Five-coordinate Tin Research Articles

3,6-Di-tert-Butyl-2-Hydroxy-4-Pyridinylphenolate and Tin(IV) Complexes it Forms: Synthesis and Structure Details and Solvatochromic Effect

Two synthetic approaches were developed for the preparation of 3,6-di-tert-butyl-2-hydroxy-4-pyridinylphenolate (LH), a new zwitter-ionic redox-active diolate type ligand. Two heteroligand five-coordinate tin(IV) derivatives were prepared with this ligand: 3,6-di-tert-butyl-2-oxy-4-pyridinylphenolato(triphenyl)tin(IV) (I) and 3,6-di-tert-butyl-2-oxy-4-pyridinylphenolato(diphenyl)chlorotin(IV) (II). The molecular structures of the ligand LH ∙ 0.5Py and complex I ∙ CH3CN were determined by X-ray diffraction (CIF files CCDC nos. 1974166 (LH), 1974165 (I)). It was shown that the ligand LH and the tin(IV) compound exhibit solvatochromism, which consists in a considerable blue shift with increasing solvent polarity.

Synthesis and structural characterization of diorganotin(IV) complexes with heteroditopic pyridyl-ONO′-ligands

A series of eight novel diorganotin(IV) complexes with heteroditopic pyridyl-ONO′-ligands were prepared viz., [Me2Sn(L1)]2⋅2(H2O) (1), [n-Bu2Sn(L1)]2 (2), [Ph2Sn(L1)] (3), [Me2Sn(L2)]2⋅2(H2L2) (4), [n-Bu2Sn(L2)]2 (5), [Ph2Sn(L2)]⋅0.5(C6H6) (6), [Me2Sn(L3)]2 (7) and [n-Bu2Sn(L3)]2 (8) and structurally characterized. Irrespective of the type of diazo L ligand, the dimethyl- and di-n-butyltin(IV) compounds are dinuclear species with an inversion center in the middle of the {Sn2O2} cores affording metals with coordination number six. The mononuclear compounds 3 and 6, with the bulky phenyl ligands, present the tin cations with highly distorted square pyramid geometries. The detection of a conformation in the (Ln)2- ligand in the solid state structures of 3, 4 and 8 which is different from the one in the remaining compounds suggests that the packing of the molecules conceivably have a greater influence than the imine substituents or the metal co-ligands. The solution 1H and 13C NMR of compounds 4–6 displayed an anisochronous behavior of dimethyl-, di-n-butyl- and diphenyltin parts while those of compounds 1–3 are isochronous. The 119Sn NMR chemical shift displacements of all the compounds are indicative of five-coordinate tin atoms, thus revealing dissociation in solution of the dinuclear 1, 2, 4, 5, 7 and 8 complexes.

Synthesis, spectroscopic characterization, crystal structure, and anti-bacterial activity of diorganotin(IV) complexes with 5-bromo-2-hydroxybenzaldehyde-N(4)-ethylthiosemicarbazone

Three new diorganotin(IV) complexes, [Me2Sn(BDET] (2), [Bu2Sn(BDET)] (3), and [Ph2Sn(BDET)] (4), were synthesized by reacting R2SnCl2 (R = Me, Bu, and Ph) with 5-bromo-2-hydroxybenzaldehyde-N(4)-ethylthiosemicarbazone [H2BDET, (1)] in the presence of KOH in absolute methanol. The newly synthesized complexes were characterized by elemental analysis, molar conductivity, UV–vis, FT-IR, 1H, 13C, and 119Sn NMR spectroscopies. The molecular structure of 4 was confirmed by X-ray crystallography. X-ray crystallography revealed that the doubly deprotonated O,N,S-tridentate thiosemicarbazone coordinates to tin(IV), resulting in a distorted trigonal bipyramidal geometry. Their 1H, 13C, and 119Sn NMR spectra support a five-coordinate tin(IV) in solution for all complexes, in accord with the solid-state X-ray structure determined for 4. Compounds 1–4 were evaluated for their antibacterial activities against Staphylococcus aureus, Enterobacter aerogenes, Escherichia coli, and Salmonella typhi. The results exhibited that 2–4 were active with comparable potency compared to the standard drug. Antibacterial studies also indicated that the complexes have potential for biological evaluation.

