Drug residues are unregulated pollutants and are frequently found in the aquatic environment. Due to their extensive use, presence in the aquatic environment and their potential for impacts on wildlife and humans, it is becoming an important environmental issue. The present study evaluates the photo-assisted electrochemical treatment of sulfamethoxazole (SMX), an antibiotic used in the prevention and treatment of human and animal diseases. The experiments were carried out in a photo illuminated flow cell reactor and the effects of current density and concentration of sodium chloride in the supporting electrolyte were determined. The Drug could be removed completely at all current densities while TOC abatement was appreciable during the process. The process followed pseudo-first order kinetics and values of electrical energy-per-order were dependent on current density and sodium chloride concentration. Different reaction intermediates were separated and identified by liquid chromatography coupled with mass spectrometry (LC-MS), thereby providing an insight into the mechanistic details of the degradation pathway. The photo-assisted electrochemical degradation proceeded through competitive reactions such as chlorination, hydroxylation and substitution on the aromatic ring, while further ring opening gave rise to more simple organic compounds and, ultimately, the mineralization of SMX. The possible degradation route were also proposed and discussed. Figure 1