Local Form Research Articles

Epididymo-orchitis with epididymal abscess in a patient with disseminated tuberculosis

Abstract Tuberculosis remains a global health concern, and while primarily affecting the lungs, extrapulmonary manifestations like genitourinary tubercular epididymitis are rare and diagnostically challenging. Accurate differentiation is crucial for appropriate treatment. This case study presents a 34-year-old male with left scrotal swelling, backache, and fever, highlighting the importance of considering tuberculosis in genitourinary conditions. High-resolution sonography revealed an edematous left testis with increased vascularity and hypoechoic nodules. Further imaging, including high-resolution computed tomography thorax and contrast-enhanced magnetic resonance imaging Dorso-lumbar spine, confirmed disseminated tuberculosis. Despite negative urine culture, aspiration cytology from the epididymal collection indicated tubercular etiology. Urogenital tuberculosis, especially isolated epididymal involvement without renal effects, presents diagnostic challenges, often occurring in immunocompromised patients. The case underscores the role of clinical, biochemical, and radiological evidence in establishing a correct diagnosis. High-resolution ultrasonography plays a crucial role in diagnosing scrotal pathologies, and when accompanied by an epididymal collection, further diagnostic steps involving biochemical parameters and aspiration followed by cytoanalysis and culture are essential. The diagnosis of tuberculous epididymitis can be confirmed through acid-fast bacilli (AFB) identification, positive AFB culture, or granulomas seen in a biopsy specimen in the right clinical context. Radiological imaging aids in detecting local and disseminated disease forms, including complications like hydrocele, testicular calcifications, scrotal abscesses, sinus tracks, and fistulous communications.

Septic Abortion Complicated by Disseminated Intravascular Coagulation.

This scenario was developed to educate emergency medicine residents on the diagnosis and management of two concurrent conditions: septic abortion and disseminated intravascular coagulation (DIC). Patients with an abortion (spontaneous or induced) of less than twenty weeks gestation may present with concurrent uterine infection, also known as septic abortion. One of the complications of septic abortion is DIC. Early management of both underlying etiology (septic abortion) and subsequent complications (DIC) is crucial to minimize morbidity and mortality. At the conclusion of the simulation session, learners will be able to: 1) Obtain a relevant focused history including pregnancy history, medication use, and past medical history. 2) Develop a differential for fever and vaginal bleeding in a pregnant patient. 3) Discuss management of septic abortion, including empiric broad-spectrum antibiotics and obstetric consultation for source control with dilation and curettage (D&C). 4) Discuss expected laboratory findings of disseminated intravascular coagulation (DIC). 5) Discuss management of DIC, including identification of underlying etiology and supportive resuscitation with blood products. 6) Review the components of blood products. 7) Identify appropriate disposition of the patient to the intensive care unit (ICU). This session was conducted using high-fidelity simulation followed by a debriefing session and discussion about the diagnosis, differential, and management of both septic abortion and DIC. Debriefing methods may be left to the discretion of participants, but the authors have utilized advocacy-inquiry techniques. In this technique, the facilitator described something they observed in the case, outlined their reasoning as a facilitator why this observation was important or why they had questions, and then asked the learners to share their frame of reference at the time. An example: "I heard the team leader state that the platelets were normal, but then another resident disagreed. No one paused to come to a consensus. I'm wondering why this wasn't explored further in real time. Tell me more." This scenario may also be run as an oral boards case or adapted for other learners such as critical care fellows. Our residents were provided a survey at the completion of the debriefing session so they could rate different aspects of the simulation, as well as provide qualitative feedback on the scenario. The local institution's simulation center's electronic feedback form is based on the Center of Medical Simulation's Debriefing Assessment for Simulation in Healthcare (DASH) Student Version Short Form,1 with the inclusion of required qualitative feedback if an element was scored less than a 6 or 7. Thirteen learners completed a feedback form out of seventeen participants. This session received all six and seven scores (consistently effective/very good and extremely effective/outstanding, respectively) other than two isolated 4 scores. This is a cost-effective method for reviewing septic abortion and DIC. The case may be modified for appropriate audiences, such as simplifying the case to septic abortion without DIC. You can also consider not showing an initial temperature with the initial set of vitals unless it is specifically asked for by the participants. We encourage readers to utilize bleeding moulage techniques as a visual stimulus to increase psychological buy-in. Medical simulation, septic abortion, pregnancy complications, hematology emergencies, obstetric emergencies, disseminated intravascular coagulation, emergency medicine.