New diorganotin(IV) complexes of salicylaldehyde based hydrazones bearing furan heterocycle moiety: X-ray structural investigation of dimethyltin(IV) and diphenyltin(IV) complexes

Some new diorganotin(IV) derivatives formulated as R2SnL (where R = Me, Bu, Ph and Oct) were obtained upon treatment of diorganotin(IV) precursors with acylhydrazones [H2La = N'-(2-hydroxy-3-methoxybenzylidene)furan-2-carbohydrazide, H2Lb = N'-(5-chloro-2-hydroxybenzylidene)furan-2-carbohydrazide and H2Lc = N'-(2-hydroxy-5-nitrobenzylidene)furan-2-carbohydrazide] derived from Schiff base condensation of furan-2-carbohydrazide and substituted salicylaldehydes in methanol in appropriate molar ratio. The enolic tridentate chelating mode of the acylhydrazones towards the diorganotin moieties [R2Sn(IV)]2+ was ascertained by micro-analysis and various spectroscopic techniques viz., Fourier-transform infrared (FT-IR), multinuclear (1H, 13C and 119Sn) magnetic resonance (NMR) and electrospray ionization mass (ESMS) spectrometry. The single crystal X-ray diffraction investigation of Me2SnLb and Ph2SnLb demonstrates that they crystallize in monoclinic space groups ‘P 21’ and ‘P 21/c’ respectively, and comprised of crystallographically discrete 2 and 4 molecules in their respective unit cells. Both mononuclear complexes adopt a highly distorted square-pyramidal geometry (SP) wherein the imine nitrogen preferably occupies the apical site whereas the more electronegative enolic and phenolic oxygen atoms of the ligand and two carbon atoms of the methyl/phenyl groups of the organotin(IV) moiety align themselves equatorially around the five-coordinated tin center in a square plane. Diorganotin(IV) derivatives were also analyzed in air by thermo-gravimetric (TG, DTG and DTA) techniques to elucidate their thermal stability and decomposition trends.

Multinuclear (Sn/Pd) complexes with disodium 2,2′-(dithiocarboxyazanediyl)diacetate hydrate; Synthesis, characterization and biological activities

Bimetallic chlorodi-/triorganotin(IV) derivatives of general formulas R2(H2O)SnLCSSSn(Cl)R2 (R=Me: 1; Ph: 2) and R3Sn(Na)LCSSSnR3·H2O (R=Bu: 3; Ph: 4) were prepared by reaction of iminodiacetic acid disodium salt hydrate (Na2LH) with CS2 and R2SnCl2/R3SnCl in methanol. The reaction between Na2LH, CS2, and PdCl2 produced [Na2LCSS]2Pd·2H2O (5) which was treated with R3SnCl to synthesize the heterobimetallic derivatives [R3Sn(Na)LCSS]2Pd·2H2O (R=Me: 6; Ph: 7). The complexes were characterized by microanalysis, spectroscopic, and thermogravimetric analyses. Elemental analysis data, mass fragmentation, and thermal degradation patterns supported the molecular composition of the complexes. FT-IR data indicated monodentate binding of carboxylate while a chelating coordination mode of the dithiocarboxylate was verified in the solid state. A five-coordinate tin(IV) was demonstrated in the solid state. In solution, a tetrahedral/trigonal bipyramidal configuration around Sn(IV) and a square planar geometry of Pd(II) was indicated by multinuclear NMR (1H and 13C) and UV-visible studies. The Pd(II) derivatives showed interaction with salmon sperm-DNA and caused an inhibition of alkaline phosphatase (ALPs). The antibacterial/antifungal potential of the coordination products varied with the nature of incorporated metal and a substitution pattern at tin(IV); the palladium metallation decreased the antimicrobial activities. The triorganotin(IV) products exhibited more powerful action against bacteria/fungi as compared to their diorganotin(IV) counterparts. The complexes displayed sufficiently lower hemolytic effects in vitro as compared to triton X-100 and slightly higher than PBS.

Synthesis, characterization, crystal structures and supramolecular features of bicycloazastannoxides derived from Schiff bases with L-tyrosine

