Final Event Research Articles

Chemical-Specific T Cell Tests Aim to Bridge a Gap in Skin Sensitization Evaluation

T cell activation is the final key event (KE4) in the adverse outcome pathway (AOP) of skin sensitization. However, validated new approach methodologies (NAMs) for evaluating this step are missing. Accordingly, chemicals that activate an unusually high frequency of T cells, as does the most prevalent metal allergen nickel, are not yet identified in a regulatory context. T cell reactivity to chemical sensitizers might be especially relevant in real-life scenarios, where skin injury, co-exposure to irritants in chemical mixtures, or infections may trigger the heterologous innate immune stimulation necessary to induce adaptive T cell responses. Additionally, cross-reactivity, which underlies cross-allergies, can only be assessed by T cell tests. To date, several experimental T cell tests are available that use primary naïve and memory CD4+ and CD8+ T cells from human blood. These include priming and lymphocyte proliferation tests and, most recently, activation-induced marker (AIM) assays. All approaches are challenged by chemical-mediated toxicity, inefficient or unknown generation of T cell epitopes, and a low throughput. Here, we summarize solutions and strategies to confirm in vitro T cell signals. Broader application and standardization are necessary to possibly define chemical applicability domains and to strengthen the role of T cell tests in regulatory risk assessment.

AOP report: Development of an adverse outcome pathway for deposition of energy leading to abnormal vascular remodeling.

Cardiovascular diseases (CVDs) are complex, encompassing many types of heart pathophysiologies and associated etiologies. Radiotherapy studieshave shown that fractionated radiation exposure at high doses (3-17 Gy) to the heart increases the incidence of CVD. However, the effects of low doses of radiation on the cardiovascular system or the effects from space travel, where radiation and microgravity are important contributors to damage, are not clearly understood. Herein, the adverse outcome pathway (AOP) framework was applied to develop an AOP to abnormal vascular remodeling from the deposition of energy. Following the creation of a preliminary pathway with the guidance of field experts and authoritative reviews, a scoping review was conducted that informed final key event (KE) selection and evaluation of the Bradford Hill criteria for the KE relationships (KERs). The AOP begins with a molecular initiating event of deposition of energy; ionization events increase oxidative stress, which when persistent concurrently causes the release of pro-inflammatory mediators, suppresses anti-inflammatory mechanisms and alters stress response signaling pathways. These KEs alter nitric oxide levels leading to endothelial dysfunction, and subsequent abnormal vascular remodeling (the adverse outcome). The work identifies evidence needed to strengthen understanding of the causal associations for the KERs, emphasizing where there are knowledge gaps and uncertainties in both qualitative and quantitative understanding. The AOP is anticipated to direct future research to better understand the effects of space on the human body and potentially develop countermeasures to better protect future space travelers.

Behavior of Polymeric Substrates and Sintered Silver Printed Hybrid Electronic Assemblies Subject to Extreme Acceleration Levels and Elevated Temperatures

Abstract This paper focuses on the response of printed hybrid electronic (PHE) assemblies with polymeric substrates and additively manufactured sintered silver electrical traces subject to extreme mechanical shocks (up to 100,000 g) and high temperatures (up to 150 °C). The substrates are hemispherical domes of injection-molded polycarbonate and polysulfone thermoplastics. Trace deposition onto the domes is accomplished by a novel process that combines conventional milling with extrusion printing to recess silver traces and dielectric insulation within the surface of the substrate. Mechanical shock testing is performed using an accelerated-fall drop tower equipped with a dual mass shock amplifier (DMSA) able to generate accelerations from 10,000 g up to 100,000 g with pulse durations of ∼0.05–0.1 ms and impact velocities of 6.5–20.5 m/s. Specimen performance is characterized by electrical and physical testing before and after testing. While polycarbonate domes survive multiple drops at all acceleration levels and temperatures, they are sensitive to heat and susceptible to warping and structural deformation at 150 °C which can compromise trace performance. Polysulfone domes can survive these temperatures without issue, but are less shock resistant and only survive 3–4 drops at 100,000 g (compared to 30+ for polycarbonate domes). Trace resistance is used as a metric to assess trace performance. All traces exhibit progressive long-term degradation over the course of multiple shocks, followed by instantaneous discontinuity during the final shock event. Trace failure (defined as the doubling of static trace resistance) occurs at ∼105–106 J/kg cumulative impact energy for all acceleration levels.

