BACKGROUND CONTEXT Postoperative fracture of the upper instrumented vertebrae (UIV) is thought to be a fracture type of proximal junctional failure (PJF), which usually needs for proximal extension of the fusion. Global sagittal imbalance has been considered as a potential risk factor to develop PJF. Spinopelvic parameters, such as the pelvic incidence (PI) angles, sacral slope (SS) angles, and pelvic tilt (PT) angles have been recognized to affect overall sagittal balance. PURPOSE To investigate the influence of spinopevic parameters including pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), lumbar lordosis (LL), and proximal local kyphosis (PLK) angle on the development of fracture type of PJF after posterior instrumentation for degenerative lumbar diseases. STUDY DESIGN/SETTING A retrospective case-control cohort study. PATIENT SAMPLE Ninety-six patients. OUTCOME MEASURES Clinical outcomes were evaluated with Oswestry Disability Index (ODI) and the visual analogue scale (VAS) for leg and back pain. The medical conditions were reviewed using the weighted Charlson Comorbidity Index (CCI), bone mineral density (BMD) with T score, and body mass index (BMI). Radiographic parameters such as coronal Cobb's angle, PI, SS, PT, LL, and PLK were measured for comparison. The prevalence of osteoporotic compression fractures (OVFx), PI-LL, and score for spinopelvic realignment achievement were calculated. METHODS Between January 2007 and December 2017, patients underwent posterior instrumented fusion were reviewed. This was a retrospective 1:3 matched case-control study. Twenty-four patients who had undergone revision surgery for UIV fracture of PJF after posterior instrumented fusion were categorized as the study group. As a control group, 72 age-, sex-, and surgical level- matched patients who had undergone posterior instrumented fusion during the same period, had no development of UIV fracture of PJF for more than two years. RESULTS Before surgery, the study group already had more comorbidities (CCI: 1.75 ± 0.90 vs 1.22± 0.61, p= 0.002), poorer bone density (T score: -3.41 ± 1.12 vs -1.81± 0.83, p= 0.001), significant higher prevalence of OVFx (46% vs 18%, p = 0.006) than the control group. In terms of preoperative radiographic parameters, the study group had significantly lower LL (22.85o ± 17.15o vs 31.66o ± 15.10o, p= 0.030), SS (22.69o ± 10.69o vs 28.34o ± 12.66o, p= 0.043), and significantly higher PLK (2.98o ± 9.23ovs -9.20o ± 12.89o, p CONCLUSIONS In addition to osteoporoitc bone quality, pre- and postoperative lower LL, and higher PI-LL/PLK were also significantly associated with development of UIV fracture in PJF. Therefore, obtaining appropriate LL and correcting PLK should be done at surgery to improve spinopelvic sagittal imbalance. The results suggest that the achievement of appropriate LL and PI-LL prevents instrumented fracture of PJF after posterior instrumented fusion. FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs.
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