Six new bicycloazastannoxides of compositions [Me2Sn(L1H)] (1), [nBu2Sn(L1H)] (2), [Ph2Sn(L1H)] (3), [Bz2Sn(L1H)] (4), [Me2Sn(L2H)(MeOH)]·MeOH (5) and [Ph2Sn(L3H)] (6), where L1H = 2-((E)-((Z)-4-hydroxypent-3-en-2-ylidene)amino)-3-(4-hydroxyphenyl)propanoate, L2H = (E)-2-((2-hydroxybenzylidene)amino)-3-(4-hydroxyphenyl)propanoate and L3H = (E)-3-(4-hydroxyphenyl)-2-((1-(2-hydroxyphenyl)ethylidene)amino)propanoate, were synthesized and spectroscopically characterized. The 1H and 13C NMR spectra of compounds 1–6 displayed two sets of signals for Sn-R2 (R = Me, nBu, Ph and Bz) indicating a diastereotopic environment according to the asymmetric nature of the ligand. The 119Sn NMR data of the compounds in CDCl3 indicate five-coordinate tin atoms, showing that the bicycloazastannoxide assemblies remain intact as observed in the solid-state structures. The crystal structures of 1–6 revealed discrete molecular structures in all cases with distorted trigonal-bipyramidal geometries for 1–4 and 6, and a strongly distorted six-fold coordination for 5 due to association of a MeOH solvent molecule. At the supramolecular level, the molecular structures in 1–4 and 6 are linked either through double-bridged O-H⋯O/C-H⋯O synthons (1 and 6) or single O-H⋯O hydrogen bonds (2–4). The resulting 1D helical strands exhibit varying Sn⋯Sn distances due to the different molecular conformations. The molecules in 5 associate to dimers through two Sn⋯O and O-H⋯O interactions, which are further connected via O-H⋯O hydrogen bonds to give 1D strands containing 22-membered macrocycles.

Synthesis, structural, and spectral studies of diorganotin(IV) complexes with 2–hydroxy-5-methylbenzaldehyde-N(4)-cyclohexylthiosemicarbazone

Three new diorganotin(IV) complexes, [Me2Sn(L)] (2), [Bu2Sn(L)] (3), and [Ph2Sn(L)] (4) [where H2L (1) = 2-hydroxy-5-methylbenzaldehyde-N(4)-cyclohexylthiosemicarbazone] have been synthesized by reacting the corresponding diorganotin(IV) dichloride with H2L (1) in absolute methanol in the presence of potassium hydroxide. All the compounds have been characterized by CHN analyses, UV–vis, FT-IR, 1H, 13C, and 119Sn NMR spectroscopy. The molecular structures of H2L (1) and 2 have been confirmed by single crystal X-ray diffraction analysis. H2L (1) is found to be in the thiol tautomeric form. The X-ray structure of 2 showed that H2L is a tridentate ligand and binds to the tin(IV) atom via the phenolic oxygen, azomethine nitrogen, and thiolate sulfur. Complex 2 has a triclinic structure and the coordination geometry of tin(IV) is distorted trigonal bipyramidal. The sulfur and oxygen are in axial positions while the azomethine nitrogen of 1 and two methyl groups occupy the equatorial positions. The C-Sn-C angles determined from 1J(119Sn, 13C) for 2, 3, and 4 are 124.35°, 123.11°, and 123.82°, respectively. The values of δ(119Sn) for 2, 3, and 4 are −153.4, −180.59, and −158.3 ppm, respectively, indicating five-coordinate tin(IV). From NMR data a distorted trigonal-bipyramidal configuration at each tin is proposed.

Tributyltin(IV) complexes with amino acid-derived Schiff bases: X-ray and solution structures

Four novel tributyltin(IV) complexes of formulae [SnBu3(balabrsalH)] (1), [SnBu3(bphalabrsalH)] (2), [SnBu3(bababrsalH)] (3), and [SnBu3(gababrsalH)] (4), were obtained from the reaction of hexabutyldistannoxane with four amino acid-derived Schiff bases. Complexes were characterized by elemental analysis, FT-IR and NMR (1H, 13C and 119Sn) spectroscopy; complexes 1–3 were characterized by single crystal X-ray diffraction studies, revealing a five-coordinated tin(IV) atom with the three organic groups occupying the equatorial plane and two oxygen atoms in the apical positions, leading to a one-dimensional polymeric chain. Based on 119Sn NMR chemical shifts and nJ(119Sn13C) (n=1–3) coupling constants it is concluded that the solid-state structures are not maintained, in accordance with the disruption of the polymer upon dissolution.

A series of organotin(IV) complexes based on (E)-3-(3-nitrophenyl) acrylic acid: Syntheses, crystal structures and biological activities

A series of organotin carboxylates based on (E)-3-(3-nitrophenyl) acrylic acid (HL), namely {[Ph3SnL]·0.5C6H6}n (1), [(Ph3Sn)2O(L)(Ph3Sn)(L)]n (2) and [Bu2LSnOSnLBu2]2 (3), have been synthesized. All the complexes have been characterized by elemental analysis, IR, 1H NMR spectroscopy and X-ray diffraction analyses. The structural analyses show that complexes 1–2 adopt 1D polymeric chain structures generated by the bridging carboxylate ligands and the five-coordinated tin centers. The structure of complex 3 is centro-symmetric and features a central rhombus Sn2O2 unit with two additional tin atoms linked at the O atoms. In addition, the antitumor activity of complex 3 has been studied.

