This article assesses the foreign policy roles of Nigeria and South Africa, given their status as regional powers, and the regional complexes within which they operate. Drawing references from a plethora of policies and speeches of the Presidents of the two States, this article argues that CFP, given its emphasis on foreign policy decision-making processes related to momentous events as well as its implication in day-to-day events, is useful as a theoretical framework in this assessment. Nigeria and South Africa are both active state actors in the international system. Unarguably, Nigeria and South Africa are two important nations in the continent of Africa whose foreign policy actions and inactions are crucial to the desire development of their areas of regional and global influence, particularly for the African continent. Methodologically, it employs the use of comparative analysis relying solely on secondary information for data generation and analysis of the direction of the foreign policy of Nigeria and South Africa. The article contributes to the literature by illustrating the potential impact and regional implications of foreign policy analysis as an approach to international relations (IR), within which the behavior of these two African States can be analyzed in the wake of new members into BRICS, African Union (AU) been made a permanent member of the G20, giving the continent an important voice on key global issues. Noting that the dynamic evolving role of South Africa and Nigeria in the global arena, should be expected to increase positioning Africa in decision making process of both regional and world politics; regional and global peace and security, such as in Ukraine crisis and reform within the United Nations security Council. Both countries need to unite their efforts and practical strategies to advance the common goal of Africa development, peace and security.