Young Doctors Program-Colorado: An Elective Elementary School Program to Improve Health Literacy, Utilization of the Healthcare System, and Osteopathic Awareness

AbstractThe Young Doctors Program (YDP) is a “mini medical school” series for fifth-grade elementary children. The YDP was designed and led by medical students in the Academic Medicine and Leadership Track at the Rocky Vista University College of Osteopathic Medicine in Colorado. The curriculum of the program was designed around the State of Colorado Learning Standards with the purpose of educating students about emergencies and common ailments in five body systems (cardiovascular, respiratory, gastrointestinal, musculoskeletal, and renal) while also providing exposure to healthcare as a profession. YDP provides children with insights into the healthcare system, an introduction to osteopathic medicine, and it enhances community outreach. This article provides a framework for the semester-long YDP curriculum as well as our final event which synthesizes learned information using standardized patients. We describe successes including community outreach and healthcare exposure in the elementary school, and challenges initiating connections with local schools and funding. Future goals include expanding outreach to other fifth-grade schools as well as growth to different age levels. Authors plan to pursue IRB approval for research to examine the benefits and efficacy of the YDP.

Use of logical-graphic methods of analysis of risks in the water supply systems of thermal power plants

Today's urgent issues in the water supply of thermal power plants are increasing the efficiency of production processes, reducing energy costs, introducing innovative technologies, as well as ensuring environmental safety and sustainable development. The analysis of the causes of industrial accidents and damages shows that the occurrence and development of accidents, as a rule, is characterized by a combination of random local events that occur with different frequency at different stages of the accident. Logical-graphic methods of fault trees and events are used to identify cause-and-effect relationships between these events. In order to investigate the identification and analysis of cause-and-effect relationships that contribute to the occurrence of failures in the water treatment system using a fault tree for the further development of effective measures to minimize risks and increase the reliability and safety of the water supply systems of thermal power plants, it is proposed to use logical-graphic methods on the previous stage of identification and assessment of technogenic risks. The analysis of the obtained results showed that: 1) the fault tree is an instantaneous display of the system at a certain moment in time t and is a graphical representation of the cause-and-effect relationships obtained as a result of identifying dangerous situations in the system in a forward and reverse order in order to find possible causes of their occurrence; 2) a complex final event should be determined using the so-called «tree top». The top of the tree consists of the final event and additional undesirable events, including potential accidents and dangerous conditions that are direct causes of the final event. The final event and additional events must be carefully defined and all the most important causes of the final event identified. Therefore, the first five heuristic rules must be used when building a rejection tree; 3) construction of a fault tree using heuristic rules can be used when considering any element of the system, however, to simplify cumbersome constructions, it is more appropriate to build trees only for the main elements that cause emergency situations and have a negative impact on people's lives and health, as well as on environment; 4) when building a fault trees for the technological scheme of water treatment, it is possible to specify and quantify events, to find events with a very high probability and a very low probability, to limit the further development of the fault trees and to establish the causes of failures at each stage of the water treatment process; 5) the rejection tree can be used for quantitative assessments using Markov models.