Cultivating Cultural Awareness in Early Childhood: The Role of Batik Tulis in Preserving Local Heritage

This study explores the efficacy of batik tulis (written) for introducing and preserving local cultural heritage in early childhood education. Conducted at TK Batik PPBI Yogyakarta, this qualitative research utilized observations, interviews, and documentation to assess how batik-making activities influence cultural awareness among preschoolers. Results reveal that the batik introduction process familiarizes children with this local art form and instills a profound appreciation for cultural traditions. The educational methodology was designed to be age-appropriate and interactive, integrating safety measures and encouraging active participation throughout all stages of learning—from understanding the cultural significance of batik to hands-on crafting. The findings highlight the pivotal role of integrating cultural elements into early education to cultivate a long-lasting appreciation and knowledge of local heritage. This approach not only aids in cultural preservation but also enriches the educational experience, fostering a generation that values and understands its cultural roots. However, the study's limited scope, focused on a single educational setting, suggests the need for further research. Future studies should aim to replicate and validate these findings across various educational contexts to understand better the effectiveness and scalability of integrating cultural education in early childhood settings. These insights advocate for educational reforms recognizing and utilizing local cultural heritage as a fundamental component of comprehensive educational strategies, potentially influencing broader pedagogical practices.

Localizing gradient damage model for anisotropic materials: Focusing on timber

This paper presents a new damage model for transversely isotropic materials, with special focus on timber. The model proposed in this study is formulated by employing the localized gradient form of continuum damage theory. The model accounts for anisotropic damage through two damage variables, delineating damage parallel and perpendicular to the grain, representing isotropic damage within the cross-sectional plane. The conditions assumed in this work pertain to loading scenarios that occur within the plane. An additional fourth-order tensor transformation is incorporated to facilitate the conversion between the global and local reference frames, allowing for arbitrary spatial orientations of the material matrix. In this work we concentrate on damage arising from tensile and shear stresses. The model is implemented as a consistent linearized coupled (monolithic) problem.The performance verification of the model relies on numerous numerical examples, incorporating experimental benchmark problems. The outcomes demonstrate that the suggested damage model adeptly captures both the initiation of failure and the propagation of damage.

Advances in Periodontal Drug Delivery Systems and the Role of Probiotics in Periodontitis Treatment

Periodontitis is a group of inflammatory diseases which results the destruction of tooth-supporting tissues and affects 20-50% of the global population. Different bacterial enzymes are released into the periodontal pockets as a result of the proliferation of varied microflora, particularly anaerobes, which affect the body's immune response. A key component of treating periodontitis is mounting along with routing. Soluble at the site of infection, nonoperative controlled-release formulations reduce the requirement for systemic dosage by providing an affordable, non-toxic, biocompatible, and long-term therapeutic alternative. To successfully deliver a drug variety, several polymer-based systems can be used, i.e., strips, microparticles, fibers, nanoparticles, films, and nanofibers. This paper reviews the potential benefits and limits of using periodontal pockets as a medication delivery platform to create an appropriate dental localized dose form. The microorganisms called probiotics are present in the human body's alimentary canal and saliva. Recent studies on the usage of these organisms in treating periodontitis have substantially sparked the interest of researchers due to the positive metabolic effects of these organisms. Therefore, more study is needed to understand better how probiotics function physiologically and to manage periodontal disease over the long term.

Local and global predictors of synapse elimination during motor learning.

