Full-text Database Research Articles

Autogenic Training for Reducing Chronic Pain: a Systematic Review and Meta-analysis of Randomized Controlled Trials

BackgroundAutogenic training (AT) is frequently used as therapeutic approach in multimodal pain therapy. The aim of this systematic review and meta-analysis is to investigate the efficacy of AT in individuals suffering from chronic pain in comparison to passive and active control groups.MethodsA comprehensive literature search in Medline, Web of Science, PsycInfo, and PubPsych and manual searches (last search April 7, 2021) were conducted to locate randomized controlled trials (RCTs). Treatment guidelines and references of relevant articles and previous reviews were checked. ProQuest Dissertations and Theses Full Text database, DART-Europe E-theses Portal, Networked Digital Library of Theses and Dissertations (NDLTD), and the Theses Database of the German National Library were screened to identify any unpublished material.ResultsA total of 13 eligible studies (k = 15 comparisons) including 576 participants were identified. Random-effects meta-analyses revealed a significantly positive, moderate effect of AT on the primary outcome pain compared to passive control groups (g = 0.58, 95% CI [0.36; 0.79], k = 9, I2 = 0%). In comparison with other psychological interventions, no difference was found (g = − 0.05, 95% CI [− 0.30; 0.20], k = 6, I2 = 0%). Sensitivity analyses proved the robustness of findings. Overall risk-of-bias judgment was ‘some concerns’ in the majority of studies.ConclusionsBeneficial effects of AT on pain reduction were demonstrated, but findings are prone to bias. Furthermore, high methodological quality RCTs are needed to strengthen the promising evidence of AT for individuals with chronic pain.

Adapting to change in academic libraries

PurposeThe purpose of this paper is to discover the main reasons for change, why change is necessary and how library professionals can adapt to change. Academic institutions are rapidly changing around the world where libraries are facing similar challenges and adapting change is a demand for growth and improvement. Library administrators need a clear vision and strategic plan to meet the upcoming challenges, they must have self-confidence, ability to work with diversity. Library professionals need to show flexibility and a willingness to develop new skills, they also need to adopt new ways of working and dealing with the academic community.Design/methodology/approachThe literature review is built on resources from offline and online full-text databases such as ProQuest, EBSCO, Emerald, Library Literature and Information Science databases. This paper is based on a systematic literature review method which includes 50 research articles and 5 print books. A total of 109 articles were collected at the beginning stage but after their analysis in detail, they were reduced to 50 articles as the rest of the articles did not exactly focus on adapting to change in academic libraries. Basic keyword and advanced searching options have been used to retrieve the relevant literature on the topic from peer-reviewed and scholarly resources.FindingsChanges are the result of organizational restructuring, user expectations and accessibility to a growing range of digital content, so library professionals are under pressure to adopt change in academic libraries and introduce new services and technology. Library professionals need to change traditional ways of working and boost their knowledge and skills, collaborative attitude, redesign and policies and procedures and create a willingness to adapt to the change. Challenges can be managed if an individual has a keen interest and eagerness to keep up to date with the current knowledge and emerging trends in academic libraries.Research limitations/implicationsAppropriate literature on the topic was reviewed systematically, not all publications were included. Literature on this topic is relatively limited so more research and publications are needed to deal with current and future scenarios of academic libraries.Practical implicationsThis paper offers a useful overview of the ways and approaches used to adopting change by library professionals and the approaches that can be used in the current and future settings of academic libraries. Suggestions and recommendations can be used in the field of LIS, as well as library professionals may apply in the academic and research libraries to effectively change.Originality/valueThis paper focuses on the concept of adapting to change in academic libraries, rather than responding to change. This piece of opinion contributes to library science in the area of how to manage and implement change, suggests ways and frameworks which can be used to adopting change by library professionals.

