Global Detection Rate Research Articles

Optimization of a GIS sensor layout based on global detection probability distribution evaluation

Gas-insulated switchgear (GIS) is an important power equipment. The implementation of health monitoring is limited by the number of sensors, and the global detection results of the system should be highly credible to ensure the reliability of the power supply system. To solve this problem, this study proposes a sensor layout optimization method based on global detection probability performance evaluation. Starting from the cost function, the GIS discharge detection problem is transformed into a Bayesian risk decision problem, the binary state of ‘with discharge’ and ‘without discharge’ is adopted to simplify the cost function and reduce the computing workload, and the objective function representing the global detection performance of the system is obtained. The solution of layout optimization is realized by the improved genetic algorithm. 3-sensor, 4-sensor and 6-sensor layouts, which are digitally simulated at different detection rates, and then the distribution diagram of the global detection rate is obtained. On this basis, the feasibility and effectiveness of the optimization method are verified through an experiment. The results show that, compared with other sensor layout optimization methods, this optimization method can obtain the correct probability distribution of the detection rate globally and realize the graphical quantization of the detection performance distribution of the system so as to ensure the system performance.

Avoiding Full Lymphadenectomies in Intermediate- and High-Risk Endometrial Cancer by Sentinel Lymph Node Biopsy Implementation.

ObjectiveTo evaluate the role of sentinel lymph node biopsy (SLNB) to avoid staging lymphadenectomies by detecting nodal metastasis in intermediate- and high-risk endometrial cancer (EC).MethodsA single institutional retrospective study was performed including all patients with intermediate- and high-risk EC who underwent surgical nodal staging between January 2012 and December 2019. Patients with disseminated disease detected on imaging techniques or at the time of surgery were excluded. Patients were evaluable if they underwent nodal staging with SLNB and pelvic (PLD) and paraaortic (PALD) lymph node dissection. We analyzed the accuracy of the sentinel lymph node technique. Only patients with at least one sentinel lymph node (SLN) detected were included in the sensitivity and negative predictive value (NPV) analyses. The tracers used were technetium 99m, blue dye, and indocyanine green.ResultsEighty-eight patients presented intermediate- and high-risk EC (51 patients and 37 patients respectively) and underwent SLNB with consecutive PLD and PALD. The median (range) number of sentinel nodes retrieved was 2.9 (0–11). The global detection rate of SLN was 96.6% with a bilateral detection of 80.7% when considering all tracers used. However, when combination of indocyanine green and technetium was used the bilateral detection rate was 90.3%. Nodal metastases were detected in 17 (19.3%) cases, 8 (47%) of them corresponded to low volume metastasis (LVM), 7 (87.5%) of them diagnosed at ultrastaging pathologic exam. Finally, we obtained a sensitivity of 90%, a NPV of 97.5%, and a false negative rate (FNR) of 10% in the intermediate-risk EC compared to sensitivity of 85.7%, NPV of 96.6%, and FNR of 14.3% in the high-risk EC group. The only patient with isolated paraaortic nodal metastasis was found at the high-risk group, 1.1%.ConclusionsAccording to our results, full lymphadenectomy could be avoided by performing SLNB in patients with intermediate-risk EC because the only false negative case detected was at the beginning of ICG learning curve. For high-risk EC patients we did not find enough evidence to support the systematic avoidance of staging full lymph node dissection. Nevertheless, SLNB should be performed in all cases of EC as it improves LVM diagnosis substantially.

Clinical Performance of New Software to Automatically Detect Angioectasias in Small Bowel Capsule Endoscopy

Background: Video capsule endoscopy (VCE) revolutionized the diagnosis and management of obscure gastrointestinal bleeding, though the rate of detection of small bowel lesions by the physician is still disappointing. Our group developed a novel algorithm (CMEMS-Uminho) to automatically detect angioectasias which display greater accuracy in VCE static frames than other methods previously published. We aimed to evaluate the algorithm overall performance and assess its diagnostic yield and usability in clinical practice. Methods: Algorithm overall performance was determined using 54 full-length VCE recordings. To assess its diagnostic yield and usability in clinical practice, 38 VCE examinations with the clinical diagnosis of angioectasias consecutively performed (2017–2018) were evaluated by three physicians with different experiences. The CMEMS-Uminho algorithm was also applied. The performance of the CMEMS-Uminho algorithm was defined by a positive concordance between a frame automatically selected by the software and a study independent capsule endoscopist. Results: Overall performance in complete VCE recordings was 77.7%, and diagnostic yield was 94.7%. There were significant differences between physicians in regard to global detection rate (p < 0.001), detection rate per capsule (p < 0.001), diagnostic yield (p = 0.007), true positive rate (p < 0.001), time (p < 0.001), and speed viewing (p < 0.001). The application of CMEMS-Uminho algorithm significantly enhanced all readers’ global detection rate (p < 0.001) and the differences between them were no longer observed. Conclusion: The CMEMS-Uminho algorithm detained a good overall performance and was able to enhance physicians’ performance, suggesting a potential usability of this tool in clinical practice.

