ABSTRACTIn this paper, we investigate the existence and stability of almost periodic solutions of impulsive fractional-order differential systems with uncertain parameters. The impulses are realised at fixed moments of time. For the first time, we determine the impact of the uncertainties on the qualitative behaviour of such systems. The main criteria for the existence of almost periodic solutions are proved by employing the fractional Lyapunov method. The global perfect robust uniform-asymptotic stability of such solutions is also considered. We apply our results to uncertain impulsive neural network systems of fractional order.