Profile Geometry Research Articles

Trabecular bone structural units (BSU) and their cement lines change with age, bone volume fraction, structure, and strength in female human vertebrae

Abstract A lifetime of successive bone remodeling events leads to trabeculae, which are composed of a patchwork of bone structural units (BSU) called hemi-osteons or trabecular packets. Traditionally, only intact surface BSU have been studied, which are those that have been created most recently. Accordingly, the complex changes in the size and distribution of BSU throughout the trabeculae have been overlooked. In this study, the BSU within the trabeculae of the second lumbar vertebrae were manually traced using ImageJ software, in osteopontin immunostained sections of eight young women (aged 19–38 years) and eight older women (aged 69–96 years). A series of BSU profile properties including area, width, length, and perimeter were quantified, along with properties of each trabecular profile such as the number of BSU and cement line length. The relationships between these properties and age, as well as selected trabecular microstructural properties assessed with microcomputed tomography, and bone strength assessed on the neighboring third lumbar vertebrae, were investigated. The median BSU profile length and perimeter decreased with age, while median BSU profile area and width was unchanged. Moreover, age was associated with an increase in the number of BSU profiles and cement line length per trabecular profile area. However, changes in BSU profile geometry, the number of BSU profiles, and the cement line length per trabecular profile were strongly correlated with trabecular bone volume fraction, structure model index, and bone strength. Further research is needed to understand how these changes in BSU properties affect the mechanical and failure properties of trabecular bone.

Twist and chord optimization using the linearization method on the taper blade of a micro-horizontal axis wind turbineTwist and chord optimization using the linearization method on the taper blade of a micro-horizontal axis wind turbine

The research aims to optimize the geometry of taper blade profiles for the Horizontal Axis Wind Turbine (HAWT) to improve aerodynamic performance and minimize fabrication complexity. The study used blade linearization as an optimization method for identifying a desirable twist (β) and chord (Cr). This approach enhances accuracy and boosts computational efficiency. It simplifies the optimization process by reducing complexity. In contrast, traditional nonlinear methods are slower and more resource-intensive due to complex aerodynamic interactions. The best β and Cr distributions were found by linearization with elements 1 and 10 of the blade length and positions 5%, 15%, 25%, 35%, 45%, 55%, 65%, 75%, 85, and 95% of the blade elements. The linearization results were used to determine the optimum performance of the HAWT design using simulation. The optimal blades for HAWT were fabricated and their performance evaluated under real wind conditions. The linearization of the 45% twist and chord of elements 1 and 10 provided the best blade shape. Optimized twist and chord yielded HAWT performance with the Cp of 45% to 47% at rotational speeds of 200–900 rpm and wind speeds of 2–10 m/s. Twist and chord optimization increased the Cp from 39.71% to 46.43% with a rotational speed of 550 rpm at a wind speed of 6 m/s, as well as the maximum mechanical power from 424.28 watts to 500.35 watts at a wind speed of 10 m/s. The result from real wind conditions showed that manufactured HWAT produced an average electrical power of 294.19 watts at a rotational speed of 590.66 rpm. These results demonstrate that the optimized design approach presents a close match and is still reasonable in comparison to practical conditions.

Novel method to assess anisotropy in formability using DIC

In this study, a novel technique was developed to identify localized neck of a tensile sample based on the curvature of the surface that is expected to work with any metal in which a localized neck forms prior to fracture. Moreover, a MATLAB-based computational tool has been developed to conduct advanced mathematical computations and numerical analysis on data generated from uniaxial tensile test of DP980 steel coupled with Digital Image Correlation (DIC) based on the novel curvature method. The presented curvature technique is a geometry-based approach that uses the specimen's surface profile and groove geometry to detect localized necking, avoiding the limitations of strain-based methods in distinguishing between localized and diffuse necking. A detailed analysis was conducted on the accuracy of the onset and anisotropy of localized neck. The results of the study revealed that specimens fabricated with 30-degree orientation with respect to the Rolling Direction (RD) of the sheet metal, exhibit a higher level of total strain at the onset of the localized necking, indicating the influence of anisotropy on the material's behavior for DP980. Moreover, consistent R-values were observed among specimens with the same orientation with respect to the RD, exhibiting a rising trend of R-value for orientations from zero to 60-degree, followed by a decrease from 60 to 90-degree. Furthermore, the results exhibited a negative linear relationship between R-values and the magnitude of thinning strain.