Participación de la población inmigrante en el cribado de cáncer de mama de Tarragona, España

ObjectiveTo evaluate the differences between autochthonous and allochthonous women's participation in a breast cancer screening programme. MethodRetrospective study based on data from the Breast Cancer Screening Programme of the province of Tarragona (2008-2015). The sample is the target population of the programme with known country of origin. ResultsCohort of 40,824 women. Allochthonous women participate less than autochthonous women (41.8% vs. 72.3%) although they have a similar global detection rate to the latter but with differences according to the human development index of their country of origin. Both groups present similar tumour stages on detection (p=.59). ConclusionsStrategies specifically aimed at the immigrant population are required to improve their participation in breast cancer screening.

Vehicle Detection with Occlusion Handling, Tracking, and OC-SVM Classification: A High Performance Vision-Based System.

This paper presents a high performance vision-based system with a single static camera for traffic surveillance, for moving vehicle detection with occlusion handling, tracking, counting, and One Class Support Vector Machine (OC-SVM) classification. In this approach, moving objects are first segmented from the background using the adaptive Gaussian Mixture Model (GMM). After that, several geometric features are extracted, such as vehicle area, height, width, centroid, and bounding box. As occlusion is present, an algorithm was implemented to reduce it. The tracking is performed with adaptive Kalman filter. Finally, the selected geometric features: estimated area, height, and width are used by different classifiers in order to sort vehicles into three classes: small, midsize, and large. Extensive experimental results in eight real traffic videos with more than 4000 ground truth vehicles have shown that the improved system can run in real time under an occlusion index of 0.312 and classify vehicles with a global detection rate or recall, precision, and F-measure of up to 98.190%, and an F-measure of up to 99.051% for midsize vehicles.

Detection of a novel Rickettsia sp. in soft ticks (Acari: Argasidae) in Algeria

Argasid ticks are vectors of viral and bacterial agents that can infect humans and animals. In Africa, relapsing fever borreliae are neglected arthropod-borne pathogens that cause mild to deadly septicemia and miscarriage. It would be incredibly beneficial to be able to simultaneous detect and identify other pathogens transmitted by Argasid ticks. From 2012 to 2014, we conducted field surveys in 4 distinct areas of Algeria. We investigated the occurrence of soft ticks in rodent burrows and yellow-legged gull (Larus michahellis) nests in 10 study sites and collected 154 soft ticks. Molecular identification revealed the occurrence of two different soft tick genera and five species, including Carios capensis in yellow-legged gull nests and Ornithodoros occidentalis, Ornithodoros rupestris, Ornithodoros sonrai, Ornithodoros erraticus in rodent burrows. Rickettsial DNA was detected in 41/154, corresponding to a global detection rate of 26.6%. Sequences of the citrate synthase (gltA) gene suggest that this agent is a novel spotted fever group Rickettsia. For the first time in Algeria, we characterize a novel Rickettsia species by molecular means in soft ticks.

Efficient detection of frequent eIF2B mutations for the rapid molecular diagnosis of CACH/VWM syndrome

