Good Score Research Articles

Effectiveness of Structured teaching program on Knowledge and Practice of Blood and Blood components Transfusion among Staff Nurses

Background: Blood is a collection of cells that have been specialized to perform a set oftasks within an organism. It is described as the fluid connective tissue that carriesoxygen and nutrients to the body. It is straw in colour, the average volume of blood inthe human body is 5 litres generally, the PH of blood is 7.4, which is slightly alkaline. The blood comprises 8% of our total body weight. It is composed of plasma, about 55% and 45% cells, respectively. Blood transfusion is when apatient receives a blood product through an intravenous line or the introduction of newmatching blood into the bloodstream or/and of any specific blood components. Objectives: The study aimed to assess the knowledge and practice of a structured teaching programme on blood and blood components among staff nurses. Methods: 50 Staff nurses were selected by a non-probabilityconvenient sampling technique. Quasi-experimental design with one grouppre-test and post-test design was used. The tools used to collect the data consisted of a structuredknowledge questionnaireand structured practice scale on blood and blood component transfusion. The reliability was checked using test-retest method showed that the tools were highly reliable. Results: The good knowledge score was increased from pretest (12%) to posttest (32%). Moderate practice score was increased from pretest (50%) to posttest (78%). There was a significant difference (p<0.05) between mean pretest knowledge and practice scores with mean post test knowledge and practice scores. So, the structured teaching program was effective in improving the knowledge and practice of staff nurses regarding blood and blood components. The Chi-square test showed that there was a significant association with knowledge and gender, practice and marital status, education. The other variables are not showing association. Conclusion: The findings revealed thatstaff nurses’ knowledge and practice regarding bloodand blood components transfusion wasimproved after the teaching program.

A study to assess the Knowledge, expressed Practice and Attitude regarding Diabetic Foot care in patient with Diabetes at Mathura Das Mathur Hospital Jodhpur

This study was to assess the knowledge, expressed practice and attitude regarding diabetic foot care in patient with diabetes “A study to assess the knowledge, expressed practice and attitude regarding diabetic foot care in patient with diabetes at Mathura Das Mathur Hospital Jodhpur” was conducted by Barkha Blossam Francis at Government College of Nursing, Jodhpur. 100 samples were selected using Non – probability convenient sampling technique The knowledge used questionnaire, practice checklist, attitude scale method to assess the knowledge, expressed practice and attitude regarding diabetic foot care in patient with diabetes. The majority of samples 49% had poor knowledge, 39% had good practice score and 46% had favorable attitude in the diabetic foot care in patient with diabetes mellitus. Data showed that that there is no relation found between the knowledge regarding diabetic foot care among patients with diabetes mellitus with the selected demographical variables, in terms of gender, religion, area of living, duration of illness diagnosed, type of diabetes, presence of diabetic complications, with the selected demographical variables. And there is relation found between knowledge regarding diabetic foot care among patients with diabetes mellitus with expressed practice and attitude of diabetic patient. There is positive correlation between knowledge, expressed practice and attitude of diabetes patients.

Quality of life and abdominal wall functionality after abdominal wall reconstruction: A prospective single center follow-up study