Assembly of triorganotin chloride with selenite ligands to macrocyclic, zigzag, helical, and linear structures: syntheses, characterizations, and crystal structures of [R3Sn(O2SeC6H4-4-Et)] n and [R3Sn(O2SeC6H4-2-Et)] n (R = Me, C6H5) complexes

Four new triorganotin(IV) complexes, [R3Sn(O2SeC6H4-4-Et)]4 (R = Me 1), [R3Sn(O2SeC6H4-4-Et)] n (R = Ph 2), [R3Sn(O2SeC6H4-2-Et)] n (R = Me 3; Ph 4) have been synthesized by the treatment of 4-ethylbenzeneseleninic acid, 2-ethylbenzeneseleninic acid, and the corresponding triorganotin(IV) chloride with sodium ethoxide in methanol. All of the complexes were characterized by elemental analysis, FT-IR, NMR (1H, 13C, and 119Sn) spectroscopy, TGA, and X-ray crystallography. Crystal structures show that all of the complexes are generated by the bidentate oxygen atoms and the five-coordinated tin centers with trigonal bipyramid geometry. The structural analyses reveal that complex 1 has a centrosymmetric tetranuclear triorganotin selenite with 16-membered macrocycle, which is formed by trimethyltin and ligand alternate linking. A series of C–H···O and π–π stacking interactions in complex 1 play an important function in the supramolecular aggregation. Complex 3 has two 1D spring-like chiral helical chains and crystallizes in the monoclinic space group P21, which is chiral. Complex 2 and 4 are both 1D infinite neutral chain polymers and complex 2 forms a 2D supramolecular framework through intermolecular C–H···O interactions.

Structures of a novel phosphoric triamide and its organotin(IV) complex

A new phosphoric triamide 4-NO2C6H4NHP(O)(NC4H8O)2 (1) and its organotin(IV) complex SnCl(C6H5)3[4-NO2C6H4NHP(O)(NC4H8O)2] (2) were synthesized and characterized by 31P, 1H, 13C NMR, IR spectroscopy and elemental analysis. The crystal structures of compounds 1 and 2 were determined by X-ray crystallography. Both compounds crystallize in monoclinic crystal system with P21/n space group. The structure of 1 contains two symmetrically independent molecules while for 2 only one independent molecule is present with a five-coordinated tin(IV) in a distorted trigonal bipyramidal configuration. Strong intermolecular N–H⋯O and N–H⋯Cl hydrogen bonds together with weak intermolecular C–H⋯O hydrogen bonds connect molecules of 1 and 2 into 3D networks. Both compounds were also prepared as nanoparticles of the size 15–20 nm and a spherical morphology, as confirmed by SEM micrographs.

Synthesis and Structural Characterization of Three New Tetraorganodistannoxanes

An efficient method was developed for the preparation of three tetraorganodistannoxane complexes, (C2H5)8Sn4Cl2(CH3O)2O2 (1), (CH3)8Sn4(C3H4N3S)2(CH3O)2O2 (2) and (C4H9)8Sn4(C3H4N3S)2(CH3O)2O2 (3). All prepared complexes were characterized by infrared, 1H, 13C and 119Sn NMR spectroscopes and elemental analysis. The molecular structure of a representative complex (1) was determined by single-crystal X-ray diffraction. Results showed that 1 is a tetranuclear, centrosymmetric dimeric, and contains two endo-cyclic five-coordinated tin atoms and two exo-cyclic five-coordinated tin atoms. Compound 1 lies about a center of inversion and the tetranuclear molecule features a three-ring-staircase Sn4O4 core. The asymmetric unit of 1 contains two independent Sn(IV) atoms and a 2D infinite rigid chain structure forms via C–H···Cl interactions between tetranuclear units.