843 Annular Closure Device for Disc Herniation: Meta-Analysis of Clinical Outcome and Complications

Abstract Aim To assist surgeons to determine a potential approach to reduce incidences of recurrent lumbar disc herniation and assess the current devices regarding their outcomes and complications. Method Four electronic full-text databases were systematically searched through September 2017. All results were pooled utilising meta-analysis with weighted mean difference and odds ratio as summary statistics. Results Four studies met inclusion criteria. Three studies reported the use of Barricaid (ACD) while one study reported the use of Anulex (AR). A total of 24 symptomatic reherniation were reported among 811 discectomies with ACD/AR as compared to 51 out of 645 in the control group (OR: 0.34; 95% CI: 0.20,0.56; I2 = 0%; P < 0.0001). Durotomies were lower among the ACD/AR patients with only 3 reported cases compared to 7 in the control group (OR: 0.54; 95% CI: 0.13, 2.23; I2 = 11%; P = 0.39). Similar outcomes for post-operative Oswestry Disability Index and visual analogue scale were obtained when both groups were compared. Conclusions Early results showed the use of Barricaid and Anulex devices are beneficial for short term outcomes demonstrating a reduction in symptomatic disc reherniation with low post-operative complication rates. Long-term studies are required to further investigate the efficacy of such devices.

Towards the assessment of business process knowledge intensity – a systematic literature review

PurposeThe aim of the article is to propose an integrated definition of knowledge-intensive business processes (kiBPs) and a model of business process (BP) knowledge intensity and develop holistic criteria and measures for the assessment of BP knowledge intensity.Design/methodology/approachA qualitative systematic literature review (SLR) was carried out as a means of evaluating and interpreting all available research relevant to the research topic, in this case, BP knowledge intensity. The SLR is based on the resources of the ProQuest, Springer Nature and ScienceDirect full-text databases. Regarding inclusion criteria, the authors considered peer-reviewed journals and conference proceedings published in English in the last 10 years. The results were summarized and synthesized narratively.FindingsBased on the review, the authors classified existing knowledge intensity definitions, starting with knowledge-intensive economy or country, sectors and services, through knowledge-intensive organizations, BPs, to tasks. Then, an integrated definition of kiBPs was proposed and the business process knowledge intensity model encompassing three domains developed. Finally, 12 knowledge intensity criteria with measures were proposed.Originality/valueThe major value of this research is that it presents a novel approach to understanding BP knowledge intensity and kiBPs. By creating the BP knowledge intensity model, supplemented by the assessment criteria and measures, the authors contribute to the more effective management of kiBP, help find similarities and differences between various knowledge-intensive processes, as well as provide important implications for their effective management and research.

Systematic review and meta-analysis on perioperative intervention to prevent postoperative atelectasis complications after thoracic surgery.

In clinical general thoracic surgery, the prevalence of atelectasis is relatively high. Perioperative interventions can affect the probability of patients with atelectasis after surgery. Therefore, the incidence of perioperative intervention to prevent atelectasis after thoracic surgery was discussed using meta-analysis in this study. The articles were searched in the English database PubMed and Chinese databases including China National Knowledge Infrastructure (CNKI), VIP, and China Journal Full-text Database (CJFD). The duration for publication time of the articles was from the database inception to March 2021, and the articles were required to be randomized controlled trials (RCTs) using interventions [such as changing the dose of general anesthesia, continuous positive end expiratory pressure (PEEP), non-invasive pressure support ventilation, and physical therapy] after thoracic surgery (such as pulmonary lobectomy, sternum surgery, and lung cancer surgery) for the treatment of atelectasis. The software RevMan 5.3 provided by the Cochrane Collaboration was used for meta-analysis. A total of 5 articles were obtained, including 375 cases in the control group and 268 cases in the intervention treatment group. A meta-analysis was performed on the included articles, combined effect model analysis results showed that compared with the control group, the use of PEEP during mechanical ventilation can significantly reduce the incidence of atelectasis [odds ratio (OR) =0.46; 95% confidence interval (CI): 0.31-0.67; Z=3.94; P<0.0001]. Perioperative intervention was more effective for postoperative atelectasis and other complications.

