 experimental viscosity values from 45 various ILs at different pressures (0.06-298.9MPa) and temperatures (253.15-573K). The models were developed based on five, six, and seven inputs, and it was found that all the models with seven inputs provided more accurate results, while the models with five and six inputs had acceptable accuracy and simpler formulas. Based on GMDH and GP proposed approaches, the suggested GMDHmodel with seven inputs gave the most exact results with an average absolute relative deviation (AARD) of 8.14% and a coefficient of determination (R2) of 0.98. The proposed techniques were compared with theoretical and empirical models available in the literature, and it was displayed that the GMDH model with seven inputs strongly outperforms the existing approaches. The leverage statistical analysis revealed that most of the experimental data were located within the applicability domains of both GMDH and GP models and were of high quality. Trend analysis also illustrated that the GMDH and GP models could follow the expected trends of viscosity with variations in pressure and temperature. In addition, the relevancy factor portrayed that the temperature had the greatest impact on the ILs viscosity. The findings of this study illustrated that the proposed models represented strong alternatives to time-consuming and costly experimental methods of ILs viscosity measurement.
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