Reconstructing deep-sea oxygenation in the Western Alboran Sea Basin during Late Pleistocene-Holocene (last 37 kyrs): Insights from a multiproxy approach

A deep-sea sediment record from the Western Alboran Basin spanning the last 37 kyr has been analysed using a multiproxy approach, integrating sediment colour, magnetic susceptibility, elemental ratios, benthic foraminiferal assemblages and bioturbation, gaining new insights into Alboran Basin deep-sea environments and palaeoceanographic conditions since the Last Glacial Maximum. The combination of a diverse set of proxies made it possible to recognise the diagenetic signals and reconstruct new low-frequency events in the deep basin, recording the significant fluctuations in deep water oxygenation occurred during the studied period. From the studied data, short-term periodic low-oxygen events are recognised during Heinrich Stadials 2 and 3 (HS2 and HS3) and Greenland Interstadial GI8, showing important responses of the deep sea environments to climate climate change. Furthermore, the presence of a not previously well-defined Organic Rich Layer 2 (ORL 2) can be defined from the observations as a sequence of events transitioning between low oxygen (associated with humid conditions and Heinrich Events) and oxygenated conditions, and not as a singular low oxygenation event. In addition, the Organic Rich Layer 1 (ORL1), associated with the most recent low oxygen event has been also recognised in the record, with low oxygen conditions starting as early as 16 kyr before the present (BP) during the HS1 and spanning to 8 kyr BP with important fluctuations in environmental conditions and oxygenation. Several climate events that have been previously recognised in the Northern Hemisphere and the Mediterranean Basin can be linked to the observed changes in oxygen conditions during ORL1 deposition, for instance reoxygenation that occurred during the pre-ORL1, between the demise of Heinrich Event 1.1 (HE1.1) and the end of HS1 and the inception of the Bølling-Allerød (BA); the start of ORL1 deposition during BA with the onset of low oxygen conditions. Interestingly, the BA is punctuated by short duration reoxygenation events that can be recognised in the record and correlated to cold events observed in the North Atlantic records. In addition, there is a partial discontinuous reoxygenation during the Younger Dryas (YD), observed also in the Eastern Mediterranean and in other Mediterranean sites which was followed by the return to lower-oxygen conditions after the YD, coinciding with the start of S1 deposition. Finally, the final reoxygenation event occurs at around 8 kyr BP along with the demise of the ORL1.

Contribution of the Moon-forming Impactor to the Volatile Inventory in the Bulk Silicate Earth

The timing and mechanism by which the present-day inventory of life-essential volatiles hydrogen–carbon–nitrogen–sulfur (H–C–N–S) in the bulk silicate Earth (BSE) was established are debated. In this study we have modeled the equilibrium partitioning of H–C–N–S between core, magma ocean (MO), and atmosphere to determine whether the Moon-forming impactor (MFI) was the primary source of volatiles in the BSE. Our findings suggest that the MFI’s core and MO-degassed atmosphere were its primary H–C–N–S reservoirs. Since the MFI likely lost its MO-degassed atmosphere before the giant impact, most of the BSE’s volatiles must come from the small fraction of the MFI’s core which reequilibrated with Earth’s post-impact MO. This implies a high H–C–N–S inventory in the MFI (up to 50% of volatile-rich carbonaceous chondrites) to establish the BSE’s volatile budget. Although isotopic compositions of nonvolatile elements do not rule out the possibility of substantial volatile-rich, carbonaceous material accretion, MFI’s collisional growth from thermally metamorphosed/differentiated planetesimals makes it improbable that it contained ∼50% carbonaceous chondrite equivalent of H–C–N during its differentiation. Therefore, the MFI was unlikely the primary source of volatiles in the BSE. A significant portion of the BSE’s volatile inventory (especially H and C) likely predates the Moon-forming event. To prevent loss to space and segregation into Earth’s core, volatile-bearing materials must be delivered during the final accretion event(s) preceding the Moon-forming event. The substantial size of the proto-Earth at this stage, combined with limited metal–silicate equilibration during the Moon-forming event, facilitated the retention of these volatiles within the BSE.

Chain-Length Dependence of Peptide-Lipid Bilayer Interaction Strength and Binding Kinetics: A Combined Theoretical and Experimental Approach.

