Gradient Slew Rate Research Articles

Minimizing electric fields and increasing peripheral nerve stimulation thresholds using a body gradient array coil.

To demonstrate the performance of gradient array coils in minimizing switched-gradient-induced electric fields (E-fields) and improving peripheral nerve stimulation (PNS) thresholds while generating gradient fields with adjustable linearity across customizable regions of linearity (ROLs). A body gradient array coil is used to reduce the induced E-fields on the surface of a body model by modulating applied currents. This is achieved by performing an optimization problem with the peak E-field as the objective function and current amplitudes as unknown variables. Coil dimensions and winding patterns are fixed throughout the optimization, whereas other engineering metrics remain adjustable. Various scenarios are explored by manipulating adjustable parameters. The array design consistently yields lower E-fields and higher PNS thresholds across all scenarios compared with a conventional coil. When the gradient array coil generates target gradient fields within a 44-cm-diameter spherical ROL, the maximum E-field is reduced by 10%, 18%, and 61% for the X, Y, and Z gradients, respectively. Transitioning to a smaller ROL (24 cm) and relaxing the gradient linearity error results in further E-field reductions. In oblique gradients, the array coil demonstrates the most substantial reduction of 40% in the Z-Y direction. Among the investigated scenarios, the most significant increase of 4.3-fold is observed in the PNS thresholds. Our study demonstrated that gradient array coils offer a promising pathway toward achieving high-performance gradient coils regarding gradient strength, slew rate, and PNS thresholds, especially in scenarios in which linear magnetic fields are required within specific target regions.

Sequence optimization for MRI acoustic noise reduction

The large acoustic noise of 80-110 dB during magnetic resonance imaging (MRI) scanning harms patients’ comfort and health. The noise can be reduced by hardware modification or active noise control, but these methods are expensive, difficult, or not very effective. In this study, a sequence optimization method is used to mitigate the acoustic noise problem while maintaining image quality. The 4th order polynomial function is applied to design the new quiet pulse sequences, decreasing the gradient slew rate and higher time derivatives of the original trapezoidal lobes. A sound pressure level (SPL) estimation method is proposed to predict the acoustic noise loudness from the gradient and is used for genetic algorithm sequence optimization. The original and quiet gradient recalled echo (GRE) sequences are applied on a 1.5 T MRI scanner. The average SPL is reduced by 18.6 dBA, and the images show small differences and have similar SNR values. This method is also applied for the scouting and shimming GRE sequences in common clinical applications with significant noise reduction.

Design and construction of new small gradient coils for mouse MRI

We represent small Z- and Y-gradient coils with higher gradient strength and slew rate for mouse MRI. The coil geometries are optimized based on predetermined conditions for the gradient strength and slew rate in terms of minimum power consumption and acceptable linearity for the variation of the magnetic fields using the particle swarm optimization algorithm in computer simulation technology. The simulation results verify that the magnitudes of the field strength and slew rate have reached up to and for the Z-gradient coil and increased to and for the Y-gradient coil, respectively. Furthermore, the optimal geometry of the Z-gradient coil derived from a simulation study was then fabricated, and its parameters were measured using a Hall sensor. The gradient strength and slew rate of the fabricated Z-gradient coil were measured at and , respectively, which have only a 9% difference from the corresponding simulated parameters.

Acoustic noise reduction for spiral MRI by gradient derating.

To show that the acoustic noise of spiral MRI can be reduced by derating the gradients with minimal penalty to image quality and scan time, and to illustrate an algorithm for optimal choice of derating parameters. Acoustic noise level was measured and compared for various values of maximum gradient amplitude and slew rate for T1 -weighted spin-echo spiral scans while maintaining image contrast, FOV and resolution, and readout time. A full gradient trajectory and a derated gradient (undersampled) trajectory were chosen for a volunteer scan followed by parallel imaging-aided reconstruction to illustrate comparable image SNR. Two auto-derating methods, which prioritize slew rate and gradient amplitude, respectively, were derived using analytical results from the WHIRLED PEAS variant of spiral waveforms and compared in their acoustic noise level under test use cases. Derating the gradients made the scan quieter by 16.6 dB(A) on average than a full gradient trajectory and required an undersampling factor R = 2 in order to maintain scan time, with no appreciable penalty in image SNR. Prioritizing reduced slew rate resulted in maximal loudness reduction. Scanner gradients can often be derated to reduce the acoustic noise for spiral MRI with minimal penalty in scan time and image quality with the help of parallel imaging. An automatic slew-priority derating method that maximizes loudness reduction is given.

