You have accessJournal of UrologyCME1 Apr 2023MP13-18 LARGE PROSTATE SIZE AND ITS EFFECT ON LUTS IMPROVEMENT AND SEXUAL PRESERVATION FOLLOWING CONVECTIVE WATER VAPOR THERMAL THERAPY Owen Lewer, Michael Felice, Gaurav Pahouja, Amy Wozniak, and Kevin McVary Owen LewerOwen Lewer More articles by this author , Michael FeliceMichael Felice More articles by this author , Gaurav PahoujaGaurav Pahouja More articles by this author , Amy WozniakAmy Wozniak More articles by this author , and Kevin McVaryKevin McVary More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003233.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: LUTS/BPH can affect quality of life in men. Convective water vapor thermal therapy (CWVTT - Rezum) is a minimally invasive surgical treatment (MIST) for LUTS/BPH which produces significant, 5-year improvement of LUTS in men with prostates between 30 and 80 cc with minimal de-novo sexual dysfunction. However, CWVTT outcomes based on variable prostate volume (PV) are incompletely described thus is an unmet need. We aim to elucidate the relationship between PV and outcomes post-CWVTT in men with LUTS/BPH. METHODS: In this retrospective study of men undergoing CWVTT from 1/2018 to 3/2022, PV was categorized by tertiles. The primary outcome measured was mean change in I-PSS post-CWVTT between tertiles over 24 months, and analyzed using general linear mixed models. Secondary outcomes include SHIM and IPSS-QOL. Results were adjusted for relevant patient characteristics. RESULTS: 232 patients were included and broken into PV tertiles: small (≤38.5 cc, N=78), medium (38.5-≤55.6 cc, N=76), and large (>55.6 cc, N=78). For IPSS, the change from baseline to 3-months post-op was -7.6 (p=<0.01), -10.4 (p=<0.01) and -11.6 (p=<0.01), small, medium, and large PV, respectively. Post-operatively, small and medium PV had decreasing IPSS scores while large PV IPSS scores were relatively stable. Large PV tended to have the lowest IPSS scores, regardless of time. These trends were similar for IPSS-QOL. For SHIM scores, all PV tertiles decreased from baseline to 3-months post-op. All 3 tertiles had improved SHIM scores over time. Large PV had significant increases in SHIM scores when unadjusted for other patient factors [0.18 per month (95% CI: 0.03 - 0.33, p=0.02)]. Small PV tended to have the lowest SHIM scores, regardless of time. In all three outcomes, when adjusted for other patient characteristics, the trends were not statistically significant. CONCLUSIONS: Interestingly, patients with larger PV may exhibit a more dramatic improvement in sexual function as measured by SHIM than those with smaller PV. In contrast, larger prostates may have a less dramatic improvement in LUTS as measured by I-PSS and I-PSS QoL than smaller ones. However, adjusted analyses show no significant improvement or decline in any of our outcomes by PV after the first post-operative appointment. Source of Funding: NIAID T35 AI125220 © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e180 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Owen Lewer More articles by this author Michael Felice More articles by this author Gaurav Pahouja More articles by this author Amy Wozniak More articles by this author Kevin McVary More articles by this author Expand All Advertisement PDF downloadLoading ...