This manuscript addresses the first time implementing binary metal alloy’s wide range work function gate electrodes along with N+ Si0.55Ge0.45 pocket in charge plasma dielectric modulated vertical TFET (LGW-CPDM-VTFET) for label-free biomolecules sensing application utilizing the single ZnO cavity. The ZnO cavity is covalently functionalized with the intended biomolecules injected in the cavity. Then the variation in the electrical characteristics and performance parameters of LGW-CPDM-VTFET are perceived for their correct recognition. Drain current sensitivity, Ion/Ioff sensitivity, and Sub-threshold Slope (SS) sensitivity are estimated and analyzed utilizing the proposed biosensor structure to identify biomolecules present in the cavity. The designed biosensor manifests higher sensitivity for immobilizing higher dielectric constant biomolecules. The attained results exhibit that Keratin (k = 8) has to drain current sensitivity of 9707, which is 44% and 93% greater than the drain current sensitivity of Bacteriophage T7 (k = 6.3) and Glucose Oxidase (k = 3.46). In contrast, its drain current sensitivity is 55% and 108% lower than the drain current sensitivity of Staphylococcal nuclease (k = 10) and Gelatin (k = 12), respectively. The designed biosensor can extend the bio-sensing applicability due to its high performance, and it would be a better alternative for CMOS biosensor and FET Biosensor.
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