The well-known slide-prone red-stratum mudstones in the Three Gorges reservoir (TGR) area are currently undergoing sharp changes in (i) water level driven by the impounding/discharging operation of the Three Gorges dam and (ii) the rain/water H+ concentration driven by recent rapid industrial/agricultural development, and these changes are expected to impact geohazards. This potential impact emphasizes the importance of understanding the role of pH in the drying-wetting disintegration of red-stratum mudstones. Although many investigations have focused on the role of pH in mudstone disintegration, the red-stratum mudstones in the TGR area differ from mudstones elsewhere, and the role of pH has seldom been studied in these rocks. This work adds to the limited body of research by (1) experimentally investigating the possible role of pH in red-stratum mudstone drying-wetting disintegration and (2) revealing the micromechanisms responsible for this role. In the experiment, six disintegration performance indexes and two mechanical indexes, i.e. particle size gradation, slake durability index, decay constant, surface energy, box dimension, fractal dimension, cohesion and friction angle, were monitored throughout the disintegration process. A tri-piecewise linear fractal model is proposed to better describe the particle size distribution. This research shows that the acid enhancements stimulate the disintegration of red-stratum mudstones and significantly affect shear strength. In comparison, alkaline environments inhibit the mudstone fragmentation and slightly degrade the shear strength. Two possible micromechanisms and three potential effects of acid or alkaline agents are presented to account for the role of pH. The findings provide insights into the potential geohazard impacts of sharp changes in the exposure environment (i.e., water level and H+ concentration) of the red-stratum mudstones in the TGR area.