Clioquinol Research Articles

Hydrogenation of graphene on Ni(111) by H2 under near ambient pressure conditions

Graphene hydrogenation on Ni(111) in the mbar region has been investigated by combining Near Ambient Pressure X-ray Photoemission Spectroscopy and Density Functional Theory calculations. A complete and nearly perfect graphene single layer and an incomplete defective monolayer were exposed to a methanation mixture (H2 + CO and H2 + CO2, respectively) with a large excess of H2. The observed behavior is quite different for the two systems. In the former case, the C 1s spectrum of the initially strongly interacting graphene shows the appearance of new components corresponding to hydrogenated C atoms and their first nearest neighbors. The defective carbon layer, grown in the presence of sulfur contamination and consisting of a mixture of strongly and weakly interacting graphene with a significant amount of dissolved C, initially shows the same C species and then evolves with the formation of sp3 carbon and patches of Ni oxide/hydroxide. NiO forms by CO2 dissociation, while sp3 carbon is indicative of a rumpling of the graphene adlayer induced by hydrogenation. Both species disappear when annealing in H2. Dissociation of H2 and graphene hydrogenation is possible thanks to the presence of the Ni substrate which makes the reaction weakly exothermic and significantly reduces the barrier for H2 dissociation.

Biosynthesis of NiO nanoparticles using Senna occidentalis leaves extract: Effects of annealing temperature and antibacterial activity

In this work a cost effective and ecofriendly green method for the preparation of NiO nanostructures employing Senna occidentalis (S. occidentalis) leaves extract has been reported. XRD studies show that the 400 °C and 500 °C annealed nanostructures were authenticated as pure face centered cubic phase with an average crystallite size are about 27 nm and 15 nm, respectively. The SEM results show that both the annealed samples were nearly spherical with grain sizes ranging between 40 and 700 nm. The band gap of 400 °C and 500 °C annealed NiO nanoparticles (NPs) was estimated to be 5.28 eV and 5.40 eV, respectively from UV-visible studies while the occurrence of Ni-O stretching in the FTIR spectra validates the formation of NiO. Further this work witnesses that the NiO NPs synthesized from the green route offer better antibacterial activity. The observed maximum zone of inhibition of 500 °C annealed NiO NPs was found to be 20 mm and 19 mm for Serratia marcescens and Bacillus cereus strains and indicates that this material can serve as a prospective drug for biomedical application.

α-Lipoic acid: a potential regulator of copper metabolism in Alzheimer's disease.

Alzheimer's disease (AD) is characterized by classic hallmarks such as amyloid plaques and neurofibrillary tangles, however, intensive research has broadened its scope to explore additional underlying mechanisms. Notably, disruptions in metal homeostasis, particularly involving copper, have gained significant attention. In AD pathology, an imbalance is evident: there is an excess of extracellular copper alongside a deficiency in intracellular copper in brain tissue. Our previous work demonstrated that α-lipoic acid (LA) can effectively shift copper from the extracellular space to the intracellular environment in a neuronal cell model. However, the precise mechanism of action and role of LA in copper metabolism remained elusive. In this study, we compared the cellular effects of LA with those of different synthetic copper-binding ligands: diethyldithiocarbamate (DETC), clioquinol (CQ), D-penicillamine (D-PA) and elesclomol (ES). Using differentiated SH-SY5Y cell culture as a neuronal model, we found that, unlike other synthetic compounds, natural ligand LA is not toxic in the presence of extracellular copper, even at high doses. LA gradually increased intracellular copper levels over 24 h. In contrast, DETC, CQ, and ES acted as fast copper ionophores, potentially explaining their higher toxicity compared to LA. D-PA did not facilitate copper uptake into cells. We demonstrated that a slow increase of LA inside the cells is enhanced in the presence of copper. Furthermore, the ability of LA to modulate the equilibrium of extra- and intracellular copper was evident when we added copper isotope 65Cu. The ratio of copper isotopes changed rapidly, reflecting the impact of LA on the equilibrium of copper distribution without affecting the copper transport network. Our results provide compelling evidence that α-lipoic acid holds promise as a non-toxic agent capable of normalizing copper metabolism in Alzheimer's disease.