ObjectivesThe aim of this study was to develop a reliable, rapid and cost-effective molecular diagnostic assay allowing widespread routine investigation of eIF2B-related disorders (CACH/VWM syndrome). This heterogeneous disease is caused by autosomal recessive mutations in the genes encoding the five subunits of the translation-initiation factor eIF2B. Such a diagnostic method would be particularly adapted to the apparently acute presentation of the disease. Design and methodsWe developed a multiplex PCR amplification method for 7 genomic regions of the eIF2B genes in a single run. This method targeted the 8 most frequent mutations representing 61.4% of all mutations identified to date in our laboratory. These mutations affected eIF2B2 exon 5, eIF2B3 exon 2, eIF2B4 exons 8 and 11 and eIF2B5 exons 5, 7 and 8. PCR products were then pooled and subjected to a primer-extension assay validated using previously genotyped samples. ResultsThe results were compared to screening and/or direct sequencing methods: 100% agreement between methods confirmed equivalent sensitivity and specificity. The new assay was highly superior in terms of cost, time to results and robustness despite sample heterogeneity. ConclusionsThis genotyping strategy allows the detection of all eIF2B mutations targeted. A second multiplex primer-extension assay is in development to detect the 11 next-most frequent mutations, thus raising the global detection rate to 76.8%. Our approach is widely applicable as it involves standard techniques and equipment. Moreover, it can easily be further adapted to the clinical and genetic heterogeneity of eIF2B-related disorders by including or excluding mutations.

Computed tomography imaging in the pediatric emergency department

Introduction. The Computerized Tomography (CT) plays a crucial role in the emergency diagnosis. Objective. Our purpose was to identify CT-scan’s utility in Pediatric Emergency Department. Materials and methods. We used a cross-sectional approach, for the year 2010. From a total of 92959 visits in the Emergency Room (ER) of the “Clinical Emergency Hospital for Children “M.S. Curie”, Bucharest, 9258 patients were considered emergencies (group A) and 90 patients were major emergencies (group B). We performed 102 CT scans. Results were given as percentages. Results. The global percent of ER visits associated with a CT scan was 1% within the group A and it scored 1‰ from all ER visits. All patients from group B underwent a CT scan. Main indications were: major head injuries - 50%, intracranial hypertension – 35%, polytrauma – 12.7%, suspicions of malformations – 5.9%. The global detection rate for any kind of lesion was 51%. For brain trauma the rate scored 49%, identifying the following lesions: diffuse cerebral edema (19%), intracranial hemorrhage (15.6%), skull fractures (15.6%) and other facial or visceral lesions (29%). For intracranial hypertension the method’s sensitivity was 43%, for multiple trauma 84.6% and for malformations’ suspicions 100%. The lesions’ detection rate, for different clinical conditions (or the method’s sensitivity) is similar with other medical studies. Conclusion. In all pediatric patients, indication of a CT scan was made after a careful selection of cases. The method proved to be useful for managing all kind of trauma and intracranial hypertension situations.

The Herschel Fornax Cluster Survey II: FIR properties of optically selected Fornax cluster galaxies

The $Herschel$ Fornax Cluster Survey (HeFoCS) is a deep, far-infrared (FIR) survey of the Fornax cluster. The survey is in 5 $Herschel$ bands (100 - 500 $\mu$m) and covers an area of 16 deg$^2$ centred on NGC1399. This paper presents photometry, detection rates, dust masses and temperatures using an optically selected sample from the Fornax Cluster Catalogue (FCC). Our results are compared with those previously obtained using data from the $Herschel$ Virgo Cluster Survey (HeViCS). In Fornax, we detect 30 of the 237 (13%) optically selected galaxies in at least one $Herschel$ band. The global detection rates are significantly lower than Virgo, reflecting the morphological make up of each cluster - Fornax has a lower fraction of late-type galaxies. For galaxies detected in at least 3 bands we fit a modified blackbody with a $\beta = 2$ emissivity. Detected early-type galaxies (E/S0) have a mean dust mass, temperature, and dust-to-stars ratio of $\log_{10}(<M_{dust}>/\mathrm{M_{\odot}}) = 5.82 \pm 0.20$, $<T_{dust}> = 20.82 \pm 1.77$K, and $\log_{10}(M_{dust}/M_{stars}) = -3.87 \pm 0.28$, respectively. Late-type galaxies (Sa to Sd) have a mean dust mass, temperature, and dust-to-stars ratio of $\log_{10}(<M_{dust}>/\mathrm{M_{\odot}}) = 6.54 \pm 0.19$, $<T_{dust}> = 17.47 \pm 0.97$K, and $\log_{10}(M_{dust}/M_{stars}) = -2.93 \pm 0.09$, respectively. The different cluster environments seem to have had little effect on the FIR properties of the galaxies and so we conclude that any environment dependent evolution, has taken place before the cluster was assembled.

