European and local practices of digitization and their impact on employment relations, determination of current directions of digitalization development in Ukraine and implementation of the best world solutions are studied. It is pointed out that COVID-19 pandemic has radically changed the role and perception of digitalization in society and the economy. It is noted that digital technologies are now necessary for work, study, entertainment, communication, shopping and access to everything from health services to culture. The digital transformation has opened up new opportunities for the creation of new enterprises, the emergence of new forms of digital employment. It is noted that in early 2018 Ukraine officially embarked on the path of digitalization and policy making in the digital segment. The Concept of Digital Economy of Ukraine and Social Development for 2018–2020 has been adopted, which contains the main goals and principles of digital development in the country, as well as plans for their implementation. As a result of digitalization, modern technology makes it to perform job functions outside the workplace, not only at home (home office), but anywhere (mobile office) in many areas of the economy. Due to the possibility of remote earning, on June 25, 2019, the Ministry of Social Policy published the bill «On amendments to the Labor Code of Ukraine (concerning flexible forms of labor organization)». It is proposed, in Art. 24 of the Labor Code in particular, to clarify that the compliance with the written form is mandatory when signing an employment agreement for remote work. The indicators of the Digital Economy and Society Index (DESI), which demonstrates the level of digital efficiency of Europe and monitors the progress of the European Union in this direction are summarized. In order to implement the influence of digitalization on employment relations in Ukraine, the experience of a number of European countries (Spain, France, Germany and the Scandinavian countries) is studied and analyzed. It is concluded that the influence of modern digital technologies significantly changes the state of the labor market, the demand for certain specialists, and the conditions of remote employment. The wages and social security are transformed and become individualized. Employees' dependence on employers is decreasing, their work is shifting into the digital space, which requires constant acquiring of new knowledge and skills in working with modern technologies.