Embryotoxicity and biochemical changes of clioquinol (CQ) and their impact on zebrafish (Danio rerio): An environmental safety concern

Antibiotic residues and their conversion into toxic products have the potential to place human health at risk and ecosystem, which is precisely the continued accumulation of antibiotics in the environment has greatly alarmed humans and aquatic animals. This work sought to assess the possible impacts of clioquinol (CQ) on hepatotoxicity, teratogenicity, and biochemical alterations in zebrafish adults and embryos. The study examined the acute toxicity of CQ treatment to zebrafish embryos, adults, and 96-hour post fertilisation (hpf), in addition to the teratogenicity of CQ to embryonic and sac-fry stages. The lethal toxicity indicates that the 96 h LC50 values of CQ treated with 48, 72, and 96- hpf larvae; adult fish were 4.78, 3.75, 2.69; 10.86, 8.75, and 6.55 mg/L. This finding implies that zebrafish were more susceptible to CQ in their early life stages than in their adult stages, which is in accordance with in silico analyses using ECOSAR and T.E.S.T. At doses of 5 mg/L or higher, CQ would suppress zebrafish embryonic motility, heart rate, hatching rate, and body length of surviving larvae. Furthermore, to pericardial oedema, CQ also resulted in morphological abnormalities, including tail, spine, and yolk sac oedema. Histopathological alterations were noted in the kidney, intestines, gills, liver, and brain. Glutathione-S-transferase, catalase, and superoxide dismutase levels in the adult zebrafish decreased in a dose-dependent manner following 96 h of treatment. In addition, the adult zebrafish exposed to CQ had significantly downregulated levels of SOD, growth hormone 1, and TNF-α in the liver and blood. The findings provided the foundation for further research into the mechanism behind CQ toxicity in zebrafish, as they demonstrated that CQ had notable detrimental effects on zebrafish at different life stages.

Ashfall characteristics and development of the ash monitoring network during three decades of the long-lived eruption of Popocatépetl Volcano, México

A long-lived eruption of Popocatépetl volcano in central México has produced almost continuous ash fall on the populated areas for 30 years. The eruptive phase that began in 1994, has been characterized since 1996 by the growth of about 90 subsequent crater domes and their destruction that has produced most of the ongoing ash emissions. Since the beginning of the ash emission in 1994, we designed, established, and maintained an ash-sampling network of more than 200 sites around the volcano. This sampling network has been improved over the years and there are currently also 19 automated samplers, that we describe in this manuscript. This ash sampling network is part of the Popocatépetl monitoring system run by Universidad Nacional Autónoma de México (UNAM). The sampling sites that are distributed over an area of ∼8000 km2 where ash fall occurs, involve collection of ash over 0.4 cm2 and 1 m2 areas during ash emission events associated with plumes over 1 km high. Community participation has greatly enhanced both, ash sample collection efficiency and public awareness.Growth and destruction of lava domes are variable over time, with growth times that could last up to weeks and residence times ranging from days to months, producing frequent ash emissions. There have been about 1225 ash emissions >1 km high, of these, 110 have been identified with ash columns from 3 to 13 km high above the crater (8.5–18.5 km asl), some of which has produced abundant ash fall in nearby populations. Ashfall has been distributed in all directions around the volcano up to 2 50 km from the crater but dominantly in the east and northeast direction. The total minimum volume of non-compacted ash emitted over these three decades is >149 × 106 m3 while the estimated total volume of lava emitted in the form of domes is >70 × 106 m3.The average ash mass load is 32 g/m2 and the ash is commonly deposited <30 km from the crater and up to 250 g/m2 have been deposited in periods of intense activity. Ash grainsizes range from coarse to extremely fine (MdPhi 1–6) with up to 37% of particles smaller than 10 μm and up to 10% smaller than 2.5 μm. Medium lapilli (MdPhi −3) was ejected during a sub Plinian event in 2001.Ash emission is common in both dome growth and destruction phases, as well as in the clearing of the conduits during explosive phases in the absence of domes. Vitreous lithic fragments are produced by fragmentation of the degassed lava domes in the vent. Higher amounts of vesicular clasts, individual glass particles and crystals, on the other hand, are associated with magma ascent into a more open vent. The higher percentage of accidental lithic particles is linked to clearing of the vent.