Physical interactions between polypeptide chains and lipid membranes underlie critical cellular processes. Yet, despite fundamental importance, key mechanistic aspects of these interactions remain elusive. Bulk experiments have revealed a linear relationship between free energy and peptide chain length in a model system, but does this linearity extend to the interaction strength and to the kinetics of lipid binding? To address these questions, we utilized a combination of coarse-grained molecular dynamics (CG MD) simulations, analytical modeling, and atomic force microscopy (AFM)-based single molecule force spectroscopy. Following previous bulk experiments, we focused on interactions between short hydrophobic peptides (WLn, n = 1, ..., 5) with 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC) bilayers, a simple system that probes peptide primary structure effects. Potentials of mean force extracted from CG MD recapitulated the linearity of free energy with the chain length. Simulation results were quantitatively connected to bulk biochemical experiments via a single scaling factor of order unity, corroborating the methodology. Additionally, CG MD revealed an increase in the distance to the transition state, a result that weakens the dependence of the dissociation force on the peptide chain length. AFM experiments elucidated rupture force distributions and, through modeling, intrinsic dissociation rates. Taken together, the analysis indicates a rupture force plateau in the WLn-POPC system, suggesting that the final rupture event involves the last 2 or 3 residues. In contrast, the linear dependence on chain length was preserved in the intrinsic dissociation rate. This study advances the understanding of peptide-lipid interactions and provides potentially useful insights for the design of peptides with tailored membrane-interacting properties.

The significance of Paleoarchean granitoids from the Saglek Block, Labrador, Canada

The Saglek Block in the Nain Province of northeast Canada is part of the North Atlantic Craton. It comprises Archean gneisses that record magmatic and metamorphic ages between ca. 3.9 and 2.5 Ga. In this study, a grey banded gneiss from Maidmonts Island records an age of 3.72 Ga, which is equated with Uivak I gneisses reported from across the Saglek Block, and contains 3.8 Ga xenocrysts. These rocks were deformed and metamorphosed prior to the intrusion of augen gneiss protoliths on both Maidmonts and Mentzel islands that record U-Pb zircon ages of 3.33 Ga. These rocks are composed of ferroan calc-alkaline granite and granodiorite and were likely generated by partial melting of pre-existing quartzo-feldspathic crust, as attested by the presence of ca. 3.8 Ga xenocrysts. Such augen gneiss was previously classified as ca. 3.6 Ga ‘Uivak II gneiss’, a term we argue should now be abandoned. The final magmatic events recorded on Maidmonts and Mentzel islands took place in the Neoproterozoic with the emplacement of granitic stocks at ca. 2.72 Ga, and sills and dykes at ca. 2.57 Ga. This sequence of magmatic events from the Eoarchean to Neoarchean is very similar to that recorded in the Itsaq Gneiss Complex of southwest Greenland, where, based on the Hf signature, it has been suggested that a change in tectonic environment resulted from the initiation of subduction at ca. 3.2 Ga. Although Lu-Hf and Sm-Nd isotopic signatures from the ca. 3.33 Ga gneisses have been interpreted in the literature as due to partial melting of Hadean mafic crust, alternatively, they can be generated by partial melting of Eoarchean continental crust in a continental arc setting. We argue this is more consistent with the non-TTG geochemistry of the augen gneisses.

Paleostress constraints on the tectonic evolution of the Central High Atlas orogen

The Central High Atlas is distinguished by map-scale, sigmoid, and narrow magmatic-cored ridges, which separate wide and open synclines. The origin of these structures has been debated for years. This study addresses this issue from a paleostress perspective, using mesostructural analysis in the Imilchil region and incorporating insights from previous research.Our analysis reveals that the Central High Atlas ridges developed through two main structural stages from the Jurassic to the Cenozoic. The first stage involved an extensional event characterized by NW-SE-oriented σ3, coeval with the Early Jurassic Tethyan extension. This was followed by wrench tectonics driven by oblique left-lateral motion of Africa with respect to Europe. This events is marked within the Central High Atlas by ENE-WSW-oriented σ1 and NNW-SSE-oriented σ3. The basin-scale left-lateral motion likely drove the formation of sigmoid stepovers, facilitating the emplacement of magmatic bodies from the Middle Jurassic to the Early Cretaceous. The second deformation stage is likely associated with the convergence between Africa and Europe and the consecutive Alpine orogeny. In the study area, this stage consists of three events: a pre-folding strike-slip event with NNE-SSW to N–S-oriented σ1, and a pre-folding strike-slip event with NW-SE-oriented σ1. Near the diapirs, the analyzed mesostructures display syn-to post-folding patterns in some locations, indicating pre-Alpine layer tilting driven by salt tectonics. The final event is marked by significant post-folding NW-SE compression, associated with the Central High Atlas basin inversion and the compaction of pre-existing magmatic-cored salt diapirs.This study highlights the complex deformation history that has influenced the evolution of the Central High Atlas ridges and provides evidence of the significant role of strike-slip tectonics during the post-rift period and magmatic emplacement, as well as in the early phases of basin inversion.