Insight into profiled CNT/polymer interphase: A molecular dynamic simulation study of load transfer and shock response

In this paper, by utilising molecular dynamic simulations, profiled carbon nanotubes (CNT), represented by CNT containing bead and spiral structure, were built from warping graphene layers with carefully introduced defects. The tensile behaviour of profiled CNTs, pulling and shock response of profiled CNTs within the polyamide matrix were investigated and compared to the corresponding conventional CNT. The result indicates that as mechanically interlocked with the matrix, profiled CNT could effectively relieve the stress concentration during load transfer by distributing the stress into a larger part of the matrix. In this case, a more efficient load transfer could be achieved, thus contributing to the mechanical performance of the composite without modification of the chemical structure. However, the profiling geometry, which is shaped by defects, will introduce stress concentration within the profile CNTs when subject to a tensile load. The stress concentration may not only deteriorate the tensile performance of CNTs, such as ultimate load at break and modulus but also result in an earlier deformation. In this case, care should be taken during the design phase of the profiled CNT. For shocking responses, profiled CNTs were capable of constraining the local chain move thus contributing to the integrity of the composite system during shockwave propagation.

Application of Pattern Search and Genetic Algorithms to Optimize HDPE Pipe Joint Profiles and Strength in the Butt Fusion Welding Process

The rapid spread of the use of high-density polyethylene (HDPE) pipes is due to the wide variety of methods for connecting them. This study keeps pace with the developments of butt fusion welding of HDPE pipes by exploring the relationship between the performance of the weld joints by studying ultimate tensile strength and exploring the joint welding profiles by studying the shape of the joint at the outer surface of the pipe (height and width of the joint cap) and the shape of the joint at the internal surface (height and width of the joint root). Welding pressure, heater temperature, stocking time, and cooling time were the parameters for the welding process. Regression was analyzed using ANOVA, and an ANN was used to analyze the experimental results and predict the outputs. Two optimization techniques (pattern search and genetic algorithm) were applied to obtain the ideal operating conditions and compare their performance. The results showed that pattern search and genetic algorithms can determine the optimal output results and corresponding welding parameters. In comparison between the two methods, pattern search has a limited relative advantage. The optimal values for the obtained outputs revolved around a tensile strength of 35 MPa (3.45 and 4.5 mm for the cap and root heights, and 8 and 6.98 mm for the cap and root widths, respectively). When comparing the effects of welding parameters on the results, welding pressure had the best effect on tensile strength, and plate surface temperature had the most significant effect on the welding profile geometries.

Effect of the sharp profile geometry ong the cutting forces of tire recycling tools

Objective: Study the impact of blade profile geometry on cutting forces during tire recycling, focusing on how variations in the shape and design of tools affect the efficiency and quality of the cut, as well as the tools' lifespan. Methodology: Through the construction and testing of three blade geometries, based on a prior numerical study and made from DF2 and 1.2363 steel, experiments were conducted on a Universal Testing Machine with samples of used tire rubber. Results: It was demonstrated that the hollow profile blade significantly reduces energy consumption and improves cutting performance compared to the 30° straight V profile blade, for both rubber-only samples and those with reinforcing textile fibers. Additionally, the study presented the evaluation of shear stresses using a 90° blade, indicating an average shear stress value of 8.67 MPa. Conclusion: This finding suggests that the appropriate selection of blade geometry can significantly contribute to the efficiency of the tire recycling process, offering important economic and environmental implications.

Characteristics of thalweg profile and cross-sectional geometry along alluvial river bends

ABSTRACT River bends have always drawn attention for their complicated hydraulic, geometric and migration nature. Laboratory as well as field experiments have been carried out to study the geometric behaviour of channel bends. This study aims to analyse the nature of the thalweg profile, longitudinal and transverse slope and distribution of depth in the cross-sectional geometry of both single and consecutive double bends of the channel. In the single bend, the thalweg approaches to the outer bank and becomes closest after the apex of the bend whereas in the successive bends of a double bend, the thalweg is closest before the apex of the bend. These results indicate that the thalweg of a bend depends on the previous consecutive bend. The longitudinal slopes vary periodically along the river bend creating the deepest pool before the apex of the bend. The centre line transverse slope varies periodically; however, the outer transverse slope with respect to the thalweg is maximum where the thalweg is closest to the outer bank. The thalweg and outer quarter line to centre line depth ratio is higher before the apex and reduces after the apex of the bend. The inner quarter line to centre line depth ratio varies periodically with a relatively smaller amplitude.