A silent gradient axis for soundless spatial encoding to enable fast and quiet brain imaging.

PurposeA novel silent imaging method is proposed that combines a gradient insert oscillating at the inaudible frequency 20 kHz with slew rate‐limited gradient waveforms to form a silent gradient axis that enable quiet and fast imaging.MethodsThe gradient insert consisted of a plug‐and‐play (45 kg) single axis z‐gradient, which operated as an additional fourth gradient axis. This insert was made resonant using capacitors and combined with an audio amplifier to allow for operation at 20 kHz. The gradient field was characterized using field measurements and the physiological effects of operating a gradient field at 20 kHz were explored using peripheral nerve stimulation experiments, tissue heating simulations and sound measurements. The imaging sequence consisted of a modified gradient‐echo sequence which fills k‐space in readout lanes with a width proportional to the oscillating gradient amplitude. The feasibility of the method was demonstrated in‐vivo using 2D and 3D gradient echo (GRE) sequences which were reconstructed using a conjugate‐gradient SENSE reconstruction.ResultsField measurements yielded a maximum gradient amplitude and slew rate of 40.8 mT/m and 5178T/m/s at 20 kHz. Physiological effects such as peripheral nerve stimulation and tissue heating were found not to be limiting at this amplitude and slew rate. For a 3D GRE sequence, a maximum sound level of 85 db(A) was measured during scanning. Imaging experiments using the silent gradient axis produced artifact free images while also featuring a 5.3‐fold shorter scan time than a fully sampled acquisition.ConclusionA silent gradient axis provides a novel pathway to fast and quiet brain imaging.

On the dependence of quantitative diffusion-weighted imaging on scanner system characteristics and acquisition parameters: A large multicenter and multiparametric phantom study with unsupervised clustering analysis.

The purpose of this multicenter phantom study was to exploit an innovative approach, based on an extensive acquisition protocol and unsupervised clustering analysis, in order to assess any potential bias in apparent diffusion coefficient (ADC) estimation due to different scanner characteristics. Moreover, we aimed at assessing, for the first time, any effect of acquisition plan/phase encoding direction on ADC estimation. Water phantom acquisitions were carried out on 39 scanners. DWI acquisitions (b-value=0-200-400-600-800-1000s/mm2) with different acquisition plans (axial, coronal, sagittal) and phase encoding directions (anterior/posterior and right/left, for the axial acquisition plan), for 3 orthogonal diffusion weighting gradient directions, were performed. For each acquisition setup, ADC values were measured in-center and off-center (6 different positions), resulting in an entire dataset of 84×39=3276 ADC values. Spatial uniformity of ADC maps was assessed by means of the percentage difference between off-center and in-center ADC values (Δ). No significant dependence of in-center ADC values on acquisition plan/phase encoding direction was found. Ward unsupervised clustering analysis showed 3 distinct clusters of scanners and an association between Δ-values and manufacturer/model, whereas no association between Δ-values and maximum gradient strength, slew rate or static magnetic field strength was revealed. Several acquisition setups showed significant differences among groups, indicating the introduction of different biases in ADC estimation. Unsupervised clustering analysis of DWI data, obtained from several scanners using an extensive acquisition protocol, allows to reveal an association between measured ADC values and manufacturer/model of scanner, as well as to identify suboptimal DWI acquisition setups for accurate ADC estimation.

A plug-and-play, lightweight, single-axis gradient insert design for increasing spatiotemporal resolution in echo planar imaging-based brain imaging.