Synthesis of [C<sub>5</sub>H<sub>5</sub>NH][Ph<sub>2</sub>Sn(μ<sup>2</sup>-SCH<sub>2</sub>COO)CI] with Good Biological Activity <i>In Vitro</i> Anti-Tumor

Five-coordinated anionic tin (IV) complexes [C5H5NH][Ph2Sn (μ2-SCH2COO)C was synthesized by the reaction of mercaptoacetic acid with diphenyltin dichloride in the present of pyridine. The structure was characterized by elemental analysis, IR, 1H NMR. The crystal structure of [C5H5N[Ph2Sn (μ2-SCH2COO)C was determined by X-ray crystallography. The structure consists of an anion part, and a pyridinium cation part as a counterion. The tin atom has a distorted cis-tbp geometry with two carbon and one sulfur atoms occupying the equatorial positions and the o atom and Cl atom occupying the axial positions. We tested the activity of the product in vitro antitumor for A-549, HCT-8 and Bel-7402, results showed that the compound has a strong anti-tumor activity for A-549, HCT-8, IC50 values were 0.91 and 0.34 μg ml-1, respectively.

Synthesis and spectral characterization of stannocanes of the type [O(CH2CH2S)2SnR2](R=Me1,Bun2,Ph3)

Abstract The stannocanes of the type [O(CH2CH2S)2SnR2](R=Me1,Bun2,Ph3) have been synthesized in an improved method by the reaction of R2SnCl2 with 2, 2′-oxydiethanethiol O(CH2CH2SH)2 in molar ratio of 1:1 at the presence of sodium ethoxide in anhydrous ethanol. The reactions are carried out under inert atmosphere. These compounds have been extensively characterized by FT-IR, UV-Vis spectrophotometry, multi-nuclear (1H, 13C, 119Sn) NMR, elemental analysis and mass spectrometry. The obtained data clearly indicates that, there is a strong interaction between oxygen atom of the ligand as a donor and Sn atom of the organotin species as a Lewis acid acceptor. Therefore, the resulted dithiostannocanes possess a transannular secondary bonding and hypervalency at the central Sn atom which leads to an increase in the coordination number of tin from four to five-coordinated tin.

Synthesis and structural studies of diorganotin(IV) compounds derived from (E)-3-hydroxy-2-((2-hydroxybenzylidene)amino)propanoate and (E)-3-hydroxy-2-((1-(2-hydroxyphenyl)ethylidene)amino)propanoate

Five new diorganotin(IV) compounds were prepared by reacting diorganotin dichlorides R2SnCl2 (R = Me, nBu and Ph) with sodium salts of the tridentate NO2 ligands (E)-3-hydroxy-2-((2-hydroxybenzylidene)amino)propanoic acid (L1H2Na) and (E)-3-hydroxy-2-((1-(2-hydroxyphenyl)ethylidene)amino)propanoic acid (L2H2Na). The molecular structures of the resulting diorganotin (IV) compounds have been established by elemental analysis and a combination of IR and NMR (1H, 13C, 119Sn) spectroscopy. In all cases, the 119Sn NMR chemical shifts were indicative of five-coordinate tin atoms in solution. However, investigation of compounds [Me2SnL1H]·H2O (1), [Ph2SnL1H]·2C6H6 (3), [Me2SnL2H]·CHCl3 (4) and [Ph2SnL2H] (5) by single-crystal X-ray diffraction revealed that only compound 3 has a distorted trigonal–bipyramidal geometry in the solid state. For compounds 1, 4 and 5 the coordination geometries are distorted octahedral, either due to intermolecular association through Sn⋯O interactions (1) or coordination through the oxygen atom from the pendant CH2OH group (4 and 5). At the supramolecular level, the molecular structures are linked through O–H⋯O hydrogen bonds to give discrete dimeric assemblies (4), 1D chains (3, 5) and 2D hydrogen bonded layers (1).

Triorganotin(IV) complexes with substituted benzeneseleninic acids: syntheses, characterization, crystal structures, and antitumor activity

Nine new organotin(IV) selenites have been prepared by the reaction of 2-methylbenzeneseleninic acid, 2-methoxybenzeneseleninic acid, 4-isopropylbenzeneseleninic acid, and the corresponding triorganotin(IV) chloride with sodium ethoxide in methanol. The complexes have been characterized by elemental analysis, FT-IR, (1H, 13C, and 119Sn) NMR spectroscopy, and thermogravimetric analysis. Except for 3, 6, and 9, all of the complexes were also characterized by X-ray crystallography diffraction analyses. The structural analyses reveal that 1, 2, 4, 5, 7, and 8 exhibit 1-D infinite chain structures which are generated by bidentate oxygen atoms and five-coordinated tin. Complex 5 forms a 2-D organotin framework linked by intermolecular C–H ··· O interactions. Additionally, 1 and 2 were tested for antitumor activity in vitro.