Results from a synthetic model of the ITER XRCS-Core diagnostic based on high-fidelity x-ray ray tracing.

A high-fidelity synthetic diagnostic has been developed for the ITER core x-ray crystal spectrometer diagnostic based on x-ray ray tracing. This synthetic diagnostic has been used to model expected performance of the diagnostic, to aid in diagnostic design, and to develop engineering tolerances. The synthetic model is based on x-ray ray tracing using the recently developed xicsrt ray tracing code and includes a fully three-dimensional representation of the diagnostic based on the computer aided design. The modeled components are: plasma geometry and emission profiles, highly oriented pyrolytic graphite pre-reflectors, spherically bent crystals, and pixelated x-ray detectors. Plasma emission profiles have been calculated for Xe44+, Xe47+, and Xe51+, based on an ITER operational scenario available through the Integrated Modelling & Analysis Suite database, and modeled within the ray tracing code as a volumetric x-ray source; the shape of the plasma source is determined by equilibrium geometry and an appropriate wavelength distribution to match the expected ion temperature profile. All individual components of the x-ray optical system have been modeled with high-fidelity producing a synthetic detector image that is expected to closely match what will be seen in the final as-built system. Particular care is taken to maintain preservation of photon statistics throughout the ray tracing allowing for quantitative estimates of diagnostic performance.

On the feasibility of ultrasound Doppler-based personalized hemodynamic modeling of the abdominal aorta

BackgroundPersonalized modeling is a promising tool to improve abdominal aortic aneurysm (AAA) rupture risk assessment. Computed tomography (CT) and quantitative flow (Q-flow) magnetic resonance imaging (MRI) are widely regarded as the gold standard for acquiring patient-specific geometry and velocity profiles, respectively. However, their frequent utilization is hindered by various drawbacks. Ultrasound is used extensively in current clinical practice and offers a safe, rapid and cost-effective method to acquire patient-specific geometries and velocity profiles. This study aims to extract and validate patient-specific velocity profiles from Doppler ultrasound and to examine the impact of the velocity profiles on computed hemodynamics.MethodsPulsed-wave Doppler (PWD) and color Doppler (CD) data were successfully obtained for six volunteers and seven patients and employed to extract the flow pulse and velocity profile over the cross-section, respectively. The US flow pulses and velocity profiles as well as generic Womersley profiles were compared to the MRI velocities and flows. Additionally, CFD simulations were performed to examine the combined impact of the velocity profile and flow pulse.ResultsLarge discrepancies were found between the US and MRI velocity profiles over the cross-sections, with differences for US in the same range as for the Womersley profile. Differences in flow pulses revealed that US generally performs best in terms of maximum flow, forward flow and ratios between forward and backward flow, whereas it often overestimates the backward flow. Both spatial patterns and magnitude of the computed hemodynamics were considerably affected by the prescribed velocity boundary conditions. Larger errors and smaller differences between the US and generic CFD cases were observed for patients compared to volunteers.ConclusionThese results show that it is feasible to acquire the patient-specific flow pulse from PWD data, provided that the PWD acquisition could be performed proximal to the aneurysm region, and resulted in a triphasic flow pattern. However, obtaining the patient-specific velocity profile over the cross-section using CD data is not reliable. For the volunteers, utilizing the US flow profile instead of the generic flow profile generally resulted in improved performance, whereas this was the case in more than half of the cases for the patients.

Gyrokinetic simulations of electrostatic microturbulence in ADITYA-U tokamak with argon impurity

The effect of impurity on the electrostatic microturbulence in ADITYA-U tokamak is assessed using global gyrokinetic simulations. The realistic geometry and experimental profiles of the ADITYA-U are used, before and after argon gas seeding, to perform the simulations. Before the impurity seeding, the simulations show the existence of the trapped electron mode (TEM) instability in three distinct regions on the radial-poloidal plane. The mode is identified by its linear eigenmode structure and its characteristic propagation in the electron diamagnetic direction. The simulations with Ar1+ impurity ions in the outer-core region show a significant reduction in the turbulence and transport due to a reduction in the linear instability drive, with respect to the case without impurity. A decrease in particle and heat transport in the outer-core region modifies the plasma density profile measured after the impurity seeding. It, thus, results in the stabilization of the TEM instability in the core region. Due to the reduced turbulence activity, the electron and ion temperatures in the central region increase by about 10%.