Remote Functionalization by Pd-Catalyzed Isomerization of Alkynyl Alcohols.

In recent years, progress has been made in the development of catalytic methods that allow remote functionalizations based on alkene isomerization. In contrast, protocols based on alkyne isomerization are comparatively rare. Herein, we report a general Pd-catalyzed long-range isomerization of alkynyl alcohols. Starting from aryl-, heteroaryl-, or alkyl-substituted precursors, the optimized system provides access preferentially to the thermodynamically more stable α,β-unsaturated aldehydes and is compatible with potentially sensitive functional groups. We showed that the migration of both π-components of the carbon-carbon triple bond can be sustained over several methylene units. Computational investigations served to shed light on the key elementary steps responsible for the reactivity and selectivity. These include an unorthodox phosphine-assisted deprotonation rather than a more conventional β-hydride elimination in the final tautomerization event.

Structural anatomy of the newly recognized Paleozoic Dacaotan composite mélange belt: Implications for the subduction-accretion processes in the North Tianshan Ocean, southwestern Central Asian Orogenic belt

The North Tianshan Belt occupies a pivotal geological position within the southwestern Central Asian Orogenic Belt, making it an ideal location to unravel the long-term evolutionary history of the North Tianshan Ocean. However, how, and when the Tianshan oceanic basin was finally consumed and closed remains highly debated. To resolve these questions, here, we conducted a comprehensive investigation of the different litho-tectonic assemblages of the Dacaotan composite mélange belt in the North Tianshan Belt. Using detailed geological mapping, structural analyses, rock associations, and new geochemical and geochronological data, we divide the Dacaotan composite mélange belt into three litho-tectonic assemblages: (1) the southern sedimentary forearc (ca. 423–398 Ma) assemblage that is characterized by relatively coherent and well-bedded flysch sequences; (2) the central supra-subduction zone-type ophiolitic mélange assemblage (ca. 468–461 Ma) consisting of petrogenetically linked upper mantle and oceanic crustal components, which are exposed as tectonic slices or blocks within a serpentinite and sedimentary matrix; and (3) the northern accreted ocean plate stratigraphy mélange assemblage (ca.448–398 Ma) that is composed of accreted trench-fill turbidites, seamounts (OIB-like basic rocks) and ocean floor rocks (MORB-like basic rocks) dispersed in a sandy to pelitic matrix. Post-kinematic pluton and dyke reveal that the final accretionary event was completed prior to ca. 371 Ma. In conjunction with the spatial–temporal configurations of the different litho-tectonic assemblages, we conclude that the North Tianshan Ocean underwent bi-directional subduction and intra-oceanic subduction events during the Early Paleozoic. Our findings suggest the final consumption of the North Tianshan Ocean basin occurred before the Latest Devonian, resulting in the formation of the ultimate suture between the Central Tianshan Block and the North Tianshan Belt along the Kanggguertag-Dacantao composite mélange belt.