During learning, synaptic connections between excitatory neurons in the brain display considerable dynamism, with new connections being added and old connections eliminated. Synapse elimination offers an opportunity to understand the features of synapses that the brain deems dispensable. However, with limited observations of synaptic activity and plasticity in vivo, the features of synapses subjected to elimination remain poorly understood. Here, we examined the functional basis of synapse elimination in the apical dendrites of L2/3 neurons in the primary motor cortex throughout motor learning. We found no evidence that synapse elimination is facilitated by a lack of activity or other local forms of plasticity. Instead, eliminated synapses display asynchronous activity with nearby synapses, suggesting that functional synaptic clustering is a critical component of synapse survival. In addition, eliminated synapses show delayed activity timing with respect to postsynaptic output. Thus, synaptic inputs that fail to be co-active with their neighboring synapses or are mistimed with neuronal output are targeted for elimination.

Pathogenesis and clinical forms of human listeriosis

Listeriosis is a saprozoonotic infection caused in humans mainly by the species Listeria monocytogenes. Its source can be objects of the external environment (soil and water of open reservoirs with a high content of organic compounds, plants) and more than 90 species of animals. The high metabolic activity of listeria and resistance to adverse factors create the possibility of an easy transition from a saprophytic to a parasitic type of metabolism when ingested by the host. A variety of transmission routes and "entrance gates" cause the emergence of a variety of primary localized forms of infection, the most common of which is gastrointestinal. Invasive forms of listeriosis develop mainly in people with immunological insufficiency. "Risk groups" are pregnant women, newborns, people with comorbid conditions, over 60 years old, drug addicts, etc. They are characterized by polymorphism of symptoms, the absence of specific manifestations. Pathogenicity factors of L. are important in the pathogenesis of infection. monocytogenes, providing their incomplete phagocytosis, intracellular parasitism, high rate of colonization of neighboring healthy cells, the formation of antibiotic resistance. The pathological expression of changes caused by listeria in cells is the formation of small granulomas — listeriomas. The "diversity" of listeriosis, the high mortality rate (up to 50% or more) and the low alertness of doctors regarding this infection create difficulties in making a diagnosis, and therefore the improvement of microbiological diagnostic methods is of particular importance.

Innovative local shear forming method for enhanced formability of tubular parts with high stiffened ribs

Large-sized thin-walled tubular parts with high stiffened ribs are key lightweight structural components used in transportation. To address the challenges of integral forming, a novel local shear forming (LSF) technique that combines the advantages of spinning and shear forging (SFG) is proposed. Finite element (FE) simulations and experimental work have revealed the distinct deformation mechanisms of local shear forming in contrast to those of conventional shear forging or spinning. During local shear forming, the surface material of the billet undergoes sequentially axial upsetting deformation, primary shear deformation, reverse shear deformation, circumferential tensile deformation and radial displacement to form the rib. Gradient plastic deformation is observed through the thickness of the formed wall rather than near the wall surface. The effects of local loading include reduction of the secondary shear deformation zone, reduction of circumferential constraint in the loading zone, material circumferential transfer, and expansion-shrinkage deformation of the billet. The former two decrease the rib thickness and promote radial transfer of the material. The latter two result in a significant strengthening of the formed rib and wall. Moreover, tearing and buckling are suppressed, which enhances the relative wedge thickness up to 50 % of the wall thickness of the billet. The aspect ratio of the formed rib can be as high as 3 for the high strength 2A12 alloy and 6 for the highly ductile 1A30 alloy. Shear deformation in the rib promotes recrystallization in the subsequent T6 heat treatment and refines the microstructure. Corrosion resistance is not degraded though microstructural change. Local shear forming shows good potential for forming tubular parts with an external rib structure.

Efficacy and safety of therapeutic strategies for human brucellosis: A systematic review and network meta-analysis.