Systematic review and meta-analysis of various risk factors of death from emergency cerebrovascular diseases in the department of neurology.

Cerebrovascular disease is one of the leading causes of death and disability in China. Preventive measures to reduce the incidence of cerebrovascular disease are important, so the risk factors associated with death need to be identified. Most studies showed that cerebrovascular disease has many risk factors for death, such as hypertension, hyperlipidemia, family history of stroke, diabetes, overweight, alcohol consumption, and smoking. A literature search was conducted in the English database PubMed and Chinese databases including CNKI, VIP, and China Journal Full-text Database. The time limit for retrieval was from establishment of the database to March 2021. All randomized controlled trials (RCTs) involving hypertension, hyperlipidemia, family history of stroke, diabetes, overweight, drinking, smoking and cerebrovascular diseases (i.e., stroke and cerebral infarction) were included. Review Manager 5.3 provided by the Cochrane Collaboration was used for meta-analysis. A total of 10 studies (with 32,664 patients in trial and control groups) were included: 14,743 cases in the control group and 17,901 cases in the risk factor group. The combined odds ratio (OR) and 95% confidence interval (95% CI) of all risk factors in patients with emergency cerebrovascular diseases in the Department of Neurology were 2.33 (1.83-2.98) for hypertension, 2.65 (1.80-3.91) for hyperlipidemia, 2.18 (1.73-2.73) for family history of stroke, 4.78 (3.07-7.42) for overweight, 2.97 (1.95-4.52) for alcoholism, and 2.98 (2.11-4.2) for smoking. P values were all less than 0.05, and the differences were statistically significant. The 10 articles included in this meta-analysis studied the effects of various mortality risk factors (hypertension, hyperlipidemia, family history of stroke, diabetes, overweight, alcohol consumption, and smoking) on the death of patients with emergency cerebrovascular diseases in the Department of Neurology. Attention should be paid to the treatment or care of the above factors in clinical practice to reduce the mortality of patients.

Arthroscopic surgery combined with platelet-rich plasma for meniscus injury:a Meta analysis

To evaluate clinical efficacy of arthroscopic with platelet-rich plasma (PRP) in treating meniscus injury. From January 2015 to December 2019, clinical control study on repair meniscus injury by arthroscopic with PRP between arthroscopic were searched by PubMed, Science Direct, Cochrane library, Chinese Journal Full-text Database, Wanfang and VIP database. Literature screening, data extraction and quality evaluation according to inclusion and exclusion criteria. Visual analogue scale(VAS) of knee joint and Lysholm score at 1, 6 and 12 months after opertaion between two groups were compared, and Western Ontario and McMaster University Osteoarthritis Index (WOMAC) at 3, 6 and 12 months after opertaion between twogroups were also compared. Totally 9 literatures and 329 patients with meniscal injuries were screened, include 146 patients treated by arthroscopic with PRP and 183 patients treated by arthroscopic. There were no statistical differences in VAS between two groups at 1, 6 and 12 months after opertaion. There were differences in Lysholm score at 1 and 6 months after operation between two groups [MD=3.85, 95%CI (1.25, 6.44), P<0.05], [MD=2.88, 95%CI (0.13, 5.63), P<0.05];while there was no difference at 12 months[MD=5.88, 95%CI(-8.72, 20.48), P=0.43]. There were differneces in WOMAC score at 3 and 6 months after operation between two groups[MD=-8.07, 95%CI(-11.17, -4.89), P<0.000 01], [MD=-7.96, 95%CI(-11.44, -4.48), P<0.000 01];and no difference at 12 months after operation[MD=-6.61, 95%CI (-16.64, 3.41), P>0.05]. Arthroscopic with PRP for repair meniscus injury has short term efficacy of knee function and delay arthritis, while has similar effect in long term clinical efficacy and relieve pain.

Comparison of Different Surgical Methods for Necrotizing Pancreatitis: A Meta-Analysis.