Wall heating by subcritical energetic electrons generated by the runaway electron avalanche source *

Subcritical energetic electrons (SEEs) produced by the runaway electron (RE) avalanche source at energies below the runaway threshold are found to be the primary contributor to surface heating of plasma-facing components (PFCs) during final loss events. This finding is supported by theoretical analysis, computational modeling with the Kinetic Orbit Runaway electrons Code (KORC), and qualitative agreement with DIII-D experimental observations. The avalanche source generates significantly more secondary electrons below the runaway threshold, which thermalize rapidly when well-confined. However, during a final loss event, the RE beam impacts the first wall, and SEEs are deconfined before they can thermalize. Additionally, because the energy deposition length decreases faster than energy, the deposited energy density, and thus the maximum PFC surface temperature change, is larger for SEEs than REs. KORC simulations employ an analytic first wall to model particle deconfinement onto a non-axisymmetric wall composed of individual tiles. PFC surface heating is calculated using a 1D model extended to include an energy-dependent deposition length scale. Simulations of DIII-D qualitatively agree with infrared (IR) imaging only when SEEs from the avalanche source are included. These results demonstrate that SEEs are the dominant contributor to PFC surface heating and indicate that the avalanche source plays a critical role in the PFC damage caused during final loss events. The prominence of SEEs also has important implications for interpreting IR imaging, one of the primary diagnostics for RE-wall interaction diagnosis, despite REs dominating the energy and current density. This result improves predictions of wall damage due to post-disruption REs to estimate material lifetime and design RE mitigation systems for ITER and future reactors.

Stressful crystal histories recorded around melt inclusions in volcanic quartz

Magma ascent and eruption are driven by a set of internally and externally generated stresses that act upon the magma. We present microstructural maps around melt inclusions in quartz crystals from six large rhyolitic eruptions using synchrotron Laue X-ray microdiffraction to quantify elastic residual strain and stress. We measure plastic strain using average diffraction peak width and lattice misorientation, highlighting dislocations and subgrain boundaries. Quartz crystals across studied magma systems preserve similar and relatively small magnitudes of elastic residual stress (mean 53–135 MPa, median 46–116 MPa) in comparison to the strength of quartz (~ 10 GPa). However, the distribution of strain in the lattice around inclusions varies between samples. We hypothesize that dislocation and twin systems may be established during compaction of crystal-rich magma, which affects the magnitude and distribution of preserved elastic strains. Given the lack of stress-free haloes around faceted inclusions, we conclude that most residual strain and stress was imparted after inclusion faceting. Fragmentation may be one of the final strain events that superimposes stresses of ~ 100 MPa across all studied crystals. Overall, volcanic quartz crystals preserve complex, overprinted deformation textures indicating that quartz crystals have prolonged deformation histories throughout storage, fragmentation, and eruption.

PSVI-10 Effect of sulfate or hydroxychloride forms of zinc, manganese, and copper on growth performance, weight variation, and carcass characteristics of grow-finish pigs

Abstract A total of 1,026 grow-finish pigs (337 × 1050, PIC; initially 26.0 ± 0.33 kg) were used in a 124-d trial to compare sulfate and hydrochloride forms of Zn, Mn, and Cu on growth performance, carcass characteristics, and weight variation, of grow-finish pigs. Pigs were housed in mixed gender pens with 27 pigs per pen and 19 pens per treatment. The treatments were structured as a completely randomized design and consisted of a control diet containing 150, 16, and 110 mg/kg of Cu, Mn, and Zn, respectively, from sulfate sources or provided by hydroxychloride sources. Experimental diets were corn-soybean meal-corn-dried distiller grains with solubles based and fed in meal form in phase 1 from 26 to 50 kg, phase 2 from 50 to 75 kg, phase 3 from 75 to 100 kg, and phase 4 from 100 to 136 kg. In the grower period (26 to 78 kg), pigs fed sulfate sources of Mn, Zn, and Cu had improved (P = 0.05) gain to feed ratio (G:F) compared with pigs fed hydroxychloride forms (Table). In the finisher period (78 to 136 kg), pigs fed hydroxychloride mineral sources had improved (P = 0.041) average daily gain (ADG) compared with pigs fed sulfate sources. For pig body weight variability, there was no evidence of differences (P > 0.10) in the coefficient of variation between treatments. Pigs fed hydroxychloride mineral sources tended to have greater hot carcass weight (HCW; P = 0.054) when marketed at the end of the study compared with pigs fed sulfate sources, but no evidence for differences (P > 0.10) were found in the first marketing and overall HCW or any other carcass trait at either marketing event. In conclusion, these data suggest there were no differences in overall pig growth performance or body weight (BW) variability, but pigs fed hydroxychloride sources of Zn, Mn, and Cu tended to have heavier HCW at the final marketing event.