Human brucellosis is a neglected, re-emerging, and endemic zoonosis in many countries. The debilitating and disabling potential of the disease is a warning about its morbidity, generating socioeconomic impact. This review aims to update the current evidence on the efficacy and safety of therapeutic options for human brucellosis using the network meta-analysis (NMA). A systematic search was conducted in four different databases by independent reviewers to assess overall therapy failure, adverse events, and time to defervescence associated with different therapies. Randomized clinical trials (RCTs) evaluating any therapeutic drug intervention were selected, excluding non-original studies or studies related to localized forms of the disease or with less than 10 participants. Data were analyzed by frequentist statistics through NMA by random effects model. The risk of bias and certainty of evidence was assessed, this review was registered at PROSPERO. Thirty-one (31) RCTs involving 4167 patients were included. Three networks of evidence were identified to evaluate the outcomes of interest. Triple therapy with doxycycline + streptomycin + hydroxychloroquine for 42 days (RR: 0.08; CI 95% 0.01-0.76) had a lower failure risk than the doxycycline + streptomycin regimen. Doxycycline + rifampicin had a higher risk of failure than doxycycline + streptomycin (RR: 1.96; CI 95% 1.27-3.01). No significant difference was observed between the regimens when analyzing the incidence of adverse events and time to defervescence. In general, most studies had a high risk of bias, and the results had a very low certainty of evidence. This review confirmed the superiority of drugs already indicated for treating human brucellosis, such as the combination of doxycycline and aminoglycosides. The association of hydroxychloroquine to the dual regimen was identified as a potential strategy to prevent overall therapy failure, which is subject to confirmation in future studies.

Molecular Characterization of Vigna unguiculata (L.) Walp Collection based on ISSR Markers

Background: In Azerbaijan, cow pea is one of the fundamental legumes. This study was carried out at the Institute of Genetic Resources, Azerbaijan National Academy of Sciences to evaluate genetic diversity in 28 cowpea accessions from Azerbaijan national gene bank. The aim of this study was to evaluate the genotypic diversity, relatedness and population structure among local cow pea resources available in Azerbaijan and the cultivated VIR accessions based on ISSR markers. Methods: The studies were conducted in 2017-2019 at the Institute of Genetic Resources (IGR) of the National Academy of Sciences (NAS) of Azerbaijan. 28 samples were used as research material: 10 of them were local forms and 18 were samples obtained from VIR. Sowing of collection samples was carried out in duplicate with an area of food of one plant 10 ´ 45 cm at the optimum time, in the at the end of April. Result: In the study, 28 alleles were synthesized for the collection with five ISSR markers, with an average polymorphism index of 75%. The rich genetic diversity (GMO = 0.80; PIC = 0.34) was found in the collection. Statistical analyzes have shown that the efficiency of the UBC 835 and the UBC 818 premieres was high. The average genetic distance index in the cow pea collection was 0.33. 71% of the samples were genetically identifiable and 29% revealed that the genotype was identical across the studied loci. PCoA and cluster analysis identified 3 genetically distinct groups within the collection, with the first two coordinates explaining 57% of this genetic variation.

Mobilising in a (former)-red subculture industrial district: the case of the No-Keu permanent assembly

ABSTRACT The article contributes to the understanding of the impact of capitalism on social movements that mobilise against environmental pollution. While research on the topic has looked especially at global trends in capitalist development, the analysis switches attention to the specific local forms of economic development. It does so by focusing on the so-called district economy and related local political subcultures, looking at their decline in particular. Based on interviews and document analysis, the empirical investigation of a protest campaign in Tuscany, Italy, against the illegal disposal of dangerous industrial waste and the alleged collusion of members of the local political and economic elite with organised crime demonstrates the effects of the degeneration of the local model of development. The article explores challenges and opportunities for contentious politics in defining not only the grievances but also the networked organisational structure, the politicised collective frames and the eventful repertoire of protest.

An analytical approach to engineer multistability in the oscillatory response of a pulse-driven ReRAM

A nonlinear system, exhibiting a unique asymptotic behaviour, while being continuously subject to a stimulus from a certain class, is said to suffer from fading memory. This interesting phenomenon was first uncovered in a non-volatile tantalum oxide-based memristor from Hewlett Packard Labs back in 2016 out of a deep numerical investigation of a predictive mathematical description, known as the Strachan model, later corroborated by experimental validation. It was then found out that fading memory is ubiquitous in non-volatile resistance switching memories. A nonlinear system may however also exhibit a local form of fading memory, in case, under an excitation from a given family, it may approach one of a number of distinct attractors, depending upon the initial condition. A recent bifurcation study of the Strachan model revealed how, under specific train stimuli, composed of two square pulses of opposite polarity per cycle, the simplest form of local fading memory affects the transient dynamics of the aforementioned Resistive Random Access Memory cell, which, would asymptotically act as a bistable oscillator. In this manuscript we propose an analytical methodology, based on the application of analysis tools from Nonlinear System Theory to the Strachan model, to craft the properties of a generalised pulse train stimulus in such a way to induce the emergence of complex local fading memory effects in the nano-device, which would consequently display an interesting tuneable multistable oscillatory response, around desired resistance states. The last part of the manuscript discusses a case study, shedding light on a potential application of the local history erase effects, induced in the device via pulse train stimulation, for compensating the unwanted yet unavoidable drifts in its resistance state under power off conditions.