Purpose: To compare the effectiveness and safety of three methods of open necrosectomy, minimally invasive surgery and endoscopic step-up approach for necrotizing pancreatitis.Methods: We searched Pubmed, Embase, ScienceDirect, and CNKI full text database (CNKI) (to December 25, 2019). RCT, prospective cohort study (PCS), and retrospective cohort study (RCS) comparing the effectiveness and safety of any two of above-mentioned three methods were included.Results: There was no significant difference in major complications or death, and mortality between the minimally invasive surgery treatment group and the endoscopic step-up approach treatment group (RR = 1.66, 95%CI: 0.83–3.33, P = 0.15; RR = 1.05, 95%CI: 0.59–1.86, P = 0.87); the incidence rate of new-onset multiple organ failure, enterocutaneous fistula, pancreatic-cutaneous fistula, intra-abdominal bleeding, and endocrine pancreatic insufficiency in the endoscopic step-up approach treatment group was significantly lower than minimally invasive surgery group (RR = 2.65, 95%CI: 1.10–6.36, P = 0.03; RR = 6.63, 95%CI: 1.59–27.60, P = 0.009; RR = 7.73, 95%CI: 3.00–19.89, P < 0.0001; RR = 1.91, 95%CI: 1.13–3.24, P = 0.02; RR = 1.83, 95%CI: 1.9–3.16, P = 0.02); hospital stay in the endoscopic step-up approach group was significantly shorter than minimally invasive surgical treatment group (MD = 11.26, 95%CI: 5.46–17.05, P = 0.0001). The incidence of pancreatic-cutaneous fistula in the endoscopic escalation step therapy group was significantly lower than that in the open necrosectomy group (RR = 0.11, 95%CI: 0.02–0.58, P = 0.009).Conclusion: Compared with minimally invasive surgery and open necrosectomy, although endoscopic step-up approach cannot reduce the main complications or death and mortality of patients, it can significantly reduce the incidence of some serious complications, such as pancreatic-cutaneous fistula, enterocutaneous fistula, intra-abdominal bleeding, endocrine pancreatic insufficiency, and can significantly shorten the patient's hospital stay.

The role of electronic information resources in supporting scientific research at Northern Border University

This study aimed to realize the impact of Electronic Information Resources on the scientific research movement at the Northern Border University. As it includes Electronic Information Resources provided by the university through the Saudi Digital Library, and many forms of sources such as databases, which include full-text databases, abstracts databases, bibliographic databases, as well as electronic books and electronic periodicals, these resources are characterized by the magnitude of content, continuous modernity, and linguistic diversity, the ability to permanently meet the needs of faculty members. The study sample consisted of 150 faculty members from all disciplines and academic degrees at the university, consistently standard of 137 faculty members from this sample. The study was keen to apply the survey methodology through the main measurement tool (the questionnaire), which consists of 16 main vocabularies that constitute the direction of measurement for the study. The study reached many results, the most important of which is that the high percentage of staff members use teaching Electronic Information Resources significantly, that they can meet teaching and research needs and upgrade academic, as well as there is a broad trend of satisfaction towards the use of full-text databases from other forms of databases. The study showed that the preferred form of access to the types of Electronic Information Resources is through the Saudi Digital Library for free, and there is a tendency of faculty members towards access through the home is larger than the university campus. In general, the study found a high percentage of faculty members ’satisfaction with the use of Electronic Information Resources and the extent of their impact on the flourishing of scientific research. Also, it recommended the necessity of increasing training programs towards using research methods for Electronic Information Resources and intensifying the use of the Internet through the university campus with linking Electronic Information Resources to academic courses.