BackgroundFascial breakdown with the occurrence of an incisional hernia (IH) is an important and challenging complication of any laparotomy. For a long time, the success of the abdominal wall reconstruction (AWR) was measured only from the surgeon’s perspective by defining outcome measures such as wound morbidity and recurrence. The understanding that complete recovery is difficult to assess without considering patients has shifted the paradigm of optimal outcomes to Patient Reported Outcome Measures (PROMS) and Quality of Life (QoL), which are pivotal to evaluate the success and efficacy of AWR.MethodsWe conducted a prospective follow-up study of 91 patients undergoing mesh-augmented abdominal wall reconstruction for primary or recurrent incisional hernia between January 2021 and December 2023. Demographic data, comorbidities, and hernia characteristics were recorded. All patients were evaluated preoperatively by a native abdomino-pelvic CT scan to assess the characteristics of hernia (length, width, surface, and volume of the incisional hernia sac and of peritoneal cavity), the presence of mesh (if previously inserted), and abdominal wall muscles status. All intervention were performed by the same surgical team according to the techniques described by Rives – Stoppa (RS), Ramirez (ACS), and Novitsky (PCS). Abdominal wall function was assessed using trunk raising (TR) and double leg lowering (DLL) measurements performed preoperatively, 1 month, 6 months, and 1 year postoperatively. At the same time, pre- and post-operative quality of life was analysed using the EQ-5D score.ResultsMean age of 59.42 ± 12.28 years and a male/female ratio of 35/56 were recorded, most of them being obese. There were 36 (42%) patients with defects larger than 10 cm. The distribution of the type of surgical intervention was: RS 35 patients, ACS 13 patients, and PCS 43 patients. The mean value of combined score for the preoperative abdominal wall functionality was 4.41 ± 1.67 (2–8) while the mean value of preoperative EQ-5D index was 0.652 ± 0.026 (-0.32–1.00). QoL was poor and very poor for 48% (44) of the patients who recorded index values less than 0.56 (50% percentile). Preoperative EQ-5D index was highly correlated with Combined AWF score (r = 0.620; p < 0.0001) and the correlation was specific (AUC = 0.799; p < 0.0001; asymptotic 95%CI = 0.711–0.923). At 12 months, the AWF score increased to 8.13 ± 2.58 (1–10) and the QoL total score to 0.979 ± 0.007 (0.71–1). Good and very good total scores for QoL were recorded for 47 patients (84%) compared to 33 (36%) in the preoperative evaluation (χ2 with Yates continuity correction for two degrees of liberty = 46.04; p < 0.00001).ConclusionOur results suggest that patients can expect to see a significant overall improvement in all five components of QoL measured with the help of Eq. 5D questionnaire. This improvement is dependent by hernia size, and some individual patient’s factors (diabetes, cardiovascular diseases, and age over 60 years).

Investigation of the effect of nurses’ professional values on their perceptions of good death: a cross-sectional study in Türkiye

BackgroundThe care of patient individuals in the good death process should be planned based on nursing values. The aim of the study is to determine nurses’ perceptions of a good death and its relationship with nursing values.MethodsThe study is descriptive and cross-sectional and was completed with 210 nurses. Data were collected using the Nurse Information Form, Good Death Scale, and Revised Nursing Professional Values Scale. In the study, an attempt was made to reach nurses across Türkiye over a three-month period using the snowball sampling method without calculating the sample size beforehand. Descriptive statistics, Kruskal Wallis and Mann Whitney U test, LSD test, Spearman correlation and linear regression analyzes were used in the study.ResultsThe nurses’ Good Death Scale total mean score was 53.52 ± 7.11, and The Revised Nursing Professional Values Scale mean score was 97.77 ± 15.71. There was a moderate, positive, statistically significant relationship between the nurses’ Good Death Scale total mean scores and the Revised Nursing Professional Values Scale total mean scores (r = 0.522; p < 0.001).ConclusionsValue-based educational activities may be effective in helping nurses have positive perceptions about a good death.

Quality of Life of Healthcare College Students in Riyadh, Saudi Arabia.

The aim of this study was to assess the quality of life (QOL) and its influencing factors among healthcare college students in Riyadh, Saudi Arabia. A cross-sectional study was conducted among healthcare students at King Saud University. A modified version of the Arabic World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire, including 25 questions, was used to assess students' QOL. Data were collected through an online survey and analyzed using IBM SPSS Statistics version 26 (IBM Corp., Armonk, NY). Descriptive and regression statistics were used. A total of 547 healthcare students completed the questionnaire during the data collection period. Of all the students, 39.7% were from applied medical college, 62.5% were females, 98.9% were single, and 91.8% were non-smokers. Regarding academic status, 58.3%did not participate in any extracurricular activity, 42.6% had an academic advisor, and 80.4%had a grade point average (GPA) higher than 4.1. The average QOL score across all domains was moderately good (60.30 ± 16.0), whereas the physical domain showed the poorest score (46.89 ± 14.8) while the environmental domain had the greatest score (68.04 ± 20.6). The environmental domain was the only domain that showed significant differences between healthcare colleges (p <0.001). Moreover, students who were male (p = 0.009), non-smokers (p = 0.023), reported living with family/friends (p =0.031), and from families with high monthly income (p < 0.001) had significantly higher environmental QOL scores than their counterparts. The study found that healthcare students had moderately good mean QOL scores. The environmental domain was the only QOL domain that showed significant differences between healthcare colleges with the greatest scoreamong medical college students. Gender, smoking status, residence status, and family monthly income were found to have a strong association with students' environmental QOL scores. Institutions need to focus on the regular measurement of students' QOL, which facilitates implementing strategies that can promote their overall QOL and subsequently positively impact their performance academically and practically.