National Mythscapes and Popular New Zealand Rugby Histories: Representing the 1986 Cavaliers

This paper explores Duncan Bell’s heuristic of the mythscape as a means to conceptualize the nationalistic narrativization of the sporting past. Bell approaches the forging of national identity through evocations of the past as mythologized: that is, partial, contested, power-laden, and perpetually mutating. First, we introduce Bell’s concept as a means to evaluate the selective, contested and shifting construction of the sporting past through the prism of nationalism. We first chart the narrativisation of the New Zealand – South African rugby rivalry within popular literature during the apartheid era (1948–1994). This was characterized by the production of ‘governing’ myths and oppositional narrations from the 1960s onward. We then evaluate subsequent post-apartheid narrativizations (1994 onwards) within popular rugby histories, focussing on the 1986 Cavaliers rugby tour to South Africa – the final event in apartheid-era rugby ties between the two nations. We explore how writers use particular narratives, and what they have chosen to exclude, and how it informs a national mythscape. We find the rehabilitation of governing myths that sanitize and redact connections between New Zealand rugby and apartheid. This is symptomatic of a selective construction that valorizes rugby as a idealized national institution. Finally, we offer comments on the utility of the mythscapes concept.

Influence of clay content on repeated liquefaction resistance of sand using element test

Soil liquefaction is a major concern because of its potential to cause building collapse, roadbed settlement, and sand eruptions. Field investigations have shown that clayey sand, when liquefied during mainshock, may undergo multiple liquefaction events during the subsequent aftershocks. Although previous research has primarily focused on the initial liquefaction event in clayey sand, research on the mechanism responsible for repeated liquefaction is limited. Consequently, a series of cyclic triaxial experiments are conducted on sand with varying clay contents, and these samples are subjected to various earthquake sequences. The primary objective of this study is to evaluate the cyclic behavior of sandy soil with clay content and analyze its repeated liquefaction resistance under different load sequences. A comprehensive assessment is conducted to understand the evolution of the repeated liquefaction resistance. The test results indicate that clayey sand exhibits the lowest liquefaction resistance during the second liquefaction event. Repeated liquefaction is dominated by stress-induced anisotropy at earlier events and relative density at the final events.

Learning Event Representations for Zero-Shot Detection via Dual-Contrastive Prompting

Zero-shot event detection aims to involve the automatic discovery and classification of new events within unstructured text. Current zero-shot event detection methods have not considered addressing the problem more effectively from the perspective of improving event representations. In this paper, we propose dual-contrastive prompting (COPE) model for learning event representations to address zero-shot event detection, which leverages prompts to assist in generating event embeddings using a pretrained language model, and employs a contrastive fusion approach to capture complex interaction information between trigger representations and sentence embeddings to obtain enhanced event representations. Firstly, we introduce a sample generator to create ordered contrastive sample sequences with varying degrees of similarity for each event instance, aiding the model in better distinguishing different types of events. Secondly, we design two distinct prompts to obtain trigger representations and event sentence embeddings separately. Thirdly, we employ a contrastive fusion module, where trigger representations and event sentence embeddings interactively fuse in vector space to generate the final event representations. Experiments show that our model is more effective than the most advanced methods.

