This article investigates optimal control for a class of large-scale systems using a data-driven method. The existing control methods for large-scale systems in this context separately consider disturbances, actuator faults, and uncertainties. In this article, we build on such methods by proposing an architecture that accommodates simultaneous consideration of all of these effects, and an optimization index is designed for the control problem. This diversifies the class of large-scale systems amenable to optimal control. We first establish a min-max optimization index based on the zero-sum differential game theory. Then, by integrating all the Nash equilibrium solutions of the isolated subsystems, the decentralized zero-sum differential game strategy is obtained to stabilize the large-scale system. Meanwhile, by designing adaptive parameters, the impact of actuator failure on the system performance is eliminated. Afterward, an adaptive dynamic programming (ADP) method is utilized to learn the solution of the Hamilton-Jacobi-Isaac (HJI) equation, which does not need the prior knowledge of system dynamics. A rigorous stability analysis shows that the proposed controller asymptotically stabilizes the large-scale system. Finally, a multipower system example is adopted to illustrate the effectiveness of the proposed protocols.