Fetal Outcome Evaluation in High-risk Term Pregnancy Using Biophysical Profile at a Tertiary Hospital in Anambra State, Nigeria

Introduction: A high-risk pregnancy is defined as a pregnancy in which there is a significant probability of an adverse maternal or fetal outcome that is more than the incidence of that outcome in the general population. Aim: To determine the usefulness of biophysical profile evaluation in women with high-risk term pregnancies. Methods: Biophysical profile (BPP) parameters were used to evaluate 160 high-risk women with term pregnancies. Results: All the participants had normal amniotic fluid index values [AFI] of 8.1-24.0cm. Most of the participants 115 (71.9%) showed good BPP scores. Outcome at delivery was as follows; fetal distress [presence 8.9%, absence 91.1%], stillbirth = none, admission into the intensive care unit (ICU) [Yes 2.0%, No 88%], meconium staining [Yes 8.2%, Clear 91.8%], birth weight [&lt; 2.5kg = 5.7%, &gt; 2.5kg = 94.3%]. APGAR score at 1 minute [&lt;7 = 5.1%, &gt;7 = 94.9%] while at 5 minutes [&lt;7 = 3.2%, &gt; 7= 96.8%]. The commonest mode of delivery was vaginal 84 (52.8%). The association between gross body movement, fetal breathing movement, and fetal outcome was not statistically significant p &gt; 0.05. Conclusion: BPP parameters were found to be associated with fetal outcomes.

Bioassay-guided fractionation and in vitro and in silico biological activities of 2,4-di-tert-butylphenol isolated from Nocardiopsis sp. strain LC-8

In this study, an actinomycete strain was isolated from freshwater soil sediments to produce bioactive metabolite with a broad array of biological activities. Initially, preliminary antibacterial screening of isolate was performed by perpendicular streak method which showed the growth inhibition of all tested bacterial pathogens. Based on the culture characteristics, morphological identification, and 16S rRNA gene sequencing, the isolate was identified as Nocardiopsis sp. strain LC-8. Ethyl acetate extract of strain LC-8 showed potential antibacterial activity against tested bacterial pathogens with a maximum zone of inhibition of 16.98±0.57 mm against Staphylococcus aureus. After column chromatography, fraction 2 (F2) of the extract exhibited prominent growth inhibition activity against all tested bacterial and fungal pathogens. Antioxidant activity of F2 showed potent free radical scavenging activity with low IC50 values (DPPH - 278.15±0.35 μg/mL, ABTS - 367.55±1.13 μg/mL, and FRAP - 347.48±1.35 μg/mL). Total phenolic content of F2 was quantified as 362.44±1.25 mg gallic acid equivalent/gram extract. As per spectral analyses, the isolated compound from F2 was identified as 2,4-di-tert-butylphenol which further induced cytotoxic (IC50 value - 17.5±1.5 μg/mL) and apoptosis activity against MCF-7 cells. Molecular interaction studies of 2,4-di-tert-butylphenol with target proteins of pathogens and cancer cells displayed good docking score values. Finally, molecular dynamics simulation was performed to determine the stable structure of the protein-ligand system and effectiveness of 2,4-di-tert-butylphenol against the target protein. In conclusion, Nocardiopsis sp. strain LC-8 may act as a promising source for the production of 2,4-di-tert-butylphenol aiding diverse therapeutic roles.

Treatment of Complex Multiple Lesions in the Knee With MACI (Autologous Cultured Chondrocytes on Porcine Collagen Membrane)

Background: Multiple chondral lesions in the knee are difficult to manage. A few treatment options are available. Considering the number of lesions, size, location, and total surface area, the autologous cultured chondrocytes on porcine collagen membrane (MACI) technique can effectively treat multiple defects simultaneously. Indications: The MACI procedure is indicated for multiple chondral lesions in the knee with large surface areas when other technologies are hard to implement or lack sufficient follow-up. Technique Description: The chondral defects are debrided to subchondral bone with vertical walls. Concomitant procedures are to be completed before MACI implantation. Each defect is treated as an isolated lesion. Irregular and uncontained lesions require a unique approach. A single membrane can treat multiple lesions; however, careful presurgery analysis is necessary to analyze the requirement of an additional membrane. Results: The MACI technique for multiple lesions in the knee has a good response rate and high satisfaction scores over mid- to long-term follow-up. Discussion/Conclusions: Multiple chondral lesions of the knee can effectively be treated with MACI, providing patients with additional improved quality of life, increasing level of function, and possibly delaying total knee arthroplasty procedures. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.