Reproductive Health in First-degree Relatives of Patients With Polycystic Ovary Syndrome: A Review and Meta-analysis

Polycystic ovary syndrome (PCOS) is a highly heritable disease. Emerging evidence elucidated the elevated prevalence of reproductive abnormalities in first-degree relatives (FDRs) of patients with PCOS. To explore the reproductive health in FDRs of patients with PCOS. Ten databases were searched in December 2020 (PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Chinese Biological Medical Literature, Chinese National Knowledge Infrastructure, Chinese Journals Full-text Database, WanFang, and World Health Organization international clinical trials registry platform). This study included cohort, case-control, or cross-sectional studies. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement was followed. Dichotomous data from each of the eligible studies were combined by the Mantel-Haenszel model. Standard mean differences with 95% CIs were assessed. Heterogeneities were assessed using I2 statistics, and the quality of evidence was evaluated by a US Agency for Healthcare Research and Quality Evidence-based Practice Center program and Grading of Recommendations, Assessment, Development and Evaluation approach. Thirty-eight studies were included. The prevalence of PCOS (0.22; 95% CI, 0.16 to 0.29), menstrual irregularities (0.28; 95% CI, 0.22 to 0.34, P < .01), and ovary morphological changes were elevated in female PCOS FDRs. Female FDRs also presented with increased levels of luteinizing hormone, total testosterone (standard mean difference, 0.53; 95% CI, 0.28 to 0.78, P < .01), unconjugated testosterone, free androgen index, dehydroepiandrosterone sulfate (DHEAS), and antimüllerian hormone levels. Subgroup analyses indicated that some of these changes begun in pubertal girls. Furthermore, fathers of PCOS patients had a higher risk of premature baldness. The DHEAS level was elevated in male FDRs. The findings of this analysis suggested that FDRs of patients with PCOS suffered from reproductive endocrinological dysregulations. Thus, more attention should be focused on this population.

PubMed Central as a platform for the survival of open-access biomedical society journals published in Korea

Twenty-one years have passed since PubMed Central (PMC) launched. The present case study describes Korean editors’ history of participation in PMC and their contributions to PMC. The three main turning points in the history of Korean editors’ involvement with PMC were as follows: first, the production of PMC XML files and deposition starting in 2008; second, thorough evaluations of applying journals since 2014; and third, the feasibility of non-English journals being indexed in PMC starting in 2019. The importance of PMC is further shown by the fact that KoreaMed Synapse, a full-text XML database of biomedical journals in Korea that was launched in 2007, was created by benchmarking PMC. Scholarly societies or institutes publish 724 (34.2%) of the 2,119 PMC journals without embargo in June 2021. Out of those 724 journals, 127 (17.5%) are published in Korea. PMC has helped local journals receive more citations from researchers worldwide, increasing their likelihood of being indexed in international databases. The number of submissions from international researchers has increased, thereby making it possible for journals to achieve international diversity. As the best full-text platform of biomedical journals, PMC has provided an excellent opportunity for biomedical journal editors in Korea to change their journals’ language to English and produce full-text JATS (Journal Article Tag Suite) XML files. These factors have made Korea the second-ranked country in terms of no-embargo PMC journals published by academic societies or institutes.

The Treatment of Acne with the Addition and Subtraction of Loquat Qingfei Yin: A Meta-Analysis

Objective: To systematically evaluate the efficacy and safety of Loquat Qingfei Yin (LQFY) in the treatment of acne. Methods: Using computer retrieval, comprehensive collection of the full text database of Chinese journals till December 2020 (CNKI), Wanfang Data Knowledge Service Platform (Wanfang), Viper Database (VIP), PubMed, Cochrane Library, Medline were included in the LQFY addition or subtraction treatment of acne randomized controlled trial (RCT). Screening of the literatures included in the Note Express 3.2.0. Assessment of the risk of bias in trials using Cochrane collaboration tools, and used Rev Man 5.3 to evaluate the curative effect. Results: 25 RCT, all in Chinese, there were 2257 cases. Of the 1216 cases who were treated, control group was 1041 cases. A random effect model was used for Meta analysis. The results showed that the effective rate of the treatment group was significantly higher than that of the control group, Differences were statistically significant (P=0.94, I2=0%), RR=2.87, CI [2.25,95 per cent 3.67], P&lt;0.00001. Conclusion: There are limited evidence that LQFY is safe and effective in treating acne. However, this conclusion needs to be confirmed by a more large-scale, multi-center, high-quality RCTs.