Synthesis, characterizations, and crystal structures of triorganotin(IV) derivatives with areneseleninic acids

Six new triorganotin(IV) complexes, [R 3Sn(O 2SeC 6H 4Cl)] n (R = Me 1; Ph 2), [R 3Sn(O 2SeC 6H 4Me)] n (R = Me 3; Ph 4), [R 3Sn(O 2SeC 6H 4Bu)] n (R = Me 5; Ph 6) have been synthesized by the reaction of 4-chlorobenzeneseleninic acid, p-Tolueneseleninic acid, and 4- tert-butylbenzeneseleninic acid with triorganotin(IV) chloride in the presence of sodium ethoxide. All of the complexes were characterized by elemental analysis, FT-IR, NMR ( 1H, 13C, and 119Sn) spectroscopy, and X-ray crystallography. Crystal structures show that all of the complexes exhibit 1D infinite chain structures which are generated by the bidentate oxygen atoms and the five-coordinated tin centers.

Structural study on a sulfido-bridged dinuclear organotin(IV) complex with weak Sn ··· Sn bonding

A dinuclear anionic complex, Bu4N[Me2SnCl(S)ClSnMe2Br], has been synthesized in chloroform solution by reacting (Me2SnS)3, Me2SnCl2, and Bu4NBr. Attempts to isolate the anionic complex using tetramethylammonium cation were unsuccessful. The anion possesses two five-coordinate tin(IV) units bridged by sulfide and bromide. X-ray diffraction study revealed the possibility of a weak Sn–Sn bond in the complex. Theoretical (DFT) studies have been carried out to analyze the nature of metal–metal interaction in the complex.

Self-assembly syntheses and crystal structures of triorganotin(IV) pyridinecarboxylate: 1D polymers and a 42-membered macrocycle

A series of new triorganotin(IV) pyridinecarboxylates with 6-hydroxynicotinic acid (6-OH-3-nicH), 5-hydroxynicotinic acid (5-OH-3-nicH) and 2-hydroxyisonicotinic acid (2-OH-4-isonicH) of the types: [R 3Sn (6-OH-3-nic)·L] n ( I) (R = Ph, L = Ph·EtOH, 1; R = Bn, L = H 2O·EtOH, 2; R = Me, L = 0, 3; R = n-Bu, L = 0, 4), [R 3Sn (5-OH-3-nic)] n ( II) (R = Ph, 5; R = Bn, 6; R = Me, 7; R = n-Bu, 8), [R 3Sn (2-OH-4-isonic·L)] n ( III) (R = Bn, 9, L = MeOH; R = Me, L = 0, 10; R = Ph, 11, L = 0.5EtOH) have been synthesized. All the complexes were characterized by elemental analysis, TGA, IR and NMR ( 1H, 13C, 119Sn) spectroscopy analyses. Among them, except for complexes 5 and 6, all complexes were also characterized by X-ray crystallography diffraction analysis. Crystal structures show that complexes 1– 10 adopt 1D infinite chain structures which are generated by the bidentate O, O or N, O and the five-coordinated tin centers. Significant O–H⋯O, and N–H⋯O intermolecular hydrogen bonds stabilize these structures. Complex 11 is a 42-membered macrocycle containing six tin atoms, and forms a 2D network by intermolecular N–H⋯O hydrogen.

Synthesis, crystal structure and biological activities of two novel organotin(IV) complexes constructed from 12-(4-methylbenzoyl)-9,10-dihydro-9,l0-ethanoanthracene-11-carboxylic acid

Two complexes: [( n-Bu 2Sn) 4(L) 2O 2(OC 2H 5) 2] ( 1) and [(C 6H 5) 3Sn(L)] ( 2) (where, HL is 12-(4-methylbenzoyl)-9,10-dihydro-9,10-ethanoanthracene-11-carboxylic acid) have been prepared and structurally characterized by means of elemental analysis and vibrational, 1H NMR and FT-IR spectroscopies. The crystal structures of 1 and 2 have been determined by X-ray crystallography. Three distannoxane rings are present to the centrosymmetric dimeric tetraorganodistannoxane by virtue of μ 3-oxo form the central R 4Sn 2O 2 core with a planar Sn 2O 2 ring, resulting in a ladder type structural motif in the molecular structure of 1, and five-coordinated tin atoms are present in the distannoxane dimer. While the molecular of 2 adopts a monomeric distorted tetrahedral configuration with the carboxylate ligand coordinating in a monodentate mode. Both 1 and 2 exhibited good antibacterial and antitumour activities and have a potential to be used as drugs.