Exploring enhanced syngas production via the catalytic performance of metal‐doped X‐Ni/CeO2 (X = Zr, La, Sr) in the dry reforming of methane

AbstractBackgroundThe quest to manufacture large amounts of syngas to bridge fossil fuels and the renewable energy ecosystem stimulates the creation of efficient and stable heterogeneous catalysts. The NiCeO2 catalysts, synthesized via ultrasonic‐assisted citric acid complexation, are highly efficient for the dry reforming of methane (DRM) reaction. Different promoter metals (Zr, La and Sr) were tested for catalytic performance and syngas production. A range of analyses, including X‐ray diffraction (XRD), N2 physisorption, H2 temperature‐programmed reduction, CO2 temperature‐programmed desorption, field emission scanning electron microscopy (FESEM), transmission electron microscopy and X‐ray photoelectron spectroscopy, were employed to characterize the physicochemical properties of the catalysts.ResultsXRD results indicated the formation of NiO, CeO2, solid solution ceria–zirconia, perovskite LaNiO3 and SrNiO3 crystalline phases. FESEM results showed the promoted catalysts (Zr, La, Sr) produce large pores to facilitate reactant diffusion, with zirconia specifically creating a spiderweb morphology. At 800 °C, the CH4 and CO2 conversions follow the sequence of NiCeO2 catalyst (CH4 = 54%, CO2 = 45%) &lt; Sr/NiCeO2 (CH4 = 60%, CO2 = 67%) &lt; La/NiCeO2 (CH4 = 85%, CO2 = 84%) &lt; Zr/NiCeO2 (CH4 = 95%, CO2 = 87%). The integration of promoters in DRM catalysts has notably improved carbon formation resistance, as evidenced by the following ranking: Zr/NiCeO2 (5.1 wt%) &lt; commercial catalyst (6.0 wt%) &lt; La/NiCeO2 (7.85 wt%) &lt; Sr/NiCeO2 (10.9 wt%) &lt; NiCeO2 (11.3 wt%).ConclusionThis study demonstrates that incorporating promoters, particularly Zr, in NiCeO2 significantly enhances resistance to carbon formation. It offers valuable insights into selecting metal catalyst promoters for excellent catalytic performance in DRM. © 2024 Society of Chemical Industry (SCI).

Quantitative analysis of mixed lipid nanostructures in rat skin by HPLC-MS

Abstract Liquid chromatography-mass spectrometry (LC-MS) is a very sensitive technique for determining small concentrations of drugs in fixed dose combinations or even those deposited in skin layers. Therefore, an LC-MS method was applied for determining the drugs under investigation, namely, clioquinol (CLIO), tolnaftate (TOL), and betamethasone (BETA) in Quadriderm® cream and mixed lipid nanostructures (MLNs) prepared in laboratory in the presence of potential interferents, and was applied as a dermato-kinetic study in rat’s skin. The separation was achieved within 4.5 min by using C18 column as a stationary phase and the mobile phase used were 20% phase A composed of 0.1% formic acid (v/v) and 80% phase B composed of 0.1% formic acid in acetonitrile (v/v), coupled with triple quadrupole mass spectrometer. MLNs were prepared and characterized to be compared with the conventional commercially available Quadriderm® cream. The proposed method was accurate and precise with a linearity range of 0.2–20.0 µg·mL−1 for BETA, and 0.5–400.0 µg·mL−1 for CLIO and TOL and a better bioavailability of the new formulation was obtained ensuring the capability of the nanoparticles to accumulate the drugs within the skin layers. In conclusion, the LC-MS method was accurate and precise for the determination of the three drugs under investigation in cream dosage form and skin tissues.

