Giant Cell Granuloma Of Mandible Research Articles

Case report on aggressive central giant cell granuloma of mandible

Central giant cell granuloma (CGCG) is an uncommon, benign but aggressive osteolytic neoplasm of the craniomaxillofacial region, histologically characterized by an abundance of evenly distributed multinucleated giant cells within a sea of spindle-shaped mesenchymal stromal cells, scattered throughout the fibrovascular connective tissue stroma containing areas of hemorrhage. A rapid diagnostic assessment, together with an adequate histopathologic verification, is essential to improve the management and the prognosis of this locally destructive lesion. A rare case of a large destructive CGCG involving the entire right side of mandible, causing extensive bony resorption, and buccal, medial as well as inferior border cortical expansion, in a young female is presented. It was treated successfully by surgical excision under general anesthesia.

Surgical treatment and reconstruction of central giant cell granuloma (CGCG) of mandible of aggressive behaviour – case report and literature review

Introduction Central giant cell granuloma (CGCG) is a benign tumor-like lesion of a bone, mainly localized in mandible. It usually occurs in children and young adults under 30 y.o., predominantly in females. The etiology of the disease remains unknown. Clinically, two different types of CGCG have been distinguished – an unaggressive one, in which the granuloma grows slowly, often asymptomatically, and aggressive type which is characteristic for increased bone destruction, severe pain, large size, rapid growth, high recurrence rate and complications such as root resorption, tooth displacement or cortical bone perforation. The treatment of CGCG depends on its type. In cases of granulomas of aggressive behaviour the following therapeutic procedures have been proposed: intralesial corticosteroid injections, interferon and calcitonin therapy as well as immunotherapy with anti-bone resorptive human monoclonal antibody like denosumab. However, in most cases nonsurgical management remains insufficient. Also, local curettage of the lesion results in high risk of recurrence. Therefore, radical surgical resection, commonly combined with bone reconstruction, is the most recommended way of treatment for aggressive of CGCG. Case report The authors present a case of a 31-year-old female patient treated at the Department of Oncological and Reconstructive Surgery, Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology in Gliwice due to central giant cell granuloma of a mandible. The resection of CGCG localized in mandible on the right side together with fibular free flap reconstruction has been performed, with satisfactory aesthetic effect. Positive staining for CD68 and CD31 was found in immunohistochemic examination and expression of Ki67 marker was 13%. No complications were reported in the postoperative period. The six-month follow up revealed no recurrences. Conclusions The authors claim that radical surgical management should be performed in all patients with CGCG of aggressive behaviour. Fibular free flap is recommended for reconstruction in large bone defects. It results in tumor-free margins at the resection and satisfactory cosmetic outcome. Quality of life and facial appearance can be improved with dental implantation after certain disease-free period. A regular follow-up is essential as an element of holistic oncological process.

Central Giant Cell Granuloma of Mandible

Central giant cell granuloma is a benign lesion of a jaw which etiology is unknown. Histologically, hemosiderin pigments, sometimes woven bone trabeculae and hemorrhagic foci of the fibrovascular stroma are characterized by numerous clusters of multinucleated giant cells. Surgical curettage is widely used in the treatment and resection can be done in aggressive lesions. In our case report, a 17-years-old female patient visited our department with painless swelling in mandibular anterior region. On radiological examination, a pyramidal lesion was observed between the lateral and canine teeth. The lesion was excised under local anesthesia. Postoperative symptoms were not observed during radiological and clinical follow-up.DOI:10.21276/AOHDR.1894

Salmon calcitonin - a boon in the management of central giant cell granuloma

Central giant cell granuloma is an uncommon, benign, proliferative lesion of unknown etiology, most commonly affecting anterior mandible of younger age group. Early diagnosis may be of benefit to the patient as conservative treatment modalities may be used as compared to radical surgical treatment. Calcitonin as a therapy for central giant cell granuloma of the jaws is a promising alternative to surgical curettage, particularly for larger lesions. We report a case of central giant cell granuloma of mandible in a 14-year-old female patient, who is being treated solely with intranasal spray of salmon calcitonin for 14 months showing greater results.