The goal of this study was to introduce and evaluate the performance of a lightweight, high‐performance, single‐axis (z‐axis) gradient insert design primarily intended for high‐resolution functional magnetic resonance imaging, and aimed at providing both ease of use and a boost in spatiotemporal resolution. The optimal winding positions of the coil were obtained using a genetic algorithm with a cost function that balanced gradient performance (minimum 0.30 mT/m/A) and field linearity (≥16 cm linear region). These parameters were verified using field distribution measurements by B0‐mapping. The correction of geometrical distortions was performed using theoretical field distribution of the coil. Simulations and measurements were performed to investigate the echo planar imaging echo‐spacing reduction due to the improved gradient performance. The resulting coil featured a 16‐cm linear region, a weight of 45 kg, an installation time of 15 min, and a maximum gradient strength and slew rate of 200 mT/m and 1300 T/m/s, respectively, when paired with a commercially available gradient amplifier (940 V/630 A). The field distribution measurements matched the theoretically expected field. By utilizing the theoretical field distribution, geometrical distortions were corrected to within 6% of the whole‐body gradient reference image in the target region. Compared with a whole‐body gradient set, a maximum reduction in echo‐spacing of a factor of 2.3 was found, translating to a 344 μs echo‐spacing, for a field of view of 192 mm, a receiver bandwidth of 920 kHz and a gradient amplitude of 112 mT/m. We present a lightweight, single‐axis gradient insert design that can provide high gradient performance and an increase in spatiotemporal resolution with correctable geometrical distortions while also offering a short installation time of less than 15 min and minimal system modifications.

Simultaneous optimization of radio frequency and gradient waveforms with exact Hessians and slew rate constraints applied to [formula omitted]-points excitation

We consider an excitation pulse with piecewise constant gradient trajectories and radio frequency (RF) waveforms such that the solution of the Bloch equations without relaxation terms can be represented by rotations. Based on this analytic solution we formulate a non-linear program for finding sub-pulse durations, gradient strengths, and complex RF voltages which minimize the deviation between the achieved and desired magnetization. We develop explicit expressions for the first and second order derivatives of the objective function. We extend the non-linear program to precisely account for gradient slew rate constraints. Using an interior point solver we apply the developed theory to simultaneously optimize the positions of kT-points, their associated RF voltages and durations.

Investigating cardiac stimulation limits of MRI gradient coils using electromagnetic and electrophysiological simulations in human and canine body models.

Purpose:Cardiac stimulation (CS) limits to gradient coil switching speed are difficult to measure in humans; instead, current regulatory guidelines (IEC 60601–2-33) are based on animal experiments and electric field–to-dB/dt conversion factors computed for a simple, homogeneous body model. We propose improvement to this methodology by using more detailed CS modeling based on realistic body models and electrophysiological models of excitable cardiac fibers.Methods:We compute electric fields induced by a solenoid, coplanar loops, and a commercial gradient coil in two human body models and a canine model. The canine simulations mimic previously published experiments. We generate realistic fiber topologies for the cardiac Purkinje and ventricular muscle fiber networks using rule-based algorithms, and evaluate CS thresholds using validated electrodynamic models of these fibers.Results:We were able to reproduce the average measured canine CS thresholds within 5%. In all simulations, the Purkinje fibers were stimulated before the ventricular fibers, and therefore set the effective CS threshold. For the investigated gradient coil, simulated CS thresholds for the x-, y-, and z-axis were at least one order of magnitude greater than the International Electrotechnical Commission limit.Conclusion:We demonstrate an approach to simulate gradient-induced CS using a combination of electromagnetic and electrophysiological modeling. Pending additional validation, these simulations could guide the assessment of CS limits to MRI gradient coil switching speed. Such an approach may lead to less conservative, but still safe, operation limits, enabling the use of the maximum gradient amplitude versus slew rate parameter space of recent, powerful gradient systems.

A multi spin echo pulse sequence with optimized excitation pulses and a 3D cone readout for hyperpolarized 13 C imaging.