New applications of Clioquinol in the treatment of inflammation disease by directly targeting arginine 335 of NLRP3

The NOD-like receptor protein 3 (NLRP3) inflammasome is essential in innate immune-mediated inflammation, with its overactivation implicated in various autoinflammatory, metabolic, and neurodegenerative diseases. Pharmacological inhibition of NLRP3 offers a promising treatment strategy for inflammatory conditions, although no medications targeting the NLRP3 inflammasome are currently available. This study demonstrates that clioquinol (CQ), a clinical drug with chelating properties, effectively inhibits NLRP3 activation, resulting in reduced cytokine secretion and cell pyroptosis in both human and mouse macrophages, with a half maximal inhibitory concentration (IC50) of 0.478 μM. Additionally, CQ mitigates experimental acute peritonitis, gouty arthritis, sepsis, and colitis by lowering serum levels of interleukin-1β (IL-1β), IL-6, and tumour necrosis factor-α (TNF-α). Mechanistically, CQ covalently binds to Arginine 335 (R335) in the NACHT domain, inhibiting NLRP3 inflammasome assembly and blocking the interaction between NLRP3 and its component protein. Collectively, this study identifies CQ as an effective natural NLRP3 inhibitor and a potential therapeutic agent for NLRP3-driven diseases.

In situ constructed Bi5O7I/NiO-NF heterojunction on 3D nickel foam for photocatalytic sulfamerazine degradation: Structure-performance, application, and mechanism

Photocatalysis is a promising technology for water purification, but the inadequate separation of photogenerated charge carriers and light utilization efficiency limits its practical application. Herein, a highly solar-responds photocatalyst Bi5O7I/preoxidized nickel foam (Bi5O7I/NiO-NF) with p-n heterojunction was constructed by impregnation and microwave-assisted co-precipitation method to remove typical antibiotic efficiently. The special pretreatment is conducive to the formation of NiO on the NF surface, which participates in the construction of p-n heterogeneous structures and strengthens the bonding force between NiO-NF and surface Bi5O7I. The macroscopic renewable Bi5O7I/NiO-NF could effectively degrade sulfamerazine (SMR) nearly 100 % under sunlight irradiation and be convenient for separating from aqueous. Variety pollutants are degraded with high efficiency in the solar Bi5O7I/NiO-NF system, and the system performs the resistance to co-existing ions (≥89 % removal efficiency) and water matrix interference (≥95 % removal efficiency). Quenching experiments and electron paramagnetic resonance spectroscopy characterization results indicate that h+, 1O2 and O2− are the dominant reactive substances in SMR elimination. Based on the DFT calculation and quadrupole-time of flight-liquid chromatography/mass spectrometry (Q-TOF-LC/MS) detection, C-S and N-S bonds tend to be attacked in the SMR degradation pathway. This work opens up novel insights for constructing efficient macroscopic photocatalysts for practical water treatment.

Hierarchical core-shell Ce-doped NiO@MoO2 architecture with Ni 3d-band center modulation for enhanced high-current-density oxygen evolution

Ce-doped NiO catalyst supported on MoO₂ nanorods (Ce-NiO@MoO₂) was constructed as a high-performance oxygen evolution reaction (OER) electrocatalyst. The introduction of Ce induced the formation of nanoflower-like NiO on the MoO₂ nanorod substrate. Ce doping not only created numerous unsaturated Ni coordination sites with higher oxidation states, serving as active sites, but also strengthened the adsorption of oxygen intermediates by upshifting the Ni 3d band center, thereby reducing the energy barrier of the rate-determining OH* → O* step. Consequently, the Ce-NiO@MoO₂ catalyst exhibited remarkable OER activity, with a low overpotential of 313 mV and outstanding 200-hour stability at 1000 mA cm⁻², which is attributed to unsaturated Ni active sites and promoted charge and mass transfer facilitated by the unique hierarchical structure. These findings highlight the crucial role of Ce doping in improving electrocatalytic performance and offer insights into developing efficient and cost-effective catalysts for large-scale hydrogen production via water electrolysis.