SURGICAL TREATMENT AND RECONSTRUCTION FOR CENTRAL GIANT CELL GRANULOMA OF MANDIBLE - case report and literature review.

Introduction: Central giant cell granuloma (CGCG) is a benign aggressive destructive osteolytic lesion of osteoclastic origin. The central giant cell granuloma is often found in the mandible, anterior to the first molars. It most commonly occurs in patients under the age of 30, with a clear female prevalence Purpose: To present a case of CGCG of the lower jaw in Department of Oral and maxillofacial surgery, University Hospital ‘St Anna’. Although en bloc resection provides the lowest recurrence rate, only a few single case reports describe the use of this technique followed by reconstruction with autogenous bone grafts. Material and methods: The medical history of a 28 years patient with a large central giant cell granuloma in the mandible. Biopsy specimen taken from the lesion showed CGCG followed by curettage with peripheral ostectomy with preservation of the continuity of the mandible. Result: At the 1-year clinical and radiological follow up there was no sign of recurrence. Conclusion: After complete healing of the graft, prosthetic rehabilitation with implants will be perfomed. This allows the best functional and aesthetic results.

Management of Central Giant Cell Granuloma of Mandible Using Intralesional Corticosteroids: Case Report and Review of Literature

We read ‘‘Management of Central Giant Cell Granuloma of Mandible Using Intralesional Corticosteroids: Case Report and Review of Literature’’ by Ferretti et al. with great interest. The paper reports a case of managing central giant cell granuloma (CGCG) in a 16-year-old girl through the administration of intralesional corticosteroids. The authors state that complete opacification was noted after only 2 administrations of the steroid solution. They also report that this rapid response was unique among the cases previously reported. However, the authors did not compare the age of their patient and localization of the CGCG with previously reported cases. Even if their case was unique, their patient was only 16 years old and the lesion was located on the mandible. We believe that younger patients experience faster treatment responses. Also, the localization of the CGCG reported in their case may be related to the response. As is commonly known, the regeneration capability of the mandible is better than that of the maxilla. Because the authors did not report, in their literature review, the age and gender of the patients and the localization of the CGCGs covered, we would like to add these data to clarify things for readers (Table 1).

Aggressive Central Giant Cell Granuloma of Mandible Transformed to an Enormous Vascular Lesion

Aggressive central giant cell granuloma (ACGCG) is usually found in younger patients and is painful, grows rapidly, larger overall, often causes cortical perforation, root resorption and has a tendency to recur. This article is a case report of ACGCG in mandible. A girl 12 years old had features of typical giant cell reparative granuloma in the anterior mandible. After incision biopsy, she reported after 11 months. The lesion had rapidly increased in size and vascularity to an enormous tumorlike mass with engorged vessels. The lesion was of enormous size and extensive expansion was high in vascularity. The cortices remained but thinned out and perforated despite of extensive expansion. The lesion was curetted resulting in loss of continuity of the mandible. The microvascular surgery with free fibula graft was done to reconstruct the mandible. This is report of rarest case of ACGCG with enormous increase in size and vascularity which was treated successfully and rehabilitated.

Management of Central Giant Cell Granuloma of Mandible Using Intralesional Corticosteroids: Case Report and Review of Literature

Management of Central Giant Cell Granuloma of Mandible Using Intralesional Corticosteroids: Case Report and Review of Literature

Immunohistochemical Studies of Cell Cycle-associated Proteins in a Case of Giant Cell Granuloma of Mandible

Immunohistochemical Studies of Cell Cycle-associated Proteins in a Case of Giant Cell Granuloma of Mandible

Immunohistochemical Studies of Cell Cycle-associated Proteins in a Case of Giant Cell Granuloma of Mandible

Immunohistochemical Studies of Cell Cycle-associated Proteins in a Case of Giant Cell Granuloma of Mandible