Reformulation of snacks offered to children and adolescents at school kiosks: is this strategy enough or just the tip of the iceberg?

Several studies have reported high overweight and obesity incidence among schoolchildren and adolescents, who mostly consume packaged snacks with critical nutrients exceeding the criteria of international profiling systems during school breaks. Then, the objectives of this work were to reformulate a snack consumed by Argentinian schoolchildren and adolescents (aged 6–13 years) to decrease its critical nutrient contents and to determine if this product would still be accepted. Chocolate chip vanilla cookies were selected for reformulation considering each recommended cut-off point for critical nutrients, since a prohibition of products with warning octagons being offered at schools would come into effect in Argentina. These cookies received good acceptability scores (above 3 of 5 points) and would be consumed by 8 of 10 schoolchildren in a sample of 200 participants. These findings underscore the importance of legislation promoting awareness of healthier eating habits and increasing the availability of healthier food options in schools.

Effects of Allium ursinum L. Leaves and Egg Amount on Quality Attributes, Polyphenol Content, and Antioxidant Capacity of Pasta

Pastas enriched with vegetables are premium nutritious products and their consumption can bring significant health benefits. Recent studies have reported a high content of bioavailable phytochemical compounds in Allium ursinum L.; as such, it can be used in the development of functional food products. This study involved the evaluation of 10 varieties of pasta. Five of these varieties were made from white flour and varying amounts of egg (Ctrl_1–Ctrl_5). The other five varieties (AU_1–AU_5) contained fresh shredded wild garlic leaves in equal proportions (20 g) in addition to the corresponding ingredients (white flour and egg). All pasta variants were investigated for their cooking properties and the presence of bioactive compounds and antioxidant capacity in the raw and cooked pasta. Sensory analysis was conducted on all types of cooked pasta, and results indicated that the pasta with the least quantity of eggs was the most favoured variant. Additionally, the pasta that was enhanced with wild garlic leaves received the highest rating for “overall quality”. According to our results, the optimal cooking time (OCT) increased when the quantity of eggs was raised, but when wild garlic leaves were present, OCT decreased in comparison to the control samples. A significant decrease (p &lt; 0.05) in the cooking parameters, swelling index, and water absorption was observed in both egg pasta (Ctrl) and egg pasta enriched with A. ursinum L. (AU). However, compared to the corresponding egg pasta, the presence of wild garlic in pasta generally produced higher values in SI and WA. Pastas enriched with wild garlic are rich in polyphenols (TPh), with a content ranging from 82.44 to 94.62 µg GAE/g dw, and also exhibit antioxidant properties. The amount of total polyphenol significantly decreases (p &lt; 0.05) during cooking varies depending on the composition of the pasta. The pasta with the highest egg content (AU_5) had the lowest loss of polyphenols, equivalent to 55.35%. Our investigations indicate that producing pasta with eggs and fresh wild garlic leaves results in a valuable food product with a good sensory score, enriched in bioactive components, with essential nutrients that maintains cooking qualities.

Prevalence and incidence of pelvic organ prolapse, bowel and urinary dysfunction in the Integrated Woman's Health Program