Results from DROXO

X-rays from very young stars are powerful probes to investigate the mechanisms at work in the very first stages of the star formation and the origin of X-ray emission in very young stars. We present results from a 500 ks long observation of the Rho Ophiuchi cloud with a XMM-Newton large program named DROXO, aiming at studying the X-ray emission of deeply embedded Young Stellar Objects (YSOs). The data acquired during the DROXO program were reduced with SAS software, and filtered in time and energy to improve the signal to noise of detected sources; light curves and spectra were obtained. We detected 111 sources, 61 of them associated with rho Ophiuchi YSOs as identified from infrared observations with ISOCAM. Specifically, we detected 9 out of 11 Class I, 31 out of 48 Class II and 15 out 16 Class III objects. Six objects out of 21 classified Class III candidates are also detected. At the same time we suggest that 15 Class III candidates that remain undetected at log Lx < 28.3 are not related to the cloud population. The global detection rate is ~64%. We have achieved a flux sensitivity of ~5 x 10^{-15} erg s^{-1} cm^{-2}. The Lx to L_bol ratio shows saturation at a value of ~ -3.5 for stars with T_eff <= 5000 K or 0.7 M_sun as observed in the Orion Nebula. The plasma temperatures and the spectrum absorption show a decline with YSO class, with Class I YSOs being hotter and more absorbed than Class II and III YSOs. In one star (GY 266) with infrared counterpart in 2MASS and Spitzer catalogs we have detected a soft excess in the X-ray spectrum which is best fitted by a cold thermal component less absorbed than the main thermal component of the plasma. Such a soft component hints to the presence of plasma heated by shocks due to jets outside the dense circumstellar material.

Automatic extraction of paralinguistic information using prosodic features related to F0, duration and voice quality

The use of acoustic–prosodic features related to F0, duration and voice quality is proposed and evaluated for automatic extraction of paralinguistic information (intentions, attitudes, and emotions) in dialogue speech. Perceptual experiments and acoustic analyses were conducted for monosyllabic interjections spoken in several speaking styles, conveying a variety of paralinguistic information. Experimental results indicated that the classical prosodic features, i.e., F0 and duration, were effective for discriminating groups of paralinguistic information expressing intentions, such as affirm, deny, filler, and ask for repetition, and accounted for 57% of the global detection rate, in a task of discriminating seven groups of paralinguistic information. On the other hand, voice quality features were effective for identifying part of the paralinguistic information expressing emotions or attitudes, such as surprised, disgusted and admired, leading to a 12% improvement in the global detection rate.

Dépistage de la trisomie 21 en France: le consensus du pire

Down syndrome screening has been based on second trimester maternal serum markers assay for many years. Another late strategy was based on the "genetic sonogram" performed in early second trimester in high-risk populations selected on maternal age or second trimester maternal serum markers. New strategies for Down syndrome screening have emerged over the last 10 years, with higher sensitivity and lower false-positive rates. First trimester ultrasound examination is a successful screening test; the sensitivity of nuchal translucency measurement is of 60 to 77% for a 5% false-positive rate. Combining nuchal translucency measurement with PAPP-A and free beta-hCG assay (first trimester combined screening) increases the sensitivity up to 82%. The most specific strategy is based on the integrated test, i.e., the integration of the quadruple test performed in second trimester (inhibine dimeric A, total beta-hCG, AFP, and uE3 assay) to the first trimester combined screening: for a 85% detection rate, the false-positive rate is estimated to 0.9%. However, it is ethical only with the patient agreement because it prevents access to the results of first trimester combined screening, and deprives the patient of an early diagnosis by CVS. Therefore, alternative strategies were proposed: step-wise sequential screening and contingent sequential screening. In the step-wise screening, karyotype is offered when the result of the combined test is beyond a specified threshold. If the combined test result is below this threshold, quadruple test is offered, and the final risk is calculated in the second trimester by integrating the results of the quadruple test with those of the combined test. Contingent screening also begins with the first trimester-combined test. According to its results, the patients are considered in one of the 3 following risk groups: high, intermediate, or low risk. An early karyotype is proposed to the high-risk group after combined testing. The low risk group is reassured and thus the quadruple test is not performed. The quadruple test is proposed to the intermediate risk group and final risk is calculated by the integration of the combined test result into the quadruple test result. The global detection rate of the step-wise or contingent sequential screening is estimated to 84% for a false-positive rate of 2%.