PurposeImaging tumor metabolism in vivo using hyperpolarized [1‐13C]pyruvate is a promising technique for detecting disease, monitoring disease progression, and assessing treatment response. However, the transient nature of the hyperpolarization and its depletion following excitation limits the available time for imaging. We describe here a single‐shot multi spin echo sequence, which improves on previously reported sequences, with a shorter readout time, isotropic point spread function (PSF), and better signal‐to‐noise ratio.MethodsThe sequence uses numerically optimized spectrally selective excitation pulses set to the resonant frequencies of pyruvate and lactate and a hyperbolic secant adiabatic refocusing pulse, all applied in the absence of slice selection gradients. The excitation pulses were designed to be resistant to the effects of B0 and B1 field inhomogeneity. The gradient readout uses a 3D cone trajectory composed of 13 cones, all fully refocused and distributed among 7 spin echoes. The maximal gradient amplitude and slew rate were set to 4 G/cm and 20 G/cm/ms, respectively, to demonstrate the feasibility of clinical translation.ResultsThe pulse sequence gave an isotropic PSF of 2.8 mm. The excitation profiles of the optimized pulses closely matched simulations and a 46.10 ± 0.04% gain in image SNR was observed compared to a conventional Shinnar–Le Roux excitation pulse. The sequence was demonstrated with dynamic imaging of hyperpolarized [1‐13C]pyruvate and [1‐13C]lactate in vivo.ConclusionThe pulse sequence was capable of dynamic imaging of hyperpolarized 13C labeled metabolites in vivo with relatively high spatial and temporal resolution and immunity to system imperfections.

Oscillating diffusion-encoding with a high gradient-amplitude and high slew-rate head-only gradient for human brain imaging.

We investigate the importance of high gradient-amplitude and high slew-rate on oscillating gradient spin echo (OGSE) diffusion imaging for human brain imaging and evaluate human brain imaging with OGSE on the MAGNUS head-gradient insert (200 mT/m amplitude and 500 T/m/s slew rate). Simulations with cosine-modulated and trapezoidal-cosine OGSE at various gradient amplitudes and slew rates were performed. Six healthy subjects were imaged with the MAGNUS gradient at 3T with OGSE at frequencies up to 100 Hz and b = 450 s/mm2 . Comparisons were made against standard pulsed gradient spin echo (PGSE) diffusion in vivo and in an isotropic diffusion phantom. Simulations show that to achieve high frequency and b-value simultaneously for OGSE, high gradient amplitude, high slew rates, and high peripheral nerve stimulation limits are required. A strong linear trend for increased diffusivity (mean: 8-19%, radial: 9-27%, parallel: 8-15%) was observed in normal white matter with OGSE (20 Hz to 100 Hz) as compared to PGSE. Linear fitting to frequency provided excellent correlation, and using a short-range disorder model provided radial long-term diffusivities of D∞,MD = 911 ± 72 µm2 /s, D∞,PD = 1519 ± 164 µm2 /s, and D∞,RD = 640 ± 111 µm2 /s and correlation lengths of lc,MD = 0.802 ± 0.156 µm, lc,PD = 0.837 ± 0.172 µm, and lc,RD = 0.780 ± 0.174 µm. Diffusivity changes with OGSE frequency were negligible in the phantom, as expected. The high gradient amplitude, high slew rate, and high peripheral nerve stimulation thresholds of the MAGNUS head-gradient enables OGSE acquisition for in vivo human brain imaging.

The effect of spiral trajectory correction on pseudo-continuous arterial spin labeling with high-performance gradients on a compact 3T scanner.

To demonstrate the feasibility of pseudo-continuous arterial-spin-labeled (pCASL) imaging with 3D fast-spin-echo stack-of-spirals on a compact 3T scanner (C3T), to perform trajectory correction for eddy-current-induced deviations in the spiral readout of pCASL imaging, and to assess the correction effect on perfusion-related images with high-performance gradients (80 mT/m, 700T/m/s) of the C3T. To track eddy-current-induced artifacts with Archimedean spiral readout, the spiral readout in pCASL imaging was performed with 5 different peak gradient slew rate (Smax ) values ranging from 70 to 500 T/m/s. The trajectory for each Smax was measured using a dynamic field camera and applied in a density-compensated gridding image reconstruction in addition to the nominal trajectory. The effect of the trajectory correction was assessed with perfusion-weighted (ΔM) images and proton-density-weighted images as well as cerebral blood flow (CBF) maps, obtained from 10 healthy volunteers. Blurring artifact on ΔM images was mitigated by the trajectory correction. CBF values on the left and right calcarine cortices showed no significant difference after correction. Also, the signal-to-noise ratio of ΔM images improved, on average, by 7.6% after correction (P < .001). The greatest improvement of 12.1% on ΔM images was achieved with a spiral readout using Smax of 300~400 T/m/s. Eddy currents can cause spiral trajectory deviation, which leads to deformation of the CBF map even in cases of low value Smax . The trajectory correction for spiral-readout-based pCASL produces more reliable results for perfusion imaging. These results suggest that pCASL is feasible on C3T with high-performance gradients.

