In this work, a penalty-free hybrid stochastic-deterministic algorithm framework is proposed for large-scale heat exchanger networks (HENs) synthesis (HENS), formulated as a computationally-hard mixed-integer nonlinear programming (MINLP) problem. In the outer level, an improved genetic algorithm (GA) is developed to optimize process stream matches represented by integer variables whose values are generated by a unique heat exchanger vector. Unlike previous researches, the improved GA does not rely on any penalty terms, because we propose a feasible stream matching principle to exclude all infeasible process stream matches and only feasible matches are considered in optimization process. In the inner level, a reduced-size MINLP model is solved using deterministic methods to minimize total annualized costs (TACs), which are then used to evaluate the fitness of candidate HENs. Through this way, the proposed framework combines deterministic and stochastic methods to enhance optimization efficiency and global search capability. Illustrative tests on six benchmark cases demonstrate that the framework can efficiently achieve lower-cost solutions compared to deterministic, stochastic, or hybrid methods. The results show a decrease in TAC for all six cases and a reduction in solution time ranging from 11.1% to 97.2%. Importantly, the proposed framework can be extended to solve MINLP problems in other process networks.