Forms of organization of people as a primary stage in relations with the state

The article analyzes the legal and organizational foundations of interaction between public authorities and people. Local self-government is considered as a modern and most important form of organizing the activities of people, since it is the type of public authority closest to the population and is designed to solve issues of local importance in a particular territory. The subject of the study is the problems of interaction between public authorities and people due to the fact that at the present stage in our country there is an urgent demand for direct participation of people in solving issues of local importance, since active participation of people in the field is necessary to solve national issues. The methodological basis was general scientific and special research methods: formal legal, systemic, comparative legal analysis. For example, the formal legal method made it possible to analyze the main forms of local self-government, and the comparative legal method helped to conduct a comparative analysis of the forms of direct implementation of local self-government and forms of public participation in the implementation of local self-government. The purpose of the work is achieved by identifying and analyzing current problems of interaction between public authorities and people. Result of the research that not all forms of interaction between public authorities and people are equally effective. Some of them are outdated. The article concludes that there is a need for priority interaction of public authorities with people to resolve issues of local importance, as well as that it is the forms of organization of people that are the primary link in relations with the state. The authorities need to involve people in the development of territories and solving problems, interacting in various forms and implementing the most successful practices of the regions everywhere.

THEORETICAL BASIS OF LOCAL BUDGET EXPENDITURES AS AN INSTRUMENT OF FISCAL POLICY AND A COMPONENT OF PUBLIC FINANCE

Purpose. The purpose of the article is to substantiate the theoretical foundations of local budget expenditures as an instrument of fiscal policy and a component of public finances. Methodology of research. The research is based on the use of scientific developments of financiers on the issues of local finance, budgeting and regional policy. For the scientific understanding of the theoretical basis of local budget expenditures as a financial instrument and a component of public finance, the research used special and general scientific methods – analysis, synthesis, scientific abstraction, systematization, argumentation, in particular: dialectical, monographic, analysis and synthesis – to study the theoretical basis of local budgets; dialectical approach – to interpret the concept of “local budget expenditures”; graphical – to visually display the content of the phenomena and processes under study; abstract and logical – in the formation of theoretical generalizations, assumptions, and conclusions. Findings. The economic essence is revealed and, based on the use of methodological tools of modern financial science, a comprehensive theoretical and methodological approach to the disclosure of the essence of «local budget expenditures» is formed. The functional purpose of local budget expenditures is clarified. The expediency of adherence to the principles of local budget expenditures is argued and the most important of them are highlighted. The modern forms of budget financing are characterized, which made it possible to systematize the types of local budget expenditures depending on the forms of their implementation. The author proposes approaches to solving an important problem of local self-government bodies - lack of full budgetary resources for the provision of public services. Originality. The theoretical principles of spending local budgets in the conditions of public finance reform are summarized. Based on the use of the methodological tools of the dialectical approach to understanding the essence of local budget expenditures, a comprehensive approach to this definition is formulated. The authors have improved scientific approaches to identifying the functional purpose of local budget expenditures, principles and forms of their implementation. Practical value. The substantiated conclusions and proposals made it possible to develop the conceptual apparatus of financial science, to improve the theoretical and methodological approaches to the implementation of local budget expenditures. Implementation of the proposals on the expediency of distinguishing in the Budget Code of Ukraine between local budget expenditures for the implementation of delegated and own powers of local governments and specifying the sources of financial support for these types of powers will help to ensure that public services are fully funded. Key words: budget expenditures, local budget expenditures, public finance, principles of budget expenditures, forms of budget expenditures, estimated financing, transfer financing, financial resources of local governments, fiscal policy.