Highly efficient head-only magnetic field insert gradient coil for achieving simultaneous high gradient amplitude and slew rate at 3.0T (MAGNUS) for brain microstructure imaging.

To develop a highly efficient magnetic field gradient coil for head imaging that achieves 200 mT/m and 500 T/m/s on each axis using a standard 1 MVA gradient driver in clinical whole-body 3.0T MR magnet. A 42-cm inner diameter head-gradient used the available 89- to 91-cm warm bore space in a whole-body 3.0T magnet by increasing the radial separation between the primary and the shield coil windings to 18.6 cm. This required the removal of the standard whole-body gradient and radiofrequency coils. To achieve a coil efficiency ~4× that of whole-body gradients, a double-layer primary coil design with asymmetric x-y axes, and symmetric z-axis was used. The use of all-hollow conductor with direct fluid cooling of the gradient coil enabled ≥50 kW of total heat dissipation. This design achieved a coil efficiency of 0.32 mT/m/A, allowing 200 mT/m and 500 T/m/s for a 620 A/1500 V driver. The gradient coil yielded substantially reduced echo spacing, and minimum repetition time and echo time. In high b = 10,000 s/mm2 diffusion, echo time(TE) < 50 ms was achieved (>50% reduction compared with whole-body gradients). The gradient coil passed the American College of Radiology tests for gradient linearity and distortion, and met acoustic requirements for nonsignificant risk operation. Ultra-high gradient coil performance was achieved for head imaging without substantial increases in gradient driver power in a whole-body 3.0T magnet after removing the standard gradient coil. As such, any clinical whole-body 3.0T MR system could be upgraded with 3-4× improvement in gradient performance for brain imaging.

Peripheral nerve stimulation limits of a high amplitude and slew rate magnetic field gradient coil for neuroimaging.

To establish peripheral nerve stimulation (PNS) thresholds for an ultra-high performance magnetic field gradient subsystem (simultaneous 200-mT/m gradient amplitude and 500-T/m/s gradient slew rate; 1 MVA per axis [MAGNUS]) designed for neuroimaging with asymmetric transverse gradients and 42-cm inner diameter, and to determine PNS threshold dependencies on gender, age, patient positioning within the gradient subsystem, and anatomical landmarks. The MAGNUS head gradient was installed in a whole-body 3T scanner with a custom 16-rung bird-cage transmit/receive RF coil compatible with phased-array receiver brain coils. Twenty adult subjects (10 male, mean ± SD age = 40.4 ± 11.1 years) underwent the imaging and PNS study. The tests were repeated by displacing subject positions by 2-4 cm in the superior-inferior and anterior-posterior directions. The x-axis (left-right) yielded mostly facial stimulation, with mean ΔGmin = 111 ± 6 mT/m, chronaxie = 766 ± 76 µsec. The z-axis (superior-inferior) yielded mostly chest/shoulder stimulation (123 ± 7 mT/m, 620 ± 62 µsec). Y-axis (anterior-posterior) stimulation was negligible. X-axis and z-axis thresholds tended to increase with age, and there was negligible dependency with gender. Translation in the inferior and posterior directions tended to increase the x-axis and z-axis thresholds, respectively. Electric field simulations showed good agreement with the PNS results. Imaging at MAGNUS gradient performance with increased PNS threshold provided a 35% reduction in noise-to-diffusion contrast as compared with whole-body performance (80 mT/m gradient amplitude, 200 T/m/sec gradient slew rate). The PNS threshold of MAGNUS is significantly higher than that for whole-body gradients, which allows for diffusion gradients with short rise times (under 1 msec), important for interrogating brain microstructure length scales.

Magnetic Resonance Examinations of Patients With Implanted Active Devices. A Low-Cost Approach in Slew Rate Evaluation.