A Modified High-Selective Frequency Selective Surface Designed by Multilevel Green’s Function Interpolation Method

A compact high-selective band-pass frequency selective surface (FSS) with the unit cell less than λ/7 is presented. For the simulation of the structure, the multilevel Green’s function interpolation method (MLGFIM) using Floquet theory is adopted to accelerate the calculation of the complex unit cell. The radial basis function (RBF)-QR method is used in the interpolation, which makes the shape parameter in the RBF function not required to be retested for different periodicity. In this design, with an aperture coupling structure between the top and bottom layers patterned by triangular patches and meander lines, the FSS has two transmission zeros (TZs) on both sides of the pass-band and achieves a steep roll-off rate of 192 dB/GHz. Consequently, the FSS has high selectivity and out-of-band suppression, besides profiting from the low profile and symmetric geometry, this FSS exhibits good angular and polarization stabilities. The prototype of the proposed FSS is fabricated and good performance is obtained.

Axial Load Transfer Mechanism in Fully Grouted Rock Bolting System: A Systematic Review

The main objective of implementing primary ground-controlling methods, such as applying rock bolting systems, is to increase the strength of surrounding rock mass. Among all rock bolting systems, fully grouted rock bolting systems are the most popular and reliable retaining systems due to their simplicity, availability of materials, ease of installation in the field, and cost-effectiveness. While these types of rock bolts experience both axial and shear forces, understanding their response to axial loads remains complex and dependent on several factors. Extensive research has addressed the overall behaviour of the fully grouted rock bolting system, but a systematic review of the axial load transfer mechanism and its impact on overall performance is lacking. This study addresses this gap by employing a bibliometric analysis of 77 peer-reviewed publications to explore the current state of knowledge regarding the axial load transfer mechanism in fully grouted rock bolting systems. The analysis identifies influential journals, publishers, researchers, highly cited articles, and emerging keywords within this field. Furthermore, it reveals three key parameters significantly impacting the axial behaviour: (a) rock mass and boundary conditions, (b) mechanical behaviours of the grouts, and (c) the geometry and surface profile of the rock bolt. These parameters are subsequently discussed in detail, highlighting their influence on the axial performance of the system. Finally, this article concludes by suggesting promising directions for future research.

Scour at the rear side of rubble mound revetments due to random wave overtopping: Laboratory experiments

This study presents the physical model experiments on the wave overtopping induced bed level changes at an unprotected rear side of a rubble mound revetment with a crown wall. In the experiments, the wave conditions, the backfill material size, and the backfill depth (vertical distance from the crest level to the rear side bed level) are varied. Two mobility parameters, namely the densimetric overtopping discharge and the relative fall velocity, are introduced to represent the initiation of motion and suspension of the backfill material, respectively. The temporal evolution of scour depth at the rear side is related to the mobility parameter, the number of waves and the backfill depth utilizing regression analyses. The effect of the backfill depth on the scour is found very limited for the available data set. However, the time scale of the scour is found to be related with the backfill depth only. For the present data set, it varied within a range of 1500–16000 number of waves approximately, with an average of 5600 waves. An equilibrium scour profile is reached 3 to 4 times the time scale. The geometry of the scour profile is expressed in terms of the scour depth, based on the equilibrium scour profile data.

Onset of thermal convection in a solid spherical shell with melting at either or both boundaries

SUMMARY Thermal convection in planetary solid (rocky or icy) mantles sometimes occurs adjacent to liquid layers with a phase equilibrium at the boundary. The possibility of a solid–liquid phase change at the boundary has been shown to greatly help convection in the solid layer in spheres and plane layers and a similar study is performed here for a spherical shell with a radius-independent central gravity subject to a destabilizing temperature difference. The solid–liquid phase change is considered as a mechanical boundary condition and applies at either or both horizontal boundaries. The boundary condition is controlled by a phase change number, Φ, that compares the timescale for latent heat exchange in the liquid side to that necessary to build a topography at the boundary. We introduce a numerical tool, available at https://github.com/amorison/stablinrb, to carry out the linear stability analysis of the studied setup as well as other similar situations (Cartesian geometry, arbitrary temperature and viscosity depth-dependent profiles). Decreasing Φ makes the phase change more efficient, which reduces the importance of viscous resistance associated to the boundary and makes the critical Rayleigh number for the onset of convection smaller and the wavelength of the critical mode larger, for all values of the radii ratio, γ. In particular, for a phase change boundary condition at the top or at both boundaries, the mode with a spherical harmonics degree of 1 is always favoured for Φ ≲ 10−1. Such a mode is also favoured for a phase change at the bottom boundary for small (γ ≲ 0.45) or large (γ ≳ 0.75) radii ratio. Such dynamics could help explaining the hemispherical dichotomy observed in the structure of many planetary objects.

