A frequent mode of discovery since the improvement of imaging techniques is the pituitary incidentaloma, defined as the discovery of a pituitary adenoma without clinical signs on a scanner or magnetic resonance imaging (MRI) performed for another reason. We report a case of pituitary macroadenoma complicated by panhypopituitarism, discovered incidentally as part of the macroangiopathic complications of type 2 diabetes at the reference health centre in commune III of the Bamako district. It has poor semiological characteristics but poses a diagnostic problem. In our case, the patient presented with physical asthenia and headaches. On biology, the patient presented with 5 lines of anteropituitary insufficiency. A scan revealed a pituitary adenoma measuring 27x22. Anatomopathological examination of the surgical specimen concluded that it was a pituitary adenoma. The patient received hydrocortisone and thyroid hormones prior to excision. This case highlights the delay in the diagnosis and management of pituitary adenomas.