Geographic information systems representations in resources description and access (RDA)

The study aimed at linking geographic information systems and their use in library and information science, as they represent spatial and geographical information represented in processing in machine-readable cataloging (MARC) fields, which are represented in the Resources Description and Access in the form of an internationally agreed drawing or scheme, and geographic information is of interest to a wide range of beneficiaries in various fields, and to develop work in the field of libraries and information in light of the rules for characterization and availability of resources and in view of the lack of previous studies dealing with this topic; It was necessary to think about good planning to equip libraries and information centers at a high level so that they would be able to deal with information sources and the correct representation of geographical data through geographic information systems, the study was keen to apply the standards of the analytical and applied approach where all the appropriate fields to represent data geographically are reviewed. and the application of the appropriate subfields to it, the study reached the possibility of using the field 651 specifically and activating the hyperlink feature through it to display more links that include drawings, maps, data, and vital statistics associated with it, and thus the field 651 turns into an interactive feature to display bibliography, geography and information data with linking to all Pages and links via the Internet or in full-text databases as well as abstract databases, and innovative addition to the performance of field 651 to become a descriptive field and a tool for geographical and informational representation at the same time.

Current methodologies for chemical compound searching in patents: A case study

In a case study current methodologies for chemical compound searching in patents were assessed. The dyestuff Disperse Orange 25 was used to compare search results obtained from different database categories. Namely, search results from three databases with automated chemical compound recognition (SciWalker, SureChEMBL, Patentscope), a full-text database (FullPat), and a value added database (CAPLUS) were compared. Most databases retrieved unique hit documents. The working thesis that databases with automated chemical compound recognition might substitute traditional databases could not be confirmed. For patent searches aiming completeness with regard to specific chemical compounds, the combined use of databases from all categories is needed.

A two-stage approach to serials review: minimizing journal costs through title-by-title selection with package-based acquisition

Many academic libraries evaluate their journal holdings with an emphasis on deselection rather than selection. Likewise, many consider each journal package or full-text database as a whole, through indicators such as cost per download, without explicitly accounting for the quality of the journals included in each package. Better results can be achieved through a two-stage process that first identifies the ‘wanted journals’ most important to the university’s teaching and research programs, then objectively determines the most cost-effective means of acquiring those journals. Our procedure combines an emphasis on the quality of individual journals with an iterative database/subscription selection method that minimizes costs and avoids any bias toward the journals initially held by the library. Although the process involves considerable effort, it can be used to increase the library’s holdings of wanted journals without increasing total expenditure, or to maintain the number of wanted journals while reducing total expenditure. Our results also demonstrate that title-by-title selection of journals is not inconsistent with acquisition through full-text databases.

Systematic review of the epidemiological characteristics of inhalation injury in burn patients in China

Objective: To study the epidemiological characteristics of inhalation injury in burn patients in China. Methods: The systematic review method was performed. Chinese Journal Full-text Database, Wanfang Database, and Chinese Biomedical Literature Database were searched with the Chinese search terms of ", , ", and PubMed and Embase were searched with the search terms of "burns, inhalation injury" to retrieve the collected retrospective studies on the epidemiological characteristics of inhalation injury in burn patients in China from the establishment of each database to January 2019. Data were extracted from the included articles, including the first author, study institution, study period, study subjects, number of burn patients, incidence of inhalation injury, and gender, age, causes of injury, mortality, and causes of death in patients with inhalation injury. Results: A total of 24 articles were included in this study with the first authors being from multiple research institutions across the country. The articles reported single or multi-center epidemiological studies with statistics on the incidence of inhalation injury in burn patients or severe burn patients admitted to key burn treatment institutions in many provinces/cities in China from 1958 to 2016. The number of burn patients included was 103-64 320 cases in the studies, and the incidence of inhalation injury in hospitalized burn patients ranged from 4.89% to 11.28%, with no obvious trend. The incidence of inhalation injury in severe burn patients was still high, from 19.09% to 32.38% as most articles reported. The number of men with inhalation injury was larger than that of women, with a male-to-female ratio of 1.61 ∶1.00-4.95 ∶1.00; young and middle-aged people were the high-risk population, and flame burn was the main cause of injury. The mortality of patients with inhalation injury was 5.17%-58.67%, of which the mortality was 5.17%-24.75% since 2000, in accordance with reports from hospitals in various regions that the mortality in the later period decreased significantly compared with the previous period. The causes of death in patients with inhalation injury included upper respiratory tract obstruction, sepsis, respiratory failure, and severe pulmonary infection. Conclusions: From 1958 to 2016, there is no obvious trend in the incidence of inhalation injury among burn patients in China; the incidence of inhalation injury is high in young and middle-aged males, and the main cause of inhalation injury is flame burn. The mortality of inhalation injury generally decreased since 2000 compared with the previous period.