Time-varying magnetic field gradients involved in magnetic resonance examinations can damage implanted electronic systems. The quantity related to this side effect is the gradient slew rate, which is usually not directly available on magnetic resonance console. The present study proposes a low-cost approach in slew rate assessment, which is useful in risks versus benefits evaluation as well as in sequences optimization. The experimental method is based on an analog circuit, which senses the output voltage of the scanner waveform generator. This allows taking easy and reliable slew rate measurements, even during clinical examinations on patients. Whereas previous studies required managing a considerable amount of data, the present work addresses only the maximal slew rate of any clinical sequence. Experimental results show that the smooth gradient mode, selectable on the two scanners examined, is very effective in patient safety improvement. In particular, it reduces slew rate values in the range from 52.4 up to 132.4 T m-1 s-1 , i.e. far below the interval 216-346 T m-1 s-1 , indicated as slew rate tolerance limit of modern implanted electronic devices. Bioelectromagnetics. 2019;40:512-521. © 2019 Bioelectromagnetics Society.

Gradient-Induced Mechanical Vibration of Neural Interfaces During MRI.

Resonant vibrations of implanted structures during a magnetic resonance imaging (MRI) procedure pose a risk to the patient in the form of soft tissue irritation and degradation of the implant. In this paper, the mechanical behavior of implant structures in air, water, and viscoelastic materials was explored. The static and dynamic transfer functions of various test samples in air and immersed in both water and hydrogels were analyzed. The laser-based acquisition method allowed for high-angular-resolution (10 μDeg) and high-dynamic-range (0-6 kHz) measurements. Additional MRI experiments were conducted to investigate the dependence of vibration strength on magnetic resonance (MR) sequence parameters in combination with the obtained transfer functions. The largest forces were found to be in the micronewton to millinewton range, which is comparable to forces applied during implantation. Of additional concern was the damping introduced by viscoelastic tissue, which was less than expected, leading to an underdamped system. In contrast to current wisdom, the imaging experiments demonstrated drastically different vibration amplitudes for identical gradient slew rates, but different timing parameters TR, mainly due to resonant amplification. The results showed that a safe force-free MR procedure depends not only on the gradient slew rate, but also and more drastically on the choice of secure timing parameters. These findings delineate design improvements to achieve longevity of implants and will lead to increased patient safety during MRI. A prudent choice of mechanical characteristics of implanted structures is sufficient to avoid resonant excitation due to mismatched MR sequence parameters.

SPARKLING: variable-density k-space filling curves for accelerated T2* -weighted MRI.

To present a new optimition-driven design of optimal k-space trajectories in the context of compressed sensing: Spreading Projection Algorithm for Rapid K-space sampLING (SPARKLING). The SPARKLING algorithm is a versatile method inspired from stippling techniques that automatically generates optimized sampling patterns compatible with MR hardware constraints on maximum gradient amplitude and slew rate. These non-Cartesian sampling curves are designed to comply with key criteria for optimal sampling: a controlled distribution of samples (e.g., variable density) and a locally uniform k-space coverage. Ex vivo and in vivo prospective -weighted acquisitions were performed on a 7-Tesla scanner using the SPARKLING trajectories for various setups and target densities. Our method was compared to radial and variable-density spiral trajectories for high-resolution imaging. Combining sampling efficiency with compressed sensing, the proposed sampling patterns allowed up to 20-fold reductions in MR scan time (compared to fully sampled Cartesian acquisitions) for two-dimensional -weighted imaging without deterioration of image quality, as demonstrated by our experimental results at 7 Tesla on in vivo human brains for a high in-plane resolution of 390μm. In comparison to existing non-Cartesian sampling strategies, the proposed technique also yielded superior image quality. The proposed optimization-driven design of k-space trajectories is a versatile framework that is able to enhance MR sampling performance in the context of compressed sensing.

A surface loop array for in vivo small animal MRI/fMRI on 7T human scanners

Small animals such as non-human primate (NHP) and rodent are valuable models in frontier neuroscience researches, and comparative research between the animal model and human is helpful to understand and reveal the functional brain circuits in cognition and underlying mechanism in psychological disease. Small animals can be trained or anesthetized to endure long-term and multiple imaging scans; however, the concomitant needs in subcortical structure and function investigations pose major challenges in, e.g. spatial resolution, scan time efficiency, spatial/temporal signal-to-noise-ratio, as well as apparatus mechanical fixation. In addition, comparative investigations across species are also expected to be conducted under similar physical environment (such as the main magnetic field strength, RF pulse shape, sequence protocols, gradient waveform, system stability, etc in MRI), in order to avoid possible deviation in signal detection under different platforms, as well as to reduce experiment complexity. We have proposed a novel 5-channel surface coil that is equipped on 7T human MRI scanners and designed for small animal structural and functional MRI. Through a series of in vivo experiments over an anesthetized rat and macaque, the presented coil shows its main characteristics in, i.e. flexible coil mounting, reduced FOV, high temporal SNR, and parallel imaging capability. Such design is able to compensate the relatively lower gradient slew rate of human scanners versus those with smaller bores, and thus effectively facilitates in vivo microscopic structural MR images being obtained within a shortened and safe period of anesthesia; besides, it also enables high-resolution functional MRI (i.e. spin-echo based) being achieved with reasonable temporal resolution, distortion level and functional contrast.