Hemorrhage Expansion Rates Before and After Minimally Invasive Surgery for Intracerebral Hemorrhage: Post Hoc Analysis of MISTIE II/III

Background Stereotactic thrombolysis for evacuation of large spontaneous intracerebral (ICH) and intraventricular hemorrhage (IVH) typically requires stabilizing the hemorrhage preoperatively. We investigated intracranial hemorrhage expansion (HE) in the pre‐ and postrandomization phase of 2 clinical trials of surgical candidates with protocolized computed tomography (CT) imaging up to 10 days after presentation. Methods Prospective assessment of sequential pre‐ and post‐randomization CT scans of 141 patients enrolled in MISTIE (Minimally Invasive Surgery Plus Alteplase for Intracerebral Hemorrhage Evacuation) II/ICES (Intraoperative CT‐guided Endoscopic Surgery for ICH) and 499 patients enrolled in MISTIE III. Primary outcomes were prerandomization HE of ICH >6 mL and IVH >5 mL. Secondary outcome was postrandomization HE. Stability was defined as CT time after which no further HE was observed. We evaluated risk factors for ICH/IVH expansion using multivariable logistic regression analyses after adjustment for demographics, ICH characteristics and treatment. Results Median (interquartile range) diagnostic ICH volume was 40.4 (29.5–54.1) mL. Prerandomization HE >6 mL was detected in 216 (33.8%) subjects. Median time to hematoma stability from diagnostic CT was 7 (4.7–13.6) hours. Median diagnostic IVH volume was 0 (0–1.9) mL. IVH expansion >5 mL occurred in 40 (6.3%) with stability at 6.9 (4.7–11.2) hours. Of subjects with HE, final expansion events were not yet detected at 12 hours from diagnostic CT in 36% (ICH expansion) and 33% (IVH expansion), respectively, with 91% detected by 24 hours. Independent associations with ICH expansion included age, male sex, White race, anticoagulation, ICH volume, deep ICH location, IVH, and time from symptom onset to diagnostic CT. Postsurgical ICH expansion occurred in 24 patients (6.9%) and was associated with delay in achieving stability, number of alteplase doses, and fewer CT hypodensities on diagnostic CT but not with functional outcome. Conclusion In patients with a large ICH eligible for surgical evacuation, about two thirds of HE events stabilize within 12 hours and most within 24 hours. An earlier time window for stereotactic thrombolysis may be feasible.

The large granitic pegmatite Li deposits formed at final collision of a three micro-continent amalgamation in the Central Altun Tagh, Northwest China

Micro-continent collision and amalgamation play pivotal roles in continental convergence and contribute significantly to continental crustal growth. However, the understanding of multiple micro-continent amalgamation processes, particularly their influence on the formation of large Li-Be deposits, remains limited. The Altun orogenic system, resulting from the collision and amalgamation of three micro-continents in the Proto-Tethys Ocean, has recently revealed numerous granitic pegmatite-type Li-Be deposits, presenting an ideal opportunity to investigate the mineralization. Our research focused on two large granitic pegmatite Li deposits, South Washixia and Tamuqie in the Central Altun Tagh, Northwest China. Our findings suggest: 1) The structural and photomicrograph characteristics observed in both the Tamuqie and South Washixia granitic pegmatite Li deposits, indicate that the pegmatites emplaced in shear zone within a contractional deformation zone. 2) The age of the large granitic pegmatite Li deposit in South Washixia between 447 ∼ 445 Ma, while the Tamuqie Li pegmatites formed at 448 Ma with Li-barren pegmatites formed at around 418 Ma. It is suggested that the large granitic pegmatite Li deposit in the Central Altun Block, encompassing South Washixia and Tamuqie granitic pegmatite Li deposits, originated during the final collision event of three micro-continent blocks (Qaidam, Altun-Qilian, and Dunhuang-Alex). We suggest that during the final collision and amalgamation event of multiple micro-continents triggering intense compression and thickening of the crust, and the thickened lower crust may undergo shear-driven dehydration melting of biotite in granulite facies to produce large-volume granitic magmas. These magmas crystallize and differentiate into lithium-rich pegmatitic magmas along shear zones, forming large lithium pegmatite deposits. Our research presents a novel mechanism for the formation of granitic pegmatite Li deposits, which emphasizes the role of shear-driven dehydration melting during the final collision and amalgamation events of three micro-continents.