On Volganism and Tectonics in the Evolution of the Guyots of the Magellan Seamounts (Pacific Ocean)

This report is devoted to the analysis of original geological materials on the Magellan Seamounts in the Pacific Ocean, obtained by the authors in numerous voyages of R/V ʺGelendzhikʺ. This chain of guyouts does not have a common volcanic basement and apparently was formed in the second half of the Early Cretaceous on the oldest (middle-last Jurassic) fragment of the Pacific plate. The main points of view on the genesis of the Magellan Mountains are as follows: either they originated at the crossing of the transform fractures, or the Pacific plate moved them from the southern hemisphere to their present-day position. Because of their high degree of study, the Magellan Seamounts are one of the key sites for understanding the mechanism of the origin of linear chains in the ocean. A comprehensive analysis of new geological on the Magellan Seamounts has established the important role of magmatism and tectonics in the formation of the modern morphological shapes, sedimentation and influence on the paleooceangraphy. The periodic renewal of these processes from the Early Cretaceous to Late Cenozoic can be traced in the cyclicity of sedimentation, the permanent growth of ore crusts and the formation of secondary volcanic domes and cones.

Study of nickel doping induced optical band gap modulation in ZnO nanorods

Nickel doping into ZnO induces morphological change, causes enhancement in the defect states, and leads to better exploitation of visible photons. Nickel ions have a solubility limit of 3% in ZnO, as beyond that, the formation of NiO causes a change of nickel coordination from tetrahedral to octahedral. This changes the hybridization of VB and CB of ZnO, resulting in modulation of the band gap. Raman studies indicate an increase in defect states of ZnO, whereas the PL spectra depict a decrease in its emission due to the trapping of charge carriers by the defect states.

Gravity Investigations Applied to the Geological Framework Study of the Mambasa Territory in Democratic Republic of Congo

This study concerns the gravity survey carried out in the territory of Mambasa in the province of Ituri in DR Congo, with the aim of studying its subsurface framework. We applied Free-Air and Bouguer corrections to the gravity measurements in order to eliminate gravity variations of non-geological origin. As for the graphical representation of the results, the spatial interpolation tools were useful to us in the elaboration of Bouguer anomaly maps. Then, we classified the study zone into Bouguer anomaly zones based on intensity. Gravity highs could indicate basement uplifts due to compressional movements. These uplifts would have led to the formation of granite domes which could be associated with mineralization. The enormous gravity depression would, for its part, be synonymous with a ditch or the presence of very low-density geological formations. The gravity profiles drawn support the analyzes of the maps: the anomaly curves are very fluctuating and uneven, highlighting several gravity highs and depressions. These fluctuations are probably induced by the presence of faults which separate the different anomaly zones.

Water entry of a sphere moving along a circular path at a constant speed

When a marine propeller rotates in partially submerged conditions, air is entrained from above the undisturbed free-surface, which is called the reference surface, and the ventilated air surrounds the propeller blades, causing thrust loss and excessive vibration, all of which seriously damage the durability of the propeller shaft system of a ship. In the present study, the entry of a propeller blade is simplified by the water entry problem of a sphere moving along a circular path at a constant speed. A high-speed camera was employed to capture the rapidly changing flow structures in detail. Above the reference surface, we focused on the free-surface disturbances, including splash and dome formation. Beneath the reference surface, the development and collapse of ventilated cavities, followed by the line-vortex cavity and cavity undulation, were observed. The ventilated cavity of the present study appears to be more elongated than those of the free-falling sphere's water entry experiments. Two parallel vortical structures appeared after the cavity pinch-off, and bubbles were entrained into these structures to form the line-vortex cavity. The sphere's drag was directly measured via the torque meter attached to the sphere's rotating axis. The relation between the measured drag and the flow around the sphere was identified.