Magnetic field gradient waveform correction of motion-sensitized SPRITE by pre-equalization.

Eddy currents caused by pulsed field gradients in magnetic resonance measurements of high-speed flow cause the magnetic field gradient amplitude waveform experienced by the sample to be different from the waveform demanded of the magnetic field gradient amplifiers. By measuring and using the system impulse response, pre-equalization magnetic field gradient waveform correction can be used to counteract the resulting errors in measured signal phase at the cost of minimal additional experimental time. The effectiveness of the pre-equalization method of magnetic field gradient waveform correction is tested with a motion-sensitized (pulsed field gradient) version of the SPRITE imaging pulse sequence which requires extreme gradient slew rates in excess of 1000 T/m/s in a 6.7-cm-bore set of gradient windings. Pre-equalized, motion-sensitized SPRITE is used to create velocity maps of high-speed (c. 4 m/s) water flow through a pipe constriction.

Optimized MR Simulation Protocol for Framed Stereotactic Radiosurgery at 3T

Magnetic resonance imaging is often the primary imaging modality for framed stereotactic radiosurgery (SRS). However, eddy currents, chemical shift, gradient nonlinearities, and the magnetic susceptibility distribution of the patient can all contribute to geometric distortions that may affect the accuracy of SRS if not properly controlled. The goal of this work was to establish an optimized MR simulation protocol for framed SRS at 3T, and assess the severity of any residual geometric distortions. Imaging was performed on a 3T scanner using an SRS phantom (CIRS, model 603A). A titanium Leksell head frame was secured to the phantom. The fiducial box was then affixed to the head frame. The combined, phantom, head frame, and fiducial box assembly were then immobilized in treatment position using a holder of our design. The combination of two flexible phase-array coils and the integrated spine RF coil was used for signal reception. Magnetic field mapping was performed using a dual echo GRE sequence. Different shimming modes (tune up, standard, standard + local shim, standard + brain shim, advanced, advanced + local shim, advanced + brain shim) were applied prior to acquisition of each field map. In addition, 3D T1 FLASH images were acquired with different gradient slew rate modes (whisper, normal, fast) and readout bandwidths. Vendor-provided 3D gradient nonlinearity distortion correction was applied to all images prior to them being sent to a commercial deformable registration algorithm system for analysis. Large magnetic field variations were observed with tune up and standard shim modes. The advanced + brain shim mode resulted in smallest magnetic field variations over the brain. Shimming over the brain did not affect the geometric accuracy of the fiducial markers. The low slew rate whisper gradient mode reduced eddy current-induced distortion by 1.5mm compared to normal gradient mode. Reducing the readout bandwidth from 980 Hz/pixel to 440 Hz/pixel reduced eddy current-induced distortion further by 2mm and increased SNR, while minimizing the severity of chemical shift. Eddy currents induced by the gradients in the titanium frame can result in geometric distortions of fiducial that exceed 1mm in regions of the fiducial box within 2cm of the SRS frame. We established an optimized MR simulation protocol for framed SRS at 3T. Our recommendations include: 1) use of low slew rate gradient modes to reduce eddy current induced distortions, 2) reduce readout bandwidths to 440 Hz/pixel as a tradeoff between eddy current induced distortions and water-fat shift, 3) scan with the prescription volume centered at isocenter, 4) perform advanced high-order shimming with shim volume localized to brain, 5) confirm A-P phase encode direction to avoid flow artifacts, 6) apply 3D gradient nonlinearity distortion correction prior to using images for treatment planning, 7) avoid registering images in treatment planning system using fiducials within 2cm of the SRS frame.