ObjectiveDespite its high prevalence, little information is available on the natural history of pelvic floor dysfunction. We aimed to determine the prevalence, incidence and persistence of pelvic organ prolapse (POP), bowel and urinary symptoms over 6–7 years and its associated factors. Study designWomen from a midlife cohort in Asia completed baseline and 6–7-year follow-up assessments. Sociodemographic characteristics and health conditions were obtained at baseline using validated questionnaires. Body mass index (BMI) and physical performance were objectively measured. Main outcome measuresPOP, bowel, and urinary dysfunction were measured using the Pelvic Floor Distress Inventory Short Form 20 at both timepoints. Binary logistic regression was used to analyze independent associations between baseline risk factors and prevalent, new, and persistent symptoms. ResultsOf the 1201 women enrolled at baseline, 62.3 % had symptoms in at least one domain of pelvic floor dysfunction. Poor sleep, poorer perceived health, and disability were associated with prevalent pelvic floor symptoms, while poor sleep doubled the adjusted risk of incident POP (adjusted odds ratio, aOR: 2.3, 95 % Confidence Interval: 1.4–3.9), bowel (aOR: 2.3, 1.4–3.7) and urinary (aOR: 1.7, 1.1–2.9) symptoms at the 6.6-year follow-up visit. Postmenopausal women had reduced risks of prevalent POP (aOR: 0.5, 0.3–0.7) and urinary symptoms (aOR: 0.4, 0.3–0.6), as well as a reduced risk of developing incident urinary symptoms (aOR: 0.4, 0.2–0.8). Good physical performance scores at baseline reduced the risk of incident bowel symptoms (aOR: 0.5, 0.2–0.9), whereas obesity increased the risks of persistent symptoms. ConclusionPoor sleep quality independently predicted incident pelvic floor dysfunction, while poor physical performance was associated with incident bowel symptoms.

Synthesis, characterization, anti-inflammatory activity and molecular docking studies of aromatic aldehydes substituted oxazine derivatives derived from 3-methoxy chalcone

In this study, a novel synthesis series (R4, D1-D10) of 4-[2-Amino-4-(3‑methoxy-phenyl)-6H-[1,3]oxazin-6-yl]-phenol derivatives was synthesised by the condensation of substituted aromatic aldehydes. Structures of the synthesised compounds were characterised using 1H and 13C nuclear magnetic resonance (NMR), fourier transform infrared spectroscopy (FT-IR), and mass spectrometry (MS) spectroscopic data. Further, the compounds were screened for in vivo anti-inflammatory activity by the carrageenan-induced paw edema method. Tested compounds have shown mild-to-moderate anti-inflammatory activity. The COX-2 selective compounds anti-inflammatory of five-oxazine derivatives (D7, D9, D5, D10, and D2) was modest. In comparison to the reference drug parecoxib (% edema inhibition = 29.2, 1 h; 23.30, 3 h; 21, 6 h), the most active compounds demonstrated exceptional In vivo anti-inflammatory action (% edema inhibition = 40–52, 1 h; 40.70–60.40, 3 h; 30–47.80, 6 h). Also, compounds 4-{6-(3-Methoxy-phenyl)-2-[(4-nitro-benzylidene)-amino]-6H-[1,3]oxazin-4-yl}-phenol (D7) and 4-[2-[(3-Fluoro-benzylidene)-amino]-6-(3-methoxy-phenyl)-6H-[1,3]oxazin-4-yl]-phenol (D9) have shown excellent anti-inflammatory action (% edema inhibition = 52–59.3 & 46.7–60.40). The molecular docking studies were also carried out at the active sites of COX-1 and COX-2 enzymes (PDB ID: 4O1Z, 4M11) using the docking algorithm offered by AutoDock Vina. The compounds D7, D9, and D5 exhibited good docking scores of −10.30, −10.20, and −10.10 onto the active site of COX-2 and least dock scores of −10.10, −9.80, and −10.00 on COX-1 enzymes and were comparable with standard COX-2 inhibitor parecoxib. A significant correlation was observed between the in silico and the in vivo studies. The anti-inflammatory and docking results highlight the fact that the synthesised compounds D7, D9, and D5 could be considered as possible hits as therapeutic agents.

Awareness, knowledge, attitude, and practice of adverse drug reaction reporting among health workers in primary health centres participating in seasonal malaria chemoprevention campaign in Nigeria in 2022: a cross-sectional survey