Feasibility of sustainable reusability of Ni/char catalyst for synthetic gas production via catalytic steam gasification

Ni/char catalyst is one of the most promising catalysts for enhancing gas production, particularly syngas from catalytic steam gasification of biomass. In the current study, one unmodified (Ni/MMchar) and two modified catalysts (Ni/NaMMchar and Ni/NaAceMMchar) were utilized to investigate the reusability potential of Ni/char catalyst for catalytic steam gasification of bamboo in a two-stage fixed-bed reactor including the changes in catalyst characteristics. N2 adsorption-desorption by BET, scanning electron microscope connected with energy-dispersive X-ray spectrometer (SEM-EDS), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analyses were utilized for examining their characteristics. The findings indicated that the three catalysts could maintain the reusability potential in catalytic steam gasification of bamboo for twice cycles. The syngas reduction percentages in the second cycles of the catalysts ranged between 11.0 and 22.8 %. H2/CO ratios of all spent catalysts lined in the range of 4.10 − 2.45. The low heating values of syngas products were in the range of 8.83–8.19 MJ/Nm3. Considering the catalyst characteristics, the increasing cycles of catalyst operations induced carbon deposition, resulting in the reduction of specific surface areas. SEM-EDS images of the used catalysts appeared the coke layer and the Ni metal sintering on the surfaces. The uses of catalysts encouraged the transformation of Ni metal active site into NiO, Ni2O3 and Ni3C forms. These phenomena were the major causes of catalyst deactivation. The changes in the characteristics and catalyst activity controlled the gasification reactions, resulting in the catalyst deactivation and gaseous products.

Electron beam irradiation-induced atomically thin domes of two-dimensional materials: Graphene and MoS[formula omitted]

The local strain-induced indirect-to-direct band gap transition in bulk transition metal dichalcogenides (TMDCs) holds great potential for optoelectronic applications. The formation of domes on the topmost layer of a multilayered flake through hydrogen ion H+ irradiation is an effective technique for tuning the band gap locally via molecular hydrogen (H2) confinement. In this work, we present an alternative robust, simpler, and faster technique for concurrently forming and visualizing dome-like structures of two-dimensional (2D) materials through low-energy electron beam irradiation. We investigated the growth mechanism and dynamics of the domes under exposure to electron beams at different energy levels. The simultaneous production and imaging of atomically thin domes of 2D materials has several practical and fundamental applications, such as mass storage and transport, single photon emission, nano/micro-electromechanical sensors, strain engineering, etc.

Simple processing via thermal treatment and catalyst infiltration to enhance nickel electrode performance for liquid alkaline water electrolyzers

Two simple processes for enhancing liquid alkaline water electrolyzer performance are demonstrated. Both enhance 3D Ni electrodes by introducing a micron-scale rough structure throughout the bulk of the electrode. Oxidation/reduction relies on a simple thermal treatment cycle to create surface roughening through the volumetric expansion during NiO formation and volume contraction during reduction back to Ni metal. Catalyst infiltration introduces a washcoat of additional metal particles throughout the electrode, by flooding the electrode with catalyst precursor and converting it to micron-scale particles via a reducing thermal treatment. The largest improvement in performance (211 mV at 1.8 A cm−2) is observed for infiltrated NiFe-3x catalyst. For Fe-free Ni-only electrodes, oxidation/reduction provides a larger improvement (157 mV at 1.8 A cm−2) than infiltrated Ni-3X (106 mV at 1.8 A cm−2). For both processes, the observed electrode surface structure and performance is quite sensitive to the thermal treatment temperature.

Transition of dome formation to sudden explosive eruptions at Popocatépetl, Mexico: magnetic indicators