Rapid identification of chemical components in Qi-Yu-San-Long decoction by ultra high performance liquid chromatography-quadrupole time-of-flight mass spectrometry

利用超高效液相色谱-四极杆-飞行时间质谱(UPLC-QTOF-MS)的数据非依赖性采集(DIA)技术,结合靶向筛查方法,快速辨识芪玉三龙汤(Qi-Yu-San-Long decoction, QYSLD)化学成分。以Waters ACQUITY UPLC BEH C18柱(100 mm×2.1 mm, 1.7 μm)为色谱柱,流速为0.2 mL/min,柱温为35 ℃,进样量为2 μL,以0.1%(v/v)甲酸水溶液-乙腈为流动相进行梯度洗脱。采用电喷雾电离(ESI)源,以全信息串联质谱(MSE)技术在正、负离子模式下分别采集QYSLD复杂组分的质谱数据。通过检索文献和在线数据库,建立QYSLD中各单味药材化学成分库。将采集到的样品原始质谱数据与QYSLD化学成分库导入天然产物后处理筛查(UNIFI)平台;在UNIFI平台中设置参数(保留时间偏差为±0.1 min,精确质量数偏差阈值为±5×10-6,正离子模式下,选择[M+H]+和[M+Na]+为准分子离子或加合离子,负离子模式下,选择[M-H]-和[M+HCOO]-)。经UNIFI平台对MSE模式下采集的质谱数据与自建数据库中成分作靶向筛查,结合化合物准分子离子、质谱裂解途径及部分对照品进行结构确认。从QYSLD中共识别出166种化学成分,其中皂苷类22种,生物碱类13种,黄酮类27种,萜类32种,氨基酸类20种,苯丙素类16种,有机酸类9种,甾醇类6种,蒽醌类6种,其他类15种。其中16种成分使用对照品作验证。研究建立的方法能够快速、可靠的表征QYSLD中的化学成分,为该复方的药效物质及质量控制研究奠定了基础。

Trends in Surgical Patents Held by Surgeons From 1993 to 2018.

This study aims to quantify the number of patent-holding surgeons and determine their specialty demographics. The number of intellectual property filings related to surgery has exponentially increased over the past 40 years, yet surgeon inventor status among these inventions remains poorly defined. A query of the United States Patent and Trademark Office (USPTO) Patent Full-Text and Image Database was performed over the years 1993 to 2018. Patents related to surgery were defined as surgical devices, implantables, dressings, introducers, and sterilization equipment based on Cooperative Patent Classification (CPC) code. Inventor names were cross-indexed with names of active Fellows in the American College of Surgeons (FACS) as of 2019. Surgeon inventors were identified and differences between specialty and sex were evaluated. A total of 275,260 patents related to surgery were issued over the study period. The number of surgical patents has increased by 462% from 4593 per year to 21,241 per year. A total of 9008 patents were held by a total of 2164 surgeons (4% of FACS). This represents 3.3% of all surgical patents with a mean of 5 patents (range 1-346) per patent-holding surgeon. Specialties with the largest number of patent holders include neurosurgery (9%) and orthopedic surgery (8%). Ninety-seven percent of patent-holding surgeons were male. 3.3% of patents related to surgery involve a surgeon inventor, and although the number of surgical patents has shown an exponential increase, surgeon involvement in these inventions has grown minimally. Surgical innovation training may offer an opportunity to reduce these discrepancies and increase surgeon involvement as patent holders.