BackgroundEvaluating health workers’ knowledge and practice of adverse drug reaction (ADR) reporting is an important step in identifying gaps in quality ADR reporting during public health interventions like the seasonal malaria chemoprevention (SMC) campaign. Pharmacovigilance (PV) monitoring is vital in SMC due to the number of children exposed to malaria medicines for a period of 4 or 5 months during the campaign. In Nigeria more than 10 million children are exposed to SMC medicines every year. The scale of this intervention emphasised the need for efficient and effective safety monitoring during the campaign. Thus, the objective of this study was to evaluate healthcare workers’ (HCW) awareness, knowledge, attitude and practice (KAP) of ADR reporting in health facilities participating in SMC campaign to identify pharmacovigilance gaps which may suggest possible ways to ensure safety during the campaign.MethodsWorld Health Organization’s service availability and readiness assessment (SARA) recommendations were used to sample 2,598 out of 5,195 used as supervising health facilities (HFs) during the 2022 SMC campaign across nine states of the country. Out of the sampled HFs, 2,144 eligible and consented health facility workers (HFWs) were assessed for awareness, and KAP of ADR using the validated 45-item self-administered questionnaire. The data was analysed using descriptive statistics and correlation analysis at p < 0.05.ResultsThe majority of the respondents are males (n = 1,333, 62.2%). The HFWs showed good awareness (n = 2,037, 95.0%) of pharmacovigilance (PV). However, only 809 (37.7%) of them had good knowledge scores. The mean ADR reporting attitude score (85.0 ± 15.3%) was good with many of the respondents (n = 1,548, 72.2%) having a good score. However, the respondents’ ADR practice was suboptimal, only 1,356 (63.2%) of them had encounters with ADR, and a lot of negative perceived barriers to ADR reporting were identified in the study. For example, 493 (23%) believed that ADRs were not reported because they were not serious and life-threatening while 248 (11.6%) reported a fear of liability. Correlation analysis revealed female gender (r = 0.163, p < 0.001), older age (r = 0.207, p < 0.001) and years of practice (r = 0.050, p = 0.021) as factors significantly associated with ADR knowledge and attitude scores.ConclusionThe study indicated that HCWs across health facilities participating in SMC campaigns have ADR reporting knowledge and practice gaps. The study suggest training alone may not be effective in addressing gaps in ADR reporting. In addition to PV training, implementers can include continuous mentoring of health care workers or other similar interventions as part of strategy to improve ADR reporting. Also, context specific strategies to improve ADR reporting among health care worker needs to be implemented to address under-reporting of ADRs during SMC campaigns and other malaria public health interventions.

Demographic and socioeconomic disparity in knowledge, attitude, and practice towards tuberculosis in Northwest, China: evidence from multilevel model study

BackgroundTuberculosis (TB) remains a serious global public health problem in China. The right knowledge, attitude, and practice (KAP) towards TB are indispensable to appropriate healthcare-seeking behaviors and treatment services timely. However, there are few studies that addressed the KAP towards TB in high-risk and under-developing regions in China. This study aims to evaluate the KAP towards TB in Ningxia Northwest, China, and identify factors that influence it. The findings can guide future health education and promotion interventions.MethodsA stratified multistage random sampling method was used to conduct a face-to-face questionnaire survey with 33 items for selected residents. The composite score of Knowledge, Attitudes, and Practices (KAP) was divided into two groups, which are poor (scores below the average) and good (scores above the average). A two-level logistic model with a random intercept equation accounted for the similarity of residents within communities to examine the association between individual-level KAP and demographic and socioeconomic factors.ResultsA total of 2,341 residents were recruited, the mean age was 50, and 41.2% were female. The percentages of residents who were total awareness of TB knowledge and had positive attitudes and behavior toward TB were 51.9%, 75.3%, and 76.2%, respectively. The two-level logistic model demonstrated that residents with a high annual family income, urban living, primary school education or higher, occupation of teacher or doctor, a very good self-perceived status, medical insurance, knowing DOTS, and family members or friends with TB history had better knowledge of TB (P < 0.05). Residents living in urban areas, with junior and senior high school education, a very good self-perceived status, health insurance, knowing DOTS, and family members or friends with TB history had positive attitude of TB (P < 0.05). Residents living in urban areas, a primary school education or higher, occupation of teacher, doctor and workers, a very good self-perceived status, medical insurance, knowing DOTS, and family members or friends with TB history had positive practice of TB (P < 0.05).ConclusionsFavorable demographic (higher education levels, teachers or doctors) and socioeconomic (high income, living in urban area) factors are associated to better knowledge, attitudes and practices toward TB in Northwest China. Interventions to improve KAP at the community level are required to speed up the TB reduction rate, which may benefit to ensure the End TB Strategy will be achieved.

Factors that interfere with immediate return to activity following volar locking plate fixation for distal radius fractures.