“If Earth Were Freed From Those Who Buy and Sell”: Albery Allson Whitman’s Abolition Agriculture

Abstract: This article examines three major works by nineteenth-century Black Appalachian poet Albery Allson Whitman, focusing on georgic scenes of agricultural labor to highlight the most radical of his agrarian visions. I show how Whitman imagines ecological thriving, decolonial cohabitation, and racial justice in terrains charted outside the political, economic, and geographic bounds of the expanding United States. On one hand, Whitman’s poetic reflections on the interface of land and labor in Black historical experience yield transformative visions that offer abolitionist alternatives to the violently extractive paradigms of racial capitalism, settler colonialism, industrial agriculture, and United States imperialism. On the other, Whitman’s rhetoric of racial uplift tends to uphold some of those extractive paradigms, precisely to the extent that it buys into the ideology of American exceptionalism. While acknowledging Whitman’s occasional lapses into the belief that labor contributing to national growth is the key to both individual and collective thriving, I reveal how Whitman’s works ultimately privilege local, subsistence, and regenerative forms of Afro-Indigenous agriculture as world-making enterprises that contest the racial and colonial order of the plantation form, as well as the United States settler state that upholds it.

Not Nuremberg—Histories of Alternative Criminalization Paradigms, 1945–2021: An Introduction

Abstract: The Western myth of Nuremberg has dominated understandings of the evolution of international criminal law. Enshrining the International Military Tribunal as a critical point of origin, this paradigm has developed a narrative of post-war liberal progress, in which a universal model of externally-delivered, individualised criminal justice was interrupted by the exigencies of the Cold War then rediscovered through various international and hybrid tribunals in the 1990s and early 2000s, culminating in the creation of the International Criminal Court in 2002. Often instrumentalised to protect Western interests, the Nuremberg myth marginalises the histories of a wide range of criminalisation and accountability practices that existed, both at the time and since. In this essay, we introduce alternative practices and alliances that challenged both the Nuremberg myth and the specific accountability model it propagates: from the United Nations War Crimes Commission, which contested the colonial erasures of Nuremberg at the time, to the move towards localised forms of post-atrocity justice such as the gacaca courts in Rwanda in the 2000s. The essays in this dossier question the idea that international criminal law hibernated for four decades after Nuremberg and demonstrate how ideas of criminalisation have been shaped by numerous shifting mid- to -late twentieth and early twenty-first century ideologies, such as anti-colonialism, Communism, various iterations of human rights, racial justice, neoliberalism, or, more recently, populist re-imaginings of the global. Shorter Abstract: The Western myth of Nuremberg has dominated understandings of the evolution of international criminal law. This paradigm has developed a narrative of post-war liberal progress, in which a universal model of externally-delivered, individualised criminal justice was interrupted by the Cold War then rediscovered through various international tribunals in the 1990s, culminating in the International Criminal Court in 2002. The essay introduces alternative practices challenging the Nuremberg myth and the accountability model it propagates. The dossier's essays question the supposed 40-year hibernation of international criminal law after Nuremberg and demonstrate how ideas of criminalisation draw on numerous shifting post-war ideologies.

Developing Sex: From Recremental Semen to Developmental Endocrinology.

During the 1890s, animal development became associated with glandular activity, with profound implications for pediatric nosology and treatment. The significance of this endocrinological turn of developmental physiology and pathophysiology in part hinges on an often-overlooked continuity with ubiquitous early modern medical thought concerning semen as a recrementitious (reabsorbed) nutrient or stimulant. Mid-19th-century interests in adult sexual physiology were increasingly nerve-centered and antihumoral. Scattered empirical, particularly veterinarian, interests in gonadal developmental functions failed to moderate these explanatory trends. While Brown-Séquard's rejuvenation experiments still offered no clear starting point for a developmental endocrinology, in 1892 Gaston Variot and Paul Bezançon more explicitly deduced a testicular developmental endocrinological function from various observations on testicular ectopy and a local form of animal "demi-castration." Ensuing interest in thethyroid, thethymus and in thetesticles led to various working conceptions of their respective and putatively reciprocal developmental properties, including the idea of a thyroid-testis axis. From 1896, the pubertal affliction of chlorosis became the subject of multiple opotherapeutic approaches, providing an experimental basis for theories of ovarian internal secretion. Polyglandular therapy, piloted for divergent developmental conditions, remained routine until the 1930s despite the biological inefficacy of many endocrine products.