Hepatitis B virus related stigma among Chinese living in mainland China: a scoping review

ABSTRACT Stigma related to hepatitis B virus (HBV) has a detrimental impact on health outcomes of people living with HBV. A scoping review of published peer-reviewed articles focused on the Chinese population in mainland China published between 2010 and 2019 was undertaken. This review consists of five stages: identifying the research question, identifying relevant literature, study selection, charting the data, and collating, summarizing and reporting the results. Articles in Chinese were identified from the collection of Core Journals in the database of CNKI (China Academic Journals Full-text Database). Publications in English were identified in Global Health, Scopus, PsycINFO, Proquest and Web of Science. Forty-five peer-reviewed articles were selected for inclusion. Most studies under review focused on negative individual attitude and discrimination against people living with HBV (PLHBV) in employment, education, community and healthcare settings. There is limited information on lived experiences of those living with HBV and how they manage this stigma. The reviewed studies provide evidence for the existence of different forms of HBV-related stigma in a variety of settings. Knowledge about HBV and the level of education of research participants were the most frequently identified factors related to this stigma. These findings are useful to support HBV responses in China and countries with migration from China.

Economic status and catastrophic health expenditures in China in the last decade of health reform: a systematic review and meta-analysis

BackgroundIn order to solve the problem of “expensive medical treatment and difficult medical treatment” for patients and improve the equity of medical services, China started the health-care reform in 2009, and proposed ambitious goals of providing fair and high-quality basic medical and health services to all citizens and reducing economic burden of diseases. This study was to systematically explore the association between population economic status and incidence of catastrophic health expenditures (CHE) in mainland China in the last decade since 2009 health reform.MethodsThis systematic review was reported according to the standard of preferred reporting items for systematic reviews and meta-analyses (PRISMA). We systematically searched Chinese Electronic literature Database of China Journal Full Text Database, Chinese Biomedical Journal Database, Wan fang Data Resource System, VIP Database, and English literature databases of PubMed, SCI, EMbase and Cochrane Library from January 2000 to June 2020, and references of included studies. Two reviewers independently selected all reports from 2000 to 2020 for empirical studies of CHE in mainland China, extracted data and evaluated the quality of the study. We conducted meta-analysis of the incidence of CHE and subgroup analysis according to the time of the study and the economic characteristics of residents.ResultsFour thousand eight hundred seventy-four records were retrieved and eventually 47 studies with 151,911 participants were included. The quality scores of most of studies were beyond 4 points (91.49%). The pooled incidence of CHE of Chinese residents in the last two decades was 23.3% (95% CI: 21.1 to 25.6%). The CHE incidence increased from 2000 to 2017, then decreased over time from 2017 to 2020. From 2000 to 2020, the CHE incidence in rural areas was 25.0% (95% CI: 20.9 to 29.1%) compared to urban 20.9% (95% CI: 18.3 to 23.4%); the CHE incidence in eastern, central and western China was 25.0% (95% CI: 19.2 to 30.8%), 25.4% (95% CI: 18.4 to 32.3%), and 23.1% (95% CI: 17.9 to 28.2%), respectively; the CHE incidence was 30.9% (95% CI: 22.4 to 39.5%), 20.3% (95% CI: 17.0 to 23.6%), 19.9% (95% CI: 15.6 to 24.1%), and 23.7% (95% CI: 18.0 to 29.3%) in poverty group, low-income group, middle-income group, and high-income group, respectively.ConclusionsIn the past two decade, the incidence of CHE in rural areas is higher than that of urban residents; higher in central areas than in eastern, western and other regions; in poverty households than in low-income, middle-income and high-income regions. Further measures should be taken to reduce the incidence of CHE in susceptible people.