Evolution of Tuberculosis Control and Prospects for Reducing Tuberculosis Incidence, Prevalence, and Deaths Globally

The United Nations Millennium Development Goals (MDGs) are stimulating more rigorous evaluations of the impact of DOTS (the WHO-recommended approach to tuberculosis control based on 5 essential elements) and other possible strategies for tuberculosis (TB) control. To evaluate the prospects for detecting 70% of new sputum smear-positive cases and successfully treating 85% of these by the end of 2005, for reducing TB incidence, and for halving TB prevalence and deaths globally between 1990 and 2015, as specified by the MDGs. TB case notifications (1980-2003) from DOTS and non-DOTS programs and cohort treatment outcomes (1994-2002) reported annually to the World Health Organization (WHO) by up to 200 countries, TB death registrations, and prevalence surveys of infection and disease. Case notification series that reflect trends in incidence, treatment outcomes from DOTS cohorts, death statistics from countries with WHO-validated vital registration systems, and national prevalence surveys of infection and disease. Case reports, treatment outcomes, prevalence surveys, and death registrations from WHO's global TB database covering 1990-2003 to estimate TB incidence, prevalence, and death rates through 2015 for 9 epidemiologically different world regions. TB incidence increased globally in 2003, but incidence, prevalence, and death rates were approximately stable or decreased in 7 of 9 regions. The exceptions were regions of Africa with low (<4% in adults 15-49 years) and high rates (> or =4%) of HIV infection. The global detection rate of new smear-positive cases by DOTS programs increased from 11% in 1995 to 45% in 2003 (with the lowest case-detection rates in Eastern Europe and the highest rates in the Western Pacific) and could reach 60% by 2005. More than 17 million patients were treated in DOTS programs between 1994 and 2003, with overall treatment success rates more than 80% since 1998. In 2003, overall reported treatment success was 82%, with much variation among regions. The highest rates were reported in the Western Pacific region (89%) and lowest rates in African countries with high and low HIV infection rates (71% and 74%, respectively), in established market economies (77%), and in Eastern Europe (75%). To halve the prevalence rate by 2015, TB control programs must reach global targets for detection (70%) and treatment success (85%) and also reduce the incidence rate by at least 2% annually. To halve the death rate, incidence must decrease more steeply, by at least 5% to 6% annually. Reduction of TB incidence, prevalence, and deaths by 2015 could be achieved in most of the world, but the challenge will be greatest in Africa and Eastern Europe.

Taxa de detecção do papilomavírus humano pela captura híbrida II, em mulheres com neoplasia intra-epitelial cervical

OBJETIVO: avaliar a taxa de deteccao do papilomavirus humano (HPV) de alto risco oncogenico em pacientes portadoras de neoplasia intra-epitelial cervical (NIC) e verificar se existe associacao entre a presenca do virus e a carga viral com a gravidade da lesao cervical, assim como qual o melhor ponto de corte para predizer a gravidade desta lesao. METODOS: estudo de corte transversal, no qual foram selecionadas 110 mulheres com citologia e/ou biopsia com diagnostico de NIC. Todas foram submetidas a coleta de nova citologia oncologica, captura hibrida II (CH II), colposcopia e conizacao pela cirurgia de alta frequencia com alca. RESULTADOS: a taxa global de deteccao do HPV de alto risco oncogenico na populacao estudada foi de 77,3%. A avaliacao histopatologica, 81 (73,7%) mulheres apresentavam NIC e, nestas mulheres, a taxa de deteccao do DNA-HPV foi de 87,6%, sendo de 85,9% nas mulheres com NIC 2 ou 3. A CH II apresentou sensibilidade de 87,7%, especificidade de 56%, valor preditivo positivo de 86,6% e valor preditivo negativo de 58,3%, com odds ratio (OR) de 7,76 (2,47 < OR < 25,15) no diagnostico de NIC 2 ou 3. Com ponto de corte de carga viral de 20 pg/mL, selecionado a partir da curva ROC, o valor preditivo positivo da CH II no diagnostico da NIC 2 ou 3, na populacao estudada, foi de 81,3%. CONCLUSOES: a taxa de deteccao do DNA-HPV nas pacientes portadoras de NIC foi de 77,3% e, em mulheres com NIC 2 e 3, foi de 85,9%. O melhor ponto de corte da carga viral para a predicao da lesao cervical de alto grau foi de 20 pg/mL. Acima deste ponto a probabilidade de deteccao do HPV de alto risco oncogenico e maior que 80%.