Determining the optimal dome shape using a novel variable slippage coefficient non‐geodesic

AbstractThe research of high‐performance composite pressure vessels in practical application has become the focus of attention, and fiber paths play an important role in the structural performance of composite pressure vessels. Therefore, a method is proposed for determining the optimal geometric parameters of the pressure vessel head shape under a novel variable slippage coefficient non‐geodesic(NVSCNG). First, NVSCNG is used as the dome fiber path design mode, and the classical lamination theory is used to construct a dome stress field model. In addition, on the basis of the Tsai‐Wu failure criterion, the minimum laminate thickness is determined to satisfy the strength constraints. Second, the performance factor (pressure*volume/weight) is used to calculate the structural performance of the dome with variable geometric parameters under the novel variable slippage coefficient fiber path. Moreover, the stability constraints are considered to determine the optimal geometric parameter values of the dome. Finally, the structural properties, stress response and thickness were analyzed under two types of fiber paths based on the optimal dome profile. Results show that compared to the conventional variable slippage coefficient, the performance factor can be maximally improved by nearly 60.94% using the novel variable slippage coefficient, and the thickness of the composite layer at the equator of the dome can be maximally reduced by nearly 34.88%. In addition, the research shows that NVSCNG can improve the structural performance of the dome and realize the lightweight of dome components, which are greatly important in guiding the design of fiber paths for pressure vessels.Highlights No unconstrained linear problem between NVSCNG and initial winding angle. Optimal dome profile geometry parameters are m = 0.8, rc = 0.5. The dome structural failure is controlled by the longitudinal stresses. Winding angle distribution has a strong influence on dome stress distribution. Higher dimensionless performance factor and lighter mass for NVSCNG.

Designing a Novel Hybrid Technique Based on Enhanced Performance Wideband Millimeter-Wave Antenna for Short-Range Communication.

This paper presents the design of a performance-improved 4-port multiple-input-multiple-output (MIMO) antenna proposed for millimeter-wave applications, especially for short-range communication systems. The antenna exhibits compact size, simplified geometry, and low profile along with wide bandwidth, high gain, low coupling, and a low Envelope Correlation Coefficient (ECC). Initially, a single-element antenna was designed by the integration of rectangular and circular patch antennas with slots. The antenna is superimposed on a Roger RT/Duroid 6002 with total dimensions of 17 × 12 × 1.52 mm3. Afterward, a MIMO configuration is formed along with a novel decoupling structure comprising a parasitic patch and a Defected Ground Structure (DGS). The parasitic patch is made up of strip lines with a rectangular box in the center, which is filled with circular rings. On the other side, the DGS is made by a combination of etched slots, resulting in separate ground areas behind each MIMO element. The proposed structure not only reduces coupling from -17.25 to -44 dB but also improves gain from 9.25 to 11.9 dBi while improving the bandwidth from 26.5-30.5 GHz to 25.5-30.5 GHz. Moreover, the MIMO antenna offers good performance while offering strong MIMO performance parameters, including ECC, diversity gain (DG), channel capacity loss (CCL), and mean effective gain (MEG). Furthermore, a state-of-the-art comparison is provided that results in the overperforming results of the proposed antenna system as compared to already published work. The antenna prototype is also fabricated and tested to verify software-generated results obtained from the electromagnetic (EM) tool HFSS.