In the present study, the clinical findings that interfere with the immediate return to activity following volar locking plate (VLP) fixation for distal radius fractures were investigated. A total of 95 patients who underwent VLP fixation for distal radius fracture between July, 2014 and January, 2022 were divided into a good group (good score and outcome; n=86; 22 males and 64 females; median age, 61 years) and a poor group (poor score and outcome; n=8; 8 females; median age, 63.6 years) according to the quartiles of the disabilities of the arm, shoulder and hand (Q-DASH) score, at 1 month following VLP fixation. The duration from injury to surgery, the direction of fracture dislocation and radiographic parameters [radial inclination (RI), volar tilt (VT) and ulnar variance (UV)] at the time of injury were examined. Radiographic parameters (RI, VT and UV), the range of motion of the wrist joint, grip strength ratio and visual analog scale (VAS) at 1 month following VLP fixation were also examined. These parameters were compared among both groups. Moreover, logistic regression analysis was performed to determine whether these factors were independently associated with a poor Q-DASH score at 1 month following VLP fixation. At the time of injury, fracture displacement was significantly higher in the poor group (VT, -23.8˚; UV, 4.2 mm) than the good group (VT, -6.5˚; P=0.02; UV, 1.3 mm; P=0.01). No differences in the other parameters were observed between the groups. At 1 month following VLP fixation, the grip strength ratio (17.2%) in the poor group was significantly lower than that in the good group (43.8%, P<0.001), while the VAS score (5.6) in the poor group was significantly higher than that in the good group (2.4, P<0.001). Logistic regression analysis revealed that VT and UV at injury (P<0.05), grip strength ratio (P<0.001) and pain (VAS score) (P<0.001) were all independently associated with a poor Q-DASH score. On the whole, the present study suggests that large amounts of fracture displacement, weakness of grip strength and post-operative pain can be factors interfering with the return to activity immediately following VLP fixation.

Assessment of Patient Safety Culture Amongst Pharmacy Staff of Selected Healthcare Facilities in Delta North, Nigeria

The strategy for improving patient safety in hospitals heavily relies on safety culture. The study aimed to evaluate patient safety cultures amongst pharmacy staffs of selected health facilities in Delta North, Delya State, Nigeria. Data on patient safety amongst 70 pharmacy personnel in two major secondary and 5 general health facilities across Delta North senatorial district, Delta State, were collected using the Hospital Survey on Patient Safety Culture (HSOPSC) tool. Information on communication openness, the frequency of documenting different types of mistakes, as well as the overall patient safety culture rating, was collected. Composite scores were analyzed using SPSS version 22. Measurement data were presented as mean ± standard deviation (SD) and compared using a student t-test. The results were considered significant at p&amp;lt;0.05. The mean scores of all the various composite item responses were calculated and grouped into positive and negative responses with a mean score of ≥4 and &amp;lt;4, respectively. The safety cultures of physical space and environment, staff training and skills, and communication openness had a good composite score of 4.0 – 4.1. The safety culture of procedures for communicating prescriptions across shifts was poorly rated, with composite scores of 3.8. The safety culture of patient counselling had the highest composite score of 4.3. The safety composites for documenting various shades of mistakes had a mean score of 3.5. Overall, 68.1% of the healthcare facilities were rated excellent, although there were some loopholes (documenting mistakes and poor communication across shifts) in the safety composite scores requiring areas for improvement.

Molecular Docking and Modelling Studies for Identifying Novel Oxadiazole Derivatives to Inhibit COX-2 Enzyme as an Anti-Inflammatory Treatment

The objective of the study was to develop new Oxadiazole compounds using docking simulation studies for inhibitory action against the Cycloxoygenase-2(COX-2) enzyme. The study aimed at the development and identification of novel and potent derivatives of 1,3,4-oxadiazole for targeting anti-inflammatory disease by screening their inhibitory action against COX-2 enzyme with schrodinger molecular docking software and molecular simulation by GROMACS 2022. A library of 375 novel compounds of 1,3,4-oxadiazoles derivatives was designed and proposed for docking against cyclooxygenase-2 enzyme (COX-2)PDB ID: 6BL4, which was downloaded from protein data bank site https://www.rcsb.org/. MD simulations for three models were performed, namely, compound A-Cox-2, E-Cox-2, and G-Cox-2, for 100 ns. Out of 375 proposed compounds, the top 16 compounds with good docking scores and binding energy were selected for further ADME profile studies in which all compounds showed good results as compared to Standard drugs. RMSD values of 0.2 nm showed that all ligand-Cox-2 complexes were stable during simulation. Compound G was the most efficient in decent interactions with the residues ARG120 and TYR355 of cyclooxygenase- 2, which were stable for 29.32, 21.52, and 12.00% duration of simulation along with comparatively better h-bond contacts. All potential inhibitors met Lipinski's rule of five, indicating oral availability. The potential compounds may be further evaluated for pharmacological activities using different in vitro and in vivo evaluations.