Management of Vaipadika (Palmo Plantar Psoriasis) through Shodhana and Shamana- A Case Study

A localized form of Psoriasis known as Palmo plantar psoriasis is characterized by the development of thick, scaly and hyperkeratotic plaques. Despite the fact that this disease mostly affects the palms and soles, the hardness of the skin makes it difficult to do daily tasks. This condition is related to Vaipadika in Ayurveda. In the framework of Kshudra kusta, Vaipidika is explained. This illness is mostly caused by the Vatakapha dosha, which is identified by Pani pada sphuthana and Teerva vedhana. Here is a case of a 55 years old female with history of dryness ,scaling and cracks over her bilateral palms and soles associated with pain , blackish discoloration and severe itching and burning sensation, associated with bloody discharge since 1 year .Patient was treated with Snehana and Swedana and later Shamana oushadi were given for 7 days along with life style modification. Patient had good relief in symptoms.

Transformation of the Geological Environment under the Influence of Liquid Radioactive Waste (Russian Experience in Studying Historical Nuclear Disposal)

Due to various historical events, in the Russian Federation, in addition to the radioactive waste storage facilities used in world practice, there are various nuclear and radiation hazardous facilities that require special procedures for monitoring and decommissioning. One of these facilities is the disposal site for LRW on the territory of the JSC Siberian Chemical Plant, where specially prepared waste is injected into sand reservoirs lying at depths of 300–350 m between clayey strata. This study examines in detail the features of the lithological and mineral composition of reservoir sands and aquitards. The processes of environmental transformation in reservoir sands, which lead to changes in the composition and structure of rocks, were characterized. These processes manifest themselves in the form of the development of leaching zones and their “healing” with newly formed smectite, the destruction of terrigenous grains, including the development of cracks, and the growth of newly formed smectite in the pore space of reservoirs. The forms of occurrence and localization of authigenic smectite formed as a result of technogenic impact are described. It has been shown that, despite the obvious impact of highly reactive solutions accompanying liquid radioactive waste, the insulating properties of the geological environment are maintained and even improved to some extent.

Autoimmune pancreatitis: Cornerstones and future perspectives.

Autoimmune pancreatitis (AIP) is an autoimmune subtype of chronic pancreatitis resulting from the aberrant immune response against the pancreas, leading to inflammation and fibrosis. Although AIP is rare, its incidence is increasing and is often misdiagnosed as other pancreatic diseases. AIP is commonly classified into two types. Type 1 AIP (AIP-1) is typically associated with elevated serum immunoglobulin G4 (IgG4) levels and systemic manifestations, while type 2 AIP is typically a more localized form of the disease, and may coexist with other autoimmune disorders, especially inflammatory bowel diseases. Additionally, there is emerging recognition of a third type (type 3 AIP), which refers to immunotherapy-triggered AIP, although this classification is still gaining acceptance in medical literature. The clinical manifestations of AIP mainly include painless jaundice and weight loss. Elevated serum IgG4 levels are particularly characteristic of AIP-1. Diagnosis relies on a combination of clinical, laboratory, radiological, and histological findings, given the similarity of AIP symptoms to other pancreatic disorders. The mainstay of treatment for AIP is steroid therapy, which is effective in most cases. Severe cases might require additional imm-unosuppressive agents. This review aims to summarize the current knowledge of AIP, encompassing its epidemiology, etiology, clinical presentation, diagnosis, and treatment options. We also address the challenges and controversies in diagnosing and treating AIP, such as distinguishing it from pancreatic cancer and managing long-term treatment, highlighting the need for increased awareness and knowledge of this complex disease.