Hydroacoustic optimization with using Noise-GAN

In recent years, noise pollution has a significant impact on marine organisms, hence requiring some restrictions and safety protocols. The primary objective of these restrictions is to minimize the noise generated by human-driven vehicles in aquatic environments. As a result, hydroacoustical studies are becoming increasingly integrated into design studies. The objective of this study is to provide an innovative approach to the design of hydrofoils, are considered a crucial component in the field of hydroacoustic engineering. The objective of this approach is to create a cutting-edge optimization tool through the integration of machine learning and hydroacoustic performance calculations. This article presents the development of a novel method called Noise-GAN, combines Generative Adversarial Networks (GAN) algorithms with hydroacoustic optimization capabilities. The GAN algorithm is used as a dimensionality reduction method in the optimization process, allowing for quick exploration of the design space and obtaining unique profile geometries during optimization. This method is used to generate optimal hydrofoil geometry for various conditions. The hydroacoustic and hydrodynamic performances of the generated geometry are analyzed to determine the applicability and performance of the method. The results are compared to two existing dimensionality reduction method to enhance comprehension of the performance. In order to gain insight into the performance of generated geometries compared to traditional geometries, the results are also compared to the performance data of the profiles available in the literature. This article also includes comparing the performance results of the NACA0009 profile, which is typically employed in hydrofoil research, with the optimal geometries to evaluate of the method and the performance of the generated geometries. In order to determine the real-life applicability of the hydrofoil geometries generated by the method, optimization studies were performed at the five different Angle of Attack (AoA) conditions within the range of 0o - 15o. In this way, the feasibility of the method at different AoA values was also examined. The results of all these comparisons demonstrate that the Noise-GAN method, which was developed to generate hydroacoustically optimized hydrofoil geometry, is highly effective in a variety of respects. The optimization tool developed in this study generates hydrodynamically efficient and unique hydrofoil profiles while optimizing for hydroacoustical performance. The results of this study are presented in this paper.

Straightening rollformed profiles by controlled partial rolling

Roll forming is a sheet metal forming process in which flat sheets are incrementally formed into a desired profile geometry. The process is characterized by high material utilization and output. Along with these advantages, process-related longitudinal strains occur, causing profile defects such as bowing and twisting of the profile, which require subsequent straightening. Conventional straightening methods use overbending and twisting to eliminate existing profile defects. However, this approach is purely experience-based and iterative due to the complex interactions between the various bending and twisting operations. Therefore, a closed-loop control of the straightening process is currently not implemented. This can be remedied by the novel knowledge-based straightening method of partial rolling.In this paper, the basic idea of partial rolling will be introduced and the idea of knowledge-based process control will be demonstrated. A simulation model is then presented to test different process control strategies and evaluate their impact on the profile defects. Finally, an outlook is given on how a closed-loop controlled partial rolling process could be set up in a real process.

Effect of Geometry and Size of Fiber Reinforced Plastic Deck Profile on Behavior of Bridges

Due to the important role that bridges play in rescue operations after an earthquake, it is necessary that these structures have a higher level of protection against seismic attacks. Earthquake identifies the weak points of the structure and causes the most damage there. Bridges are very vulnerable to these attacks due to their low degree of uncertainty. All bridges built before 1971 were designed with the elastic design method (permissible stress). In this method, the effects of plasticity, section cracking, and plastic deformation are not taken into account. The change of seismic locations based on the principles of elastic design is much less. It is because the structure experiences in a real earthquake, one of the consequences of which is the falling of the decks due to the loss of the support surface. The decision to strengthen the bridge was made when there were many bending and shear cracks on the king beams. The bridge was created. The use of FRP profiles can significantly prevent the damage caused by corrosion and is a good alternative to the traditional methods of strengthening the structure. In this study, a design for the deck of a steel bridge with I beams is presented. The shape of reinforcement using FRP fibers with vinyl ester resins has also been investigated, the effect of the geometry of FRP profiles has been investigated. The presented specifications are optimized to obtain a lasting shape and section, especially for the pultrusion process. FRP materials are light, resistant to corrosion and have high tensile strength. These materials come in different forms and range from multi-layer factory sheets to dry sheets that can be twisted on various structural forms before adding resin, is available. The durability and high tensile strength of FRP materials are among the advantages of these materials. The durability and long-term performance of FRP requires more research, which is ongoing and continues.

Characterization of mass distribution in a biomimetic aerosol exposure system

Objective Lack of biomimicry in geometry and flow conditions of emissions systems for analytical testing and biological exposure has led to fundamental limitations, including a poor understanding of dose delivered to specific airway locations. This work characterizes mass distribution of a JUUL® brand e-cigarette in a Biomimetic Aerosol Exposure System (BAES). Materials and Methods A combination of mass balance, direct measurements, and inferences based on direct measurements were used to characterize regional and local dose as a function of system flow path configuration and emissions topography profile. Results Doses produced by the emissions topography profile with only puffing were significantly different from profiles with clean air inhalation following puffs. Mass characterization results support that dose can be manipulated using flow path geometry. Local and regional deposition was mapped throughout the system. Discussion and Conclusions We estimate the fraction of yield to the mouth deposited at several locations throughout the system for a variety of puffing and respiration topographies and show that emissions topography profile and system flow path geometry affect dose. This work provides proof-of-concept for assessing mass distribution as a function of aerosol generator (e-cigarette product), user airway geometry, and inhalation and puffing topography.