Jet rotational metrics

Embedding symmetries in the architectures of deep neural networks can improve classification and network convergence in the context of jet substructure. These results hint at the existence of symmetries in jet energy depositions, such as rotational symmetry, arising from the physical features of the underlying processes. We introduce new jet observables, Jet Rotational Metrics (JRMs), which provide insights into the substructure of jets by comparing them to jets with perfect discrete rotational symmetry. We show that JRMs are formidable jet features, achieving good classification scores when used as inputs to deep neural networks. We also show that when used in combination with other jet observables, like N-subjettiness and EFPs, our features increase classification performance. The results suggest that JRMs may capture information not efficiently captured by the other observables, motivating the design of future jet observables for learning the underlying symmetries in the physical processes.

A data-driven approach to detect upper limb functional use during daily life in breast cancer survivors using wrist-worn sensors

To gain insights into the impact of upper limb (UL) dysfunctions after breast cancer treatment, this study aimed to develop a temporal convolutional neural network (TCN) to detect functional daily UL use in breast cancer survivors using data from a wrist-worn accelerometer. A pre-existing dataset of 10 breast cancer survivors was used that contained raw 3-axis acceleration data and simultaneously recorded video data, captured during four daily life activities. The input of our TCN consists of a 3-axis acceleration sequence with a receptive field of 243 samples. The 4 ResNet TCN blocks perform dilated temporal convolutions with a kernel of size 3 and a dilation rate that increases by a factor of 3 after each iteration. Outcomes of interest were functional UL use (minutes) and percentage UL use. We found strong agreement between the video and predicted data for functional UL use (ICC = 0.975) and moderately strong agreement for %UL use (ICC = 0.794). The TCN model overestimated the functional UL use by 0.71 min and 3.06%. Model performance showed good accuracy, f1, and AUPRC scores (0.875, 0.909, 0.954, respectively). In conclusion, using wrist-worn accelerometer data, the TCN model effectively identified functional UL use in daily life among breast cancer survivors.

A radiant shift: Attention-embedded CNNs for accurate solar irradiance forecasting and prediction from sky images

The continuous increase in solar power integration with energy systems can be attributed to the push for cleaner energy use globally, highlighting the importance of accurate solar forecasts. Conventional prediction methods, although valuable, often fall short of delivering the precision required for dynamic energy management systems due to their inability to effectively capture the intricate relationships inherent in solar irradiance variations. This research addresses this limitation by introducing a novel approach that harnesses the potential of Attention-embedded Convolutional Neural Networks (ATT_CNN) to forecast Global Horizontal Irradiance (GHI), Direct Normal Irradiance (DNI), and Diffuse Horizontal Irradiance (DHI) for intra-hour solar forecasting utilizing sequences of sky images. The main contribution of this study is the integration of attention mechanisms into the CNN architecture, strategically designed to enhance their efficacy in predicting GHI, DNI, and DHI by fostering an adaptive focus on sky image features. First, we use SRRL dataset with GHI, DNI, and DHI features as predicting labels, then the Mean Bias Error (MBE), Root Mean Square Error (RMSE), and Forecasting RMSE skill score (FSS) are used to evaluate the model's performance. This study utilized six lead times and four sequence lengths, based on this the best combination is: Sequence length: 4 with Minutes: 20. This combination provides a balanced and optimal performance with low RMSE (62.75 W/m2), low MBE (2.71 W/m2), and a high FSS (38.81), indicating good accuracy, minimal bias, and high skill score. Furthermore, when compared with state-of-the-art models, the proposed model yielded superior results. This advancement holds profound implications for the optimization of solar power utilization within mainstream energy systems, further underscoring the significance of cutting-edge deep learning (DL) techniques in advancing sustainable energy technologies. The findings of this study indicate that integrating attention mechanisms is essential to enhance the accuracy and reliability of forecasts, and using longer sequences of images can further improve forecasting performance.