Transitions from effusive to explosive activity can increase hazards making it crucial to define early indicators such as changes in the magnetic signals. After more than 80 cycles of crater-dome extrusion and destruction from 1996 on, Popocatépetl volcano (Mexico) experienced changes in its behavior from March 15 to 18 July 2019, when no lava domes were observed. Some of the domes behaved as contained lava flows within the crater floor (pancakes) while others were more irregular-shaped. Activity decreased considerably over this 2019 interval except for the unexpected explosions in March and June, that produced ash plumes reaching up to 14,000 m a.s.l. In order to investigate the causes of the transition from effusive to explosive behavior in March and June, we analyzed the time series from the magnetic monitoring network at Popocatépetl volcano between October 2018 and December 2019. The raw signals were analyzed by weighted differences (WD) based on the elimination of non-local changes from the total intensity values of the geomagnetic field and the discrete-time continuous wavelet transform was used to evaluate the local variations of energy within the time series. The high energy periods (linked to negative magnetic anomalies) are induced by magma ascent associated with movement within the conduit. They indicate that the sudden explosions were due to the ascent of several magma batches that were slowed during ascent and were not able to reach the surface. Changes in the rheology of the lava are linked to the influx of several batches of magma with different compositions as well as to compaction by gas loss when ascending andesitic magma pushed out overlying more viscous degassed magma clearing the conduit, which can explain why these sudden explosions were more energetic. Several geophysical data sets as well as tephra compositions were integrated to support this conclusion. The correlated multiparameters also confirm that geomagnetic volcano monitoring has been essential in understanding the processes that drive the observed changes in eruptive behavior. We present new evidence for the detection of transient events produced by magma ascent and changes in the feeding system of Popocatépetl volcano with wavelet analysis. Detailed vulcanomagnetic processing, especially when it is correlated with other monitoring parameters, provides information on ascending magma and several conduit processes that would otherwise be camouflaged. Ascending batches may precede an eruption but they can also ascend in several pulses indicating how dome growth occurs.

Flexible Substrate-Compatible and Efficiency-Improved Quantum-Dot Light-Emitting Diodes with Reduced Annealing Temperature of NiOx Hole-Injecting Layer

The growing demand for wearable and attachable displays has sparked significant interest in flexible quantum-dot light-emitting diodes (QLEDs). However, the challenges of fabricating and operating QLEDs on flexible substrates persist due to the lack of stable and low-temperature processable charge-injection/-transporting layers with aligned energy levels. In this study, we utilized NiOx nanoparticles that are compatible with flexible substrates as a hole-injection layer (HIL). To enhance the work function of the NiOx HIL, we introduced a self-assembled dipole modifier called 4-(trifluoromethyl)benzoic acid (4–CF3–BA) onto the surface of the NiOx nanoparticles. The incorporation of the dipole molecules through adsorption treatment has significantly changed the wettability and electronic characteristics of NiOx nanoparticles, resulting in the formation of NiO(OH) at the interface and a shift in vacuum level. The alteration of surface electronic states of the NiOx nanoparticles not only improves the carrier balance by reducing the hole injection barrier but also prevents exciton quenching by passivating defects in the film. Consequently, the NiOx-based red QLEDs with interfacial modification demonstrate a maximum current efficiency of 16.1 cd/A and a peak external quantum efficiency of 10.3%. This represents a nearly twofold efficiency enhancement compared to control devices. The mild fabrication requirements and low annealing temperatures suggest potential applications of dipole molecule-modified NiOx nanoparticles in flexible optoelectronic devices.

Clioquinol rescues yeast cells from Aβ42 toxicity via the inhibition of oxidative damage.

Alzheimer's disease (AD), the most common form of dementia, has gotten considerable attention. Previous studies have demonstrated that clioquinol (CQ) as a metal chelator is a potential drug for the treatment of AD. However, the mode of action of CQ in AD is still unclear. In our study, the antioxidant effects of CQ on yeast cells expressing Aβ42 were investigated. We found that CQ could reduce Aβ42 toxicity by alleviating reactive oxygen species (ROS) generation and lipid peroxidation level in yeast cells. These alterations were mainly attributable to the increased reduced glutathione (GSH) content and independent of activities of superoxide dismutase (SOD) and/or catalase (CAT). CQ could affect antioxidant enzyme activity by altering the transcription level of related genes. Interestingly, it was noted for the first time that CQ could combine with antioxidant enzymes to reduce their enzymatic activities by molecular docking and circular dichroism spectroscopy. In addition, CQ restored Aβ42-mediated disruption of GSH homeostasis via regulating YAP1 expression to protect cells against oxidative stress. Our findings not only improve the current understanding of the mechanism of CQ as a potential drug for AD treatment but also provide ideas for subsequent drug research and development.