Hydrogen (H2) is considered an alternative energy carrier to reduce greenhouse gas (GHG) emissions related to power and heat generation. A quantitative analysis was conducted to estimate the energy intensity and GHG emissions associated with the transportation of NG/H2 mixture in high-pressure transmission pipeline, considering blending ratios up to 100% of low-carbon H2. The life cycle emissions were obtained by including upstream supply chain emissions, compression and transportation emissions, and end use combustion emissions of the NG/H2 blend. This study accounts for global warming potential of fugitive methane and H2 emissions associated with pipeline transportation of the blend in the life cycle analysis. A significant reduction in the overall life cycle GHG emissions can be achieved when delivering the same volume throughput but at a reduced energy flow to end users. However, to maintain the nominal energy throughput of the pipeline regardless of the H2 mole fraction, a maximum reduction of about 6% is obtained as the H2 mole fraction in the blend will be practically limited to approximately 30% H2 when the pipeline operates at capacity.